Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01073:Vmn2r23'

51257

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r23

Ensembl Gene

ENSMUSG00000091620

Gene Name

vomeronasal 2, receptor 23

Synonyms

EG435916

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL01073

Quality Score

Status

Chromosome

Chromosomal Location

123702821-123742291 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 123712800 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Proline at position 212 (T212P)

Ref Sequence

ENSEMBL: ENSMUSP00000126682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172391]

AlphaFold

E9PXI5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000172391
AA Change: T212P

PolyPhen 2 Score 0.817 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: T212P

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	79	461	1.7e-31	PFAM
Pfam:NCD3G	513	566	1.2e-23	PFAM
Pfam:7tm_3	596	834	1.5e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd24	A	G	10: 81,639,322 (GRCm38)	D110G	possibly damaging	Het
Ccnd3	A	G	17: 47,594,845 (GRCm38)	T104A	probably benign	Het
Cntnap5b	A	T	1: 100,076,030 (GRCm38)	D245V	probably benign	Het
Cryab	A	G	9: 50,754,555 (GRCm38)	K82R	probably damaging	Het
Dnmt3b	G	A	2: 153,670,842 (GRCm38)		probably benign	Het
Eif2b5	A	T	16: 20,500,296 (GRCm38)	K99*	probably null	Het
Fam222b	A	G	11: 78,154,488 (GRCm38)	I292V	probably damaging	Het
Itpr1	A	C	6: 108,413,820 (GRCm38)	N1560T	probably benign	Het
Lca5	T	A	9: 83,395,475 (GRCm38)	K605N	probably damaging	Het
Letm1	T	C	5: 33,748,800 (GRCm38)	D424G	possibly damaging	Het
Mtif3	C	A	5: 146,958,980 (GRCm38)	R99L	probably damaging	Het
Nrxn3	A	G	12: 89,254,740 (GRCm38)	M430V	probably benign	Het
Olfr1226	A	T	2: 89,193,137 (GRCm38)	L299Q	possibly damaging	Het
Pgap2	T	A	7: 102,226,454 (GRCm38)		probably benign	Het
Phf11c	A	T	14: 59,389,348 (GRCm38)	S129T	probably benign	Het
Ptpro	A	G	6: 137,377,088 (GRCm38)	N154S	probably damaging	Het
Rfng	C	T	11: 120,783,921 (GRCm38)	R81H	probably benign	Het
Rnf38	A	G	4: 44,137,645 (GRCm38)	M280T	probably benign	Het
Rrp7a	G	A	15: 83,118,081 (GRCm38)	A185V	probably benign	Het
Slc22a2	C	A	17: 12,584,349 (GRCm38)	F23L	probably benign	Het
Slc35f1	A	G	10: 53,021,960 (GRCm38)	T156A	probably benign	Het
Slfn1	A	T	11: 83,121,337 (GRCm38)	Y93F	probably benign	Het
Snrnp200	A	T	2: 127,214,912 (GRCm38)		probably benign	Het
Sos1	A	G	17: 80,422,747 (GRCm38)	F701S	probably damaging	Het
Tmem203	A	C	2: 25,255,724 (GRCm38)	I19L	probably benign	Het
Usp8	A	T	2: 126,718,114 (GRCm38)	K18N	probably damaging	Het
Vmn2r115	G	A	17: 23,345,997 (GRCm38)	R286K	probably benign	Het

