Mutagenetix > Incidental Mutation

Incidental Mutation 'FR4737:Zfhx3'

511676

Institutional Source

Beutler Lab

Gene Symbol

Zfhx3

Ensembl Gene

ENSMUSG00000038872

Gene Name

zinc finger homeobox 3

Synonyms

A230102L03Rik, Atbf1, WBP9

Accession Numbers

Genbank: NM_007496

Essential gene?

Probably essential (E-score: 0.945) question?

Stock #

FR4737 ()

Quality Score

217.468

Status

Not validated

Chromosome

Chromosomal Location

107942644-108961630 bp(+) (GRCm38)

Type of Mutation

small insertion (3 aa in frame mutation)

DNA Base Change (assembly)

AGCA to AGCAACAGACGCA at 108956102 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000152353 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000043896] [ENSMUST00000220518]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000043896

SMART Domains

Protein: ENSMUSP00000044612
Gene: ENSMUSG00000038872

Domain	Start	End	E-Value	Type
ZnF_C2H2	79	103	7.89e0	SMART
low complexity region	110	127	N/A	INTRINSIC
low complexity region	148	165	N/A	INTRINSIC
ZnF_C2H2	282	305	1.36e1	SMART
low complexity region	393	411	N/A	INTRINSIC
coiled coil region	453	496	N/A	INTRINSIC
low complexity region	500	523	N/A	INTRINSIC
ZnF_C2H2	641	664	3.47e0	SMART
ZnF_C2H2	672	695	6.78e-3	SMART
ZnF_U1	724	758	5.71e-1	SMART
ZnF_C2H2	727	751	4.87e-4	SMART
low complexity region	771	785	N/A	INTRINSIC
low complexity region	796	804	N/A	INTRINSIC
ZnF_C2H2	805	829	6.67e-2	SMART
ZnF_U1	982	1016	2.35e0	SMART
ZnF_C2H2	985	1009	4.57e0	SMART
ZnF_C2H2	1041	1065	3.99e0	SMART
ZnF_U1	1086	1120	1.36e0	SMART
ZnF_C2H2	1089	1113	1.33e-1	SMART
ZnF_C2H2	1233	1256	4.11e-2	SMART
ZnF_C2H2	1262	1285	4.34e-1	SMART
ZnF_C2H2	1370	1395	1.08e-1	SMART
ZnF_C2H2	1411	1433	3.34e-2	SMART
ZnF_C2H2	1439	1462	8.09e-1	SMART
low complexity region	1500	1512	N/A	INTRINSIC
ZnF_U1	1552	1586	1.05e0	SMART
ZnF_C2H2	1555	1579	8.22e-2	SMART
ZnF_U1	1603	1637	4.19e0	SMART
ZnF_C2H2	1606	1630	1.16e-1	SMART
low complexity region	1643	1669	N/A	INTRINSIC
low complexity region	1734	1776	N/A	INTRINSIC
low complexity region	1792	1802	N/A	INTRINSIC
low complexity region	1842	1878	N/A	INTRINSIC
low complexity region	1881	1894	N/A	INTRINSIC
low complexity region	1967	1985	N/A	INTRINSIC
ZnF_C2H2	1990	2013	1.62e0	SMART
low complexity region	2041	2088	N/A	INTRINSIC
low complexity region	2110	2125	N/A	INTRINSIC
HOX	2152	2214	1.13e-16	SMART
HOX	2249	2311	2.41e-20	SMART
ZnF_C2H2	2335	2355	1.72e1	SMART
low complexity region	2383	2414	N/A	INTRINSIC
low complexity region	2458	2473	N/A	INTRINSIC
low complexity region	2476	2521	N/A	INTRINSIC
ZnF_C2H2	2539	2561	1.79e-2	SMART
low complexity region	2606	2619	N/A	INTRINSIC
HOX	2650	2712	2.97e-20	SMART
ZnF_C2H2	2720	2743	7.67e-2	SMART
low complexity region	2929	2950	N/A	INTRINSIC
HOX	2954	3016	1.07e-17	SMART
ZnF_U1	3029	3063	1.8e-1	SMART
ZnF_C2H2	3032	3056	8.31e0	SMART
low complexity region	3130	3144	N/A	INTRINSIC
low complexity region	3181	3235	N/A	INTRINSIC
low complexity region	3237	3256	N/A	INTRINSIC
low complexity region	3268	3282	N/A	INTRINSIC
low complexity region	3290	3299	N/A	INTRINSIC
coiled coil region	3362	3417	N/A	INTRINSIC
low complexity region	3452	3476	N/A	INTRINSIC
ZnF_C2H2	3489	3509	1.45e2	SMART
ZnF_U1	3546	3580	1.36e0	SMART
ZnF_C2H2	3549	3573	1.77e1	SMART
low complexity region	3602	3633	N/A	INTRINSIC
low complexity region	3642	3674	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000220518

