Mutagenetix > Incidental Mutation

Incidental Mutation 'FR4976:Nacad'

511902

Institutional Source

Beutler Lab

Gene Symbol

Nacad

Ensembl Gene

ENSMUSG00000041073

Gene Name

NAC alpha domain containing

Synonyms

mKIAA0363

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

FR4976 ()

Quality Score

217.468

Status

Not validated

Chromosome

Chromosomal Location

6597823-6606053 bp(-) (GRCm38)

Type of Mutation

small insertion (2 aa in frame mutation)

DNA Base Change (assembly)

A to ACCAGGG at 6599749 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000388] [ENSMUST00000045713] [ENSMUST00000109721] [ENSMUST00000109722]

AlphaFold

Q5SWP3

Predicted Effect

probably benign
Transcript: ENSMUST00000000388

SMART Domains

Protein: ENSMUSP00000000388
Gene: ENSMUSG00000000378

Domain	Start	End	E-Value	Type
low complexity region	2	12	N/A	INTRINSIC
Blast:PTB	60	230	2e-35	BLAST
low complexity region	242	252	N/A	INTRINSIC
Pfam:CCM2_C	296	396	8.9e-50	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000045713

SMART Domains

Protein: ENSMUSP00000049490
Gene: ENSMUSG00000041073

Domain	Start	End	E-Value	Type
low complexity region	2	28	N/A	INTRINSIC
low complexity region	70	87	N/A	INTRINSIC
low complexity region	228	235	N/A	INTRINSIC
low complexity region	266	277	N/A	INTRINSIC
low complexity region	294	306	N/A	INTRINSIC
low complexity region	328	354	N/A	INTRINSIC
low complexity region	391	422	N/A	INTRINSIC
low complexity region	454	479	N/A	INTRINSIC
internal_repeat_1	537	689	6.19e-8	PROSPERO
low complexity region	692	713	N/A	INTRINSIC
internal_repeat_1	732	889	6.19e-8	PROSPERO
low complexity region	924	939	N/A	INTRINSIC
low complexity region	1159	1170	N/A	INTRINSIC
low complexity region	1308	1325	N/A	INTRINSIC
Pfam:NAC	1357	1413	2.9e-24	PFAM
low complexity region	1449	1466	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000109721

SMART Domains

Protein: ENSMUSP00000105343
Gene: ENSMUSG00000000378

Domain	Start	End	E-Value	Type
Blast:PTB	2	166	2e-32	BLAST
low complexity region	178	188	N/A	INTRINSIC
low complexity region	230	244	N/A	INTRINSIC
PDB:4FQN\|D	245	324	5e-52	PDB

Predicted Effect

probably benign
Transcript: ENSMUST00000109722

SMART Domains

Protein: ENSMUSP00000105344
Gene: ENSMUSG00000000378

Domain	Start	End	E-Value	Type
Blast:PTB	2	166	2e-32	BLAST
low complexity region	178	188	N/A	INTRINSIC
low complexity region	230	244	N/A	INTRINSIC
PDB:4FQN\|D	245	324	5e-52	PDB

