Incidental Mutation 'R6362:Vmn2r72'
| ID |
512515 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r72
|
| Ensembl Gene |
ENSMUSG00000051877 |
| Gene Name |
vomeronasal 2, receptor 72 |
| Synonyms |
Vmn2r72-ps, EG244114 |
| MMRRC Submission |
044512-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.113)
|
| Stock # |
R6362 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
85737784-85754981 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 85751174 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 222
(F222L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133014
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000063425]
|
| AlphaFold |
D3Z4N8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000063425
AA Change: F222L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877
AA Change: F222L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
469 |
2.3e-28 |
PFAM |
|
Pfam:NCD3G
|
512 |
564 |
1.2e-18 |
PFAM |
|
Pfam:7tm_3
|
594 |
832 |
4e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.5%
- 20x: 96.0%
|
| Validation Efficiency |
99% (78/79) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700021F07Rik |
T |
G |
2: 173,528,174 (GRCm38) |
|
probably null |
Het |
| Aldh5a1 |
T |
G |
13: 24,918,550 (GRCm38) |
D310A |
probably benign |
Het |
| Als2cl |
T |
A |
9: 110,895,446 (GRCm38) |
|
probably null |
Het |
| Amacr |
C |
A |
15: 10,984,805 (GRCm38) |
R170S |
probably damaging |
Het |
| Brwd1 |
C |
T |
16: 96,002,307 (GRCm38) |
R2221Q |
probably damaging |
Het |
| Cacna1g |
A |
T |
11: 94,439,707 (GRCm38) |
|
probably null |
Het |
| Cd3d |
G |
A |
9: 44,986,291 (GRCm38) |
D157N |
probably damaging |
Het |
| Cep131 |
T |
C |
11: 120,064,690 (GRCm38) |
D1043G |
probably damaging |
Het |
| Cit |
A |
G |
5: 115,886,676 (GRCm38) |
D326G |
probably benign |
Het |
| Col16a1 |
G |
C |
4: 130,066,190 (GRCm38) |
G370R |
unknown |
Het |
| Col6a3 |
T |
A |
1: 90,810,563 (GRCm38) |
Y1078F |
probably damaging |
Het |
| Colgalt2 |
A |
C |
1: 152,471,798 (GRCm38) |
Y161S |
probably damaging |
Het |
| Cyp2j13 |
A |
G |
4: 96,071,695 (GRCm38) |
Y75H |
probably damaging |
Het |
| Daxx |
G |
A |
17: 33,911,364 (GRCm38) |
V118I |
probably damaging |
Het |
| Dennd5a |
G |
T |
7: 109,934,265 (GRCm38) |
C75* |
probably null |
Het |
| Diaph3 |
A |
G |
14: 86,772,130 (GRCm38) |
L1071P |
probably damaging |
Het |
| Disp3 |
A |
G |
4: 148,254,308 (GRCm38) |
L802P |
possibly damaging |
Het |
| Dmc1 |
A |
G |
15: 79,588,823 (GRCm38) |
V141A |
probably benign |
Het |
| Dsc2 |
A |
T |
18: 20,035,463 (GRCm38) |
Y45* |
probably null |
Het |
| Dspp |
A |
G |
5: 104,176,034 (GRCm38) |
I348V |
probably benign |
Het |
| Epb42 |
C |
A |
2: 121,025,779 (GRCm38) |
C428F |
possibly damaging |
Het |
| Fam227a |
G |
T |
15: 79,643,350 (GRCm38) |
P100Q |
possibly damaging |
Het |
| Fer1l4 |
C |
T |
2: 156,048,250 (GRCm38) |
V252I |
probably benign |
Het |
| Fhod1 |
C |
A |
8: 105,331,641 (GRCm38) |
|
probably null |
Het |
| Fhod3 |
G |
T |
18: 24,754,255 (GRCm38) |
A68S |
probably benign |
Het |
| Gatm |
T |
C |
2: 122,598,196 (GRCm38) |
D328G |
