Mutagenetix > Incidental Mutation

Incidental Mutation 'R6368:Vmn2r111'

512821

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r111

Ensembl Gene

ENSMUSG00000095093

Gene Name

vomeronasal 2, receptor 111

Synonyms

EG210876

MMRRC Submission

044518-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

R6368 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

22547941-22573273 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 22571908 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Asparagine at position 136 (K136N)

Ref Sequence

ENSEMBL: ENSMUSP00000090148 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092491]

AlphaFold

K7N674

Predicted Effect

probably benign
Transcript: ENSMUST00000092491
AA Change: K136N

PolyPhen 2 Score 0.380 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000090148
Gene: ENSMUSG00000095093
AA Change: K136N

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	2.5e-29	PFAM
Pfam:NCD3G	512	565	1.1e-20	PFAM
Pfam:7tm_3	595	833	5.6e-54	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.4%
20x: 95.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930563M21Rik	C	A	9: 55,990,132 (GRCm38)	E272D	possibly damaging	Het
Abi2	A	G	1: 60,453,651 (GRCm38)	T158A	possibly damaging	Het
Acacb	T	C	5: 114,216,823 (GRCm38)	S1221P	probably damaging	Het
Agbl1	A	G	7: 76,419,830 (GRCm38)	D370G	probably benign	Het
Apeh	A	G	9: 108,087,243 (GRCm38)	I487T	probably damaging	Het
Arid1b	C	A	17: 5,332,533 (GRCm38)	N1297K	possibly damaging	Het
Ascc3	G	A	10: 50,699,985 (GRCm38)	G779S	probably damaging	Het
Atp7b	A	C	8: 22,020,755 (GRCm38)		probably null	Het
Bsn	C	T	9: 108,111,314 (GRCm38)		probably benign	Het
Caps2	C	T	10: 112,194,968 (GRCm38)	Q268*	probably null	Het
Cnfn	C	T	7: 25,367,961 (GRCm38)		probably null	Het
Cr2	A	G	1: 195,168,472 (GRCm38)	S229P	probably damaging	Het
Cubn	T	C	2: 13,430,995 (GRCm38)	Y1050C	probably damaging	Het
Cubn	T	C	2: 13,476,123 (GRCm38)	E307G	probably damaging	Het
Cyb5r3	A	C	15: 83,160,124 (GRCm38)	Y182D	possibly damaging	Het
Dclre1a	A	T	19: 56,546,791 (GRCm38)	H120Q	probably benign	Het
Ddx6	T	C	9: 44,635,776 (GRCm38)	I457T	probably damaging	Het
E2f1	A	T	2: 154,564,476 (GRCm38)	H93Q	possibly damaging	Het
Fam186a	T	C	15: 99,943,317 (GRCm38)	K1682R	possibly damaging	Het
Farsb	A	G	1: 78,466,965 (GRCm38)		probably null	Het
Flii	A	T	11: 60,721,136 (GRCm38)	L347Q	probably damaging	Het
Galntl6	T	G	8: 58,911,441 (GRCm38)	T12P	probably damaging	Het
Gm11595	G	A	11: 99,772,555 (GRCm38)	R100C	unknown	Het
Gm21680	T	C	5: 25,969,036 (GRCm38)	N190S	probably damaging	Het
Ifit1bl2	T	C	19: 34,619,125 (GRCm38)	S364G	probably benign	Het
Kdm2a	A	G	19: 4,350,317 (GRCm38)	I234T	probably damaging	Het
Kdm5b	T	C	1: 134,599,207 (GRCm38)	C356R	probably damaging	Het
Kel	A	T	6: 41,688,851 (GRCm38)	C174*	probably null	Het
Krt16	T	A	11: 100,246,676 (GRCm38)	D401V	probably damaging	Het
Ltb4r1	A	C	14: 55,767,743 (GRCm38)	I168L	probably benign	Het
Luzp1	T	A	4: 136,541,780 (GRCm38)	M438K	probably benign	Het
Mtf1	C	T	4: 124,824,352 (GRCm38)	T281M	probably damaging	Het
Myo9a	T	A	9: 59,924,948 (GRCm38)	S2587T	probably benign	Het
Olfr1311	A	T	2: 112,021,551 (GRCm38)	I101N	probably damaging	Het
Olfr1377	T	A	11: 50,984,786 (GRCm38)	F28L	probably benign	Het
Olfr532	G	T	7: 140,419,667 (GRCm38)	Y35*	probably null	Het
Olfr860	T	C	9: 19,846,409 (GRCm38)	D70G	probably damaging	Het
Pcm1	T	A	8: 41,293,544 (GRCm38)	F1221Y	probably benign	Het
Pnldc1	A	T	17: 12,905,864 (GRCm38)	N90K	probably damaging	Het
Prickle2	A	T	6: 92,420,237 (GRCm38)	L169Q	probably damaging	Het
Ralgps2	A	T	1: 156,884,574 (GRCm38)	L147I	probably damaging	Het
Rfx3	A	T	19: 27,768,609 (GRCm38)	L674Q	possibly damaging	Het
Rpl3	C	A	15: 80,082,544 (GRCm38)	L14F	probably damaging	Het
Rrbp1	C	T	2: 143,989,555 (GRCm38)	G231R	probably damaging	Het
Sema3d	C	T	5: 12,571,013 (GRCm38)	L529F	probably damaging	Het
Slain1	A	T	14: 103,656,955 (GRCm38)	T193S	probably benign	Het
Slc2a6	G	T	2: 27,024,587 (GRCm38)	Q256K	possibly damaging	Het
Slk	A	G	19: 47,620,183 (GRCm38)	E525G	possibly damaging	Het
Spsb4	G	T	9: 96,944,645 (GRCm38)	Q252K	probably benign	Het
Taf1b	A	G	12: 24,558,257 (GRCm38)	T552A	possibly damaging	Het
Tmprss15	T	C	16: 79,006,057 (GRCm38)		probably null	Het
Tph2	T	C	10: 115,179,326 (GRCm38)	H177R	probably damaging	Het
Ttll1	A	G	15: 83,489,617 (GRCm38)	S332P	probably damaging	Het
Twf2	T	G	9: 106,212,833 (GRCm38)	N128K	probably benign	Het
Vegfc	T	A	8: 54,181,230 (GRCm38)	C315S	probably damaging	Het
Wnk2	T	C	13: 49,061,338 (GRCm38)	E496G	probably damaging	Het
Zfp148	C	A	16: 33,497,198 (GRCm38)	Q705K	probably damaging	Het
Zw10	C	T	9: 49,073,235 (GRCm38)	A539V	probably damaging	Het