Predicted Effect

probably benign
Transcript: ENSMUST00000177050

Predicted Effect

probably benign
Transcript: ENSMUST00000177391

Coding Region Coverage

1x: 99.8%
3x: 99.6%
10x: 98.7%
20x: 96.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 220 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001K19Rik	TTC	TTCGTC	12: 110,668,450 (GRCm38)		probably benign	Het
1700001K19Rik	TTC	TTCATC	12: 110,668,447 (GRCm38)		probably benign	Het
2010300C02Rik	T	A	1: 37,625,035 (GRCm38)	E594V	probably benign	Homo
2010300C02Rik	C	A	1: 37,625,036 (GRCm38)	E594*	probably null	Homo
2010300C02Rik	A	G	1: 37,625,102 (GRCm38)	S47P	probably damaging	Homo
4930402H24Rik	C	CTCG	2: 130,770,753 (GRCm38)		probably benign	Het
4930402H24Rik	TCC	TCCACC	2: 130,770,742 (GRCm38)		probably benign	Het
4930402H24Rik	TCC	TCCCCC	2: 130,770,739 (GRCm38)		probably benign	Het
Abt1	TTCTTGCT	TT	13: 23,423,711 (GRCm38)		probably benign	Het
AI837181	GGC	GGCCGC	19: 5,425,229 (GRCm38)		probably benign	Het
Akap12	AAA	AAACAA	10: 4,353,837 (GRCm38)		probably benign	Het
Alg1	GCTCACTCAC	GCTCAC	16: 5,244,561 (GRCm38)		probably null	Homo
Alg9	G	GCGA	9: 50,775,431 (GRCm38)		probably benign	Het
Amfr	GCC	GCCGGCGCGAGCTCC	8: 94,012,292 (GRCm38)		probably benign	Het
Anapc2	TGGCGGTGGCGGCGGCGGCGGCGGCGGCGG	TGGCGGCGGCGGCGGCGG	2: 25,272,532 (GRCm38)		probably benign	Het
Anxa7	C	T	14: 20,469,411 (GRCm38)	G113E	probably damaging	Homo
Apc	CCAATAAAG	CCAATAAAGTCAATAAAG	18: 34,281,998 (GRCm38)		probably benign	Het
Apc	AAGC	AAGCCAATATAGC	18: 34,282,004 (GRCm38)		probably null	Het
Apc	AATAAAGC	AATAAAGCCTATAAAGC	18: 34,282,000 (GRCm38)		probably benign	Het
Atad3a	C	A	4: 155,753,939 (GRCm38)	R207L	probably damaging	Homo
BC051142	AGC	AGCGGC	17: 34,460,061 (GRCm38)		probably benign	Het
BC051142	AGC	AGCGGC	17: 34,460,058 (GRCm38)		probably benign	Het
Blm	ACCT	ACCTCCCT	7: 80,463,767 (GRCm38)		probably benign	Homo
Blm	TCCTCCTCCTCCTCCTCCTCCTCC	TCCTCCTCCTCCACCTCCTCCTCCTCCTCCTCCTCC	7: 80,512,907 (GRCm38)		probably benign	Het
Bmp5	GAGGAGT	G	9: 75,776,375 (GRCm38)		probably benign	Homo
Bpifa6	A	T	2: 153,986,376 (GRCm38)	Q134L	probably benign	Homo
Bpifa6	A	T	2: 153,986,398 (GRCm38)	R141S	probably benign	Homo
Btnl10	AGA	AGAGGA	11: 58,923,929 (GRCm38)		probably benign	Homo
Cacna1a	ACC	ACCTCC	8: 84,638,726 (GRCm38)		probably benign	Het
Cacna1a	ACC	ACCGCC	8: 84,638,717 (GRCm38)		probably benign	Het
Calhm1	TGGCTGTGGCTG	TGGCTGTGGCTGCGGCTGTGGCTG	19: 47,141,262 (GRCm38)		probably benign	Het
Catsper2	CAT	CATTAT	2: 121,397,782 (GRCm38)		probably benign	Het
Catsper2	ATCGTCGTCGTC	ATCGTCGTCGTCGTC	2: 121,397,795 (GRCm38)		probably benign	Het
Catsper2	TGTC	TGTCGTC	2: 121,397,779 (GRCm38)		probably benign	Homo
Catsper2	C	CTTTTACTTTTTT	2: 121,397,542 (GRCm38)		probably benign	Homo
Ccdc170	ACCGCC	ACCGCCGCC	10: 4,561,008 (GRCm38)		probably benign	Het
Ccdc170	ACC	ACCGCC	10: 4,561,023 (GRCm38)		probably benign	Het
Ccdc170	AC	ACCTC	10: 4,561,029 (GRCm38)		probably benign	Het
Ccnk	TTCCCAC	T	12: 108,202,507 (GRCm38)		probably benign	Het