probably benign |
Het |
| Gm13103 |
A |
G |
4: 143,852,865 (GRCm38) |
Y340C |
probably damaging |
Het |
| Gm6401 |
G |
T |
14: 41,967,770 (GRCm38) |
H44N |
probably benign |
Het |
| Gm884 |
G |
C |
11: 103,620,652 (GRCm38) |
N163K |
unknown |
Het |
| Gpat2 |
G |
C |
2: 127,431,918 (GRCm38) |
G294R |
possibly damaging |
Het |
| Gpr84 |
G |
A |
15: 103,308,510 (GRCm38) |
A380V |
probably damaging |
Het |
| Herc1 |
G |
T |
9: 66,471,908 (GRCm38) |
W3492L |
probably damaging |
Het |
| Hjurp |
A |
T |
1: 88,275,050 (GRCm38) |
Y71N |
possibly damaging |
Het |
| Jag2 |
T |
A |
12: 112,920,122 (GRCm38) |
K246N |
probably damaging |
Het |
| Klhl32 |
T |
C |
4: 24,629,195 (GRCm38) |
D524G |
probably null |
Het |
| Lax1 |
A |
G |
1: 133,680,596 (GRCm38) |
S136P |
possibly damaging |
Het |
| Lefty1 |
A |
G |
1: 180,937,160 (GRCm38) |
K217E |
probably benign |
Het |
| Lgr5 |
A |
G |
10: 115,478,525 (GRCm38) |
L169P |
probably damaging |
Het |
| Mad1l1 |
A |
T |
5: 140,315,055 (GRCm38) |
S29T |
possibly damaging |
Het |
| Man1a |
T |
C |
10: 54,074,795 (GRCm38) |
H77R |
probably benign |
Het |
| Met |
C |
T |
6: 17,558,733 (GRCm38) |
S1120F |
probably damaging |
Het |
| Mfsd4b2 |
A |
T |
10: 39,921,609 (GRCm38) |
I250N |
probably damaging |
Het |
| Myod1 |
A |
G |
7: 46,376,881 (GRCm38) |
H70R |
possibly damaging |
Het |
| Neb |
T |
C |
2: 52,212,692 (GRCm38) |
N4280S |
probably benign |
Het |
| Nudt6 |
T |
C |
3: 37,419,489 (GRCm38) |
T28A |
possibly damaging |
Het |
| Nup85 |
A |
G |
11: 115,583,734 (GRCm38) |
E628G |
probably damaging |
Het |
| Oaz3 |
A |
T |
3: 94,434,988 (GRCm38) |
D120E |
probably damaging |
Het |
| Olfr1031 |
C |
A |
2: 85,991,941 (GRCm38) |
N41K |
probably damaging |
Het |
| Olfr1105 |
C |
T |
2: 87,033,289 (GRCm38) |
A311T |
probably benign |
Het |
| Olfr131 |
A |
T |
17: 38,082,729 (GRCm38) |
M83K |
probably damaging |
Het |
| Olfr1454 |
A |
T |
19: 13,063,345 (GRCm38) |
|
probably benign |
Het |
| Olfr786 |
A |
C |
10: 129,436,943 (GRCm38) |
I44L |
probably damaging |
Het |
| Osbpl8 |
A |
T |
10: 111,273,068 (GRCm38) |
K404* |
probably null |
Het |
| Pcdhga2 |
A |
G |
18: 37,670,905 (GRCm38) |
N601D |
probably damaging |
Het |
| Pld2 |
T |
C |
11: 70,554,675 (GRCm38) |
Y638H |
probably damaging |
Het |
| Prickle2 |
C |
G |
6: 92,458,615 (GRCm38) |
V2L |
possibly damaging |
Het |
| Psmd6 |
G |
A |
14: 14,116,949 (GRCm38) |
R125C |
probably benign |
Het |
| Rnaset2b |
G |
A |
17: 6,991,694 (GRCm38) |
V24I |
probably benign |
Het |
| Rusc2 |
A |
T |
4: 43,416,416 (GRCm38) |
D574V |
probably benign |
Het |
| Scn8a |
T |
A |
15: 100,940,115 (GRCm38) |
|
probably null |
Het |
| Sec11a |
T |
C |
7: 80,923,131 (GRCm38) |
E134G |
probably benign |
Het |
| Senp5 |
A |
G |
16: 31,989,884 (GRCm38) |
V157A |
probably damaging |
Het |
| Shkbp1 |
C |
T |
7: 27,351,695 (GRCm38) |
|
probably null |
Het |
| Slc43a1 |
T |
C |
2: 84,859,784 (GRCm38) |
L435P |
probably damaging |
Het |
| Spn |
G |
A |
7: 127,136,723 (GRCm38) |
P204L |
possibly damaging |
Het |
| Srr |
T |
A |
11: 74,910,202 (GRCm38) |
Q173L |
probably damaging |
Het |
| Star |
C |
