Mutagenetix > Incidental Mutation

Incidental Mutation 'FR4976:Mast4'

511933

Institutional Source

Beutler Lab

Gene Symbol

Mast4

Ensembl Gene

ENSMUSG00000034751

Gene Name

microtubule associated serine/threonine kinase family member 4

Synonyms

4930420O11Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.304) question?

Stock #

FR4976 ()

Quality Score

175.495

Status

Not validated

Chromosome

Chromosomal Location

102868994-103471005 bp(-) (GRCm39)

Type of Mutation

small insertion (2 aa in frame mutation)

DNA Base Change (assembly)

TGG to TGGGGGCGG at 102872820 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099202] [ENSMUST00000166726] [ENSMUST00000167058] [ENSMUST00000170878] [ENSMUST00000171791] [ENSMUST00000172138]

AlphaFold

Q811L6

Predicted Effect

probably benign
Transcript: ENSMUST00000099202

SMART Domains

Protein: ENSMUSP00000096808
Gene: ENSMUSG00000034751

Domain	Start	End	E-Value	Type
low complexity region	13	38	N/A	INTRINSIC
Pfam:DUF1908	76	353	2.2e-146	PFAM
S_TKc	391	664	4.13e-98	SMART
S_TK_X	665	729	3.79e-2	SMART
low complexity region	745	758	N/A	INTRINSIC
low complexity region	818	831	N/A	INTRINSIC
low complexity region	840	857	N/A	INTRINSIC
low complexity region	925	960	N/A	INTRINSIC
PDZ	970	1050	2.34e-15	SMART
low complexity region	1070	1087	N/A	INTRINSIC
low complexity region	1111	1122	N/A	INTRINSIC
low complexity region	1127	1139	N/A	INTRINSIC
low complexity region	1142	1164	N/A	INTRINSIC
low complexity region	1202	1219	N/A	INTRINSIC
low complexity region	1290	1306	N/A	INTRINSIC
low complexity region	1345	1361	N/A	INTRINSIC
low complexity region	1937	1953	N/A	INTRINSIC
low complexity region	1996	2010	N/A	INTRINSIC
low complexity region	2150	2161	N/A	INTRINSIC
low complexity region	2296	2307	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000166726

SMART Domains

Protein: ENSMUSP00000132263
Gene: ENSMUSG00000034751

Domain	Start	End	E-Value	Type
low complexity region	23	51	N/A	INTRINSIC
Pfam:DUF1908	256	530	4.2e-145	PFAM
S_TKc	568	841	4.13e-98	SMART
S_TK_X	842	906	3.79e-2	SMART
low complexity region	922	935	N/A	INTRINSIC
low complexity region	995	1008	N/A	INTRINSIC
low complexity region	1035	1070	N/A	INTRINSIC
PDZ	1080	1160	2.34e-15	SMART
low complexity region	1180	1201	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000167058

SMART Domains

Protein: ENSMUSP00000128464
Gene: ENSMUSG00000034751

Domain	Start	End	E-Value	Type
low complexity region	23	51	N/A	INTRINSIC
Pfam:DUF1908	256	529	5.1e-134	PFAM
S_TKc	568	841	4.13e-98	SMART
S_TK_X	842	906	3.79e-2	SMART
low complexity region	922	935	N/A	INTRINSIC
low complexity region	995	1008	N/A	INTRINSIC
low complexity region	1017	1034	N/A	INTRINSIC
low complexity region	1102	1137	N/A	INTRINSIC
PDZ	1147	1227	2.34e-15	SMART
low complexity region	1247	1264	N/A	INTRINSIC
low complexity region	1288	1299	N/A	INTRINSIC
low complexity region	1304	1316	N/A	INTRINSIC
low complexity region	1319	1341	N/A	INTRINSIC
low complexity region	1379	1396	N/A	INTRINSIC
low complexity region	1467	1483	N/A	INTRINSIC
low complexity region	1522	1538	N/A	INTRINSIC
low complexity region	2114	2130	N/A	INTRINSIC
low complexity region	2173	2187	N/A	INTRINSIC
low complexity region	2327	2338	N/A	INTRINSIC
low complexity region	2473	2484	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000170878

SMART Domains

Protein: ENSMUSP00000127880
Gene: ENSMUSG00000021624

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
PDB:3T6Q\|B	21	86	3e-38	PDB
SCOP:d1m0za_	35	84	4e-4	SMART
Blast:LRR	51	75	1e-5	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000171791

SMART Domains

Protein: ENSMUSP00000131651
Gene: ENSMUSG00000034751

Domain	Start	End	E-Value	Type
Pfam:DUF1908	64	338	1.2e-144	PFAM
S_TKc	376	649	4.13e-98	SMART
S_TK_X	650	714	3.79e-2	SMART
low complexity region	730	743	N/A	INTRINSIC
low complexity region	803	816	N/A	INTRINSIC
low complexity region	825	842	N/A	INTRINSIC
low complexity region	910	945	N/A	INTRINSIC
PDZ	955	1035	2.34e-15	SMART
low complexity region	1055	1072	N/A	INTRINSIC
low complexity region	1096	1107	N/A	INTRINSIC
low complexity region	1112	1124	N/A	INTRINSIC
low complexity region	1127	1149	N/A	INTRINSIC
low complexity region	1187	1204	N/A	INTRINSIC
low complexity region	1275	1291	N/A	INTRINSIC
low complexity region	1330	1346	N/A	INTRINSIC
low complexity region	1922	1938	N/A	INTRINSIC
low complexity region	1981	1995	N/A	INTRINSIC
low complexity region	2135	2146	N/A	INTRINSIC
low complexity region	2281	2292	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000172138

Predicted Effect

probably benign
Transcript: ENSMUST00000194446

Coding Region Coverage

1x: 99.8%
3x: 99.6%
10x: 98.7%
20x: 96.9%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit malocclusion. [provided by MGI curators]

