Incidental Mutation 'R6362:Lrrc37'
ID 512536
Institutional Source Beutler Lab
Gene Symbol Lrrc37
Ensembl Gene ENSMUSG00000034239
Gene Name leucine rich repeat containing 37
Synonyms LOC380730, Gm884
MMRRC Submission 044512-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.257) question?
Stock # R6362 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 103425403-103511966 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to C at 103511478 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 163 (N163K)
Ref Sequence ENSEMBL: ENSMUSP00000058511 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059279]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000059279
AA Change: N163K
SMART Domains Protein: ENSMUSP00000058511
Gene: ENSMUSG00000034239
AA Change: N163K

DomainStartEndE-ValueType
Pfam:LRRC37 149 223 5.4e-10 PFAM
low complexity region 244 264 N/A INTRINSIC
low complexity region 298 308 N/A INTRINSIC
Pfam:LRRC37 335 403 1.9e-14 PFAM
Pfam:LRRC37 419 514 1.2e-8 PFAM
Pfam:LRRC37 565 620 2e-10 PFAM
Pfam:LRRC37 669 739 7.6e-18 PFAM
Pfam:LRRC37 741 792 1.6e-9 PFAM
Pfam:LRRC37 789 860 1.4e-23 PFAM
Pfam:LRRC37 861 914 2.8e-9 PFAM
Pfam:LRRC37 911 983 1.9e-23 PFAM
Pfam:LRRC37 979 1038 1e-8 PFAM
Pfam:LRRC37 1034 1105 2.7e-24 PFAM
Pfam:LRRC37 1105 1158 2.3e-9 PFAM
Pfam:LRRC37 1155 1219 2.4e-17 PFAM
Pfam:LRRC37 1222 1265 9.2e-7 PFAM
Pfam:LRRC37 1263 1330 4.9e-24 PFAM
Pfam:LRRC37 1331 1384 1.4e-10 PFAM
Pfam:LRRC37 1380 1451 4.3e-15 PFAM
Pfam:LRRC37 1487 1558 1.9e-15 PFAM
Pfam:LRRC37 1594 1665 2.9e-18 PFAM
Pfam:LRRC37 1701 1772 5.6e-23 PFAM
Pfam:LRRC37 1808 1910 2.8e-18 PFAM
Pfam:LRRC37 1915 1986 7.2e-17 PFAM
Pfam:LRRC37 2022 2093 4.9e-22 PFAM
Pfam:LRRC37 2129 2200 4.4e-22 PFAM
Pfam:LRRC37 2236 2307 2.1e-21 PFAM
Pfam:LRRC37 2343 2414 3.8e-17 PFAM
Pfam:LRRC37 2449 2519 1.6e-19 PFAM
LRR 2777 2796 3.09e1 SMART
LRR_TYP 2797 2820 2.09e-3 SMART
LRR 2821 2844 4.44e0 SMART
LRR 2848 2872 8.26e1 SMART
low complexity region 2991 3002 N/A INTRINSIC
low complexity region 3220 3230 N/A INTRINSIC
low complexity region 3382 3393 N/A INTRINSIC
Pfam:LRRC37AB_C 3424 3570 7.7e-76 PFAM
low complexity region 3571 3589 N/A INTRINSIC
low complexity region 3622 3640 N/A INTRINSIC
Meta Mutation Damage Score 0.0852 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 96.0%
Validation Efficiency 99% (78/79)
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh5a1 T G 13: 25,102,533 (GRCm39) D310A probably benign Het
Als2cl T A 9: 110,724,514 (GRCm39) probably null Het
Amacr C A 15: 10,984,891 (GRCm39) R170S probably damaging Het
Brwd1 C T 16: 95,803,507 (GRCm39) R2221Q probably damaging Het
Cacna1g A T 11: 94,330,533 (GRCm39) probably null Het
Cd3d G A 9: 44,897,589 (GRCm39) D157N probably damaging Het