Coding Region Coverage

1x: 99.8%
3x: 99.6%
10x: 98.8%
20x: 97.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit normal initial pituitary development but reduced GH and TSH-beta staining within the pituitary by E17.5. Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for the same allele exhibit partial postnatal lethality, decreased body size and prolonged conception time. [provided by MGI curators]

Allele List at MGI

All alleles(18) : Gene trapped(18)

Other mutations in this stock

Total: 209 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001K19Rik	TCT	TCTCCT	12: 110,668,448		probably benign	Het
2010300C02Rik	T	A	1: 37,625,035	E594V	probably benign	Homo
2010300C02Rik	C	A	1: 37,625,036	E594*	probably null	Homo
4930402H24Rik	CC	CCTGC	2: 130,770,752		probably benign	Het
4932415D10Rik	TTCA	T	10: 82,285,469		probably benign	Homo
4932438A13Rik	TTATTAT	TTATTATTATTATTACTATTAT	3: 37,050,754		probably benign	Het
A630001G21Rik	CTGTT	CT	1: 85,723,135		probably benign	Homo
Abcb11	C	A	2: 69,243,518	R1221L	probably damaging	Homo
Abcb4	GAAA	G	5: 8,896,597		probably benign	Homo
Ahdc1	CT	CTCGT	4: 133,062,759		probably benign	Homo
Alpk3	TCT	TCTACT	7: 81,077,762		probably benign	Het
Amfr	C	G	8: 94,005,159	G30R	probably damaging	Homo
Ankrd35	GC	GCTAC	3: 96,683,849		probably benign	Homo
Anxa7	C	T	14: 20,469,411	G113E	probably damaging	Homo
Apc	CAATAAAGC	CAATAAAGCTAATAAAGC	18: 34,281,999		probably benign	Homo
Apol6	GTTT	GTTTCTTT	15: 77,051,442		probably null	Homo
Arpc1b	GGTGGC	GGTGGCGTGGC	5: 145,126,787		probably null	Het
AY358078	C	T	14: 51,805,698	S281L	unknown	Homo
BC051142	CAG	CAGAAG	17: 34,460,051		probably benign	Het
BC051142	GCA	GCATCA	17: 34,460,068		probably benign	Het
Blm	ACCTGC	ACCTGCCTGC	7: 80,463,771		probably null	Het
Blm	T	TACCA	7: 80,463,774		probably null	Het
Blzf1	TTGT	TT	1: 164,303,917		probably null	Homo
Btnl10	A	AAGG	11: 58,923,931		probably benign	Homo
Cacna1a	ACC	ACCCCC	8: 84,638,726		probably benign	Homo
Cacna1a	ACC	ACCGCC	8: 84,638,720		probably benign	Het
Catsper2	TTC	TTCTTTTACTTTGTC	2: 121,397,540		probably benign	Homo
Ccdc170	ACC	ACCTCC	10: 4,561,023		probably benign	Het
Ccdc170	AC	ACCCC	10: 4,561,029		probably benign	Het
Ccdc73	TAAG	T	2: 104,991,840		probably benign	Homo
Ccnk	TTCCCAC	T	12: 108,202,507		probably benign	Het
Cdan1	A	C	2: 120,724,971	V763G	probably damaging	Het
Cdk6	A	G	5: 3,344,211		probably benign	Het
Cdx1	TGCTGC	TGCTGCCGCTGC	18: 61,019,874		probably benign	Het
Cdx1	GCTGCT	GCTGCTTCTGCT	18: 61,019,878		probably benign	Het
Cfap46	CCTTCT	CCTTCTTCT	7: 139,638,930		probably benign	Homo
Chd4	GC	GCTCCCCC	6: 125,122,131		probably benign	Homo
Cluh	CCCCGAGCC	CCCCGAGCCCGAGCC	11: 74,669,514		probably benign	Het
Cluh	AGCCTG	AGCCTGCGCCTG	11: 74,669,519		probably benign	Het
Cluh	GAGCCT	GAGCCTAAGCCT	11: 74,669,524		probably benign	Het
Cluh	CC	CCTGAGGC	11: 74,669,533		probably benign	Het
Cntnap1	AGCCCC	AGCCCCCGCCCC	11: 101,189,569		probably benign	Het
Cntnap1	GCCCCA	GCCCCAACCCCA	11: 101,189,576		probably benign	Het
Cntnap1	GCCCCA	GCCCCACCCCCA	11: 101,189,582		probably benign	Het
Cntnap1	CCCAGC	CCCAGCGCCAGC	11: 101,189,590		probably benign	Het