Cdx1	GGGCTGC	GGGCTGCGGCTGC	18: 61,019,867 (GRCm38)		probably benign	Het
Cdx1	GCTGCT	GCTGCTTCTGCT	18: 61,019,869 (GRCm38)		probably benign	Het
Cep112	G	GCTCT	11: 108,425,352 (GRCm38)		probably benign	Het
Cep89	GACT	G	7: 35,409,641 (GRCm38)		probably benign	Het
Cfap46	CCTTCT	CCTTCTTCT	7: 139,638,930 (GRCm38)		probably benign	Homo
Chd4	GC	GCTCCCTC	6: 125,122,131 (GRCm38)		probably benign	Homo
Cluh	GCCTGA	GCCTGAACCTGA	11: 74,669,520 (GRCm38)		probably benign	Het
Cnpy3	CCT	CCTACT	17: 46,736,747 (GRCm38)		probably null	Het
Cntnap1	GCCCCA	GCCCCACCCCCA	11: 101,189,588 (GRCm38)		probably benign	Het
Cntnap1	CCAGCC	CCAGCCTCAGCC	11: 101,189,585 (GRCm38)		probably benign	Het
Cntnap1	CCCAGC	CCCAGCACCAGC	11: 101,189,572 (GRCm38)		probably benign	Het
Cntnap1	A	ACCCCCC	11: 101,189,569 (GRCm38)		probably benign	Het
Col4a3	CGTTTTTTTTTTTTTTTT	C	1: 82,718,906 (GRCm38)		probably null	Het
Cpne1	AGA	AGAGAGA	2: 156,072,025 (GRCm38)		probably null	Homo
Ctsm	AGTG	AGTGGGTG	13: 61,537,836 (GRCm38)		probably null	Homo
Cttnbp2	GCTGCT	GCTGCTTCTGCT	6: 18,367,467 (GRCm38)		probably benign	Het
Cttnbp2	GCTGCT	GCTGCTCCTGCT	6: 18,367,461 (GRCm38)		probably benign	Het
Cul9	TCC	TCCCCC	17: 46,500,856 (GRCm38)		probably benign	Het
Cul9	TCC	TCCCCC	17: 46,500,853 (GRCm38)		probably benign	Het
Cul9	TCC	TCCGCC	17: 46,500,850 (GRCm38)		probably benign	Het
Cul9	CTTC	CTTCTTC	17: 46,500,848 (GRCm38)		probably benign	Het
Cybrd1	GAAT	G	2: 71,138,511 (GRCm38)		probably benign	Homo
Dbr1	GG	GGAGGAAG	9: 99,583,702 (GRCm38)		probably benign	Het
Dbr1	AGG	AGGAGGCGG	9: 99,583,701 (GRCm38)		probably benign	Het
Dbr1	AGGAGG	AGGAGGCGGAGG	9: 99,583,692 (GRCm38)		probably benign	Het
Dbr1	AGGAGG	AGGAGGCGGAGG	9: 99,583,689 (GRCm38)		probably benign	Het
Dcaf8	C	T	1: 172,172,856 (GRCm38)	H194Y	probably damaging	Homo
Dnajc19	AC	ACGC	3: 34,057,994 (GRCm38)		probably null	Het
Dthd1	GAC	GACTAC	5: 62,843,024 (GRCm38)		probably benign	Homo
Dusp10	G	T	1: 184,037,056 (GRCm38)	C73F	probably damaging	Homo
Eif3a	A	ATTTTT	19: 60,775,291 (GRCm38)		probably benign	Homo
Ermn	TC	TCTAC	2: 58,048,088 (GRCm38)		probably benign	Het
Ermn	CTT	CTTGTT	2: 58,048,080 (GRCm38)		probably benign	Het
Fam45a	ACTC	ACTCCTC	19: 60,814,618 (GRCm38)		probably benign	Homo
Fam45a	T	TTCA	19: 60,814,622 (GRCm38)		probably benign	Homo
Fbxo38	TGCAGC	TGC	18: 62,515,347 (GRCm38)		probably benign	Het
Frem3	CT	CTTGT	8: 80,615,241 (GRCm38)		probably benign	Homo
Fsip2	TT	TTTTTCT	2: 82,984,365 (GRCm38)		probably benign	Het
Fsip2	TTTTT	TTTTTGTTTT	2: 82,984,362 (GRCm38)		probably benign	Het
Gabre	AGGCT	AGGCTGCGGCT	X: 72,270,418 (GRCm38)		probably benign	Homo
Gabre	T	TGAGGCC	X: 72,270,422 (GRCm38)		probably benign	Homo
Gm10800	A	AC	2: 98,667,033 (GRCm38)		probably null	Homo
Gm14393	T	G	2: 175,061,820 (GRCm38)	N98T	probably benign	Het
Gm16503	G	A	4: 147,541,253 (GRCm38)	G68E	unknown	Het
Gm28040	TG	TGGCACCTTTCGAG	1: 133,327,323 (GRCm38)		probably benign	Homo
Gm4340	AGC	AGCCGC	10: 104,196,079 (GRCm38)		probably benign	Het
