Mutagenetix > Incidental Mutation

Incidental Mutation 'FR4737:Alpk3'

511661

Institutional Source

Beutler Lab

Gene Symbol

Alpk3

Ensembl Gene

ENSMUSG00000038763

Gene Name

alpha-kinase 3

Synonyms

Midori

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.322) question?

Stock #

FR4737 ()

Quality Score

210.482

Status

Not validated

Chromosome

Chromosomal Location

81057600-81105612 bp(+) (GRCm38)

Type of Mutation

small insertion (1 aa in frame mutation)

DNA Base Change (assembly)

TCT to TCTACT at 81077762 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000102971 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000107348]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000107348

SMART Domains

Protein: ENSMUSP00000102971
Gene: ENSMUSG00000038763

Domain	Start	End	E-Value	Type
low complexity region	2	21	N/A	INTRINSIC
low complexity region	48	62	N/A	INTRINSIC
IGc2	89	159	2.78e-11	SMART
low complexity region	183	192	N/A	INTRINSIC
low complexity region	400	427	N/A	INTRINSIC
low complexity region	514	532	N/A	INTRINSIC
low complexity region	586	598	N/A	INTRINSIC
low complexity region	958	971	N/A	INTRINSIC
low complexity region	1048	1058	N/A	INTRINSIC
low complexity region	1076	1087	N/A	INTRINSIC
IG_like	1264	1330	5.73e-2	SMART
low complexity region	1350	1359	N/A	INTRINSIC
Alpha_kinase	1395	1592	1.17e-44	SMART