Cul9	CTCTTC	CTCTTCTTC	17: 46,500,846		probably benign	Het
Cul9	CTC	CTCTTC	17: 46,500,858		probably benign	Het
Cyth2	C	A	7: 45,813,042	S102I	possibly damaging	Het
Dbr1	AGGAGG	AGGAGGCGGAGG	9: 99,583,686		probably benign	Het
Dbr1	GGAGG	GGAGGACGAGG	9: 99,583,699		probably benign	Het
Dhx8	GACCGA	GACCGATACCGA	11: 101,738,179		probably benign	Homo
Dhx8	CGAGAC	CGAGACGGAGAC	11: 101,738,182		probably benign	Homo
Dhx8	GAGACC	GAGACCCAGACC	11: 101,738,189		probably benign	Homo
Dnah8	ACTGCCCCT	ACT	17: 30,635,465		probably benign	Het
Dnah8	CCTCCCG	C	17: 30,635,477		probably benign	Homo
Dnajb5	AGGTG	A	4: 42,957,126		probably null	Het
Dusp10	G	T	1: 184,037,056	C73F	probably damaging	Homo
E4f1	CCG	CCGACG	17: 24,455,192		probably benign	Homo
Eif3a	TTA	TTATTATA	19: 60,775,289		probably benign	Het
Fam81b	TTC	TTCGTC	13: 76,271,319		probably benign	Het
Fbxo22	G	A	9: 55,209,382	R56H	probably damaging	Het
Fcgr1	T	C	3: 96,287,094	D159G	probably benign	Homo
Fcgr1	CTTCT	C	3: 96,284,504		probably null	Het
Fmn1	CCTCCT	CCTCCTACTCCT	2: 113,525,778		probably benign	Het
Fmn1	CC	CCCCCTGC	2: 113,525,781		probably benign	Het
Fmn1	CC	CCTCCTTC	2: 113,525,784		probably benign	Het
G530012D18Rik	GA	GACAGAGATA	1: 85,577,178		probably null	Het
Gli3	G	A	13: 15,644,357	R248H	probably damaging	Het
Gm16503	G	A	4: 147,541,253	G68E	unknown	Het
Gm19345	GGATGGCAGGTG	GG	7: 19,857,602		probably null	Het
Gm4340	GCA	GCAACA	10: 104,196,077		probably benign	Het
Gm4340	AGC	AGCTGC	10: 104,196,097		probably benign	Het
Gm4340	AG	AGCGG	10: 104,196,100		probably benign	Het
Gm6309	C	T	5: 146,168,183	V307I	probably benign	Het
Gpatch11	AAGAGG	AAGAGGCAGAGG	17: 78,842,171		probably benign	Het
Gpatch11	AGGAA	AGGAAGCGGAA	17: 78,842,180		probably benign	Het
Hoxa10	T	A	6: 52,234,186	Q250L	possibly damaging	Homo
Hrh1	T	C	6: 114,481,123	I455T	possibly damaging	Het
Hspa1b	GCGCC	GC	17: 34,957,129		probably benign	Homo
Iba57	GAAA	GAAAAA	11: 59,161,505		probably null	Homo
Igf1r	TGGAGC	TGGAGCTGGAGAGGGAGC	7: 68,226,181		probably benign	Het
Il17rd	CGG	CGGAGG	14: 27,082,680		probably benign	Het
Il2	AGGTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTG	AGCTGCTGCTGCTGCTGCTGCTGCTG	3: 37,125,764		probably benign	Het
Il2	TGG	TGGGGCTTGAAGCGG	3: 37,125,828		probably benign	Het
Kcng4	G	T	8: 119,633,519	Y39*	probably null	Homo
Klra2	G	GAAATCCACAT	6: 131,221,852		probably null	Het
Kmt2b	TCCTCC	TCCTCCCCCTCC	7: 30,586,366		probably benign	Het
Kmt2b	CCTCCT	CCTCCTTCTCCT	7: 30,586,367		probably benign	Het
Kmt2b	CCTCCT	CCTCCTGCTCCT	7: 30,586,370		probably benign	Het
Kmt2b	TCCTCC	TCCTCCCCCTCC	7: 30,586,378		probably benign	Het
Krt10	TCCTCC	TCCTCCGCCTCC	11: 99,389,273		probably benign	Het
Krt10	TCCGCC	TCCGCCGCC	11: 99,386,197		probably benign	Homo
Krt10	TCC	TCCTCCACC	11: 99,389,279		probably benign	Homo
Krtap28-10	TCCCACA	TCCCACACCCACA	1: 83,042,123		probably benign	Homo
Krtap4-2	A	ACAC	11: 99,635,013		probably benign	Het
Krtap9-3	AC	ACAGGTGTCGC	11: 99,598,004		probably benign	Het
Las1l	AGG	AGGGGG	X: 95,940,821		probably benign	Het
Las1l	AGG	AGGCGG	X: 95,940,827		probably benign	Het
Las1l	GAG	GAGCAG	X: 95,940,829		probably benign	Het
Lrit3	AC	ACATTC	3: 129,803,913		probably null	Homo