Allele List at MGI

All alleles(8) : Gene trapped(8)

Other mutations in this stock

Total: 221 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001K19Rik	TTC	TTCATC	12: 110,634,881 (GRCm39)		probably benign	Het
1700001K19Rik	TTC	TTCGTC	12: 110,634,884 (GRCm39)		probably benign	Het
Abt1	TTCTTGCT	TT	13: 23,607,881 (GRCm39)		probably benign	Het
AI837181	GGC	GGCCGC	19: 5,475,257 (GRCm39)		probably benign	Het
Akap12	AAA	AAACAA	10: 4,303,837 (GRCm39)		probably benign	Het
Alg1	GCTCACTCAC	GCTCAC	16: 5,062,425 (GRCm39)		probably null	Homo
Alg9	G	GCGA	9: 50,686,731 (GRCm39)		probably benign	Het
Amfr	GCC	GCCGGCGCGAGCTCC	8: 94,738,920 (GRCm39)		probably benign	Het
Anapc2	TGGCGGTGGCGGCGGCGGCGGCGGCGGCGG	TGGCGGCGGCGGCGGCGG	2: 25,162,544 (GRCm39)		probably benign	Het
Anxa7	C	T	14: 20,519,479 (GRCm39)	G113E	probably damaging	Homo
Apc	AATAAAGC	AATAAAGCCTATAAAGC	18: 34,415,053 (GRCm39)		probably benign	Het
Apc	CCAATAAAG	CCAATAAAGTCAATAAAG	18: 34,415,051 (GRCm39)		probably benign	Het
Apc	AAGC	AAGCCAATATAGC	18: 34,415,057 (GRCm39)		probably null	Het
Atad3a	C	A	4: 155,838,396 (GRCm39)	R207L	probably damaging	Homo
Blm	ACCT	ACCTCCCT	7: 80,113,515 (GRCm39)		probably benign	Homo
Blm	TCCTCCTCCTCCTCCTCCTCCTCC	TCCTCCTCCTCCACCTCCTCCTCCTCCTCCTCCTCC	7: 80,162,655 (GRCm39)		probably benign	Het
Bmp5	GAGGAGT	G	9: 75,683,657 (GRCm39)		probably benign	Homo
Bpifa6	A	T	2: 153,828,296 (GRCm39)	Q134L	probably benign	Homo
Bpifa6	A	T	2: 153,828,318 (GRCm39)	R141S	probably benign	Homo
Btnl10	AGA	AGAGGA	11: 58,814,755 (GRCm39)		probably benign	Homo
Cacna1a	ACC	ACCGCC	8: 85,365,346 (GRCm39)		probably benign	Het
Cacna1a	ACC	ACCTCC	8: 85,365,355 (GRCm39)		probably benign	Het
Calhm1	TGGCTGTGGCTG	TGGCTGTGGCTGCGGCTGTGGCTG	19: 47,129,701 (GRCm39)		probably benign	Het
Catsper2	TGTC	TGTCGTC	2: 121,228,260 (GRCm39)		probably benign	Homo
Catsper2	C	CTTTTACTTTTTT	2: 121,228,023 (GRCm39)		probably benign	Homo
Catsper2	ATCGTCGTCGTC	ATCGTCGTCGTCGTC	2: 121,228,276 (GRCm39)		probably benign	Het
Catsper2	CAT	CATTAT	2: 121,228,263 (GRCm39)		probably benign	Het
Ccdc170	ACCGCC	ACCGCCGCC	10: 4,511,008 (GRCm39)		probably benign	Het
Ccdc170	AC	ACCTC	10: 4,511,029 (GRCm39)		probably benign	Het
Ccdc170	ACC	ACCGCC	10: 4,511,023 (GRCm39)		probably benign	Het
Ccnk	TTCCCAC	T	12: 108,168,766 (GRCm39)		probably benign	Het
Cdx1	GGGCTGC	GGGCTGCGGCTGC	18: 61,152,939 (GRCm39)		probably benign	Het
Cdx1	GCTGCT	GCTGCTTCTGCT	18: 61,152,941 (GRCm39)		probably benign	Het
Cep112	G	GCTCT	11: 108,316,178 (GRCm39)		probably benign	Het
Cep89	GACT	G	7: 35,109,066 (GRCm39)		probably benign	Het
Cfap46	CCTTCT	CCTTCTTCT	7: 139,218,846 (GRCm39)		probably benign	Homo
Chd4	GC	GCTCCCTC	6: 125,099,094 (GRCm39)		probably benign	Homo
Cluh	GCCTGA	GCCTGAACCTGA	11: 74,560,346 (GRCm39)		probably benign	Het
Cnpy3	CCT	CCTACT	17: 47,047,673 (GRCm39)		probably null	Het
Cntnap1	CCCAGC	CCCAGCACCAGC	11: 101,080,398 (GRCm39)		probably benign	Het
Cntnap1	CCAGCC	CCAGCCTCAGCC	11: 101,080,411 (GRCm39)		probably benign	Het
Cntnap1	GCCCCA	GCCCCACCCCCA	11: 101,080,414 (GRCm39)		probably benign	Het
Cntnap1	A	ACCCCCC	11: 101,080,395 (GRCm39)		probably benign	Het
Col4a3	CGTTTTTTTTTTTTTTTT	C	1: 82,696,627 (GRCm39)		probably null	Het
Cpne1	AGA	AGAGAGA	2: 155,913,945 (GRCm39)		probably null	Homo
Cracdl	C	A	1: 37,664,117 (GRCm39)	E594*	probably null	Homo
Cracdl	A	G	1: 37,664,183 (GRCm39)	S47P	probably damaging	Homo
Cracdl	T	A	1: 37,664,116 (GRCm39)	E594V	probably benign	Homo
Ctsm	AGTG	AGTGGGTG	13: 61,685,650 (GRCm39)		probably null	Homo
Cttnbp2	GCTGCT	GCTGCTTCTGCT	6: 18,367,466 (GRCm39)		probably benign	Het
Cttnbp2	GCTGCT	GCTGCTCCTGCT	6: 18,367,460 (GRCm39)		probably benign	Het
Cul9	TCC	TCCGCC	17: 46,811,776 (GRCm39)		probably benign	Het
