Incidental Mutation 'R6368:Or1ad1'
ID 512805
Institutional Source Beutler Lab
Gene Symbol Or1ad1
Ensembl Gene ENSMUSG00000061952
Gene Name olfactory receptor family 1 subfamily AD member 1
Synonyms Olfr1377, MOR129-1, GA_x6K02T2QP88-4453480-4452557
MMRRC Submission 044518-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R6368 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 50875530-50876453 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 50875613 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 28 (F28L)
Ref Sequence ENSEMBL: ENSMUSP00000151087 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075177] [ENSMUST00000213291] [ENSMUST00000216101]
AlphaFold Q8VGH1
Predicted Effect probably benign
Transcript: ENSMUST00000075177
AA Change: F28L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000074672
Gene: ENSMUSG00000061952
AA Change: F28L

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2e-51 PFAM
Pfam:7tm_1 41 289 1.4e-26 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000118780
Predicted Effect probably benign
Transcript: ENSMUST00000213291
AA Change: F28L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000216101
AA Change: F28L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930563M21Rik C A 9: 55,897,416 (GRCm39) E272D possibly damaging Het
Abi2 A G 1: 60,492,810 (GRCm39) T158A possibly damaging Het
Acacb T C 5: 114,354,884 (GRCm39) S1221P probably damaging Het
Agbl1 A G 7: 76,069,578 (GRCm39) D370G probably benign Het
Apeh A G 9: 107,964,442 (GRCm39) I487T probably damaging Het
Arid1b C A 17: 5,382,808 (GRCm39) N1297K possibly damaging Het
Ascc3 G A 10: 50,576,081 (GRCm39) G779S probably damaging Het
Atp7b A C 8: 22,510,771 (GRCm39) probably null Het
Bsn C T 9: 107,988,513 (GRCm39) probably benign Het
Caps2 C T 10: 112,030,873 (GRCm39) Q268* probably null Het
Cnfn C T 7: 25,067,386 (GRCm39) probably null Het
Cr2 A G 1: 194,850,780 (GRCm39) S229P probably damaging Het
Cubn T C 2: 13,435,806 (GRCm39) Y1050C probably damaging Het
Cubn T C 2: 13,480,934 (GRCm39) E307G probably damaging Het
Cyb5r3 A C 15: 83,044,325 (GRCm39) Y182D possibly damaging Het
Dclre1a A T 19: 56,535,223 (GRCm39) H120Q probably benign Het
Ddx6 T C 9: 44,547,073 (GRCm39) I457T probably damaging Het
E2f1 A T 2: 154,406,396 (GRCm39) H93Q possibly damaging Het
Fam186a T C 15: 99,841,198 (GRCm39) K1682R possibly damaging Het
Farsb A G 1: 78,443,602 (GRCm39) probably null Het
Flii A T 11: 60,611,962 (GRCm39) L347Q probably damaging Het
Galntl6 T G 8: 59,364,475 (GRCm39) T12P probably damaging Het
Gm11595 G A 11: 99,663,381 (GRCm39) R100C unknown Het
Gm21680 T C 5: 26,174,034 (GRCm39) N190S probably damaging Het
Ifit1bl2 T C 19: 34,596,525 (GRCm39) S364G probably benign Het
Kdm2a A G 19: 4,400,345 (GRCm39) I234T probably damaging Het
Kdm5b T C 1: 134,526,945 (GRCm39) C356R probably damaging Het
Kel A T 6: 41,665,785 (GRCm39) C174* probably null Het
Krt16 T A 11: 100,137,502 (GRCm39) D401V probably damaging Het
Ltb4r1 A C 14: 56,005,200 (GRCm39) I168L probably benign Het
Luzp1 T A 4: 136,269,091 (GRCm39) M438K probably benign Het
Mtf1 C T 4: 124,718,145 (GRCm39) T281M probably damaging Het
Myo9a T A 9: 59,832,231 (GRCm39) S2587T probably benign Het