Other mutations in Vmn2r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Vmn2r23	APN	6	123,729,725 (GRCm38)	missense	possibly damaging	0.89
IGL01012:Vmn2r23	APN	6	123,729,596 (GRCm38)	missense	probably benign
IGL01547:Vmn2r23	APN	6	123,704,424 (GRCm38)	missense	possibly damaging	0.88
IGL01571:Vmn2r23	APN	6	123,704,407 (GRCm38)	missense	probably damaging	1.00
IGL01950:Vmn2r23	APN	6	123,741,886 (GRCm38)	missense	possibly damaging	0.80
IGL02028:Vmn2r23	APN	6	123,741,860 (GRCm38)	missense	probably damaging	1.00
IGL02248:Vmn2r23	APN	6	123,741,744 (GRCm38)	missense	probably damaging	0.96
IGL02318:Vmn2r23	APN	6	123,741,836 (GRCm38)	missense	probably benign	0.10
IGL02649:Vmn2r23	APN	6	123,704,478 (GRCm38)	missense	probably benign
IGL02831:Vmn2r23	APN	6	123,704,385 (GRCm38)	missense	probably benign	0.22
IGL02832:Vmn2r23	APN	6	123,704,396 (GRCm38)	missense	probably benign	0.00
IGL02865:Vmn2r23	APN	6	123,741,619 (GRCm38)	missense	probably damaging	1.00
IGL02964:Vmn2r23	APN	6	123,741,782 (GRCm38)	missense	possibly damaging	0.93
IGL03347:Vmn2r23	APN	6	123,704,374 (GRCm38)	missense	probably benign	0.01
IGL03396:Vmn2r23	APN	6	123,729,626 (GRCm38)	missense	probably damaging	1.00
PIT4472001:Vmn2r23	UTSW	6	123,712,977 (GRCm38)	missense	possibly damaging	0.62
R0597:Vmn2r23	UTSW	6	123,729,721 (GRCm38)	missense	probably benign	0.08
R0677:Vmn2r23	UTSW	6	123,713,451 (GRCm38)	missense	probably benign	0.00
R0904:Vmn2r23	UTSW	6	123,742,135 (GRCm38)	missense	probably damaging	1.00
R1330:Vmn2r23	UTSW	6	123,742,004 (GRCm38)	missense	probably damaging	1.00
R1424:Vmn2r23	UTSW	6	123,713,270 (GRCm38)	nonsense	probably null
R1629:Vmn2r23	UTSW	6	123,713,427 (GRCm38)	missense	probably benign	0.05
R1842:Vmn2r23	UTSW	6	123,729,690 (GRCm38)	missense	possibly damaging	0.77
R1867:Vmn2r23	UTSW	6	123,702,915 (GRCm38)	missense	probably damaging	1.00
R1919:Vmn2r23	UTSW	6	123,713,010 (GRCm38)	missense	possibly damaging	0.94
R2087:Vmn2r23	UTSW	6	123,741,499 (GRCm38)	missense	probably benign	0.00
R2338:Vmn2r23	UTSW	6	123,704,425 (GRCm38)	missense	possibly damaging	0.88
R2568:Vmn2r23	UTSW	6	123,742,188 (GRCm38)	nonsense	probably null
R2867:Vmn2r23	UTSW	6	123,713,164 (GRCm38)	missense	possibly damaging	0.94
R2867:Vmn2r23	UTSW	6	123,713,164 (GRCm38)	missense	possibly damaging	0.94
R3500:Vmn2r23	UTSW	6	123,713,170 (GRCm38)	missense	possibly damaging	0.81
R3789:Vmn2r23	UTSW	6	123,741,389 (GRCm38)	missense	probably damaging	1.00
R4164:Vmn2r23	UTSW	6	123,729,738 (GRCm38)	missense	probably benign
R4506:Vmn2r23	UTSW	6	123,702,925 (GRCm38)	missense	probably damaging	1.00
R4652:Vmn2r23	UTSW	6	123,741,730 (GRCm38)	missense	probably damaging	1.00
R4697:Vmn2r23	UTSW	6	123,741,826 (GRCm38)	missense	probably damaging	1.00