Gm6309	C	T	5: 146,168,183 (GRCm38)	V307I	probably benign	Het
Gm7534	TG	TGCCG	4: 134,202,630 (GRCm38)		probably benign	Homo
Golga5	G	A	12: 102,475,660 (GRCm38)		probably null	Homo
Gpatch11	GAAGAG	GAAGAGCAAGAG	17: 78,842,170 (GRCm38)		probably benign	Het
Gpatch11	AAGAGG	AAGAGGCAGAGG	17: 78,842,171 (GRCm38)		probably benign	Het
Gpatch11	AGAGGA	AGAGGATGAGGA	17: 78,842,172 (GRCm38)		probably benign	Het
Gpatch11	GAGGAA	GAGGAATAGGAA	17: 78,842,173 (GRCm38)		probably null	Het
Gpatch11	AGGAA	AGGAAGTGGAA	17: 78,842,180 (GRCm38)		probably benign	Het
H2-K1	GTTT	G	17: 33,997,042 (GRCm38)		probably benign	Homo
Hcn1	GCAGC	GCAGCGACAGC	13: 117,975,808 (GRCm38)		probably benign	Homo
Hoxa10	T	A	6: 52,234,186 (GRCm38)	Q250L	possibly damaging	Homo
Igf1r	C	CTGGAGATGGAGA	7: 68,226,186 (GRCm38)		probably benign	Het
Igf1r	TGGAGC	TGGAGCTGGAGAGGGAGC	7: 68,226,181 (GRCm38)		probably benign	Het
Il17rd	CGG	CGGTGG	14: 27,082,677 (GRCm38)		probably benign	Het
Il2	GG	GGGGCTTGAAGTAG	3: 37,125,829 (GRCm38)		probably benign	Het
Ipo9	TCC	TCCCCC	1: 135,386,281 (GRCm38)		probably benign	Het
Iqcc	T	TGTCAGCCTCCTTGTACCC	4: 129,616,676 (GRCm38)		probably benign	Het
Isg20l2	AAG	AAGTAG	3: 87,931,715 (GRCm38)		probably null	Het
Kcng4	G	T	8: 119,633,519 (GRCm38)	Y39*	probably null	Homo
Kmt2b	CCTCCT	CCTCCTGCTCCT	7: 30,586,373 (GRCm38)		probably benign	Het
Kmt2b	TCCTCC	TCCTCCACCTCC	7: 30,586,366 (GRCm38)		probably benign	Het
Kmt2b	CCTCCT	CCTCCTACTCCT	7: 30,586,364 (GRCm38)		probably null	Het
Kmt2b	CTCCTC	CTCCTCGTCCTC	7: 30,586,362 (GRCm38)		probably benign	Het
Kmt2b	TCCTCC	TCCTCCCCCTCC	7: 30,586,360 (GRCm38)		probably benign	Het
Kmt2c	TGCTGCTGCTGTTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCT	TGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCT	5: 25,315,763 (GRCm38)		probably benign	Homo
Krtap9-3	AC	ACAGGTGCCTC	11: 99,598,004 (GRCm38)		probably benign	Homo
Las1l	A	AGGC	X: 95,940,833 (GRCm38)		probably benign	Het
Las1l	GA	GAGAA	X: 95,940,832 (GRCm38)		probably benign	Het
Las1l	AGG	AGGGGG	X: 95,940,827 (GRCm38)		probably benign	Het
Lce1m	TGCCAC	TGCCACTGCTGCAGCCAC	3: 93,018,148 (GRCm38)		probably benign	Het
Leo1	GGTACCATGCAG	GG	9: 75,450,572 (GRCm38)		probably benign	Het
Lrit3	CATA	CATAAATA	3: 129,803,910 (GRCm38)		probably benign	Homo
Lrmp	CACATTG	CACATTGAGGACATTG	6: 145,173,785 (GRCm38)		probably benign	Homo
Mamld1	GCA	GCAACA	X: 71,118,818 (GRCm38)		probably benign	Het
Mamld1	GCAACA	GCAACAACA	X: 71,118,812 (GRCm38)		probably benign	Het
Mast4	GGACAAGCTGTGAGTTGGGGAACCCGGGAG	GG	13: 102,739,247 (GRCm38)		probably null	Homo
Mast4	TGG	TGGGGGCGG	13: 102,736,312 (GRCm38)		probably benign	Het
Med12l	GCA	GCACCA	3: 59,275,977 (GRCm38)		probably benign	Het
Mn1	CAG	CAGAAG	5: 111,419,702 (GRCm38)		probably benign	Het
Morf4l2	T	C	X: 136,733,622 (GRCm38)	K286E	probably benign	Het
Msantd4	A	T	9: 4,384,937 (GRCm38)	I221F	possibly damaging	Homo
Mup21	TT	TTTTTATATACT	4: 62,149,350 (GRCm38)		probably benign	Het