Cep131 T C 11: 119,955,516 (GRCm39) D1043G probably damaging Het
Cimip1 T G 2: 173,369,967 (GRCm39) probably null Het
Cit A G 5: 116,024,735 (GRCm39) D326G probably benign Het
Col16a1 G C 4: 129,959,983 (GRCm39) G370R unknown Het
Col6a3 T A 1: 90,738,285 (GRCm39) Y1078F probably damaging Het
Colgalt2 A C 1: 152,347,549 (GRCm39) Y161S probably damaging Het
Cyp2j13 A G 4: 95,959,932 (GRCm39) Y75H probably damaging Het
Daxx G A 17: 34,130,338 (GRCm39) V118I probably damaging Het
Dennd5a G T 7: 109,533,472 (GRCm39) C75* probably null Het
Diaph3 A G 14: 87,009,566 (GRCm39) L1071P probably damaging Het
Disp3 A G 4: 148,338,765 (GRCm39) L802P possibly damaging Het
Dmc1 A G 15: 79,473,024 (GRCm39) V141A probably benign Het
Dsc2 A T 18: 20,168,520 (GRCm39) Y45* probably null Het
Dspp A G 5: 104,323,900 (GRCm39) I348V probably benign Het
Epb42 C A 2: 120,856,260 (GRCm39) C428F possibly damaging Het
Fam227a G T 15: 79,527,551 (GRCm39) P100Q possibly damaging Het
Fer1l4 C T 2: 155,890,170 (GRCm39) V252I probably benign Het
Fhod1 C A 8: 106,058,273 (GRCm39) probably null Het
Fhod3 G T 18: 24,887,312 (GRCm39) A68S probably benign Het
Gatm T C 2: 122,428,677 (GRCm39) D328G probably benign Het
Gm6401 G T 14: 41,789,727 (GRCm39) H44N probably benign Het
Gpat2 G C 2: 127,273,838 (GRCm39) G294R possibly damaging Het
Gpr84 G A 15: 103,216,937 (GRCm39) A380V probably damaging Het
Herc1 G T 9: 66,379,190 (GRCm39) W3492L probably damaging Het
Hjurp A T 1: 88,202,772 (GRCm39) Y71N possibly damaging Het
Jag2 T A 12: 112,883,742 (GRCm39) K246N probably damaging Het
Klhl32 T C 4: 24,629,195 (GRCm39) D524G probably null Het
Lax1 A G 1: 133,608,334 (GRCm39) S136P possibly damaging Het
Lefty1 A G 1: 180,764,725 (GRCm39) K217E probably benign Het
Lgr5 A G 10: 115,314,430 (GRCm39) L169P probably damaging Het
Mad1l1 A T 5: 140,300,810 (GRCm39) S29T possibly damaging Het
Man1a T C 10: 53,950,891 (GRCm39) H77R probably benign Het
Met C T 6: 17,558,732 (GRCm39) S1120F probably damaging Het
Mfsd4b2 A T 10: 39,797,605 (GRCm39) I250N probably damaging Het
Myod1 A G 7: 46,026,305 (GRCm39) H70R possibly damaging Het
Neb T C 2: 52,102,704 (GRCm39) N4280S probably benign Het
Nudt6 T C 3: 37,473,638 (GRCm39) T28A possibly damaging Het
Nup85 A G 11: 115,474,560 (GRCm39) E628G probably damaging Het
Oaz3 A T 3: 94,342,295 (GRCm39) D120E probably damaging Het
Or2y3 A T 17: 38,393,620 (GRCm39) M83K probably damaging Het
Or5b102 A T 19: 13,040,709 (GRCm39) probably benign Het
Or5be3 C T 2: 86,863,633 (GRCm39) A311T probably benign Het
Or5m8 C A 2: 85,822,285 (GRCm39) N41K probably damaging Het
Or6c1b A C 10: 129,272,812 (GRCm39) I44L probably damaging Het
Osbpl8 A T 10: 111,108,929 (GRCm39) K404* probably null Het