Lrit3	TGC	TGCAGC	3: 129,788,806		probably benign	Het
Lrit3	GCT	GCTTCT	3: 129,788,810		probably benign	Het
Luzp1	A	AGGTGGCCTCTTCAGT	4: 136,543,196		probably benign	Het
Mamld1	AGC	AGCCGC	X: 71,118,835		probably benign	Het
Mamld1	GCA	GCAACA	X: 71,118,839		probably benign	Het
Mapk8ip3	G	A	17: 24,902,119		probably null	Homo
Mbd1	TGTCTGCATCTGCGTCTTCGTCTGCATCTGCATCTGCGTCTTCGTCTGCATCTGCATCTGC	TATCTGCATCTGCGTCTTCGTCTGCATCTGCATCTGC	18: 74,273,573		probably benign	Het
Nat8f2	T	A	6: 85,867,686	L231F	possibly damaging	Homo
Nfxl1	CC	CCGGGGAC	5: 72,559,121		probably benign	Het
Noc2l	GCT	GCTTCT	4: 156,240,094		probably benign	Het
Noc2l	CTG	CTGTTG	4: 156,240,095		probably benign	Het
Noc2l	GGTAG	GG	4: 156,241,501		probably benign	Homo
Nxpe5	C	T	5: 138,229,934		probably benign	Het
Olfr1038-ps	CAG	CAGAG	2: 86,122,760		probably null	Homo
Olfr418	GGGCTGCTTGTGGCAAT	G	1: 173,270,630		probably null	Het
Olfr568	CT	CTAATTGCCTT	7: 102,877,233		probably benign	Homo
Olfr644	G	C	7: 104,071,292		probably benign	Homo
Olfr890	A	G	9: 38,143,188	I13V	probably benign	Homo
Osmr	C	CTCA	15: 6,837,706		probably null	Homo
Patl2	CTG	CTGTTG	2: 122,126,136		probably benign	Het
Patl2	GC	GCTAC	2: 122,126,144		probably null	Het
Patl2	C	CTGA	2: 122,126,145		probably benign	Het
Pdik1l	ACCACC	ACCACCCCCACC	4: 134,279,506		probably benign	Het
Pdik1l	GTTTTTGTTTT	GTTTTTGTTTTTTTTTTGTTTT	4: 134,279,367		probably null	Homo
Phc1	GCTG	GCTGCTTCTG	6: 122,323,598		probably benign	Het
Piezo1	G	A	8: 122,495,569	R503W	probably damaging	Homo
Pitrm1	TTTTA	T	13: 6,560,596		probably benign	Homo
Pkdrej	TG	TGGGAGCG	15: 85,819,680		probably benign	Homo
Pla2g4e	AGGG	A	2: 120,244,724		probably benign	Homo
Plekhs1	AC	ACCTCCCCCGAGCC	19: 56,479,863		probably benign	Het
Pnmal1	CCTCATGATGCACCTGCTTCAACATC	CCTCATGATGCACCTGCTTCAACATCTCATGATGCACCTGCTTCAACATC	7: 16,961,425		probably benign	Homo
Pnmal2	TGGA	T	7: 16,946,006		probably benign	Het
Ppp1r3f	C	A	X: 7,560,336	G562V	probably damaging	Homo
Prr13	CTC	CTCATC	15: 102,462,173		probably benign	Het
Prss41	CACA	C	17: 23,844,097		probably benign	Het
Prtg	GTAAC	G	9: 72,857,081		probably benign	Het
Ptk2b	C	T	14: 66,173,849	R411Q	possibly damaging	Homo
Ptms	TCT	TCTGCT	6: 124,914,457		probably benign	Homo
Ptms	TTC	TTCGTC	6: 124,914,459		probably benign	Homo
Ptms	C	CTTG	6: 124,914,461		probably benign	Homo
Ptpn23	G	T	9: 110,387,633	P1052T	probably benign	Homo
Rab3il1	C	A	19: 10,033,751	A264E	probably damaging	Homo
Rbm6	GCTGT	G	9: 107,782,755		probably null	Homo
Rtbdn	TAG	TAGGGGCAG	8: 84,956,161		probably benign	Het
Rtbdn	AGCG	AGCGTCCGCG	8: 84,956,168		probably benign	Het
Rtbdn	CGGC	CGGCAGGGGC	8: 84,956,176		probably benign	Het
Rtbdn	GGC	GGCAGCTGC	8: 84,956,177		probably benign	Het
Sbp	CAAAG	CAAAGCTGCTGACAAAAAAG	17: 23,945,382		probably benign	Het
Sbp	G	GCTGACAACAAAGATC	17: 23,945,389		probably benign	Het
Setd1a	GTGGTAGTG	GTGGTAGTGTTGGTAGTG	7: 127,785,312		probably benign	Het
Sfswap	GCCCACTC	GCCCACTCATCCCACTC	5: 129,569,756		probably benign	Het
Six3	GGC	GGCAGC	17: 85,621,357		probably benign	Het
Six3	GCG	GCGCCG	17: 85,621,358		probably benign	Het
Six3	CGG	CGGGGG	17: 85,621,362		probably benign	Het