G |
8: 25,811,807 (GRCm38) |
T222S |
probably benign |
Het |
| Timm22 |
T |
A |
11: 76,411,127 (GRCm38) |
Y93N |
probably damaging |
Het |
| Tmc4 |
G |
T |
7: 3,675,459 (GRCm38) |
Q58K |
probably benign |
Het |
| Tmem86b |
C |
T |
7: 4,629,836 (GRCm38) |
M1I |
probably null |
Het |
| Tmtc2 |
A |
T |
10: 105,369,970 (GRCm38) |
I488N |
probably damaging |
Het |
| Tnxb |
A |
T |
17: 34,694,388 (GRCm38) |
Y1792F |
probably damaging |
Het |
| Tph1 |
T |
A |
7: 46,647,443 (GRCm38) |
R443W |
possibly damaging |
Het |
| Ttyh1 |
T |
A |
7: 4,129,324 (GRCm38) |
V253E |
possibly damaging |
Het |
| Usf3 |
A |
G |
16: 44,218,577 (GRCm38) |
D1140G |
probably benign |
Het |
| Usp10 |
T |
C |
8: 119,941,316 (GRCm38) |
S118P |
probably benign |
Het |
| Vmn2r63 |
C |
T |
7: 42,903,297 (GRCm38) |
C845Y |
probably benign |
Het |
| Zfp654 |
G |
A |
16: 64,786,094 (GRCm38) |
Q582* |
probably null |
Het |
| Zfp791 |
C |
T |
8: 85,119,650 (GRCm38) |
|
probably benign |
Het |
| Zfp879 |
T |
A |
11: 50,838,475 (GRCm38) |
D32V |
probably damaging |
Het |
|
| Other mutations in Vmn2r72 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00931:Vmn2r72
|
APN |
7 |
85,749,646 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01019:Vmn2r72
|
APN |
7 |
85,738,334 (GRCm38) |
missense |
probably benign |
0.26 |
|
IGL01445:Vmn2r72
|
APN |
7 |
85,749,646 (GRCm38) |
missense |
probably benign |
0.06 |
|
IGL02076:Vmn2r72
|
APN |
7 |
85,738,367 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02082:Vmn2r72
|
APN |
7 |
85,738,166 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02086:Vmn2r72
|
APN |
7 |
85,738,166 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02089:Vmn2r72
|
APN |
7 |
85,738,166 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02125:Vmn2r72
|
APN |
7 |
85,750,711 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02146:Vmn2r72
|
APN |
7 |
85,737,962 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02272:Vmn2r72
|
APN |
7 |
85,750,693 (GRCm38) |
missense |
probably benign |
|
|
IGL02514:Vmn2r72
|
APN |
7 |
85,738,699 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
IGL02662:Vmn2r72
|
APN |
7 |
85,738,183 (GRCm38) |
missense |
probably benign |
0.26 |
|
IGL02697:Vmn2r72
|
APN |
7 |
85,738,671 (GRCm38) |
missense |
probably benign |
0.36 |
|
IGL02733:Vmn2r72
|
APN |
7 |
85,751,813 (GRCm38) |
missense |
probably benign |
0.05 |
|
IGL03070:Vmn2r72
|
APN |
7 |
85,752,041 (GRCm38) |
splice site |
probably benign |
|
|
IGL03150:Vmn2r72
|
APN |
7 |
85,751,176 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03159:Vmn2r72
|
APN |
7 |
85,754,954 (GRCm38) |
missense |
probably benign |
0.05 |
|
IGL03333:Vmn2r72
|
APN |
7 |
85,750,867 (GRCm38) |
missense |
probably benign |
0.10 |
|
R0081:Vmn2r72
|
UTSW |
7 |
85,751,836 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0090:Vmn2r72
|
UTSW |
7 |
85,754,876 (GRCm38) |
missense |
probably benign |
|
|
R0655:Vmn2r72
|
UTSW |
7 |
85,738,111 (GRCm38) |
nonsense |
probably null |
|
|
R0778:Vmn2r72
|
UTSW |
7 |
85,749,739 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1169:Vmn2r72
|