Coding Region Coverage

1x: 99.8%
3x: 99.6%
10x: 98.8%
20x: 97.0%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a gene-trappped allele exhibit altered cardiomyocyte architecture and develop a non-progressive cardiomyopathy that presents features of both hypertrophic and dilated forms of cardiomyopathy, [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 211 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001K19Rik	TCT	TCTCCT	12: 110,668,448 (GRCm38)		probably benign	Het
A630001G21Rik	CTGTT	CT	1: 85,723,135 (GRCm38)		probably benign	Homo
Abcb11	C	A	2: 69,243,518 (GRCm38)	R1221L	probably damaging	Homo
Abcb4	GAAA	G	5: 8,896,597 (GRCm38)		probably benign	Homo
Ahdc1	CT	CTCGT	4: 133,062,759 (GRCm38)		probably benign	Homo
Amfr	C	G	8: 94,005,159 (GRCm38)	G30R	probably damaging	Homo
Ankrd35	GC	GCTAC	3: 96,683,849 (GRCm38)		probably benign	Homo
Anxa7	C	T	14: 20,469,411 (GRCm38)	G113E	probably damaging	Homo
Apc	CAATAAAGC	CAATAAAGCTAATAAAGC	18: 34,281,999 (GRCm38)		probably benign	Homo
Apol6	GTTT	GTTTCTTT	15: 77,051,442 (GRCm38)		probably null	Homo
Arpc1b	GGTGGC	GGTGGCGTGGC	5: 145,126,787 (GRCm38)		probably null	Het
AY358078	C	T	14: 51,805,698 (GRCm38)	S281L	unknown	Homo
Blm	ACCTGC	ACCTGCCTGC	7: 80,463,771 (GRCm38)		probably null	Het
Blm	T	TACCA	7: 80,463,774 (GRCm38)		probably null	Het
Bltp1	TTATTAT	TTATTATTATTATTACTATTAT	3: 37,050,754 (GRCm38)		probably benign	Het
Blzf1	TTGT	TT	1: 164,303,917 (GRCm38)		probably null	Homo
Btnl10	A	AAGG	11: 58,923,931 (GRCm38)		probably benign	Homo
Cacna1a	ACC	ACCCCC	8: 84,638,726 (GRCm38)		probably benign	Homo
Cacna1a	ACC	ACCGCC	8: 84,638,720 (GRCm38)		probably benign	Het
Catsper2	TTC	TTCTTTTACTTTGTC	2: 121,397,540 (GRCm38)		probably benign	Homo
Ccdc170	AC	ACCCC	10: 4,561,029 (GRCm38)		probably benign	Het
Ccdc170	ACC	ACCTCC	10: 4,561,023 (GRCm38)		probably benign	Het
Ccdc73	TAAG	T	2: 104,991,840 (GRCm38)		probably benign	Homo
Ccnk	TTCCCAC	T	12: 108,202,507 (GRCm38)		probably benign	Het
Cdan1	A	C	2: 120,724,971 (GRCm38)	V763G	probably damaging	Het
Cdk6	A	G	5: 3,344,211 (GRCm38)		probably benign	Het
Cdx1	GCTGCT	GCTGCTTCTGCT	18: 61,019,878 (GRCm38)		probably benign	Het
Cdx1	TGCTGC	TGCTGCCGCTGC	18: 61,019,874 (GRCm38)		probably benign	Het
Cfap46	CCTTCT	CCTTCTTCT	7: 139,638,930 (GRCm38)		probably benign	Homo
Chd4	GC	GCTCCCCC	6: 125,122,131 (GRCm38)		probably benign	Homo
Cluh	CC	CCTGAGGC	11: 74,669,533 (GRCm38)		probably benign	Het
Cluh	GAGCCT	GAGCCTAAGCCT	11: 74,669,524 (GRCm38)		probably benign	Het
Cluh	AGCCTG	AGCCTGCGCCTG	11: 74,669,519 (GRCm38)		probably benign	Het
Cluh	CCCCGAGCC	CCCCGAGCCCGAGCC	11: 74,669,514 (GRCm38)		probably benign	Het
Cntnap1	AGCCCC	AGCCCCCGCCCC	11: 101,189,569 (GRCm38)		probably benign	Het
Cntnap1	GCCCCA	GCCCCAACCCCA	11: 101,189,576 (GRCm38)		probably benign	Het
Cntnap1	GCCCCA	GCCCCACCCCCA	11: 101,189,582 (GRCm38)		probably benign	Het
