Incidental Mutation 'IGL01063:Olfr213'
ID51230
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr213
Ensembl Gene ENSMUSG00000081649
Gene Nameolfactory receptor 213
SynonymsGA_x54KRFPKN04-58174409-58175392, MOR119-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #IGL01063
Quality Score
Status
Chromosome6
Chromosomal Location116538456-116544292 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 116541007 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Serine at position 185 (C185S)
Ref Sequence ENSEMBL: ENSMUSP00000151916 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000121958] [ENSMUST00000220008]
Predicted Effect probably damaging
Transcript: ENSMUST00000121958
AA Change: C185S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000112931
Gene: ENSMUSG00000081649
AA Change: C185S

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 4e-45 PFAM
Pfam:7tm_1 47 296 5.4e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000220008
AA Change: C185S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,950,275 V124I probably damaging Het
4930444P10Rik A T 1: 16,078,646 L61* probably null Het
Abca7 T C 10: 80,011,297 I1705T probably damaging Het
Ablim1 T A 19: 57,061,328 I393F probably damaging Het
Adamts5 A G 16: 85,899,834 L145P probably damaging Het
Ano6 T C 15: 95,948,429 I537T probably damaging Het
AU018091 T C 7: 3,162,313 I190V possibly damaging Het
Camk1 T A 6: 113,338,372 D155V probably damaging Het
Cdh6 A C 15: 13,064,495 I103S probably damaging Het
Cntnap1 A G 11: 101,181,788 D537G probably benign Het
Col6a3 T C 1: 90,802,332 K1144E probably damaging Het
Cpeb1 T A 7: 81,372,181 E71D probably benign Het
Cps1 T C 1: 67,195,166 L904P possibly damaging Het
Cyfip1 T A 7: 55,904,210 F700I probably damaging Het
Dmp1 G A 5: 104,207,099 M1I probably null Het
Efcab6 A T 15: 84,054,512 M1K probably null Het
Extl2 A T 3: 116,027,482 H312L possibly damaging Het
Fat4 C A 3: 38,890,579 A1207D possibly damaging Het
Flnb T C 14: 7,926,518 probably benign Het
Hdac10 G T 15: 89,123,868 A593E possibly damaging Het
Hdhd2 T C 18: 76,965,273 probably null Het
Kcnq2 A G 2: 181,109,789 probably benign Het
Kdm7a A G 6: 39,165,130 F405L probably damaging Het
Lypd6b C A 2: 49,943,630 probably benign Het
Mki67 A T 7: 135,694,922 D2794E possibly damaging Het
Mtmr14 T A 6: 113,266,326 F40I probably damaging Het
Olfr131 G T 17: 38,082,653 S108R possibly damaging Het
Olfr476 A T 7: 107,967,534 I46F probably damaging Het
Olfr986 A T 9: 40,187,756 I214F probably benign Het
Ppargc1a C A 5: 51,474,322 V322L probably benign Het
Ppfibp1 T A 6: 147,029,697 M917K probably benign Het
Prkg2 C T 5: 98,969,936 probably null Het
Rfx4 A G 10: 84,868,382 E296G possibly damaging Het
Rfx8 T A 1: 39,682,950 K292* probably null Het
Scamp3 C A 3: 89,177,666 probably benign Het
Scn4a A T 11: 106,330,364 I823N possibly damaging Het
Sdk2 A G 11: 113,830,842 V1316A probably damaging Het
Setd2 T C 9: 110,573,673 V1794A probably damaging Het
Stard8 G T X: 99,073,088 R983L probably damaging Het
Tbc1d23 A T 16: 57,192,675 D311E probably benign Het
Tex21 T C 12: 76,198,818 H568R probably benign Het
Tex35 T C 1: 157,105,097 probably benign Het
Tgs1 T A 4: 3,591,292 F442I possibly damaging Het
Traf2 C A 2: 25,524,919 C303F probably benign Het
Trim56 A T 5: 137,114,500 V54D possibly damaging Het
Yars2 C T 16: 16,306,542 R338* probably null Het
Zfp668 A T 7: 127,866,282 C577S probably damaging Het
Other mutations in Olfr213
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02671:Olfr213 APN 6 116541143 missense possibly damaging 0.50
IGL03107:Olfr213 APN 6 116540939 missense possibly damaging 0.82
R0041:Olfr213 UTSW 6 116541334 missense possibly damaging 0.55
R0426:Olfr213 UTSW 6 116540485 missense probably damaging 1.00
R0627:Olfr213 UTSW 6 116540988 missense possibly damaging 0.56
R0829:Olfr213 UTSW 6 116541265 missense probably benign 0.01
R2111:Olfr213 UTSW 6 116540650 missense possibly damaging 0.95
R2112:Olfr213 UTSW 6 116540650 missense possibly damaging 0.95
R2120:Olfr213 UTSW 6 116540455 start codon destroyed probably null 0.04
R3161:Olfr213 UTSW 6 116540846 missense probably damaging 1.00
R3700:Olfr213 UTSW 6 116540528 missense probably benign 0.10
R4710:Olfr213 UTSW 6 116540650 missense possibly damaging 0.95
R5244:Olfr213 UTSW 6 116541226 missense probably damaging 1.00
R5859:Olfr213 UTSW 6 116540900 missense probably damaging 1.00
R6273:Olfr213 UTSW 6 116541316 missense possibly damaging 0.74
R6505:Olfr213 UTSW 6 116540600 missense probably benign 0.01
R7350:Olfr213 UTSW 6 116540534 missense probably benign 0.28
R7380:Olfr213 UTSW 6 116540933 missense probably benign 0.03
R7474:Olfr213 UTSW 6 116541038 missense probably damaging 0.99
R8054:Olfr213 UTSW 6 116540999 missense probably damaging 1.00
R8476:Olfr213 UTSW 6 116540546 missense probably benign
Posted On2013-06-21