Pcdhga2 A G 18: 37,803,958 (GRCm39) N601D probably damaging Het
Pld2 T C 11: 70,445,501 (GRCm39) Y638H probably damaging Het
Pramel27 A G 4: 143,579,435 (GRCm39) Y340C probably damaging Het
Prickle2 C G 6: 92,435,596 (GRCm39) V2L possibly damaging Het
Psmd6 G A 14: 14,116,949 (GRCm38) R125C probably benign Het
Rnaset2b G A 17: 7,259,093 (GRCm39) V24I probably benign Het
Rusc2 A T 4: 43,416,416 (GRCm39) D574V probably benign Het
Scn8a T A 15: 100,837,996 (GRCm39) probably null Het
Sec11a T C 7: 80,572,879 (GRCm39) E134G probably benign Het
Senp5 A G 16: 31,808,702 (GRCm39) V157A probably damaging Het
Shkbp1 C T 7: 27,051,120 (GRCm39) probably null Het
Slc43a1 T C 2: 84,690,128 (GRCm39) L435P probably damaging Het
Spn G A 7: 126,735,895 (GRCm39) P204L possibly damaging Het
Srr T A 11: 74,801,028 (GRCm39) Q173L probably damaging Het
Star C G 8: 26,301,835 (GRCm39) T222S probably benign Het
Timm22 T A 11: 76,301,953 (GRCm39) Y93N probably damaging Het
Tmc4 G T 7: 3,678,458 (GRCm39) Q58K probably benign Het
Tmem86b C T 7: 4,632,835 (GRCm39) M1I probably null Het
Tmtc2 A T 10: 105,205,831 (GRCm39) I488N probably damaging Het
Tnxb A T 17: 34,913,362 (GRCm39) Y1792F probably damaging Het
Tph1 T A 7: 46,296,867 (GRCm39) R443W possibly damaging Het
Ttyh1 T A 7: 4,132,323 (GRCm39) V253E possibly damaging Het
Usf3 A G 16: 44,038,940 (GRCm39) D1140G probably benign Het
Usp10 T C 8: 120,668,055 (GRCm39) S118P probably benign Het
Vmn2r63 C T 7: 42,552,721 (GRCm39) C845Y probably benign Het
Vmn2r72 G T 7: 85,400,382 (GRCm39) F222L probably damaging Het
Zfp654 G A 16: 64,606,457 (GRCm39) Q582* probably null Het
Zfp791 C T 8: 85,846,279 (GRCm39) probably benign Het
Zfp879 T A 11: 50,729,302 (GRCm39) D32V probably damaging Het
Other mutations in Lrrc37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00572:Lrrc37 APN 11 103,506,236 (GRCm39) missense probably benign 0.01
IGL00576:Lrrc37 APN 11 103,508,212 (GRCm39) unclassified probably benign
IGL00813:Lrrc37 APN 11 103,505,324 (GRCm39) missense probably benign 0.05
IGL01311:Lrrc37 APN 11 103,425,502 (GRCm39) missense unknown
IGL01946:Lrrc37 APN 11 103,503,759 (GRCm39) missense probably benign 0.28
IGL02217:Lrrc37 APN 11 103,503,697 (GRCm39) splice site probably benign
IGL02556:Lrrc37 APN 11 103,504,109 (GRCm39) missense probably benign 0.01
IGL02825:Lrrc37 APN 11 103,507,894 (GRCm39) unclassified probably benign
IGL02868:Lrrc37 APN 11 103,505,965 (GRCm39) missense probably benign 0.10
IGL02904:Lrrc37 APN 11 103,507,187 (GRCm39) unclassified probably benign
IGL03008:Lrrc37 APN 11 103,511,293 (GRCm39) missense unknown
IGL03120:Lrrc37 APN 11 103,507,801 (GRCm39) unclassified probably benign
IGL03159:Lrrc37 APN 11 103,495,328 (GRCm39) splice site probably benign