Cntnap1	CCCAGC	CCCAGCGCCAGC	11: 101,189,590 (GRCm38)		probably benign	Het
Cracdl	C	A	1: 37,625,036 (GRCm38)	E594*	probably null	Homo
Cracdl	T	A	1: 37,625,035 (GRCm38)	E594V	probably benign	Homo
Cul9	CTC	CTCTTC	17: 46,500,858 (GRCm38)		probably benign	Het
Cul9	CTCTTC	CTCTTCTTC	17: 46,500,846 (GRCm38)		probably benign	Het
Cyth2	C	A	7: 45,813,042 (GRCm38)	S102I	possibly damaging	Het
Dbr1	AGGAGG	AGGAGGCGGAGG	9: 99,583,686 (GRCm38)		probably benign	Het
Dbr1	GGAGG	GGAGGACGAGG	9: 99,583,699 (GRCm38)		probably benign	Het
Dhx8	GACCGA	GACCGATACCGA	11: 101,738,179 (GRCm38)		probably benign	Homo
Dhx8	CGAGAC	CGAGACGGAGAC	11: 101,738,182 (GRCm38)		probably benign	Homo
Dhx8	GAGACC	GAGACCCAGACC	11: 101,738,189 (GRCm38)		probably benign	Homo
Dnaaf9	CC	CCTGC	2: 130,770,752 (GRCm38)		probably benign	Het
Dnah8	ACTGCCCCT	ACT	17: 30,635,465 (GRCm38)		probably benign	Het
Dnah8	CCTCCCG	C	17: 30,635,477 (GRCm38)		probably benign	Homo
Dnajb5	AGGTG	A	4: 42,957,126 (GRCm38)		probably null	Het
Dusp10	G	T	1: 184,037,056 (GRCm38)	C73F	probably damaging	Homo
E4f1	CCG	CCGACG	17: 24,455,192 (GRCm38)		probably benign	Homo
Eif3a	TTA	TTATTATA	19: 60,775,289 (GRCm38)		probably benign	Het
Fam81b	TTC	TTCGTC	13: 76,271,319 (GRCm38)		probably benign	Het
Fbxo22	G	A	9: 55,209,382 (GRCm38)	R56H	probably damaging	Het
Fcgr1	T	C	3: 96,287,094 (GRCm38)	D159G	probably benign	Homo
Fcgr1	CTTCT	C	3: 96,284,504 (GRCm38)		probably null	Het
Fmn1	CCTCCT	CCTCCTACTCCT	2: 113,525,778 (GRCm38)		probably benign	Het
Fmn1	CC	CCCCCTGC	2: 113,525,781 (GRCm38)		probably benign	Het
Fmn1	CC	CCTCCTTC	2: 113,525,784 (GRCm38)		probably benign	Het
G530012D18Rik	GA	GACAGAGATA	1: 85,577,178 (GRCm38)		probably null	Het
Gli3	G	A	13: 15,644,357 (GRCm38)	R248H	probably damaging	Het
Gm16503	G	A	4: 147,541,253 (GRCm38)	G68E	unknown	Het
Gm19345	GGATGGCAGGTG	GG	7: 19,857,602 (GRCm38)		probably null	Het
Gm4340	GCA	GCAACA	10: 104,196,077 (GRCm38)		probably benign	Het
Gm4340	AGC	AGCTGC	10: 104,196,097 (GRCm38)		probably benign	Het
Gm4340	AG	AGCGG	10: 104,196,100 (GRCm38)		probably benign	Het
Gm6309	C	T	5: 146,168,183 (GRCm38)	V307I	probably benign	Het
Gpatch11	AAGAGG	AAGAGGCAGAGG	17: 78,842,171 (GRCm38)		probably benign	Het
Gpatch11	AGGAA	AGGAAGCGGAA	17: 78,842,180 (GRCm38)		probably benign	Het
Hoxa10	T	A	6: 52,234,186 (GRCm38)	Q250L	possibly damaging	Homo
Hrh1	T	C	6: 114,481,123 (GRCm38)	I455T	possibly damaging	Het
Hspa1b	GCGCC	GC	17: 34,957,129 (GRCm38)		probably benign	Homo
Iba57	GAAA	GAAAAA	11: 59,161,505 (GRCm38)		probably null	Homo
Igf1r	TGGAGC	TGGAGCTGGAGAGGGAGC	7: 68,226,181 (GRCm38)		probably benign	Het
Il17rd	CGG	CGGAGG	14: 27,082,680 (GRCm38)		probably benign	Het
Il2	TGG	TGGGGCTTGAAGCGG	3: 37,125,828 (GRCm38)		probably benign	Het
Il2	AGGTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTG	AGCTGCTGCTGCTGCTGCTGCTGCTG	3: 37,125,764 (GRCm38)		probably benign	Het
Kcng4	G	T	8: 119,633,519 (GRCm38)	Y39*	probably null	Homo