UTSW |
7 |
85,751,309 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1172:Vmn2r72
|
UTSW |
7 |
85,751,944 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1173:Vmn2r72
|
UTSW |
7 |
85,751,944 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1175:Vmn2r72
|
UTSW |
7 |
85,751,944 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1248:Vmn2r72
|
UTSW |
7 |
85,749,188 (GRCm38) |
missense |
probably benign |
0.02 |
|
R1302:Vmn2r72
|
UTSW |
7 |
85,738,257 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1506:Vmn2r72
|
UTSW |
7 |
85,749,211 (GRCm38) |
missense |
probably benign |
|
|
R1632:Vmn2r72
|
UTSW |
7 |
85,751,792 (GRCm38) |
missense |
probably benign |
0.13 |
|
R1775:Vmn2r72
|
UTSW |
7 |
85,738,170 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1962:Vmn2r72
|
UTSW |
7 |
85,749,161 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2201:Vmn2r72
|
UTSW |
7 |
85,738,236 (GRCm38) |
missense |
probably benign |
0.12 |
|
R2290:Vmn2r72
|
UTSW |
7 |
85,738,341 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2327:Vmn2r72
|
UTSW |
7 |
85,738,256 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2424:Vmn2r72
|
UTSW |
7 |
85,750,953 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2655:Vmn2r72
|
UTSW |
7 |
85,751,269 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R2860:Vmn2r72
|
UTSW |
7 |
85,750,836 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2861:Vmn2r72
|
UTSW |
7 |
85,750,836 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2862:Vmn2r72
|
UTSW |
7 |
85,750,836 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3009:Vmn2r72
|
UTSW |
7 |
85,749,642 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3797:Vmn2r72
|
UTSW |
7 |
85,738,077 (GRCm38) |
missense |
probably benign |
0.44 |
|
R3798:Vmn2r72
|
UTSW |
7 |
85,738,077 (GRCm38) |
missense |
probably benign |
0.44 |
|
R3902:Vmn2r72
|
UTSW |
7 |
85,749,735 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R3959:Vmn2r72
|
UTSW |
7 |
85,751,131 (GRCm38) |
missense |
probably benign |
0.36 |
|
R3974:Vmn2r72
|
UTSW |
7 |
85,749,809 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4399:Vmn2r72
|
UTSW |
7 |
85,738,500 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4421:Vmn2r72
|
UTSW |
7 |
85,738,500 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4426:Vmn2r72
|
UTSW |
7 |
85,737,828 (GRCm38) |
nonsense |
probably null |
|
|
R4522:Vmn2r72
|
UTSW |
7 |
85,751,926 (GRCm38) |
missense |
probably benign |
0.44 |
|
R4523:Vmn2r72
|
UTSW |
7 |
85,751,926 (GRCm38) |
missense |
probably benign |
0.44 |
|
R4533:Vmn2r72
|
UTSW |
7 |
85,751,926 (GRCm38) |
missense |
probably benign |
0.44 |
|
R4691:Vmn2r72
|
UTSW |
7 |
85,737,911 (GRCm38) |
nonsense |
probably null |
|
|
R4781:Vmn2r72
|
UTSW |
7 |
85,737,861 (GRCm38) |
missense |
probably benign |
0.14 |
|
R4863:Vmn2r72
|
UTSW |
7 |
85,750,598 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4952:Vmn2r72
|
UTSW |
7 |
85,751,109 (GRCm38) |
missense |
probably benign |
|
|
R4991:Vmn2r72
|
UTSW |
7 |
85,751,130 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4995:Vmn2r72
|
UTSW |
7 |