IGL03181:Lrrc37 APN 11 103,507,242 (GRCm39) unclassified probably benign
IGL03202:Lrrc37 APN 11 103,506,199 (GRCm39) missense probably benign 0.03
IGL03263:Lrrc37 APN 11 103,504,525 (GRCm39) missense possibly damaging 0.86
esteemed UTSW 11 103,509,656 (GRCm39) missense unknown
lauded UTSW 11 103,503,929 (GRCm39) missense possibly damaging 0.62
PIT4486001:Lrrc37 UTSW 11 103,509,027 (GRCm39) missense unknown
R0040:Lrrc37 UTSW 11 103,433,816 (GRCm39) missense probably damaging 0.99
R0135:Lrrc37 UTSW 11 103,508,873 (GRCm39) unclassified probably benign
R0141:Lrrc37 UTSW 11 103,504,512 (GRCm39) missense probably damaging 1.00
R0226:Lrrc37 UTSW 11 103,494,067 (GRCm39) missense probably benign 0.08
R0547:Lrrc37 UTSW 11 103,510,990 (GRCm39) missense unknown
R0646:Lrrc37 UTSW 11 103,503,986 (GRCm39) nonsense probably null
R0685:Lrrc37 UTSW 11 103,507,714 (GRCm39) unclassified probably benign
R0732:Lrrc37 UTSW 11 103,510,664 (GRCm39) missense unknown
R1015:Lrrc37 UTSW 11 103,436,622 (GRCm39) missense probably benign 0.01
R1166:Lrrc37 UTSW 11 103,506,209 (GRCm39) missense probably benign 0.21
R1168:Lrrc37 UTSW 11 103,509,776 (GRCm39) unclassified probably benign
R1257:Lrrc37 UTSW 11 103,425,467 (GRCm39) missense unknown
R1545:Lrrc37 UTSW 11 103,499,745 (GRCm39) missense probably benign 0.16
R1570:Lrrc37 UTSW 11 103,500,764 (GRCm39) missense possibly damaging 0.76
R1677:Lrrc37 UTSW 11 103,505,768 (GRCm39) missense probably benign 0.19
R1703:Lrrc37 UTSW 11 103,431,700 (GRCm39) missense probably benign 0.39
R1719:Lrrc37 UTSW 11 103,507,897 (GRCm39) unclassified probably benign
R1752:Lrrc37 UTSW 11 103,505,381 (GRCm39) missense possibly damaging 0.67
R1870:Lrrc37 UTSW 11 103,511,431 (GRCm39) missense unknown
R2155:Lrrc37 UTSW 11 103,511,285 (GRCm39) missense unknown
R2191:Lrrc37 UTSW 11 103,509,793 (GRCm39) unclassified probably benign
R2271:Lrrc37 UTSW 11 103,505,033 (GRCm39) missense possibly damaging 0.53
R2378:Lrrc37 UTSW 11 103,510,537 (GRCm39) unclassified probably benign
R2405:Lrrc37 UTSW 11 103,511,810 (GRCm39) missense unknown
R2864:Lrrc37 UTSW 11 103,431,744 (GRCm39) missense probably benign 0.34
R3011:Lrrc37 UTSW 11 103,503,929 (GRCm39) missense possibly damaging 0.62
R3415:Lrrc37 UTSW 11 103,505,435 (GRCm39) missense possibly damaging 0.82
R3417:Lrrc37 UTSW 11 103,505,435 (GRCm39) missense possibly damaging 0.82
R3835:Lrrc37 UTSW 11 103,510,836 (GRCm39) missense unknown
R3974:Lrrc37 UTSW 11 103,509,927 (GRCm39) unclassified probably benign
R4019:Lrrc37 UTSW 11 103,506,119 (GRCm39) missense probably benign 0.19
R4020:Lrrc37 UTSW 11 103,506,119 (GRCm39) missense probably benign 0.19
R4176:Lrrc37 UTSW 11 103,427,426 (GRCm39) missense unknown
R4361:Lrrc37 UTSW 11 103,508,327 (GRCm39) frame shift probably null