Klra2	G	GAAATCCACAT	6: 131,221,852 (GRCm38)		probably null	Het
Kmt2b	TCCTCC	TCCTCCCCCTCC	7: 30,586,366 (GRCm38)		probably benign	Het
Kmt2b	CCTCCT	CCTCCTTCTCCT	7: 30,586,367 (GRCm38)		probably benign	Het
Kmt2b	CCTCCT	CCTCCTGCTCCT	7: 30,586,370 (GRCm38)		probably benign	Het
Kmt2b	TCCTCC	TCCTCCCCCTCC	7: 30,586,378 (GRCm38)		probably benign	Het
Krt10	TCCGCC	TCCGCCGCC	11: 99,386,197 (GRCm38)		probably benign	Homo
Krt10	TCCTCC	TCCTCCGCCTCC	11: 99,389,273 (GRCm38)		probably benign	Het
Krt10	TCC	TCCTCCACC	11: 99,389,279 (GRCm38)		probably benign	Homo
Krtap28-10	TCCCACA	TCCCACACCCACA	1: 83,042,123 (GRCm38)		probably benign	Homo
Krtap4-2	A	ACAC	11: 99,635,013 (GRCm38)		probably benign	Het
Krtap9-3	AC	ACAGGTGTCGC	11: 99,598,004 (GRCm38)		probably benign	Het
Las1l	AGG	AGGGGG	X: 95,940,821 (GRCm38)		probably benign	Het
Las1l	AGG	AGGCGG	X: 95,940,827 (GRCm38)		probably benign	Het
Las1l	GAG	GAGCAG	X: 95,940,829 (GRCm38)		probably benign	Het
Lrit3	TGC	TGCAGC	3: 129,788,806 (GRCm38)		probably benign	Het
Lrit3	GCT	GCTTCT	3: 129,788,810 (GRCm38)		probably benign	Het
Lrit3	AC	ACATTC	3: 129,803,913 (GRCm38)		probably null	Homo
Luzp1	A	AGGTGGCCTCTTCAGT	4: 136,543,196 (GRCm38)		probably benign	Het
Mamld1	GCA	GCAACA	X: 71,118,839 (GRCm38)		probably benign	Het
Mamld1	AGC	AGCCGC	X: 71,118,835 (GRCm38)		probably benign	Het
Mapk8ip3	G	A	17: 24,902,119 (GRCm38)		probably null	Homo
Mbd1	TGTCTGCATCTGCGTCTTCGTCTGCATCTGCATCTGCGTCTTCGTCTGCATCTGCATCTGC	TATCTGCATCTGCGTCTTCGTCTGCATCTGCATCTGC	18: 74,273,573 (GRCm38)		probably benign	Het
Nat8f2	T	A	6: 85,867,686 (GRCm38)	L231F	possibly damaging	Homo
Nfxl1	CC	CCGGGGAC	5: 72,559,121 (GRCm38)		probably benign	Het
Noc2l	GGTAG	GG	4: 156,241,501 (GRCm38)		probably benign	Homo
Noc2l	CTG	CTGTTG	4: 156,240,095 (GRCm38)		probably benign	Het
Noc2l	GCT	GCTTCT	4: 156,240,094 (GRCm38)		probably benign	Het
Nxpe5	C	T	5: 138,229,934 (GRCm38)		probably benign	Het
Or10j2	GGGCTGCTTGTGGCAAT	G	1: 173,270,630 (GRCm38)		probably null	Het
Or51a43	G	C	7: 104,071,292 (GRCm38)		probably benign	Homo
Or51f2	CT	CTAATTGCCTT	7: 102,877,233 (GRCm38)		probably benign	Homo
Or8b41	A	G	9: 38,143,188 (GRCm38)	I13V	probably benign	Homo
Or8u3-ps	CAG	CAGAG	2: 86,122,760 (GRCm38)		probably null	Homo
Osmr	C	CTCA	15: 6,837,706 (GRCm38)		probably null	Homo
Patl2	C	CTGA	2: 122,126,145 (GRCm38)		probably benign	Het
Patl2	GC	GCTAC	2: 122,126,144 (GRCm38)		probably null	Het
Patl2	CTG	CTGTTG	2: 122,126,136 (GRCm38)		probably benign	Het
Pdik1l	GTTTTTGTTTT	GTTTTTGTTTTTTTTTTGTTTT	4: 134,279,367 (GRCm38)		probably null	Homo
Pdik1l	ACCACC	ACCACCCCCACC	4: 134,279,506 (GRCm38)		probably benign	Het
Phc1	GCTG	GCTGCTTCTG	6: 122,323,598 (GRCm38)		probably benign	Het
Piezo1	G	A	8: 122,495,569 (GRCm38)	R503W	probably damaging	Homo
Pitrm1	TTTTA	T	13: 6,560,596 (GRCm38)		probably benign	Homo
Pkdrej	TG	TGGGAGCG	15: 85,819,680 (GRCm38)		probably benign	Homo