Cul9	TCC	TCCCCC	17: 46,811,779 (GRCm39)		probably benign	Het
Cul9	TCC	TCCCCC	17: 46,811,782 (GRCm39)		probably benign	Het
Cul9	CTTC	CTTCTTC	17: 46,811,774 (GRCm39)		probably benign	Het
Cybrd1	GAAT	G	2: 70,968,855 (GRCm39)		probably benign	Homo
Dbr1	AGGAGG	AGGAGGCGGAGG	9: 99,465,742 (GRCm39)		probably benign	Het
Dbr1	AGGAGG	AGGAGGCGGAGG	9: 99,465,745 (GRCm39)		probably benign	Het
Dbr1	AGG	AGGAGGCGG	9: 99,465,754 (GRCm39)		probably benign	Het
Dbr1	GG	GGAGGAAG	9: 99,465,755 (GRCm39)		probably benign	Het
Dcaf8	C	T	1: 172,000,423 (GRCm39)	H194Y	probably damaging	Homo
Dennd10	ACTC	ACTCCTC	19: 60,803,056 (GRCm39)		probably benign	Homo
Dennd10	T	TTCA	19: 60,803,060 (GRCm39)		probably benign	Homo
Dnaaf9	C	CTCG	2: 130,612,673 (GRCm39)		probably benign	Het
Dnaaf9	TCC	TCCCCC	2: 130,612,659 (GRCm39)		probably benign	Het
Dnaaf9	TCC	TCCACC	2: 130,612,662 (GRCm39)		probably benign	Het
Dnajc19	AC	ACGC	3: 34,112,143 (GRCm39)		probably null	Het
Dthd1	GAC	GACTAC	5: 63,000,367 (GRCm39)		probably benign	Homo
Dusp10	G	T	1: 183,769,253 (GRCm39)	C73F	probably damaging	Homo
Eif3a	A	ATTTTT	19: 60,763,729 (GRCm39)		probably benign	Homo
Ermn	CTT	CTTGTT	2: 57,938,092 (GRCm39)		probably benign	Het
Ermn	TC	TCTAC	2: 57,938,100 (GRCm39)		probably benign	Het
Fbxo38	TGCAGC	TGC	18: 62,648,418 (GRCm39)		probably benign	Het
Frem3	CT	CTTGT	8: 81,341,870 (GRCm39)		probably benign	Homo
Fsip2	TT	TTTTTCT	2: 82,814,709 (GRCm39)		probably benign	Het
Fsip2	TTTTT	TTTTTGTTTT	2: 82,814,706 (GRCm39)		probably benign	Het
Gabre	T	TGAGGCC	X: 71,314,028 (GRCm39)		probably benign	Homo
Gabre	AGGCT	AGGCTGCGGCT	X: 71,314,024 (GRCm39)		probably benign	Homo
Gm10800	A	AC	2: 98,497,378 (GRCm39)		probably null	Homo
Gm14393	T	G	2: 174,903,613 (GRCm39)	N98T	probably benign	Het
Gm16503	G	A	4: 147,625,710 (GRCm39)	G68E	unknown	Het
Gm28040	TG	TGGCACCTTTCGAG	1: 133,255,061 (GRCm39)		probably benign	Homo
Gm4340	AGC	AGCCGC	10: 104,031,940 (GRCm39)		probably benign	Het
Gm6309	C	T	5: 146,104,993 (GRCm39)	V307I	probably benign	Het
Golga5	G	A	12: 102,441,919 (GRCm39)		probably null	Homo
Gpatch11	AGGAA	AGGAAGTGGAA	17: 79,149,609 (GRCm39)		probably benign	Het
Gpatch11	GAGGAA	GAGGAATAGGAA	17: 79,149,602 (GRCm39)		probably null	Het
Gpatch11	AGAGGA	AGAGGATGAGGA	17: 79,149,601 (GRCm39)		probably benign	Het
Gpatch11	AAGAGG	AAGAGGCAGAGG	17: 79,149,600 (GRCm39)		probably benign	Het
Gpatch11	GAAGAG	GAAGAGCAAGAG	17: 79,149,599 (GRCm39)		probably benign	Het
H2-K2	GTTT	G	17: 34,216,016 (GRCm39)		probably benign	Homo
Hcn1	GCAGC	GCAGCGACAGC	13: 118,112,344 (GRCm39)		probably benign	Homo
Hoxa10	T	A	6: 52,211,166 (GRCm39)	Q250L	possibly damaging	Homo
Igf1r	C	CTGGAGATGGAGA	7: 67,875,934 (GRCm39)		probably benign	Het
Igf1r	TGGAGC	TGGAGCTGGAGAGGGAGC	7: 67,875,929 (GRCm39)		probably benign	Het
Il17rd	CGG	CGGTGG	14: 26,804,634 (GRCm39)		probably benign	Het
Il2	GG	GGGGCTTGAAGTAG	3: 37,179,978 (GRCm39)		probably benign	Het
Ipo9	TCC	TCCCCC	1: 135,314,019 (GRCm39)		probably benign	Het
Iqcc	T	TGTCAGCCTCCTTGTACCC	4: 129,510,469 (GRCm39)		probably benign	Het
Irag2	CACATTG	CACATTGAGGACATTG	6: 145,119,511 (GRCm39)		probably benign	Homo
Isg20l2	AAG	AAGTAG	3: 87,839,022 (GRCm39)		probably null	Het
Kcng4	G	T	8: 120,360,258 (GRCm39)	Y39*	probably null	Homo
Kmt2b	CCTCCT	CCTCCTACTCCT	7: 30,285,789 (GRCm39)		probably null	Het
Kmt2b	TCCTCC	TCCTCCACCTCC	7: 30,285,791 (GRCm39)		probably benign	Het
Kmt2b	CCTCCT	CCTCCTGCTCCT	7: 30,285,798 (GRCm39)		probably benign	Het
Kmt2b	TCCTCC	TCCTCCCCCTCC	7: 30,285,785 (GRCm39)		probably benign	Het
Kmt2b	CTCCTC	CTCCTCGTCCTC	7: 30,285,787 (GRCm39)		probably benign	Het
Kmt2c	TGCTGCTGCTGTTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCT	TGCTGCTGCTGCTGCTGTTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCT	5: 25,520,761 (GRCm39)		probably benign	Homo
Krtap9-3	AC	ACAGGTGCCTC	11: 99,488,830 (GRCm39)		probably benign	Homo
Las1l	AGG	AGGGGG	X: 94,984,433 (GRCm39)		probably benign	Het
Las1l	A	AGGC	X: 94,984,439 (GRCm39)		probably benign	Het
Las1l	GA	GAGAA	X: 94,984,438 (GRCm39)		probably benign	Het
Lce1m	TGCCAC	TGCCACTGCTGCAGCCAC	3: 92,925,455 (GRCm39)		probably benign	Het
Leo1	GGTACCATGCAG	GG	9: 75,357,854 (GRCm39)		probably benign	Het
Lrit3	CATA	CATAAATA	3: 129,597,559 (GRCm39)		probably benign	Homo
Mamld1	GCAACA	GCAACAACA	X: 70,162,418 (GRCm39)		probably benign	Het
Mamld1	GCA	GCAACA	X: 70,162,424 (GRCm39)		probably benign	Het
Med12l	GCA	GCACCA	3: 59,183,398 (GRCm39)		probably benign	Het
Mn1	CAG	CAGAAG	5: 111,567,568 (GRCm39)		probably benign	Het
Morf4l2	T	C	X: 135,634,371 (GRCm39)	K286E	probably benign	Het
Msantd4	A	T	9: 4,384,937 (GRCm39)	I221F	possibly damaging	Homo
Mup21	TT	TTTTTATATACT	4: 62,067,587 (GRCm39)		probably benign	Het
Nacad	TCAGGG	TCAGGGACAGGG	11: 6,549,756 (GRCm39)		probably benign	Het
Nacad	A	ACCAGGG	11: 6,549,749 (GRCm39)		probably benign	Het
Nacad	C	CAGGGTA	11: 6,549,763 (GRCm39)		probably benign	Het
Nars1	CCACTCAC	CCAC	18: 64,643,516 (GRCm39)		probably benign	Homo
Ndufc2	C	T	7: 97,049,481 (GRCm39)	P29L	probably damaging	Het
Nkx2-6	C	T	14: 69,412,678 (GRCm39)	T282M	probably damaging	Homo
Noc2l	AGGC	AGGCGGC	4: 156,324,549 (GRCm39)		probably benign	Homo
Noc2l	CTG	CTGGTG	4: 156,324,555 (GRCm39)		probably benign	Het
Nolc1	CAG	CAGAAGCAGAAG	19: 46,069,795 (GRCm39)		probably benign	Het
Nolc1	AGC	AGCAGCAGCGGC	19: 46,069,814 (GRCm39)		probably benign	Het
Or10j2	GGGCTGCTTGTGGCAAT	G	1: 173,098,197 (GRCm39)		probably null	Het
Or51f1e	T	TTAC	7: 102,747,516 (GRCm39)		probably benign	Homo
Or51v8	AG	AGAGG	7: 103,320,173 (GRCm39)		probably benign	Homo
Or52b4	A	AAACCG	7: 102,184,888 (GRCm39)		probably null	Homo
Or5af2	T	A	11: 58,708,266 (GRCm39)	V144D	possibly damaging	Homo
Patl2	GCT	GCTTCT	2: 121,956,622 (GRCm39)		probably benign	Het
Patl2	CTG	CTGGTG	2: 121,956,620 (GRCm39)		probably benign	Het
Patl2	C	CTGA	2: 121,956,626 (GRCm39)		probably benign	Het
Patl2	GC	GCTTC	2: 121,956,625 (GRCm39)		probably benign	Het
Pdik1l	ACCACC	ACCACCCCCACC	4: 134,006,817 (GRCm39)		probably benign	Homo
Phc1	TG	TGCTGCGG	6: 122,300,559 (GRCm39)		probably benign	Het
Phf3	ACTGCCGCTCCCGCTCC	AC	1: 30,844,104 (GRCm39)		probably benign	Het
Pick1	TTC	TTCTC	15: 79,140,146 (GRCm39)		probably null	Homo
Piezo1	G	A	8: 123,222,308 (GRCm39)	R503W	probably damaging	Homo
Pik3ap1	AG	AGGGG	19: 41,270,384 (GRCm39)		probably benign	Homo
Pik3c2g	AGAGG	AGAGGGAGG	6: 139,612,652 (GRCm39)		probably null	Homo
Pitrm1	TTTTA	T	13: 6,610,632 (GRCm39)		probably benign	Homo
Pogz	GTAAT	G	3: 94,782,006 (GRCm39)		probably benign	Het
Ppp1r3f	C	A	X: 7,426,575 (GRCm39)	G562V	probably damaging	Homo
Ppp2r5c	G	T	12: 110,507,172 (GRCm39)		probably null	Homo
Prag1	CCGC	CCGCCGC	8: 36,571,037 (GRCm39)		probably benign	Homo
Prr13	CTC	CTCTTC	15: 102,370,611 (GRCm39)		probably benign	Homo
Prr13	CACT	CACTACT	15: 102,370,606 (GRCm39)		probably benign	Homo
Ptms	TCT	TCTCCT	6: 124,891,417 (GRCm39)		probably benign	Homo
Ptpn23	G	T	9: 110,216,701 (GRCm39)	P1052T	probably benign	Homo
Raph1	GG	GGGGG	1: 60,528,426 (GRCm39)		probably benign	Homo
Rpa1	TGCTGCC	T	11: 75,209,345 (GRCm39)		probably benign	Het
Rpgrip1	GGA	GGATGA	14: 52,386,851 (GRCm39)		probably benign	Het
Rpgrip1	GGAAGAAGA	GGA	14: 52,387,001 (GRCm39)		probably benign	Het
Rps19	AGCGG	AG	7: 24,588,421 (GRCm39)		probably benign	Homo
Rsf1	G	GACC	7: 97,229,116 (GRCm39)		probably benign	Homo
Serpina3m	A	G	12: 104,324,882 (GRCm39)		probably null	Homo