R4418:Lrrc37 UTSW 11 103,509,140 (GRCm39) unclassified probably benign
R4633:Lrrc37 UTSW 11 103,509,957 (GRCm39) unclassified probably benign
R4693:Lrrc37 UTSW 11 103,510,686 (GRCm39) missense unknown
R4758:Lrrc37 UTSW 11 103,505,290 (GRCm39) missense possibly damaging 0.48
R4878:Lrrc37 UTSW 11 103,508,717 (GRCm39) unclassified probably benign
R4887:Lrrc37 UTSW 11 103,505,698 (GRCm39) missense probably benign 0.03
R4944:Lrrc37 UTSW 11 103,504,286 (GRCm39) missense possibly damaging 0.68
R4952:Lrrc37 UTSW 11 103,505,033 (GRCm39) missense possibly damaging 0.53
R5030:Lrrc37 UTSW 11 103,425,675 (GRCm39) missense unknown
R5183:Lrrc37 UTSW 11 103,433,947 (GRCm39) missense probably damaging 0.99
R5294:Lrrc37 UTSW 11 103,507,057 (GRCm39) unclassified probably benign
R5317:Lrrc37 UTSW 11 103,504,971 (GRCm39) missense possibly damaging 0.73
R5334:Lrrc37 UTSW 11 103,504,699 (GRCm39) missense probably benign 0.18
R5426:Lrrc37 UTSW 11 103,511,586 (GRCm39) missense unknown
R5467:Lrrc37 UTSW 11 103,494,091 (GRCm39) nonsense probably null
R5518:Lrrc37 UTSW 11 103,506,079 (GRCm39) missense probably benign 0.03
R5634:Lrrc37 UTSW 11 103,432,840 (GRCm39) missense possibly damaging 0.95
R5647:Lrrc37 UTSW 11 103,508,300 (GRCm39) unclassified probably benign
R5663:Lrrc37 UTSW 11 103,503,949 (GRCm39) missense probably benign 0.01
R5668:Lrrc37 UTSW 11 103,507,880 (GRCm39) unclassified probably benign
R5763:Lrrc37 UTSW 11 103,504,469 (GRCm39) missense probably damaging 0.97
R5829:Lrrc37 UTSW 11 103,432,712 (GRCm39) missense possibly damaging 0.95
R5871:Lrrc37 UTSW 11 103,507,280 (GRCm39) unclassified probably benign
R5905:Lrrc37 UTSW 11 103,505,081 (GRCm39) missense probably damaging 0.98
R5940:Lrrc37 UTSW 11 103,504,712 (GRCm39) missense probably benign 0.18
R5964:Lrrc37 UTSW 11 103,432,946 (GRCm39) missense possibly damaging 0.92
R5988:Lrrc37 UTSW 11 103,506,722 (GRCm39) unclassified probably benign
R5992:Lrrc37 UTSW 11 103,504,618 (GRCm39) missense possibly damaging 0.81
R6114:Lrrc37 UTSW 11 103,508,617 (GRCm39) unclassified probably benign
R6154:Lrrc37 UTSW 11 103,504,969 (GRCm39) missense probably benign 0.33
R6233:Lrrc37 UTSW 11 103,504,214 (GRCm39) missense probably damaging 0.98
R6301:Lrrc37 UTSW 11 103,509,756 (GRCm39) unclassified probably benign
R6471:Lrrc37 UTSW 11 103,510,448 (GRCm39) unclassified probably benign
R6806:Lrrc37 UTSW 11 103,511,950 (GRCm39) missense unknown
R6962:Lrrc37 UTSW 11 103,505,126 (GRCm39) missense possibly damaging 0.67
R6996:Lrrc37 UTSW 11 103,509,583 (GRCm39) nonsense probably null
R7028:Lrrc37 UTSW 11 103,505,363 (GRCm39) missense probably benign 0.28
R7034:Lrrc37 UTSW 11 103,506,638 (GRCm39) unclassified probably benign
R7036:Lrrc37 UTSW 11 103,506,638 (GRCm39) unclassified probably benign