Pla2g4e	AGGG	A	2: 120,244,724 (GRCm38)		probably benign	Homo
Plekhs1	AC	ACCTCCCCCGAGCC	19: 56,479,863 (GRCm38)		probably benign	Het
Pnma8a	CCTCATGATGCACCTGCTTCAACATC	CCTCATGATGCACCTGCTTCAACATCTCATGATGCACCTGCTTCAACATC	7: 16,961,425 (GRCm38)		probably benign	Homo
Pnma8b	TGGA	T	7: 16,946,006 (GRCm38)		probably benign	Het
Ppp1r3f	C	A	X: 7,560,336 (GRCm38)	G562V	probably damaging	Homo
Prr13	CTC	CTCATC	15: 102,462,173 (GRCm38)		probably benign	Het
Prss41	CACA	C	17: 23,844,097 (GRCm38)		probably benign	Het
Prtg	GTAAC	G	9: 72,857,081 (GRCm38)		probably benign	Het
Ptk2b	C	T	14: 66,173,849 (GRCm38)	R411Q	possibly damaging	Homo
Ptms	C	CTTG	6: 124,914,461 (GRCm38)		probably benign	Homo
Ptms	TTC	TTCGTC	6: 124,914,459 (GRCm38)		probably benign	Homo
Ptms	TCT	TCTGCT	6: 124,914,457 (GRCm38)		probably benign	Homo
Ptpn23	G	T	9: 110,387,633 (GRCm38)	P1052T	probably benign	Homo
Rab3il1	C	A	19: 10,033,751 (GRCm38)	A264E	probably damaging	Homo
Rbm6	GCTGT	G	9: 107,782,755 (GRCm38)		probably null	Homo
Rtbdn	GGC	GGCAGCTGC	8: 84,956,177 (GRCm38)		probably benign	Het
Rtbdn	CGGC	CGGCAGGGGC	8: 84,956,176 (GRCm38)		probably benign	Het
Rtbdn	AGCG	AGCGTCCGCG	8: 84,956,168 (GRCm38)		probably benign	Het
Rtbdn	TAG	TAGGGGCAG	8: 84,956,161 (GRCm38)		probably benign	Het
Sbp	G	GCTGACAACAAAGATC	17: 23,945,389 (GRCm38)		probably benign	Het
Sbp	CAAAG	CAAAGCTGCTGACAAAAAAG	17: 23,945,382 (GRCm38)		probably benign	Het
Setd1a	GTGGTAGTG	GTGGTAGTGTTGGTAGTG	7: 127,785,312 (GRCm38)		probably benign	Het
Sfswap	GCCCACTC	GCCCACTCATCCCACTC	5: 129,569,756 (GRCm38)		probably benign	Het
Six3	CGG	CGGGGG	17: 85,621,368 (GRCm38)		probably benign	Het
Six3	CGG	CGGGGG	17: 85,621,365 (GRCm38)		probably benign	Het
Six3	GGC	GGCAGC	17: 85,621,363 (GRCm38)		probably benign	Het
Six3	CGG	CGGGGG	17: 85,621,362 (GRCm38)		probably benign	Het
Six3	GCG	GCGCCG	17: 85,621,358 (GRCm38)		probably benign	Het
Six3	GGC	GGCAGC	17: 85,621,357 (GRCm38)		probably benign	Het
Slc12a1	ACC	ACCTTTGGCCACAACTCC	2: 125,154,214 (GRCm38)		probably benign	Homo
Smarca2	CAGCAGCAGCAGCAGCAGCA	CAGCAGCAGCAGCAGCAGCAGCAGCA	19: 26,630,999 (GRCm38)		probably benign	Homo
Spaca1	TCGCTC	TCGCTCGCGCTC	4: 34,049,836 (GRCm38)		probably benign	Het
Spag1	TTC	TTCGTC	15: 36,197,733 (GRCm38)		probably benign	Het
Spag17	AGG	AGGCGG	3: 100,056,257 (GRCm38)		probably benign	Het
Spata31h1	TTCA	T	10: 82,285,469 (GRCm38)		probably benign	Homo
Srebf2	G	T	15: 82,185,335 (GRCm38)	A693S	probably damaging	Homo
Srpk2	T	C	5: 23,545,196 (GRCm38)		probably null	Homo
Sry	AACTGCT	A	Y: 2,663,195 (GRCm38)		probably benign	Het
Sry	TGG	TGGGGG	Y: 2,662,838 (GRCm38)		probably benign	Homo
Sry	GTG	GTGTTG	Y: 2,662,837 (GRCm38)		probably benign	Homo
St5	CACCACACTGGGGCAGCCCACACTGGGGCAG	CCCCACACTGGGGCAG	7: 109,556,921 (GRCm38)		probably benign	Het
Stard9	C	CTAAGGGACTAGTAGG	2: 120,696,085 (GRCm38)		probably benign	Het
Supt20	GCAGCA	GCAGCAACAGCA	3: 54,727,657 (GRCm38)		probably benign	Het