Six3	GGC	GGCAGC	17: 85,621,363		probably benign	Het
Six3	CGG	CGGGGG	17: 85,621,365		probably benign	Het
Six3	CGG	CGGGGG	17: 85,621,368		probably benign	Het
Slc12a1	ACC	ACCTTTGGCCACAACTCC	2: 125,154,214		probably benign	Homo
Smarca2	CAGCAGCAGCAGCAGCAGCA	CAGCAGCAGCAGCAGCAGCAGCAGCA	19: 26,630,999		probably benign	Homo
Spaca1	TCGCTC	TCGCTCGCGCTC	4: 34,049,836		probably benign	Het
Spag1	TTC	TTCGTC	15: 36,197,733		probably benign	Het
Spag17	AGG	AGGCGG	3: 100,056,257		probably benign	Het
Srebf2	G	T	15: 82,185,335	A693S	probably damaging	Homo
Srpk2	T	C	5: 23,545,196		probably null	Homo
Sry	GTG	GTGTTG	Y: 2,662,837		probably benign	Homo
Sry	TGG	TGGGGG	Y: 2,662,838		probably benign	Homo
Sry	AACTGCT	A	Y: 2,663,195		probably benign	Het
St5	CACCACACTGGGGCAGCCCACACTGGGGCAG	CCCCACACTGGGGCAG	7: 109,556,921		probably benign	Het
Stard9	C	CTAAGGGACTAGTAGG	2: 120,696,085		probably benign	Het
Supt20	GCAGCA	GCAGCAACAGCA	3: 54,727,657		probably benign	Het
Supt20	CAGCAG	CAGCAGGAGCAG	3: 54,727,658		probably benign	Het
Supt20	CAGCAG	CAGCAGAAGCAG	3: 54,727,661		probably benign	Het
Tcof1	GGGTA	G	18: 60,828,650		probably benign	Homo
Tdpoz3	A	C	3: 93,826,674	N219H	probably benign	Het
Tesk1	C	CCCCG	4: 43,447,004		probably null	Homo
Tob1	CACA	CACAACA	11: 94,214,451		probably benign	Het
Tob1	GCA	GCAACA	11: 94,214,464		probably benign	Het
Tob1	A	AGCC	11: 94,214,478		probably benign	Het
Trav15-2-dv6-2	AG	AGAGG	14: 53,649,756		probably benign	Homo
Trav15-2-dv6-2	G	GAAA	14: 53,649,757		probably benign	Homo
Trim63	GAGT	G	4: 134,327,725		probably benign	Het
Tsen2	G	GAGA	6: 115,560,077		probably benign	Het
Ttf2	TC	TCCCC	3: 100,963,160		probably benign	Homo
Tusc1	ACCGCC	ACCGCCCCCGCC	4: 93,335,313		probably benign	Homo
Ubqlnl	TGAG	T	7: 104,149,835		probably benign	Homo
Ubtf	CCT	CCTACT	11: 102,306,948		probably null	Het
Ubtf	TCC	TCCACC	11: 102,306,950		probably benign	Het
Vps13b	G	T	15: 35,846,957	A2629S	probably damaging	Homo
Wasf3	G	T	5: 146,470,250	R460L	probably damaging	Het
Zc3h13	ATGTGCGAG	ATGTGCGAGGTGTGCGAG	14: 75,323,596		probably benign	Homo
Zc3h13	TGCGAGATG	TGCGAGATGAGCGAGATG	14: 75,323,599		probably benign	Homo
Zfp111	TCA	TCAACA	7: 24,199,805		probably benign	Homo
Zfp112	CATGA	CATGATGA	7: 24,125,407		probably benign	Homo
Zfp26	C	A	9: 20,438,546	A241S	probably benign	Homo
Zfp282	CGG	CGGGGG	6: 47,904,790		probably benign	Het
Zfp282	CGG	CGGGGG	6: 47,904,799		probably benign	Het
Zfp335	CTC	CTCGTC	2: 164,907,474		probably benign	Het
Zfp335	TCC	TCCGCC	2: 164,907,475		probably benign	Het
Zfp335	TC	TCCCC	2: 164,907,484		probably benign	Het
Zfp462	CCACC	CCACCTCAGCCACAGTCACC	4: 55,009,758		probably benign	Het
Zfp462	ACC	ACCTCAGCCACAGTCGCC	4: 55,009,760		probably benign	Het
Zfp598	ACCACC	ACCACCCCCACC	17: 24,680,776		probably benign	Het
Zfp598	ACCACC	ACCACCGCCACC	17: 24,680,782		probably benign	Het
Zfp598	AC	ACCACCGC	17: 24,680,791		probably benign	Het
Zfp831	TCC	TCCCCC	2: 174,645,471		probably benign	Het
Zfp831	CTC	CTCATC	2: 174,645,476		probably benign	Het
Zfp831	TC	TCCGC	2: 174,645,483		probably benign	Het
Zfp93	CAGGCATAG	CAG	7: 24,275,389		probably benign	Homo
Zscan10	TGACG	TG	17: 23,609,445		probably benign	Homo