Nars	CCACTCAC	CCAC	18: 64,510,445 (GRCm38)		probably benign	Homo
Ndufc2	C	T	7: 97,400,274 (GRCm38)	P29L	probably damaging	Het
Nkx2-6	C	T	14: 69,175,229 (GRCm38)	T282M	probably damaging	Homo
Noc2l	AGGC	AGGCGGC	4: 156,240,092 (GRCm38)		probably benign	Homo
Noc2l	CTG	CTGGTG	4: 156,240,098 (GRCm38)		probably benign	Het
Nolc1	AGC	AGCAGCAGCGGC	19: 46,081,375 (GRCm38)		probably benign	Het
Nolc1	CAG	CAGAAGCAGAAG	19: 46,081,356 (GRCm38)		probably benign	Het
Olfr313	T	A	11: 58,817,440 (GRCm38)	V144D	possibly damaging	Homo
Olfr418	GGGCTGCTTGTGGCAAT	G	1: 173,270,630 (GRCm38)		probably null	Het
Olfr547	A	AAACCG	7: 102,535,681 (GRCm38)		probably null	Homo
Olfr585	T	TTAC	7: 103,098,309 (GRCm38)		probably benign	Homo
Olfr624	AG	AGAGG	7: 103,670,966 (GRCm38)		probably benign	Homo
Patl2	C	CTGA	2: 122,126,145 (GRCm38)		probably benign	Het
Patl2	GC	GCTTC	2: 122,126,144 (GRCm38)		probably benign	Het
Patl2	GCT	GCTTCT	2: 122,126,141 (GRCm38)		probably benign	Het
Patl2	CTG	CTGGTG	2: 122,126,139 (GRCm38)		probably benign	Het
Pdik1l	ACCACC	ACCACCCCCACC	4: 134,279,506 (GRCm38)		probably benign	Homo
Phc1	TG	TGCTGCGG	6: 122,323,600 (GRCm38)		probably benign	Het
Phf3	ACTGCCGCTCCCGCTCC	AC	1: 30,805,023 (GRCm38)		probably benign	Het
Pick1	TTC	TTCTC	15: 79,255,946 (GRCm38)		probably null	Homo
Piezo1	G	A	8: 122,495,569 (GRCm38)	R503W	probably damaging	Homo
Pik3ap1	AG	AGGGG	19: 41,281,945 (GRCm38)		probably benign	Homo
Pik3c2g	AGAGG	AGAGGGAGG	6: 139,635,654 (GRCm38)		probably null	Homo
Pitrm1	TTTTA	T	13: 6,560,596 (GRCm38)		probably benign	Homo
Pogz	GTAAT	G	3: 94,874,695 (GRCm38)		probably benign	Het
Ppp1r3f	C	A	X: 7,560,336 (GRCm38)	G562V	probably damaging	Homo
Ppp2r5c	G	T	12: 110,540,738 (GRCm38)		probably null	Homo
Prag1	CCGC	CCGCCGC	8: 36,103,883 (GRCm38)		probably benign	Homo
Prr13	CTC	CTCTTC	15: 102,462,176 (GRCm38)		probably benign	Homo
Prr13	CACT	CACTACT	15: 102,462,171 (GRCm38)		probably benign	Homo
Ptms	TCT	TCTCCT	6: 124,914,454 (GRCm38)		probably benign	Homo
Ptpn23	G	T	9: 110,387,633 (GRCm38)	P1052T	probably benign	Homo
Raph1	GG	GGGGG	1: 60,489,267 (GRCm38)		probably benign	Homo
Rpa1	TGCTGCC	T	11: 75,318,519 (GRCm38)		probably benign	Het
Rpgrip1	GGAAGAAGA	GGA	14: 52,149,544 (GRCm38)		probably benign	Het
Rpgrip1	GGA	GGATGA	14: 52,149,394 (GRCm38)		probably benign	Het
Rps19	AGCGG	AG	7: 24,888,996 (GRCm38)		probably benign	Homo
Rsf1	G	GACC	7: 97,579,909 (GRCm38)		probably benign	Homo
Serpina3m	A	G	12: 104,358,623 (GRCm38)		probably null	Homo
Setd1a	TAGTGGTGG	TAGTGGTGGGAGTGGTGG	7: 127,785,316 (GRCm38)		probably benign	Het
Setd1a	TGGTGGTGGT	TGGTGGTGGTGGTGGTGGT	7: 127,785,307 (GRCm38)		probably benign	Homo
Sfswap	ACTCAGCCC	ACTCAGCCCCCTCAGCCC	5: 129,569,751 (GRCm38)		probably benign	Het
Sh3pxd2b	GCCTGT	GCCTGTGCCTGT	11: 32,423,060 (GRCm38)		probably benign	Homo
Sh3pxd2b	CCTGTG	CCTGTGTCTGTG	11: 32,423,055 (GRCm38)		probably benign	Het
Shroom4	GCAGCAACA	GCA	X: 6,624,074 (GRCm38)		probably benign	Het
Six3	GCG	GCGTCG	17: 85,621,358 (GRCm38)		probably benign	Het