Supt20	CAGCAG	CAGCAGGAGCAG	3: 54,727,658 (GRCm38)		probably benign	Het
Supt20	CAGCAG	CAGCAGAAGCAG	3: 54,727,661 (GRCm38)		probably benign	Het
Tcof1	GGGTA	G	18: 60,828,650 (GRCm38)		probably benign	Homo
Tdpoz3	A	C	3: 93,826,674 (GRCm38)	N219H	probably benign	Het
Tesk1	C	CCCCG	4: 43,447,004 (GRCm38)		probably null	Homo
Tob1	CACA	CACAACA	11: 94,214,451 (GRCm38)		probably benign	Het
Tob1	GCA	GCAACA	11: 94,214,464 (GRCm38)		probably benign	Het
Tob1	A	AGCC	11: 94,214,478 (GRCm38)		probably benign	Het
Trav15-2-dv6-2	AG	AGAGG	14: 53,649,756 (GRCm38)		probably benign	Homo
Trav15-2-dv6-2	G	GAAA	14: 53,649,757 (GRCm38)		probably benign	Homo
Trim63	GAGT	G	4: 134,327,725 (GRCm38)		probably benign	Het
Tsbp1	GCA	GCATCA	17: 34,460,068 (GRCm38)		probably benign	Het
Tsbp1	CAG	CAGAAG	17: 34,460,051 (GRCm38)		probably benign	Het
Tsen2	G	GAGA	6: 115,560,077 (GRCm38)		probably benign	Het
Ttf2	TC	TCCCC	3: 100,963,160 (GRCm38)		probably benign	Homo
Tusc1	ACCGCC	ACCGCCCCCGCC	4: 93,335,313 (GRCm38)		probably benign	Homo
Ubqlnl	TGAG	T	7: 104,149,835 (GRCm38)		probably benign	Homo
Ubtf	CCT	CCTACT	11: 102,306,948 (GRCm38)		probably null	Het
Ubtf	TCC	TCCACC	11: 102,306,950 (GRCm38)		probably benign	Het
Vps13b	G	T	15: 35,846,957 (GRCm38)	A2629S	probably damaging	Homo
Wasf3	G	T	5: 146,470,250 (GRCm38)	R460L	probably damaging	Het
Zc3h13	TGCGAGATG	TGCGAGATGAGCGAGATG	14: 75,323,599 (GRCm38)		probably benign	Homo
Zc3h13	ATGTGCGAG	ATGTGCGAGGTGTGCGAG	14: 75,323,596 (GRCm38)		probably benign	Homo
Zfhx3	AGCA	AGCAACAGACGCA	8: 108,956,102 (GRCm38)		probably benign	Het
Zfhx3	GCA	GCAACAGCACCA	8: 108,956,103 (GRCm38)		probably benign	Het
Zfhx3	GCAACA	GCAACAACAACAACA	8: 108,956,088 (GRCm38)		probably benign	Het
Zfp111	TCA	TCAACA	7: 24,199,805 (GRCm38)		probably benign	Homo
Zfp112	CATGA	CATGATGA	7: 24,125,407 (GRCm38)		probably benign	Homo
Zfp26	C	A	9: 20,438,546 (GRCm38)	A241S	probably benign	Homo
Zfp282	CGG	CGGGGG	6: 47,904,799 (GRCm38)		probably benign	Het
Zfp282	CGG	CGGGGG	6: 47,904,790 (GRCm38)		probably benign	Het
Zfp335	TC	TCCCC	2: 164,907,484 (GRCm38)		probably benign	Het
Zfp335	TCC	TCCGCC	2: 164,907,475 (GRCm38)		probably benign	Het
Zfp335	CTC	CTCGTC	2: 164,907,474 (GRCm38)		probably benign	Het
Zfp462	CCACC	CCACCTCAGCCACAGTCACC	4: 55,009,758 (GRCm38)		probably benign	Het
Zfp462	ACC	ACCTCAGCCACAGTCGCC	4: 55,009,760 (GRCm38)		probably benign	Het
Zfp598	AC	ACCACCGC	17: 24,680,791 (GRCm38)		probably benign	Het
Zfp598	ACCACC	ACCACCGCCACC	17: 24,680,782 (GRCm38)		probably benign	Het
Zfp598	ACCACC	ACCACCCCCACC	17: 24,680,776 (GRCm38)		probably benign	Het
Zfp831	CTC	CTCATC	2: 174,645,476 (GRCm38)		probably benign	Het
Zfp831	TCC	TCCCCC	2: 174,645,471 (GRCm38)		probably benign	Het
Zfp831	TC	TCCGC	2: 174,645,483 (GRCm38)		probably benign	Het
Zfp93	CAGGCATAG	CAG	7: 24,275,389 (GRCm38)		probably benign	Homo
Zscan10	TGACG	TG	17: 23,609,445 (GRCm38)		probably benign	Homo