Setd1a	TGGTGGTGGT	TGGTGGTGGTGGTGGTGGT	7: 127,384,479 (GRCm39)		probably benign	Homo
Setd1a	TAGTGGTGG	TAGTGGTGGGAGTGGTGG	7: 127,384,488 (GRCm39)		probably benign	Het
Sfswap	ACTCAGCCC	ACTCAGCCCCCTCAGCCC	5: 129,646,815 (GRCm39)		probably benign	Het
Sh3pxd2b	GCCTGT	GCCTGTGCCTGT	11: 32,373,060 (GRCm39)		probably benign	Homo
Sh3pxd2b	CCTGTG	CCTGTGTCTGTG	11: 32,373,055 (GRCm39)		probably benign	Het
Shroom4	GCAGCAACA	GCA	X: 6,536,128 (GRCm39)		probably benign	Het
Six3	GCG	GCGTCG	17: 85,928,786 (GRCm39)		probably benign	Het
Six3	CG	CGGGG	17: 85,928,799 (GRCm39)		probably benign	Het
Skint8	C	T	4: 111,796,099 (GRCm39)	L258F	probably benign	Homo
Smoc2	AGTT	A	17: 14,621,824 (GRCm39)		probably benign	Homo
Smpx	CCCCCA	C	X: 156,503,920 (GRCm39)		probably benign	Homo
Snx1	C	CTTT	9: 66,012,212 (GRCm39)		probably benign	Homo
Snx1	TC	TCTGC	9: 66,012,211 (GRCm39)		probably benign	Homo
Sp110	CT	CTAAT	1: 85,515,210 (GRCm39)		probably benign	Het
Spaca1	CGCTCT	CGCTCTTGCTCT	4: 34,049,849 (GRCm39)		probably benign	Het
Spaca1	GCTCTC	GCTCTCCCTCTC	4: 34,049,844 (GRCm39)		probably benign	Het
Spag17	GGA	GGACGA	3: 99,963,571 (GRCm39)		probably benign	Het
Spag17	AGG	AGGTGG	3: 99,963,570 (GRCm39)		probably benign	Het
Srebf2	G	T	15: 82,069,536 (GRCm39)	A693S	probably damaging	Homo
Sry	T	TGGG	Y: 2,662,841 (GRCm39)		probably benign	Homo
Stard8	AGG	AGGTGG	X: 98,110,119 (GRCm39)		probably benign	Het
Stard8	AGG	AGGTGG	X: 98,110,131 (GRCm39)		probably benign	Het
Stk10	CCCA	C	11: 32,564,520 (GRCm39)		probably benign	Homo
Tap2	ACTG	ACTGCTG	17: 34,424,673 (GRCm39)		probably benign	Homo
Tbc1d5	G	C	17: 51,106,959 (GRCm39)	H532Q	probably benign	Homo
Tbc1d5	C	G	17: 51,106,971 (GRCm39)	Q528H	probably benign	Homo
Tfeb	GCA	GCAACA	17: 48,097,019 (GRCm39)		probably benign	Het
Tmcc1	G	A	6: 116,170,341 (GRCm39)		probably benign	Homo
Tob1	AGC	AGCCGC	11: 94,105,298 (GRCm39)		probably benign	Het
Tpsab1	TTGCACCTCCT	TT	17: 25,562,756 (GRCm39)		probably benign	Het
Trav15-2-dv6-2	GAA	GAATAA	14: 53,887,211 (GRCm39)		probably null	Het
Trav15-2-dv6-2	G	GAAC	14: 53,887,214 (GRCm39)		probably benign	Homo
Trim16	GTGA	GTGATGA	11: 62,711,515 (GRCm39)		probably benign	Homo
Tsbp1	AGC	AGCGGC	17: 34,679,032 (GRCm39)		probably benign	Het
Tsbp1	AGC	AGCGGC	17: 34,679,035 (GRCm39)		probably benign	Het
Tsen2	AGG	AGGCGG	6: 115,537,027 (GRCm39)		probably benign	Homo
Ubtf	TC	TCCGC	11: 102,197,785 (GRCm39)		probably benign	Het
Vmn1r124	G	T	7: 20,993,861 (GRCm39)	Q228K	possibly damaging	Het
Vmn1r71	A	C	7: 10,482,048 (GRCm39)	S147R	probably benign	Homo
Vmn2r99	G	A	17: 19,614,547 (GRCm39)	G756R	probably damaging	Homo
Vps13b	G	T	15: 35,847,103 (GRCm39)	A2629S	probably damaging	Homo
Wdr75	AAATAA	AAA	1: 45,862,564 (GRCm39)		probably benign	Homo
Zfp111	T	G	7: 23,898,462 (GRCm39)	K383T	probably damaging	Homo
Zfp111	A	ATCG	7: 23,899,232 (GRCm39)		probably benign	Homo
Zfp26	C	A	9: 20,349,842 (GRCm39)	A241S	probably benign	Homo
Zfp282	CGG	CGGTGG	6: 47,881,724 (GRCm39)		probably benign	Het
Zfp335	TCC	TCCACC	2: 164,749,398 (GRCm39)		probably benign	Het
Zfp335	CTC	CTCTTC	2: 164,749,394 (GRCm39)		probably benign	Het
Zfp459	A	AGTGG	13: 67,556,395 (GRCm39)		probably null	Homo
Zfp459	TGA	TGAGAGA	13: 67,556,393 (GRCm39)		probably null	Homo
Zfp459	GA	GAGTTA	13: 67,556,394 (GRCm39)		probably null	Homo
Zfp462	ACC	ACCTCAGCCACAGCCGCC	4: 55,009,760 (GRCm39)		probably benign	Het
Zfp462	CC	CCTCAGCCACAGCCATC	4: 55,009,761 (GRCm39)		probably benign	Het
Zfp598	CCACAGGC	CC	17: 24,898,346 (GRCm39)		probably benign	Het
Zfp598	ACCACC	ACCACCCCCACC	17: 24,899,756 (GRCm39)		probably benign	Het
Zfp683	AG	AGGGG	4: 133,786,190 (GRCm39)		probably benign	Homo
Zpld2	TG	TGCCG	4: 133,929,941 (GRCm39)		probably benign	Homo