Other mutations in Zfhx3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01011:Zfhx3	APN	8	108793594	missense	probably benign	0.00
IGL01946:Zfhx3	APN	8	108933929	missense	probably damaging	0.98
IGL01973:Zfhx3	APN	8	108947193	missense	probably damaging	1.00
IGL01983:Zfhx3	APN	8	108947234	missense	probably damaging	1.00
IGL02151:Zfhx3	APN	8	108793883	missense	probably damaging	1.00
IGL02405:Zfhx3	APN	8	108955742	missense	unknown
IGL02406:Zfhx3	APN	8	108955742	missense	unknown
IGL02408:Zfhx3	APN	8	108955372	splice site	probably benign
IGL02549:Zfhx3	APN	8	108800509	missense	probably damaging	1.00
IGL02601:Zfhx3	APN	8	108856830	missense	probably damaging	1.00
IGL02649:Zfhx3	APN	8	108793535	missense	possibly damaging	0.94
IGL03027:Zfhx3	APN	8	108793188	missense	probably damaging	0.98
IGL03053:Zfhx3	APN	8	108946500	missense	probably damaging	0.99
IGL03168:Zfhx3	APN	8	108946500	missense	probably damaging	0.99
IGL03194:Zfhx3	APN	8	108794727	missense	probably damaging	0.97
IGL03248:Zfhx3	APN	8	108946550	missense	probably damaging	1.00
FR4449:Zfhx3	UTSW	8	108956094	small insertion	probably benign
FR4589:Zfhx3	UTSW	8	108956101	small insertion	probably benign
FR4737:Zfhx3	UTSW	8	108956088	small insertion	probably benign
FR4737:Zfhx3	UTSW	8	108956103	small insertion	probably benign
G5030:Zfhx3	UTSW	8	108951459	missense	possibly damaging	0.86
R0016:Zfhx3	UTSW	8	108950178	missense	probably benign	0.02
R0090:Zfhx3	UTSW	8	108950057	missense	possibly damaging	0.85
R0330:Zfhx3	UTSW	8	108948957	missense	probably damaging	1.00
R0332:Zfhx3	UTSW	8	108946623	missense	probably damaging	1.00
R0398:Zfhx3	UTSW	8	108951246	missense	probably damaging	0.98
R0539:Zfhx3	UTSW	8	108800509	missense	probably damaging	1.00
R0546:Zfhx3	UTSW	8	108794187	missense	probably damaging	1.00
R0614:Zfhx3	UTSW	8	108948539	missense	probably benign	0.03
R0614:Zfhx3	UTSW	8	108948967	nonsense	probably null
R0653:Zfhx3	UTSW	8	108946808	missense	possibly damaging	0.95
R0718:Zfhx3	UTSW	8	108955650	missense	unknown
R0825:Zfhx3	UTSW	8	108949208	missense	probably damaging	0.99
R1143:Zfhx3	UTSW	8	108794411	missense	probably damaging	1.00
R1319:Zfhx3	UTSW	8	108933833	missense	probably damaging	0.99
R1347:Zfhx3	UTSW	8	108800698	splice site	probably benign
R1412:Zfhx3	UTSW	8	108914567	missense	possibly damaging	0.88
R1447:Zfhx3	UTSW	8	108948444	missense	probably benign	0.03
R1530:Zfhx3	UTSW	8	108948489	missense	probably damaging	1.00
R1745:Zfhx3	UTSW	8	108955862	missense	unknown
R1764:Zfhx3	UTSW	8	108951644	missense	probably benign	0.18
R1781:Zfhx3	UTSW	8	108793535	missense	probably benign	0.01
R1917:Zfhx3	UTSW	8	108956248	missense	unknown
R1956:Zfhx3	UTSW	8	108794142	missense	probably benign	0.02