Other mutations in Alpk3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00392:Alpk3	APN	7	81,078,009 (GRCm38)	missense	possibly damaging	0.95
IGL00472:Alpk3	APN	7	81,095,653 (GRCm38)	splice site	probably benign
IGL01732:Alpk3	APN	7	81,057,642 (GRCm38)	missense	unknown
IGL01750:Alpk3	APN	7	81,092,282 (GRCm38)	missense	probably damaging	1.00
IGL01812:Alpk3	APN	7	81,100,202 (GRCm38)	missense	probably damaging	1.00
IGL02224:Alpk3	APN	7	81,076,868 (GRCm38)	splice site	probably benign
IGL02292:Alpk3	APN	7	81,077,905 (GRCm38)	missense	possibly damaging	0.46
IGL02340:Alpk3	APN	7	81,078,507 (GRCm38)	missense	probably benign	0.03
IGL02517:Alpk3	APN	7	81,077,895 (GRCm38)	missense	probably benign	0.00
IGL02725:Alpk3	APN	7	81,093,610 (GRCm38)	missense	possibly damaging	0.91
IGL02755:Alpk3	APN	7	81,093,759 (GRCm38)	missense	possibly damaging	0.71
IGL03035:Alpk3	APN	7	81,078,604 (GRCm38)	missense	probably benign	0.00
IGL03102:Alpk3	APN	7	81,095,056 (GRCm38)	critical splice donor site	probably null
IGL03153:Alpk3	APN	7	81,093,395 (GRCm38)	missense	probably benign	0.00
IGL03255:Alpk3	APN	7	81,092,562 (GRCm38)	missense	probably benign	0.01
IGL03367:Alpk3	APN	7	81,094,990 (GRCm38)	missense	probably benign	0.01
FR4304:Alpk3	UTSW	7	81,077,762 (GRCm38)	small insertion	probably benign
IGL03097:Alpk3	UTSW	7	81,093,909 (GRCm38)	missense	probably benign	0.00
R0092:Alpk3	UTSW	7	81,092,553 (GRCm38)	missense	probably benign
R0254:Alpk3	UTSW	7	81,076,974 (GRCm38)	missense	probably benign	0.43
R0310:Alpk3	UTSW	7	81,078,610 (GRCm38)	missense	possibly damaging	0.61
R0325:Alpk3	UTSW	7	81,067,953 (GRCm38)	missense	possibly damaging	0.58
R0387:Alpk3	UTSW	7	81,104,227 (GRCm38)	missense	possibly damaging	0.93
R0971:Alpk3	UTSW	7	81,092,579 (GRCm38)	missense	possibly damaging	0.55
R1078:Alpk3	UTSW	7	81,078,600 (GRCm38)	missense	probably benign
R1146:Alpk3	UTSW	7	81,077,595 (GRCm38)	missense	probably damaging	0.99
R1146:Alpk3	UTSW	7	81,077,595 (GRCm38)	missense	probably damaging	0.99
R1168:Alpk3	UTSW	7	81,103,357 (GRCm38)	missense	probably damaging	1.00
R1306:Alpk3	UTSW	7	81,093,873 (GRCm38)	missense	probably damaging	1.00
R1822:Alpk3	UTSW	7	81,076,931 (GRCm38)	nonsense	probably null
R2173:Alpk3	UTSW	7	81,076,900 (GRCm38)	missense	probably damaging	1.00
R2350:Alpk3	UTSW	7	81,094,970 (GRCm38)	missense	probably damaging	1.00
R2414:Alpk3	UTSW	7	81,092,753 (GRCm38)	missense	probably benign	0.02
R2417:Alpk3	UTSW	7	81,092,753 (GRCm38)	missense	probably benign	0.02
R2885:Alpk3	UTSW	7	81,100,192 (GRCm38)	missense	probably damaging	1.00
R3004:Alpk3	UTSW	7	81,103,355 (GRCm38)	nonsense	probably null
R3796:Alpk3	UTSW	7	81,092,753 (GRCm38)	missense	probably benign	0.02
R3797:Alpk3	UTSW	7	81,092,753 (GRCm38)	missense	probably benign	0.02
R3798:Alpk3	UTSW	7	81,092,753 (GRCm38)	missense	probably benign	0.02
R3799:Alpk3	UTSW	7	81,092,753 (GRCm38)	missense	probably benign	0.02
R3894:Alpk3	UTSW	7	81,078,390 (GRCm38)	missense	possibly damaging	0.93
