Incidental Mutation 'R4991:Gm29106'
ID512192
Institutional Source Beutler Lab
Gene Symbol Gm29106
Ensembl Gene ENSMUSG00000102030
Gene Namepredicted gene 29106
Synonyms
MMRRC Submission 042585-MU
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.433) question?
Stock #R4991 (G1)
Quality Score87
Status Not validated
Chromosome1
Chromosomal Location118176542-118202307 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 118178391 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Threonine at position 37 (M37T)
Ref Sequence ENSEMBL: ENSMUSP00000141137 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000186264]
Predicted Effect probably benign
Transcript: ENSMUST00000186264
AA Change: M37T

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000141137
Gene: ENSMUSG00000102030
AA Change: M37T

DomainStartEndE-ValueType
KRAB 8 66 2.8e-24 SMART
ZnF_C2H2 77 97 2.3e-2 SMART
ZnF_C2H2 105 127 4.5e-6 SMART
ZnF_C2H2 133 155 3.4e-6 SMART
ZnF_C2H2 161 183 3.2e-7 SMART
ZnF_C2H2 189 211 2.1e-4 SMART
ZnF_C2H2 217 239 6.3e-7 SMART
ZnF_C2H2 245 267 3.4e-6 SMART
ZnF_C2H2 273 295 3.2e-7 SMART
ZnF_C2H2 301 323 2.1e-4 SMART
ZnF_C2H2 329 351 6.3e-7 SMART
ZnF_C2H2 357 379 2.1e-4 SMART
ZnF_C2H2 385 407 7.8e-5 SMART
ZnF_C2H2 413 435 1.1e-7 SMART
ZnF_C2H2 441 463 4e-5 SMART
ZnF_C2H2 469 491 1.3e-6 SMART
ZnF_C2H2 497 519 2.4e-6 SMART
ZnF_C2H2 525 547 2.3e-4 SMART
ZnF_C2H2 553 575 1.4e-4 SMART
ZnF_C2H2 581 603 1.9e-6 SMART
ZnF_C2H2 609 631 5.2e-5 SMART
ZnF_C2H2 637 659 1.7e-5 SMART
ZnF_C2H2 665 687 9.4e-7 SMART
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 95.7%
  • 20x: 90.0%
Validation Efficiency 95% (73/77)
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy4 G T 14: 55,773,465 T665K probably benign Het
Adgrf3 C T 5: 30,199,148 V369M probably benign Het
Als2 T C 1: 59,207,768 K571E probably benign Het
Amer3 A C 1: 34,588,741 D687A probably benign Het
Asb14 T C 14: 26,915,058 S586P probably damaging Het
Chmp4b A G 2: 154,692,625 E187G probably benign Het
Cox6b2 T C 7: 4,752,161 D38G probably damaging Het
Cpm G A 10: 117,668,103 C138Y probably damaging Het
Csmd3 G T 15: 48,001,478 P785Q probably damaging Het
Cstf1 A G 2: 172,377,800 Y277C probably damaging Het
Cstf2t T A 19: 31,084,583 N506K probably damaging Het
Dmpk C G 7: 19,088,019 L301V probably benign Het
Ebf2 A T 14: 67,389,657 T265S possibly damaging Het
Elmo1 T C 13: 20,342,519 F413S probably damaging Het
Fbp1 C T 13: 62,865,074 V102I probably benign Het
Gm13212 C A 4: 145,622,334 Q114K probably benign Het
Gm14548 T G 7: 3,895,572 Q292H probably benign Het
Gm16432 A C 1: 178,098,421 I218L probably benign Het
Gm19684 A G 17: 36,127,472 probably benign Het
Grem2 A G 1: 174,836,813 C157R probably damaging Het
Hdac5 T A 11: 102,205,624 E252D probably damaging Het
Ifitm3 A T 7: 141,010,459 F63I probably damaging Het
Igkv4-80 A C 6: 69,016,665 S81A probably benign Het
Irx4 G T 13: 73,265,507 R32L probably benign Het