Six3	CG	CGGGG	17: 85,621,371 (GRCm38)		probably benign	Het
Skint8	C	T	4: 111,938,902 (GRCm38)	L258F	probably benign	Homo
Smoc2	AGTT	A	17: 14,401,562 (GRCm38)		probably benign	Homo
Smpx	CCCCCA	C	X: 157,720,924 (GRCm38)		probably benign	Homo
Snx1	C	CTTT	9: 66,104,930 (GRCm38)		probably benign	Homo
Snx1	TC	TCTGC	9: 66,104,929 (GRCm38)		probably benign	Homo
Sp110	CT	CTAAT	1: 85,587,489 (GRCm38)		probably benign	Het
Spaca1	GCTCTC	GCTCTCCCTCTC	4: 34,049,844 (GRCm38)		probably benign	Het
Spaca1	CGCTCT	CGCTCTTGCTCT	4: 34,049,849 (GRCm38)		probably benign	Het
Spag17	AGG	AGGTGG	3: 100,056,254 (GRCm38)		probably benign	Het
Spag17	GGA	GGACGA	3: 100,056,255 (GRCm38)		probably benign	Het
Srebf2	G	T	15: 82,185,335 (GRCm38)	A693S	probably damaging	Homo
Sry	T	TGGG	Y: 2,662,841 (GRCm38)		probably benign	Homo
Stard8	AGG	AGGTGG	X: 99,066,525 (GRCm38)		probably benign	Het
Stard8	AGG	AGGTGG	X: 99,066,513 (GRCm38)		probably benign	Het
Stk10	CCCA	C	11: 32,614,520 (GRCm38)		probably benign	Homo
Tap2	ACTG	ACTGCTG	17: 34,205,699 (GRCm38)		probably benign	Homo
Tbc1d5	G	C	17: 50,799,931 (GRCm38)	H532Q	probably benign	Homo
Tbc1d5	C	G	17: 50,799,943 (GRCm38)	Q528H	probably benign	Homo
Tfeb	GCA	GCAACA	17: 47,786,094 (GRCm38)		probably benign	Het
Tmcc1	G	A	6: 116,193,380 (GRCm38)		probably benign	Homo
Tob1	AGC	AGCCGC	11: 94,214,472 (GRCm38)		probably benign	Het
Tpsab1	TTGCACCTCCT	TT	17: 25,343,782 (GRCm38)		probably benign	Het
Trav15-2-dv6-2	G	GAAC	14: 53,649,757 (GRCm38)		probably benign	Homo
Trav15-2-dv6-2	GAA	GAATAA	14: 53,649,754 (GRCm38)		probably null	Het
Trim16	GTGA	GTGATGA	11: 62,820,689 (GRCm38)		probably benign	Homo
Tsen2	AGG	AGGCGG	6: 115,560,066 (GRCm38)		probably benign	Homo
Ubtf	TC	TCCGC	11: 102,306,959 (GRCm38)		probably benign	Het
Vmn1r124	G	T	7: 21,259,936 (GRCm38)	Q228K	possibly damaging	Het
Vmn1r71	A	C	7: 10,748,121 (GRCm38)	S147R	probably benign	Homo
Vmn2r99	G	A	17: 19,394,285 (GRCm38)	G756R	probably damaging	Homo
Vps13b	G	T	15: 35,846,957 (GRCm38)	A2629S	probably damaging	Homo
Wdr75	AAATAA	AAA	1: 45,823,404 (GRCm38)		probably benign	Homo
Zfp111	T	G	7: 24,199,037 (GRCm38)	K383T	probably damaging	Homo
Zfp111	A	ATCG	7: 24,199,807 (GRCm38)		probably benign	Homo
Zfp26	C	A	9: 20,438,546 (GRCm38)	A241S	probably benign	Homo
Zfp282	CGG	CGGTGG	6: 47,904,790 (GRCm38)		probably benign	Het
Zfp335	TCC	TCCACC	2: 164,907,478 (GRCm38)		probably benign	Het
Zfp335	CTC	CTCTTC	2: 164,907,474 (GRCm38)		probably benign	Het
Zfp459	TGA	TGAGAGA	13: 67,408,274 (GRCm38)		probably null	Homo
Zfp459	GA	GAGTTA	13: 67,408,275 (GRCm38)		probably null	Homo
Zfp459	A	AGTGG	13: 67,408,276 (GRCm38)		probably null	Homo
Zfp462	CC	CCTCAGCCACAGCCATC	4: 55,009,761 (GRCm38)		probably benign	Het
Zfp462	ACC	ACCTCAGCCACAGCCGCC	4: 55,009,760 (GRCm38)		probably benign	Het
Zfp598	ACCACC	ACCACCCCCACC	17: 24,680,782 (GRCm38)		probably benign	Het
Zfp598	CCACAGGC	CC	17: 24,679,372 (GRCm38)		probably benign	Het
Zfp683	AG	AGGGG	4: 134,058,879 (GRCm38)		probably benign	Homo