Other mutations in Mast4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00703:Mast4	APN	13	102,907,275 (GRCm39)	nonsense	probably null
IGL00933:Mast4	APN	13	102,871,874 (GRCm39)	missense	probably damaging	0.97
IGL01113:Mast4	APN	13	102,910,744 (GRCm39)	missense	probably damaging	1.00
IGL01461:Mast4	APN	13	102,890,576 (GRCm39)	missense	probably damaging	1.00
IGL01569:Mast4	APN	13	102,897,523 (GRCm39)	missense	probably damaging	1.00
IGL01697:Mast4	APN	13	102,904,401 (GRCm39)	missense	probably damaging	1.00
IGL01725:Mast4	APN	13	102,887,020 (GRCm39)	critical splice donor site	probably null
IGL01734:Mast4	APN	13	102,874,123 (GRCm39)	missense	probably damaging	0.98
IGL01738:Mast4	APN	13	102,873,749 (GRCm39)	missense	probably damaging	1.00
IGL01739:Mast4	APN	13	102,910,781 (GRCm39)	missense	probably damaging	1.00
IGL02299:Mast4	APN	13	102,874,482 (GRCm39)	missense	probably benign	0.44
IGL02479:Mast4	APN	13	102,878,545 (GRCm39)	missense	probably damaging	1.00
IGL02485:Mast4	APN	13	102,872,004 (GRCm39)	missense	probably benign	0.02
IGL02528:Mast4	APN	13	102,990,331 (GRCm39)	makesense	probably null
IGL02850:Mast4	APN	13	102,890,740 (GRCm39)	missense	probably damaging	1.00
IGL02900:Mast4	APN	13	102,872,184 (GRCm39)	missense	probably benign
IGL03064:Mast4	APN	13	102,897,472 (GRCm39)	nonsense	probably null
IGL03124:Mast4	APN	13	102,874,753 (GRCm39)	missense	probably damaging	1.00
IGL03146:Mast4	APN	13	102,874,163 (GRCm39)	missense	probably benign	0.00
IGL03221:Mast4	APN	13	102,890,764 (GRCm39)	missense	possibly damaging	0.95
IGL03284:Mast4	APN	13	102,887,905 (GRCm39)	missense	probably damaging	1.00
IGL03406:Mast4	APN	13	102,873,615 (GRCm39)	missense	possibly damaging	0.46
buck	UTSW	13	102,897,801 (GRCm39)	critical splice donor site	probably null
doe	UTSW	13	103,042,185 (GRCm39)	missense	possibly damaging	0.85
skinnybones	UTSW	13	102,941,149 (GRCm39)	critical splice donor site	probably null
BB010:Mast4	UTSW	13	102,909,071 (GRCm39)	missense	probably damaging	0.99
BB020:Mast4	UTSW	13	102,909,071 (GRCm39)	missense	probably damaging	0.99
FR4304:Mast4	UTSW	13	102,871,370 (GRCm39)	utr 3 prime	probably benign
FR4340:Mast4	UTSW	13	102,872,825 (GRCm39)	small insertion	probably benign
FR4340:Mast4	UTSW	13	102,871,365 (GRCm39)	frame shift	probably null
FR4548:Mast4	UTSW	13	102,872,826 (GRCm39)	small insertion	probably benign
FR4976:Mast4	UTSW	13	102,875,755 (GRCm39)	frame shift	probably null
NA:Mast4	UTSW	13	102,878,565 (GRCm39)	missense	probably damaging	1.00
PIT4466001:Mast4	UTSW	13	102,941,226 (GRCm39)	missense	probably damaging	1.00
PIT4469001:Mast4	UTSW	13	102,941,226 (GRCm39)	missense	probably damaging	1.00
PIT4472001:Mast4	UTSW	13	102,941,226 (GRCm39)	missense	probably damaging	1.00
R0009:Mast4	UTSW	13	102,878,566 (GRCm39)	missense	probably damaging	1.00
R0063:Mast4	UTSW	13	103,470,723 (GRCm39)	start gained	probably benign
R0242:Mast4	UTSW	13	102,990,350 (GRCm39)	missense	probably damaging	1.00
R0310:Mast4	UTSW	13	102,890,669 (GRCm39)	missense	possibly damaging	0.94
R0395:Mast4	UTSW	13	102,871,781 (GRCm39)	missense	probably damaging	1.00
R0454:Mast4	UTSW	13	102,888,068 (GRCm39)	missense	probably damaging	1.00
R0646:Mast4	UTSW	13	102,895,252 (GRCm39)	splice site	probably benign
R0744:Mast4	UTSW	13	102,873,895 (GRCm39)	missense	probably damaging	0.98
R0883:Mast4	UTSW	13	102,990,408 (GRCm39)	missense	probably damaging	1.00
R0905:Mast4	UTSW	13	102,907,292 (GRCm39)	missense	probably damaging	0.99
R1023:Mast4	UTSW	13	102,872,004 (GRCm39)	missense	probably benign	0.02
R1281:Mast4	UTSW	13	102,887,086 (GRCm39)	missense	probably damaging	1.00
R1376:Mast4	UTSW	13	102,872,916 (GRCm39)	missense	possibly damaging	0.46
R1376:Mast4	UTSW	13	102,872,916 (GRCm39)	missense	possibly damaging	0.46
R1473:Mast4	UTSW	13	102,909,027 (GRCm39)	missense	probably damaging	1.00