Or13a21 G T 7: 139,999,580 (GRCm39) Y35* probably null Het
Or4f58 A T 2: 111,851,896 (GRCm39) I101N probably damaging Het
Or7e169 T C 9: 19,757,705 (GRCm39) D70G probably damaging Het
Pcm1 T A 8: 41,746,581 (GRCm39) F1221Y probably benign Het
Pnldc1 A T 17: 13,124,751 (GRCm39) N90K probably damaging Het
Prickle2 A T 6: 92,397,218 (GRCm39) L169Q probably damaging Het
Ralgps2 A T 1: 156,712,144 (GRCm39) L147I probably damaging Het
Rfx3 A T 19: 27,746,009 (GRCm39) L674Q possibly damaging Het
Rpl3 C A 15: 79,966,745 (GRCm39) L14F probably damaging Het
Rrbp1 C T 2: 143,831,475 (GRCm39) G231R probably damaging Het
Sema3d C T 5: 12,620,980 (GRCm39) L529F probably damaging Het
Slain1 A T 14: 103,894,391 (GRCm39) T193S probably benign Het
Slc2a6 G T 2: 26,914,599 (GRCm39) Q256K possibly damaging Het
Slk A G 19: 47,608,622 (GRCm39) E525G possibly damaging Het
Spsb4 G T 9: 96,826,698 (GRCm39) Q252K probably benign Het
Taf1b A G 12: 24,608,256 (GRCm39) T552A possibly damaging Het
Tmprss15 T C 16: 78,802,945 (GRCm39) probably null Het
Tph2 T C 10: 115,015,231 (GRCm39) H177R probably damaging Het
Ttll1 A G 15: 83,373,818 (GRCm39) S332P probably damaging Het
Twf2 T G 9: 106,090,032 (GRCm39) N128K probably benign Het
Vegfc T A 8: 54,634,265 (GRCm39) C315S probably damaging Het
Vmn2r111 T A 17: 22,790,889 (GRCm39) K136N probably benign Het
Wnk2 T C 13: 49,214,814 (GRCm39) E496G probably damaging Het
Zfp148 C A 16: 33,317,568 (GRCm39) Q705K probably damaging Het
Zw10 C T 9: 48,984,535 (GRCm39) A539V probably damaging Het
Other mutations in Or1ad1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01069:Or1ad1 APN 11 50,875,830 (GRCm39) missense possibly damaging 0.94
R1386:Or1ad1 UTSW 11 50,876,194 (GRCm39) missense probably damaging 0.97
R1486:Or1ad1 UTSW 11 50,875,608 (GRCm39) missense probably benign 0.00
R1613:Or1ad1 UTSW 11 50,876,045 (GRCm39) missense probably damaging 1.00
R2224:Or1ad1 UTSW 11 50,876,059 (GRCm39) missense probably damaging 1.00
R2411:Or1ad1 UTSW 11 50,875,758 (GRCm39) missense probably damaging 0.98
R3014:Or1ad1 UTSW 11 50,875,534 (GRCm39) missense probably benign 0.00
R4080:Or1ad1 UTSW 11 50,875,683 (GRCm39) missense probably damaging 1.00
R4753:Or1ad1 UTSW 11 50,875,978 (GRCm39) missense probably benign 0.05
R4764:Or1ad1 UTSW 11 50,875,602 (GRCm39) missense probably benign 0.00
R4822:Or1ad1 UTSW 11 50,875,910 (GRCm39) nonsense probably null
R4865:Or1ad1 UTSW 11 50,876,370 (GRCm39) missense probably damaging 0.99
R5053:Or1ad1 UTSW 11 50,876,137 (GRCm39) missense probably damaging 1.00
R6054:Or1ad1 UTSW 11 50,875,631 (GRCm39) missense probably benign 0.00
R7589:Or1ad1 UTSW 11 50,875,857 (GRCm39) missense probably damaging 0.98
R7843:Or1ad1 UTSW 11 50,875,845 (GRCm39) missense probably benign 0.06
R8056:Or1ad1 UTSW 11 50,876,368 (GRCm39) missense probably damaging 0.98
R9189:Or1ad1 UTSW 11 50,876,166 (GRCm39) missense probably damaging 1.00
R9486:Or1ad1 UTSW 11 50,875,691 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- TTCTCCATCAACCAGTAAAGCATTG -3'
(R):5'- TCTGGATCATGCACTCTGTG -3'

Sequencing Primer
(F):5'- TCAACCAGTAAAGCATTGCAAGATAG -3'
(R):5'- AAGAGATGGACTTGCTTCCC -3'
Posted On 2018-04-27