Other mutations in Nacad

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00597:Nacad	APN	11	6,600,921 (GRCm38)	missense	probably benign	0.24
IGL00903:Nacad	APN	11	6,600,632 (GRCm38)	missense	probably damaging	0.99
IGL01303:Nacad	APN	11	6,598,279 (GRCm38)	missense	possibly damaging	0.81
IGL01353:Nacad	APN	11	6,600,530 (GRCm38)	missense	possibly damaging	0.70
IGL01833:Nacad	APN	11	6,605,700 (GRCm38)	missense	unknown
IGL02267:Nacad	APN	11	6,602,649 (GRCm38)	missense	probably benign	0.14
IGL02531:Nacad	APN	11	6,598,580 (GRCm38)	missense	possibly damaging	0.90
IGL02994:Nacad	APN	11	6,599,528 (GRCm38)	missense	possibly damaging	0.83
IGL03121:Nacad	APN	11	6,600,933 (GRCm38)	missense	probably damaging	0.98
IGL03161:Nacad	APN	11	6,600,378 (GRCm38)	nonsense	probably null
Locusta	UTSW	11	6,602,387 (GRCm38)	missense	possibly damaging	0.88
migratoria	UTSW	11	6,601,196 (GRCm38)	missense	probably benign	0.30
FR4340:Nacad	UTSW	11	6,599,761 (GRCm38)	small insertion	probably benign
FR4342:Nacad	UTSW	11	6,599,762 (GRCm38)	small insertion	probably benign
FR4548:Nacad	UTSW	11	6,599,760 (GRCm38)	small insertion	probably benign
FR4548:Nacad	UTSW	11	6,599,752 (GRCm38)	small insertion	probably benign
FR4589:Nacad	UTSW	11	6,599,753 (GRCm38)	small insertion	probably benign
FR4976:Nacad	UTSW	11	6,599,763 (GRCm38)	small insertion	probably benign
FR4976:Nacad	UTSW	11	6,599,756 (GRCm38)	small insertion	probably benign
PIT4402001:Nacad	UTSW	11	6,598,621 (GRCm38)	missense	probably benign	0.19
R0330:Nacad	UTSW	11	6,600,903 (GRCm38)	missense	probably benign
R0331:Nacad	UTSW	11	6,599,441 (GRCm38)	missense	possibly damaging	0.84
R0409:Nacad	UTSW	11	6,599,810 (GRCm38)	missense	probably benign	0.00
R0612:Nacad	UTSW	11	6,601,382 (GRCm38)	missense	possibly damaging	0.90
R0644:Nacad	UTSW	11	6,599,486 (GRCm38)	missense	possibly damaging	0.69
R0829:Nacad	UTSW	11	6,601,158 (GRCm38)	missense	probably benign	0.18
R1483:Nacad	UTSW	11	6,602,217 (GRCm38)	missense	probably damaging	0.99
R1583:Nacad	UTSW	11	6,601,185 (GRCm38)	missense	probably benign	0.08
R1905:Nacad	UTSW	11	6,602,540 (GRCm38)	missense	probably benign	0.15
R1907:Nacad	UTSW	11	6,602,540 (GRCm38)	missense	probably benign	0.15
R2361:Nacad	UTSW	11	6,600,821 (GRCm38)	missense	probably benign
R2979:Nacad	UTSW	11	6,601,424 (GRCm38)	missense	probably benign	0.06
R4192:Nacad	UTSW	11	6,605,534 (GRCm38)	missense	probably benign	0.44
R4381:Nacad	UTSW	11	6,600,204 (GRCm38)	missense	probably benign	0.18
R4539:Nacad	UTSW	11	6,600,677 (GRCm38)	missense	possibly damaging	0.94
R4751:Nacad	UTSW	11	6,605,726 (GRCm38)	missense	unknown
R4944:Nacad	UTSW	11	6,598,507 (GRCm38)	missense	possibly damaging	0.95
R4962:Nacad	UTSW	11	6,599,169 (GRCm38)	missense	probably damaging	1.00
R5102:Nacad	UTSW	11	6,598,528 (GRCm38)	missense	probably damaging	1.00
R5189:Nacad	UTSW	11	6,601,611 (GRCm38)	missense	probably damaging	0.98