85,738,485 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5095:Vmn2r72
|
UTSW |
7 |
85,737,853 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5174:Vmn2r72
|
UTSW |
7 |
85,737,840 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5276:Vmn2r72
|
UTSW |
7 |
85,738,254 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R5395:Vmn2r72
|
UTSW |
7 |
85,750,897 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R5560:Vmn2r72
|
UTSW |
7 |
85,751,942 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R5933:Vmn2r72
|
UTSW |
7 |
85,737,850 (GRCm38) |
missense |
probably benign |
0.05 |
|
R6033:Vmn2r72
|
UTSW |
7 |
85,737,929 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6033:Vmn2r72
|
UTSW |
7 |
85,737,929 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6354:Vmn2r72
|
UTSW |
7 |
85,750,539 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6594:Vmn2r72
|
UTSW |
7 |
85,749,684 (GRCm38) |
missense |
probably benign |
0.32 |
|
R6794:Vmn2r72
|
UTSW |
7 |
85,737,996 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7113:Vmn2r72
|
UTSW |
7 |
85,749,803 (GRCm38) |
splice site |
probably null |
|
|
R7189:Vmn2r72
|
UTSW |
7 |
85,754,917 (GRCm38) |
missense |
probably benign |
0.36 |
|
R7266:Vmn2r72
|
UTSW |
7 |
85,738,274 (GRCm38) |
nonsense |
probably null |
|
|
R7323:Vmn2r72
|
UTSW |
7 |
85,750,563 (GRCm38) |
missense |
probably benign |
|
|
R7426:Vmn2r72
|
UTSW |
7 |
85,751,140 (GRCm38) |
missense |
probably benign |
|
|
R7606:Vmn2r72
|
UTSW |
7 |
85,751,154 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R7651:Vmn2r72
|
UTSW |
7 |
85,751,938 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7688:Vmn2r72
|
UTSW |
7 |
85,754,890 (GRCm38) |
missense |
probably benign |
0.32 |
|
R7753:Vmn2r72
|
UTSW |
7 |
85,750,626 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7843:Vmn2r72
|
UTSW |
7 |
85,749,630 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8157:Vmn2r72
|
UTSW |
7 |
85,751,233 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8254:Vmn2r72
|
UTSW |
7 |
85,751,019 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8389:Vmn2r72
|
UTSW |
7 |
85,751,960 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8444:Vmn2r72
|
UTSW |
7 |
85,738,175 (GRCm38) |
missense |
probably benign |
|
|
R8989:Vmn2r72
|
UTSW |
7 |
85,754,926 (GRCm38) |
missense |
probably benign |
0.10 |
|
R9015:Vmn2r72
|
UTSW |
7 |
85,749,180 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9080:Vmn2r72
|
UTSW |
7 |
85,738,256 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9269:Vmn2r72
|
UTSW |
7 |
85,751,203 (GRCm38) |
missense |
probably benign |
0.03 |
|
R9317:Vmn2r72
|
UTSW |
7 |
85,754,814 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9509:Vmn2r72
|
UTSW |
7 |
85,754,867 (GRCm38) |
missense |
probably benign |
|
|
Z1176:Vmn2r72
|
UTSW |
7 |
85,749,191 (GRCm38) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTATGGGAGAGGCATAGTCTC -3'
(R):5'- GCTAAAGCACACTCTACATCATGTTC -3'
Sequencing Primer
(F):5'- GAGAGGCATAGTCTCCATAAACTATC -3'
(R):5'- TTTTTCAGCTTTACTGCGGTC -3'
|
| Posted On |
2018-04-27 |
Incidental Mutation