R2049:Zfhx3	UTSW	8	108945177	missense	probably benign	0.01
R2196:Zfhx3	UTSW	8	108800253	missense	probably damaging	1.00
R3085:Zfhx3	UTSW	8	108956032	missense	unknown
R3765:Zfhx3	UTSW	8	108792762	missense	probably damaging	0.97
R4162:Zfhx3	UTSW	8	108956987	missense	unknown
R4243:Zfhx3	UTSW	8	108792320	missense	probably damaging	0.97
R4380:Zfhx3	UTSW	8	108956390	missense	unknown
R4433:Zfhx3	UTSW	8	108955637	missense	unknown
R4509:Zfhx3	UTSW	8	108793779	missense	probably benign	0.01
R4731:Zfhx3	UTSW	8	108956084	missense	unknown
R4788:Zfhx3	UTSW	8	108794210	missense	probably damaging	1.00
R4812:Zfhx3	UTSW	8	108947961	missense	possibly damaging	0.83
R4893:Zfhx3	UTSW	8	108957007	missense	unknown
R4907:Zfhx3	UTSW	8	108793354	missense	probably damaging	0.99
R4935:Zfhx3	UTSW	8	108947850	missense	possibly damaging	0.92
R4943:Zfhx3	UTSW	8	108948317	missense	probably damaging	0.98
R5154:Zfhx3	UTSW	8	108800575	missense	probably damaging	1.00
R5377:Zfhx3	UTSW	8	108951185	missense	possibly damaging	0.95
R5388:Zfhx3	UTSW	8	108946814	missense	possibly damaging	0.88
R5434:Zfhx3	UTSW	8	108792399	missense	probably damaging	0.99
R5445:Zfhx3	UTSW	8	108956210	missense	unknown
R5541:Zfhx3	UTSW	8	108948951	missense	probably damaging	0.99
R5571:Zfhx3	UTSW	8	108955991	missense	unknown
R5700:Zfhx3	UTSW	8	108933867	missense	probably damaging	1.00
R5754:Zfhx3	UTSW	8	108800332	missense	probably damaging	0.99
R5867:Zfhx3	UTSW	8	108793446	missense	probably damaging	1.00
R5905:Zfhx3	UTSW	8	108793503	missense	probably damaging	1.00
R5922:Zfhx3	UTSW	8	108946698	missense	probably damaging	1.00
R5972:Zfhx3	UTSW	8	108950851	missense	possibly damaging	0.91
R6020:Zfhx3	UTSW	8	108792527	missense	probably damaging	1.00
R6028:Zfhx3	UTSW	8	108793503	missense	probably damaging	1.00
R6113:Zfhx3	UTSW	8	108947421	missense	probably benign	0.04
R6253:Zfhx3	UTSW	8	108955388	missense	possibly damaging	0.96
R6356:Zfhx3	UTSW	8	108946619	missense	probably damaging	1.00
R6800:Zfhx3	UTSW	8	108949517	missense	probably benign	0.20
R6829:Zfhx3	UTSW	8	108950283	missense	probably damaging	0.98
R6872:Zfhx3	UTSW	8	108800641	missense	probably damaging	1.00
R6873:Zfhx3	UTSW	8	108800641	missense	probably damaging	1.00
R6919:Zfhx3	UTSW	8	108800528	missense	probably damaging	1.00
R6921:Zfhx3	UTSW	8	108951392	missense	possibly damaging	0.53
R6925:Zfhx3	UTSW	8	108956821	missense	unknown
R6927:Zfhx3	UTSW	8	108956821	missense	unknown
R7152:Zfhx3	UTSW	8	108948207	missense	possibly damaging	0.94
R7169:Zfhx3	UTSW	8	108951398	missense	possibly damaging	0.86
R7214:Zfhx3	UTSW	8	108948861	missense	probably damaging	0.98
R7378:Zfhx3	UTSW	8	108793248	missense	probably damaging	0.99
R7391:Zfhx3	UTSW	8	108947843	missense	probably damaging	0.96