R5296:Nacad	UTSW	11	6,605,745 (GRCm38)	missense	unknown
R5566:Nacad	UTSW	11	6,602,136 (GRCm38)	missense	probably damaging	1.00
R5634:Nacad	UTSW	11	6,602,387 (GRCm38)	missense	possibly damaging	0.88
R5725:Nacad	UTSW	11	6,601,643 (GRCm38)	missense	probably benign	0.15
R5748:Nacad	UTSW	11	6,598,370 (GRCm38)	nonsense	probably null
R5864:Nacad	UTSW	11	6,600,581 (GRCm38)	missense	probably benign
R5882:Nacad	UTSW	11	6,598,568 (GRCm38)	missense	possibly damaging	0.95
R6089:Nacad	UTSW	11	6,601,331 (GRCm38)	missense	probably benign	0.03
R6117:Nacad	UTSW	11	6,599,810 (GRCm38)	missense	probably benign	0.00
R6161:Nacad	UTSW	11	6,600,902 (GRCm38)	missense	probably benign
R6351:Nacad	UTSW	11	6,600,165 (GRCm38)	nonsense	probably null
R6351:Nacad	UTSW	11	6,599,235 (GRCm38)	missense	probably damaging	1.00
R6366:Nacad	UTSW	11	6,601,196 (GRCm38)	missense	probably benign	0.30
R6525:Nacad	UTSW	11	6,602,255 (GRCm38)	missense	probably damaging	1.00
R6811:Nacad	UTSW	11	6,599,400 (GRCm38)	missense	possibly damaging	0.66
R6931:Nacad	UTSW	11	6,601,877 (GRCm38)	missense	probably benign	0.14
R6966:Nacad	UTSW	11	6,602,634 (GRCm38)	missense	possibly damaging	0.93
R7228:Nacad	UTSW	11	6,598,412 (GRCm38)	missense	probably benign	0.19
R7248:Nacad	UTSW	11	6,598,589 (GRCm38)	nonsense	probably null
R7556:Nacad	UTSW	11	6,601,272 (GRCm38)	missense	possibly damaging	0.90
R7594:Nacad	UTSW	11	6,602,457 (GRCm38)	missense	probably damaging	0.99
R7813:Nacad	UTSW	11	6,599,071 (GRCm38)	missense	probably benign	0.38
R7841:Nacad	UTSW	11	6,601,031 (GRCm38)	missense	probably benign	0.00
R8243:Nacad	UTSW	11	6,602,643 (GRCm38)	missense	probably damaging	0.96
R8810:Nacad	UTSW	11	6,602,853 (GRCm38)	missense	probably benign	0.15
R9042:Nacad	UTSW	11	6,598,948 (GRCm38)	missense	possibly damaging	0.95
R9057:Nacad	UTSW	11	6,600,876 (GRCm38)	missense	possibly damaging	0.53
R9114:Nacad	UTSW	11	6,602,252 (GRCm38)	missense	probably damaging	1.00
R9328:Nacad	UTSW	11	6,602,417 (GRCm38)	missense	possibly damaging	0.84
R9394:Nacad	UTSW	11	6,599,390 (GRCm38)	missense	probably damaging	1.00
R9595:Nacad	UTSW	11	6,601,790 (GRCm38)	missense	probably damaging	0.99
R9755:Nacad	UTSW	11	6,599,374 (GRCm38)	critical splice donor site	probably null
R9760:Nacad	UTSW	11	6,601,662 (GRCm38)	missense	probably benign	0.02
T0975:Nacad	UTSW	11	6,601,632 (GRCm38)	missense	probably benign	0.17
T0975:Nacad	UTSW	11	6,601,622 (GRCm38)	missense	probably benign	0.03
T0975:Nacad	UTSW	11	6,599,750 (GRCm38)	small insertion	probably benign
X0011:Nacad	UTSW	11	6,601,074 (GRCm38)	missense	probably benign	0.00
Z1176:Nacad	UTSW	11	6,602,297 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCAAGCCAGGTCTTTGGTATC -3'
(R):5'- CTACGCTGAAGAGACTAGCAGG -3'

Sequencing Primer
(F):5'- TGAGAGGCTGACACGCTG -3'
(R):5'- GTGTGCACCACCCTTCCAG -3'

Posted On

2018-04-05