R7113:Lrrc37 UTSW 11 103,509,625 (GRCm39) missense unknown
R7405:Lrrc37 UTSW 11 103,505,987 (GRCm39) missense probably benign 0.02
R7420:Lrrc37 UTSW 11 103,504,451 (GRCm39) missense probably benign 0.11
R7461:Lrrc37 UTSW 11 103,507,116 (GRCm39) missense unknown
R7544:Lrrc37 UTSW 11 103,506,274 (GRCm39) missense probably benign 0.01
R7613:Lrrc37 UTSW 11 103,507,116 (GRCm39) missense unknown
R7711:Lrrc37 UTSW 11 103,505,738 (GRCm39) missense probably benign 0.02
R7714:Lrrc37 UTSW 11 103,507,719 (GRCm39) missense unknown
R7747:Lrrc37 UTSW 11 103,505,081 (GRCm39) missense probably damaging 0.98
R7814:Lrrc37 UTSW 11 103,504,999 (GRCm39) missense possibly damaging 0.53
R8053:Lrrc37 UTSW 11 103,495,392 (GRCm39) missense unknown
R8063:Lrrc37 UTSW 11 103,433,087 (GRCm39) missense unknown
R8116:Lrrc37 UTSW 11 103,434,115 (GRCm39) missense unknown
R8124:Lrrc37 UTSW 11 103,511,257 (GRCm39) missense unknown
R8141:Lrrc37 UTSW 11 103,511,855 (GRCm39) missense unknown
R8163:Lrrc37 UTSW 11 103,506,688 (GRCm39) missense unknown
R8270:Lrrc37 UTSW 11 103,434,141 (GRCm39) missense unknown
R8348:Lrrc37 UTSW 11 103,511,726 (GRCm39) missense unknown
R8362:Lrrc37 UTSW 11 103,506,163 (GRCm39) missense probably benign 0.34
R8448:Lrrc37 UTSW 11 103,511,726 (GRCm39) missense unknown
R8465:Lrrc37 UTSW 11 103,506,947 (GRCm39) unclassified probably benign
R8473:Lrrc37 UTSW 11 103,434,266 (GRCm39) missense unknown
R8781:Lrrc37 UTSW 11 103,508,958 (GRCm39) missense unknown
R8821:Lrrc37 UTSW 11 103,510,470 (GRCm39) missense unknown
R8859:Lrrc37 UTSW 11 103,506,370 (GRCm39) missense unknown
R8888:Lrrc37 UTSW 11 103,509,656 (GRCm39) missense unknown
R8895:Lrrc37 UTSW 11 103,509,656 (GRCm39) missense unknown
R9083:Lrrc37 UTSW 11 103,509,830 (GRCm39) missense unknown
R9085:Lrrc37 UTSW 11 103,507,565 (GRCm39) missense unknown
R9088:Lrrc37 UTSW 11 103,511,762 (GRCm39) missense unknown
R9124:Lrrc37 UTSW 11 103,509,721 (GRCm39) missense unknown
R9177:Lrrc37 UTSW 11 103,508,263 (GRCm39) missense unknown
R9238:Lrrc37 UTSW 11 103,509,859 (GRCm39) missense unknown
R9267:Lrrc37 UTSW 11 103,495,406 (GRCm39) missense unknown
R9444:Lrrc37 UTSW 11 103,508,846 (GRCm39) nonsense probably null
R9517:Lrrc37 UTSW 11 103,433,416 (GRCm39) missense unknown
R9564:Lrrc37 UTSW 11 103,503,822 (GRCm39) missense unknown
R9632:Lrrc37 UTSW 11 103,433,252 (GRCm39) missense unknown
R9741:Lrrc37 UTSW 11 103,504,255 (GRCm39) missense possibly damaging 0.68
Z1176:Lrrc37 UTSW 11 103,504,507 (GRCm39) missense probably benign 0.45
Predicted Primers PCR Primer
(F):5'- AGAGGACCTGGAGTCTGAGTTG -3'
(R):5'- GGTTGTTGGAAAACCTCAGTTTC -3'

Sequencing Primer
(F):5'- GAGTCTCCTCCTCATATGAAGATGAC -3'
(R):5'- GTTGGAAAACCTCAGTTTCAGAAACC -3'
Posted On 2018-04-27