Incidental Mutation 'IGL00325:Prss36'
ID5124
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prss36
Ensembl Gene ENSMUSG00000070371
Gene Nameprotease, serine 36
Synonymspolyserase-2, C330007D15Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00325
Quality Score
Status
Chromosome7
Chromosomal Location127932638-127946725 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to A at 127944927 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000112659 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094026] [ENSMUST00000118755]
Predicted Effect probably benign
Transcript: ENSMUST00000094026
SMART Domains Protein: ENSMUSP00000091565
Gene: ENSMUSG00000070371

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Tryp_SPc 47 287 3.75e-88 SMART
Pfam:Trypsin 325 556 1.2e-16 PFAM
Pfam:Trypsin 599 798 6.6e-20 PFAM
Pfam:DUF1986 607 707 1.4e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000118755
SMART Domains Protein: ENSMUSP00000112659
Gene: ENSMUSG00000070371

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Tryp_SPc 47 287 3.75e-88 SMART
Pfam:Trypsin 325 545 9.7e-18 PFAM
Pfam:Trypsin 588 787 6.5e-20 PFAM
Pfam:DUF1986 590 696 8e-10 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap1 A G 11: 69,882,691 S431P possibly damaging Het
Arid1b C A 17: 5,337,110 R1613S possibly damaging Het
Atxn2l T C 7: 126,498,288 D196G possibly damaging Het
Bag3 C A 7: 128,546,341 T560K probably benign Het
BC051076 A G 5: 87,964,495 probably benign Het
Becn1 A T 11: 101,295,622 M18K probably benign Het
C130050O18Rik G A 5: 139,414,738 C182Y probably damaging Het
Cfap43 A G 19: 47,823,188 probably benign Het
Cfap97 C T 8: 46,170,185 S204L probably damaging Het
Gaa A G 11: 119,274,960 T100A probably benign Het
Gab2 C T 7: 97,299,258 P352S probably damaging Het
Gckr T A 5: 31,307,767 I360N possibly damaging Het
Gm4553 T C 7: 142,165,227 S155G unknown Het
Gulo G T 14: 66,005,949 A40D probably damaging Het
Irs1 T C 1: 82,288,483 I671V probably benign Het
Itgax T C 7: 128,148,309 V1028A possibly damaging Het
Lamb3 T C 1: 193,320,447 C67R probably damaging Het
Mpdz A T 4: 81,317,631 V1237E probably damaging Het
Nat8 C T 6: 85,830,597 V185M probably benign Het
Ninj2 A C 6: 120,198,062 T65P probably benign Het
Nrg2 T C 18: 36,021,218 M549V probably benign Het
Nwd2 A G 5: 63,805,475 M801V probably benign Het
Pde8b T C 13: 95,034,367 D589G probably damaging Het
Ppp1r35 T A 5: 137,779,537 V155E probably damaging Het
Raver2 A G 4: 101,102,868 K182E probably damaging Het
Ring1 T G 17: 34,023,009 E142A possibly damaging Het
Sidt2 T A 9: 45,942,236 M689L possibly damaging Het
Slc45a4 A G 15: 73,587,655 V95A probably damaging Het
Ssc5d T C 7: 4,944,481 V1278A possibly damaging Het
Stk36 A T 1: 74,634,702 K1251N possibly damaging Het
Utp14b T A 1: 78,664,545 S53R probably damaging Het
Vmn2r17 A T 5: 109,427,992 E243V probably benign Het
Other mutations in Prss36
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01473:Prss36 APN 7 127944701 missense probably damaging 0.98
IGL03139:Prss36 APN 7 127933611 missense probably damaging 1.00
R0111:Prss36 UTSW 7 127934545 missense probably damaging 1.00
R0295:Prss36 UTSW 7 127935855 missense possibly damaging 0.80
R1771:Prss36 UTSW 7 127933453 missense probably damaging 1.00
R1827:Prss36 UTSW 7 127933492 missense probably damaging 1.00
R3935:Prss36 UTSW 7 127934608 missense probably damaging 1.00
R4257:Prss36 UTSW 7 127932838 unclassified probably benign
R4694:Prss36 UTSW 7 127935615 missense probably damaging 1.00
R5384:Prss36 UTSW 7 127936699 missense probably damaging 1.00
R5464:Prss36 UTSW 7 127934233 missense probably damaging 1.00
R5524:Prss36 UTSW 7 127934465 nonsense probably null
R5749:Prss36 UTSW 7 127933642 missense probably damaging 1.00
R5905:Prss36 UTSW 7 127933572 missense probably benign 0.26
R5992:Prss36 UTSW 7 127944830 missense probably damaging 1.00
R6033:Prss36 UTSW 7 127934567 missense probably benign 0.07
R6033:Prss36 UTSW 7 127934567 missense probably benign 0.07
R6971:Prss36 UTSW 7 127945238 missense probably benign 0.15
R7050:Prss36 UTSW 7 127944765 missense possibly damaging 0.71
R7232:Prss36 UTSW 7 127935591 missense probably benign 0.07
R7271:Prss36 UTSW 7 127944705 missense probably benign 0.10
Z1088:Prss36 UTSW 7 127934537 nonsense probably null
Z1177:Prss36 UTSW 7 127933833 critical splice acceptor site probably null
Posted On2012-04-20