R1572:Mast4	UTSW	13	102,873,431 (GRCm39)	missense	possibly damaging	0.51
R1575:Mast4	UTSW	13	102,875,771 (GRCm39)	missense	probably damaging	1.00
R1865:Mast4	UTSW	13	102,930,625 (GRCm39)	missense	probably damaging	1.00
R2050:Mast4	UTSW	13	102,887,917 (GRCm39)	missense	probably damaging	1.00
R2060:Mast4	UTSW	13	102,875,354 (GRCm39)	missense	probably damaging	1.00
R2062:Mast4	UTSW	13	102,895,601 (GRCm39)	missense	probably benign	0.18
R2106:Mast4	UTSW	13	102,887,054 (GRCm39)	missense	probably damaging	1.00
R2118:Mast4	UTSW	13	102,890,713 (GRCm39)	missense	probably damaging	1.00
R2143:Mast4	UTSW	13	102,871,983 (GRCm39)	missense	possibly damaging	0.89
R2256:Mast4	UTSW	13	102,872,259 (GRCm39)	missense	possibly damaging	0.62
R2261:Mast4	UTSW	13	102,934,715 (GRCm39)	splice site	probably benign
R2370:Mast4	UTSW	13	102,910,695 (GRCm39)	missense	probably damaging	1.00
R2504:Mast4	UTSW	13	102,875,147 (GRCm39)	missense	probably damaging	0.96
R2509:Mast4	UTSW	13	102,990,350 (GRCm39)	missense	probably damaging	1.00
R2842:Mast4	UTSW	13	102,872,939 (GRCm39)	missense	probably benign	0.01
R3087:Mast4	UTSW	13	102,990,434 (GRCm39)	splice site	probably benign
R3434:Mast4	UTSW	13	102,923,887 (GRCm39)	missense	probably damaging	1.00
R3435:Mast4	UTSW	13	102,923,887 (GRCm39)	missense	probably damaging	1.00
R3763:Mast4	UTSW	13	102,923,927 (GRCm39)	missense	probably damaging	1.00
R3826:Mast4	UTSW	13	102,875,319 (GRCm39)	missense	probably damaging	1.00
R3829:Mast4	UTSW	13	102,875,319 (GRCm39)	missense	probably damaging	1.00
R3830:Mast4	UTSW	13	102,875,319 (GRCm39)	missense	probably damaging	1.00
R3913:Mast4	UTSW	13	102,895,177 (GRCm39)	missense	probably damaging	1.00
R3914:Mast4	UTSW	13	102,875,829 (GRCm39)	nonsense	probably null
R4021:Mast4	UTSW	13	102,875,829 (GRCm39)	nonsense	probably null
R4022:Mast4	UTSW	13	102,990,377 (GRCm39)	missense	probably damaging	1.00
R4022:Mast4	UTSW	13	102,875,829 (GRCm39)	nonsense	probably null
R4210:Mast4	UTSW	13	102,875,713 (GRCm39)	missense	probably damaging	1.00
R4342:Mast4	UTSW	13	102,910,756 (GRCm39)	missense	probably damaging	1.00
R4580:Mast4	UTSW	13	102,873,766 (GRCm39)	nonsense	probably null
R4627:Mast4	UTSW	13	103,470,529 (GRCm39)	missense	possibly damaging	0.92
R4711:Mast4	UTSW	13	103,470,627 (GRCm39)	missense	probably benign	0.01
R4732:Mast4	UTSW	13	102,909,080 (GRCm39)	missense	probably damaging	0.99
R4733:Mast4	UTSW	13	102,909,080 (GRCm39)	missense	probably damaging	0.99
R4833:Mast4	UTSW	13	102,910,692 (GRCm39)	critical splice donor site	probably null
R4995:Mast4	UTSW	13	103,042,262 (GRCm39)	intron	probably benign
R5059:Mast4	UTSW	13	102,887,071 (GRCm39)	missense	probably damaging	1.00
R5073:Mast4	UTSW	13	102,875,391 (GRCm39)	nonsense	probably null
R5101:Mast4	UTSW	13	102,872,864 (GRCm39)	missense	probably benign	0.01
R5526:Mast4	UTSW	13	102,890,723 (GRCm39)	missense	possibly damaging	0.48
R5599:Mast4	UTSW	13	102,873,987 (GRCm39)	missense	probably damaging	1.00
R5673:Mast4	UTSW	13	102,930,580 (GRCm39)	missense	probably damaging	1.00
R5694:Mast4	UTSW	13	102,910,701 (GRCm39)	nonsense	probably null
R5906:Mast4	UTSW	13	102,872,252 (GRCm39)	missense	probably benign	0.31
R5908:Mast4	UTSW	13	102,874,764 (GRCm39)	missense	probably damaging	1.00
R5947:Mast4	UTSW	13	102,872,148 (GRCm39)	missense	probably benign
R5987:Mast4	UTSW	13	102,895,242 (GRCm39)	missense	probably damaging	1.00
R6143:Mast4	UTSW	13	102,990,391 (GRCm39)	missense	probably damaging	1.00
R6154:Mast4	UTSW	13	102,923,929 (GRCm39)	missense	probably damaging	1.00
R6169:Mast4	UTSW	13	102,923,929 (GRCm39)	missense	probably damaging	1.00
R6239:Mast4	UTSW	13	102,872,717 (GRCm39)	missense	probably benign	0.01
R6327:Mast4	UTSW	13	102,897,890 (GRCm39)	missense	probably damaging	1.00
R6356:Mast4	UTSW	13	102,872,493 (GRCm39)	missense	possibly damaging	0.80
R6432:Mast4	UTSW	13	103,042,185 (GRCm39)	missense	possibly damaging	0.85