Itgb1bp1 C T 12: 21,274,848 G69D probably damaging Het
Kcnh3 A G 15: 99,232,756 D418G probably benign Het
Kif1a T C 1: 93,078,808 T46A probably benign Het
Klk1b26 T A 7: 44,016,249 probably null Het
Lca5l T C 16: 96,159,732 E510G possibly damaging Het
Lrriq1 A G 10: 103,200,559 I911T probably damaging Het
Mios T G 6: 8,215,847 S348A probably benign Het
Mog T C 17: 37,017,489 probably null Het
Mtmr7 A G 8: 40,554,345 S516P probably damaging Het
Nat8f4 T C 6: 85,901,140 K134E probably benign Het
Nbeal2 C T 9: 110,638,767 C451Y probably damaging Het
Nkx2-1 T C 12: 56,534,939 Y41C possibly damaging Het
Nmnat1 G A 4: 149,469,127 T176M possibly damaging Het
Nrxn3 T A 12: 89,260,474 I293N probably damaging Het
Olfr1031 A G 2: 85,992,287 M157V probably damaging Het
Olfr1447 T G 19: 12,901,451 T110P probably damaging Het
Olfr313 T C 11: 58,817,718 S237P probably damaging Het
Osgin1 A G 8: 119,445,289 E274G probably damaging Het
Otof G A 5: 30,394,181 R343W probably damaging Het
Pcdha9 A T 18: 36,998,345 I156F probably damaging Het
Pcsk4 A G 10: 80,325,381 I233T possibly damaging Het
Samd4 A T 14: 47,074,010 S262C probably damaging Het
Snap91 T C 9: 86,790,154 probably null Het
Spata31d1a T C 13: 59,703,151 N388D probably benign Het
St3gal4 A G 9: 35,053,136 V190A possibly damaging Het
Sv2b T C 7: 75,117,722 N642S possibly damaging Het
Svil T A 18: 5,056,810 I561K probably benign Het
Tmem201 A T 4: 149,728,155 Y235N possibly damaging Het
Tpx2 T C 2: 152,869,724 S60P probably benign Het
Trpa1 T C 1: 14,910,746 Y144C probably benign Het
U90926 G A 5: 92,210,020 P91S probably benign Het
Utp20 G T 10: 88,746,934 H2780Q probably benign Het
Vmn1r215 T G 13: 23,076,527 F246V probably damaging Het
Vmn2r72 A G 7: 85,751,130 L237S probably damaging Het
Washc5 A G 15: 59,344,080 S817P probably damaging Het
Zbtb24 A G 10: 41,456,618 probably null Het
Zfp212 G A 6: 47,926,862 R127H probably damaging Het
Zfp740 G T 15: 102,208,279 probably null Het
Other mutations in Gm29106
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4985:Gm29106 UTSW 1 118199220 missense probably benign 0.02
R6029:Gm29106 UTSW 1 118200260 missense probably damaging 1.00
R6922:Gm29106 UTSW 1 118199794 missense probably damaging 0.98
R6954:Gm29106 UTSW 1 118200587 missense probably damaging 1.00
R6961:Gm29106 UTSW 1 118200398 nonsense probably null
R7232:Gm29106 UTSW 1 118199561 missense probably damaging 1.00
R7337:Gm29106 UTSW 1 118176912 missense unknown
R7457:Gm29106 UTSW 1 118199252 missense probably damaging 1.00
R7662:Gm29106 UTSW 1 118199407 missense possibly damaging 0.89
R7870:Gm29106 UTSW 1 118199155 missense possibly damaging 0.55
R7894:Gm29106 UTSW 1 118199535 missense probably damaging 1.00
R7953:Gm29106 UTSW 1 118199155 missense possibly damaging 0.55
R7977:Gm29106 UTSW 1 118199535 missense probably damaging 1.00
Predicted Primers
Posted On2018-04-10