R7442:Zfhx3	UTSW	8	108792836	missense	probably damaging	0.97
R7636:Zfhx3	UTSW	8	108946809	missense	probably benign	0.25
R7649:Zfhx3	UTSW	8	108951644	missense	probably benign	0.18
R7699:Zfhx3	UTSW	8	108951122	missense	probably benign	0.18
R7728:Zfhx3	UTSW	8	108951569	missense	probably benign	0.01
R7780:Zfhx3	UTSW	8	108951651	missense	possibly damaging	0.53
R7904:Zfhx3	UTSW	8	108951063	missense	probably damaging	0.98
R8032:Zfhx3	UTSW	8	108951222	missense	possibly damaging	0.51
R8158:Zfhx3	UTSW	8	108948721	missense	possibly damaging	0.82
R8163:Zfhx3	UTSW	8	108949293	missense	probably damaging	1.00
R8215:Zfhx3	UTSW	8	108950717	missense	probably benign
R8217:Zfhx3	UTSW	8	108950717	missense	probably benign
R8218:Zfhx3	UTSW	8	108950717	missense	probably benign
R8369:Zfhx3	UTSW	8	108856816	missense	possibly damaging	0.82
R8424:Zfhx3	UTSW	8	108856753	missense	probably damaging	0.98
R8482:Zfhx3	UTSW	8	108947879	missense	probably benign	0.02
R8504:Zfhx3	UTSW	8	108856917	missense	possibly damaging	0.95
R8871:Zfhx3	UTSW	8	108950235	missense	possibly damaging	0.85
R9144:Zfhx3	UTSW	8	108950162	missense	possibly damaging	0.53
R9202:Zfhx3	UTSW	8	108951288	missense	possibly damaging	0.92
R9213:Zfhx3	UTSW	8	108950124	missense	probably benign	0.18
R9218:Zfhx3	UTSW	8	108793869	missense	probably benign	0.17
R9370:Zfhx3	UTSW	8	108794708	missense	probably damaging	1.00
R9422:Zfhx3	UTSW	8	108704218	start gained	probably benign
R9530:Zfhx3	UTSW	8	108800378	missense	probably damaging	1.00
RF027:Zfhx3	UTSW	8	108956098	small insertion	probably benign
RF028:Zfhx3	UTSW	8	108956096	small insertion	probably benign
RF029:Zfhx3	UTSW	8	108956092	small insertion	probably benign
RF031:Zfhx3	UTSW	8	108956098	small insertion	probably benign
RF032:Zfhx3	UTSW	8	108956092	small insertion	probably benign
RF037:Zfhx3	UTSW	8	108956098	nonsense	probably null
RF038:Zfhx3	UTSW	8	108956101	small insertion	probably benign
RF040:Zfhx3	UTSW	8	108956101	small insertion	probably benign
RF042:Zfhx3	UTSW	8	108956088	small insertion	probably benign
RF042:Zfhx3	UTSW	8	108956098	small insertion	probably benign
RF054:Zfhx3	UTSW	8	108956096	small insertion	probably benign
RF060:Zfhx3	UTSW	8	108956088	small insertion	probably benign
X0019:Zfhx3	UTSW	8	108951653	missense	probably benign	0.00
X0026:Zfhx3	UTSW	8	108949145	missense	probably damaging	1.00
Z1088:Zfhx3	UTSW	8	108951357	missense	possibly damaging	0.72
Z1176:Zfhx3	UTSW	8	108793923	missense	probably benign	0.09
Z1176:Zfhx3	UTSW	8	108800449	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTACCTGCAGCCCATGTATG -3'
(R):5'- CCAACTTGTACTGCACCTTTGG -3'

Sequencing Primer
(F):5'- AAGGCCTGTTTCCCTACA -3'
(R):5'- GGAGTCCGCACTTGCACTTTTG -3'

Posted On

2018-04-05