R4840:Vmn2r23	UTSW	6	123,713,074 (GRCm38)	missense	probably damaging	1.00
R4983:Vmn2r23	UTSW	6	123,733,349 (GRCm38)	missense	probably damaging	1.00
R5276:Vmn2r23	UTSW	6	123,712,977 (GRCm38)	missense	possibly damaging	0.62
R5392:Vmn2r23	UTSW	6	123,704,364 (GRCm38)	missense	probably benign	0.36
R5528:Vmn2r23	UTSW	6	123,713,002 (GRCm38)	missense	probably damaging	1.00
R5529:Vmn2r23	UTSW	6	123,713,451 (GRCm38)	missense	probably benign	0.00
R5664:Vmn2r23	UTSW	6	123,713,074 (GRCm38)	missense	probably damaging	1.00
R5749:Vmn2r23	UTSW	6	123,733,273 (GRCm38)	missense	probably benign
R5761:Vmn2r23	UTSW	6	123,712,759 (GRCm38)	missense	probably benign	0.39
R5762:Vmn2r23	UTSW	6	123,733,393 (GRCm38)	missense	probably damaging	1.00
R5868:Vmn2r23	UTSW	6	123,712,942 (GRCm38)	missense	probably benign	0.12
R5935:Vmn2r23	UTSW	6	123,741,895 (GRCm38)	missense	possibly damaging	0.94
R6242:Vmn2r23	UTSW	6	123,704,400 (GRCm38)	missense	possibly damaging	0.82
R6416:Vmn2r23	UTSW	6	123,712,902 (GRCm38)	missense	probably damaging	1.00
R6524:Vmn2r23	UTSW	6	123,713,425 (GRCm38)	missense	probably damaging	1.00
R6576:Vmn2r23	UTSW	6	123,733,273 (GRCm38)	missense	probably benign
R6925:Vmn2r23	UTSW	6	123,704,553 (GRCm38)	missense	probably damaging	1.00
R7148:Vmn2r23	UTSW	6	123,713,022 (GRCm38)	missense	probably benign
R7215:Vmn2r23	UTSW	6	123,704,364 (GRCm38)	missense	probably benign	0.36
R7252:Vmn2r23	UTSW	6	123,741,581 (GRCm38)	missense	probably damaging	0.97
R7403:Vmn2r23	UTSW	6	123,704,579 (GRCm38)	missense	probably benign	0.01
R8015:Vmn2r23	UTSW	6	123,704,541 (GRCm38)	missense	probably benign	0.00
R8143:Vmn2r23	UTSW	6	123,741,353 (GRCm38)	missense	probably damaging	0.99
R8474:Vmn2r23	UTSW	6	123,704,640 (GRCm38)	missense	probably benign	0.36
R8520:Vmn2r23	UTSW	6	123,741,656 (GRCm38)	missense	probably damaging	0.99
R8679:Vmn2r23	UTSW	6	123,713,472 (GRCm38)	missense	probably damaging	0.99
R8713:Vmn2r23	UTSW	6	123,703,032 (GRCm38)	missense
R8966:Vmn2r23	UTSW	6	123,742,120 (GRCm38)	missense	possibly damaging	0.94
R9124:Vmn2r23	UTSW	6	123,742,079 (GRCm38)	missense	possibly damaging	0.57
R9163:Vmn2r23	UTSW	6	123,741,823 (GRCm38)	missense	probably damaging	1.00
R9189:Vmn2r23	UTSW	6	123,704,364 (GRCm38)	missense	probably benign	0.36
R9451:Vmn2r23	UTSW	6	123,733,393 (GRCm38)	missense	probably damaging	1.00
R9495:Vmn2r23	UTSW	6	123,712,713 (GRCm38)	missense	probably benign	0.30
R9514:Vmn2r23	UTSW	6	123,712,713 (GRCm38)	missense	probably benign	0.30
RF018:Vmn2r23	UTSW	6	123,713,116 (GRCm38)	missense	probably benign	0.00
T0975:Vmn2r23	UTSW	6	123,713,161 (GRCm38)	missense	probably benign	0.00
Z1088:Vmn2r23	UTSW	6	123,742,108 (GRCm38)	missense	probably damaging	0.98
Z1177:Vmn2r23	UTSW	6	123,729,725 (GRCm38)	frame shift	probably null

Posted On

2013-06-21