R6522:Mast4	UTSW	13	102,897,801 (GRCm39)	critical splice donor site	probably null
R6667:Mast4	UTSW	13	102,874,004 (GRCm39)	missense	probably damaging	1.00
R6941:Mast4	UTSW	13	102,941,222 (GRCm39)	missense	probably damaging	1.00
R6968:Mast4	UTSW	13	102,941,155 (GRCm39)	missense	probably damaging	1.00
R6968:Mast4	UTSW	13	102,934,586 (GRCm39)	missense	probably damaging	1.00
R6970:Mast4	UTSW	13	102,941,155 (GRCm39)	missense	probably damaging	1.00
R6980:Mast4	UTSW	13	102,941,155 (GRCm39)	missense	probably damaging	1.00
R6991:Mast4	UTSW	13	102,941,155 (GRCm39)	missense	probably damaging	1.00
R6992:Mast4	UTSW	13	102,941,155 (GRCm39)	missense	probably damaging	1.00
R6993:Mast4	UTSW	13	102,872,482 (GRCm39)	missense	probably benign	0.28
R6993:Mast4	UTSW	13	102,941,155 (GRCm39)	missense	probably damaging	1.00
R7083:Mast4	UTSW	13	102,874,223 (GRCm39)	missense	probably damaging	1.00
R7241:Mast4	UTSW	13	103,470,508 (GRCm39)	missense	possibly damaging	0.87
R7242:Mast4	UTSW	13	102,874,986 (GRCm39)	missense	probably damaging	1.00
R7246:Mast4	UTSW	13	102,930,511 (GRCm39)	missense	probably damaging	1.00
R7332:Mast4	UTSW	13	102,887,932 (GRCm39)	missense	possibly damaging	0.61
R7453:Mast4	UTSW	13	102,941,149 (GRCm39)	critical splice donor site	probably null
R7514:Mast4	UTSW	13	102,923,934 (GRCm39)	nonsense	probably null
R7697:Mast4	UTSW	13	102,875,711 (GRCm39)	missense	probably damaging	1.00
R7820:Mast4	UTSW	13	102,890,596 (GRCm39)	missense	probably damaging	1.00
R7874:Mast4	UTSW	13	102,875,783 (GRCm39)	missense	probably damaging	1.00
R7933:Mast4	UTSW	13	102,909,071 (GRCm39)	missense	probably damaging	0.99
R8042:Mast4	UTSW	13	102,917,753 (GRCm39)	missense	probably damaging	0.96
R8060:Mast4	UTSW	13	102,874,184 (GRCm39)	missense	possibly damaging	0.89
R8172:Mast4	UTSW	13	103,089,633 (GRCm39)	critical splice donor site	probably null
R8206:Mast4	UTSW	13	102,872,247 (GRCm39)	missense	probably damaging	1.00
R8248:Mast4	UTSW	13	102,875,229 (GRCm39)	missense	probably damaging	1.00
R8283:Mast4	UTSW	13	102,895,177 (GRCm39)	missense	probably damaging	1.00
R8346:Mast4	UTSW	13	102,887,986 (GRCm39)	missense	probably damaging	0.99
R8434:Mast4	UTSW	13	102,897,900 (GRCm39)	missense	probably damaging	1.00
R8796:Mast4	UTSW	13	102,919,899 (GRCm39)	missense	probably benign	0.07
R8850:Mast4	UTSW	13	102,895,174 (GRCm39)	missense	probably damaging	1.00
R9012:Mast4	UTSW	13	102,934,606 (GRCm39)	missense	probably benign	0.05
R9375:Mast4	UTSW	13	102,917,753 (GRCm39)	missense	probably damaging	0.99
R9389:Mast4	UTSW	13	103,470,438 (GRCm39)	missense	probably benign	0.00
R9404:Mast4	UTSW	13	102,887,933 (GRCm39)	missense	probably damaging	1.00
R9520:Mast4	UTSW	13	102,925,532 (GRCm39)	missense	probably damaging	1.00
R9525:Mast4	UTSW	13	102,872,944 (GRCm39)	missense	probably benign	0.00
R9526:Mast4	UTSW	13	102,873,593 (GRCm39)	missense	probably benign	0.00
R9709:Mast4	UTSW	13	102,910,711 (GRCm39)	missense	probably damaging	1.00
R9790:Mast4	UTSW	13	102,890,705 (GRCm39)	missense	probably benign	0.01
R9791:Mast4	UTSW	13	102,890,705 (GRCm39)	missense	probably benign	0.01
RF005:Mast4	UTSW	13	102,872,815 (GRCm39)	small insertion	probably benign
RF015:Mast4	UTSW	13	102,875,755 (GRCm39)	frame shift	probably null
RF019:Mast4	UTSW	13	102,872,815 (GRCm39)	small insertion	probably benign
RF037:Mast4	UTSW	13	102,875,749 (GRCm39)	small deletion	probably benign
RF039:Mast4	UTSW	13	102,875,749 (GRCm39)	small deletion	probably benign
RF040:Mast4	UTSW	13	102,875,749 (GRCm39)	small deletion	probably benign
Z1088:Mast4	UTSW	13	102,875,027 (GRCm39)	missense	probably damaging	1.00
Z1176:Mast4	UTSW	13	102,874,968 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCCTTCTCTGATGGAACCAC -3'
(R):5'- CAGGAAGGAACAGACTTCGC -3'

Sequencing Primer
(F):5'- TTCTCTGATGGAACCACCCAGG -3'
(R):5'- AGACTTCGCAAAGGCCTG -3'

Posted On

2018-04-05