R4395:Alpk3	UTSW	7	81,094,955 (GRCm38)	missense	probably damaging	1.00
R4761:Alpk3	UTSW	7	81,104,168 (GRCm38)	missense	probably damaging	0.99
R5505:Alpk3	UTSW	7	81,078,561 (GRCm38)	missense	possibly damaging	0.87
R5540:Alpk3	UTSW	7	81,095,436 (GRCm38)	missense	probably damaging	1.00
R5770:Alpk3	UTSW	7	81,078,562 (GRCm38)	missense	probably benign	0.02
R5941:Alpk3	UTSW	7	81,078,653 (GRCm38)	missense	probably damaging	1.00
R5964:Alpk3	UTSW	7	81,092,260 (GRCm38)	missense	possibly damaging	0.88
R6036:Alpk3	UTSW	7	81,093,257 (GRCm38)	missense	probably benign	0.34
R6036:Alpk3	UTSW	7	81,093,257 (GRCm38)	missense	probably benign	0.34
R6066:Alpk3	UTSW	7	81,076,950 (GRCm38)	missense	possibly damaging	0.89
R6517:Alpk3	UTSW	7	81,078,579 (GRCm38)	missense	possibly damaging	0.54
R6578:Alpk3	UTSW	7	81,078,684 (GRCm38)	missense	probably benign	0.00
R7230:Alpk3	UTSW	7	81,093,294 (GRCm38)	missense	probably damaging	1.00
R7266:Alpk3	UTSW	7	81,092,580 (GRCm38)	missense	possibly damaging	0.55
R7271:Alpk3	UTSW	7	81,078,454 (GRCm38)	missense	possibly damaging	0.92
R7402:Alpk3	UTSW	7	81,076,912 (GRCm38)	missense	probably benign	0.29
R7411:Alpk3	UTSW	7	81,092,852 (GRCm38)	missense	probably benign	0.11
R7454:Alpk3	UTSW	7	81,078,562 (GRCm38)	missense	probably benign	0.02
R7468:Alpk3	UTSW	7	81,100,998 (GRCm38)	nonsense	probably null
R7940:Alpk3	UTSW	7	81,093,945 (GRCm38)	missense	probably damaging	1.00
R8157:Alpk3	UTSW	7	81,093,722 (GRCm38)	missense	probably benign	0.00
R8246:Alpk3	UTSW	7	81,092,776 (GRCm38)	missense	probably benign	0.00
R8357:Alpk3	UTSW	7	81,093,318 (GRCm38)	missense	probably damaging	1.00
R8444:Alpk3	UTSW	7	81,057,720 (GRCm38)	missense	probably benign	0.08
R8457:Alpk3	UTSW	7	81,093,318 (GRCm38)	missense	probably damaging	1.00
R8775:Alpk3	UTSW	7	81,077,850 (GRCm38)	missense	probably benign	0.00
R8775-TAIL:Alpk3	UTSW	7	81,077,850 (GRCm38)	missense	probably benign	0.00
R8794:Alpk3	UTSW	7	81,057,655 (GRCm38)	missense	unknown
R8982:Alpk3	UTSW	7	81,099,002 (GRCm38)	missense	probably damaging	1.00
R9259:Alpk3	UTSW	7	81,093,554 (GRCm38)	missense	probably damaging	1.00
R9343:Alpk3	UTSW	7	81,092,331 (GRCm38)	missense	probably benign	0.27
R9567:Alpk3	UTSW	7	81,092,939 (GRCm38)	missense	possibly damaging	0.55
R9792:Alpk3	UTSW	7	81,101,133 (GRCm38)	critical splice donor site	probably null
R9793:Alpk3	UTSW	7	81,101,133 (GRCm38)	critical splice donor site	probably null
R9798:Alpk3	UTSW	7	81,092,652 (GRCm38)	missense	probably benign	0.02
RF034:Alpk3	UTSW	7	81,092,414 (GRCm38)	small deletion	probably benign
RF057:Alpk3	UTSW	7	81,092,417 (GRCm38)	frame shift	probably null
X0022:Alpk3	UTSW	7	81,093,897 (GRCm38)	missense	probably damaging	0.96
Z1176:Alpk3	UTSW	7	81,078,626 (GRCm38)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- CCTCTAGGTGTCAGGAAGAAGATG -3'
(R):5'- CTCTCCAGGAGCAAAACTGTTG -3'

Sequencing Primer
(F):5'- TGTCAGGAAGAAGATGCTGCCATC -3'
(R):5'- TGTTGATCAAACCCAACCCCG -3'

Posted On

2018-04-05