Other mutations in Vmn2r111

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00932:Vmn2r111	APN	17	22,548,753 (GRCm38)	missense	probably benign	0.00
IGL01306:Vmn2r111	APN	17	22,568,984 (GRCm38)	missense	probably damaging	0.99
IGL01309:Vmn2r111	APN	17	22,569,016 (GRCm38)	missense	possibly damaging	0.51
IGL01457:Vmn2r111	APN	17	22,571,985 (GRCm38)	nonsense	probably null
IGL01465:Vmn2r111	APN	17	22,548,737 (GRCm38)	missense	probably benign	0.00
IGL01505:Vmn2r111	APN	17	22,548,572 (GRCm38)	missense	probably benign	0.00
IGL01571:Vmn2r111	APN	17	22,571,392 (GRCm38)	missense	probably damaging	0.99
IGL01715:Vmn2r111	APN	17	22,569,073 (GRCm38)	splice site	probably benign
IGL01962:Vmn2r111	APN	17	22,548,284 (GRCm38)	missense	possibly damaging	0.90
IGL02190:Vmn2r111	APN	17	22,570,773 (GRCm38)	missense	probably benign	0.00
IGL02496:Vmn2r111	APN	17	22,568,856 (GRCm38)	missense	probably benign
IGL02519:Vmn2r111	APN	17	22,548,339 (GRCm38)	missense	possibly damaging	0.80
IGL02616:Vmn2r111	APN	17	22,571,050 (GRCm38)	missense	possibly damaging	0.67
IGL02641:Vmn2r111	APN	17	22,573,224 (GRCm38)	missense	possibly damaging	0.82
IGL02690:Vmn2r111	APN	17	22,559,042 (GRCm38)	critical splice donor site	probably null
IGL02698:Vmn2r111	APN	17	22,571,245 (GRCm38)	missense	probably damaging	1.00
IGL03017:Vmn2r111	APN	17	22,570,858 (GRCm38)	missense	probably damaging	1.00
R0046:Vmn2r111	UTSW	17	22,548,009 (GRCm38)	missense	probably benign
R0064:Vmn2r111	UTSW	17	22,572,072 (GRCm38)	missense	probably benign	0.00
R0519:Vmn2r111	UTSW	17	22,573,121 (GRCm38)	missense	probably benign	0.02
R1439:Vmn2r111	UTSW	17	22,571,116 (GRCm38)	missense	probably benign	0.00
R1467:Vmn2r111	UTSW	17	22,571,047 (GRCm38)	missense	probably damaging	0.99
R1467:Vmn2r111	UTSW	17	22,571,047 (GRCm38)	missense	probably damaging	0.99
R1636:Vmn2r111	UTSW	17	22,571,399 (GRCm38)	missense	probably damaging	1.00
R1647:Vmn2r111	UTSW	17	22,569,061 (GRCm38)	missense	probably benign	0.03
R1648:Vmn2r111	UTSW	17	22,569,061 (GRCm38)	missense	probably benign	0.03
R1697:Vmn2r111	UTSW	17	22,548,060 (GRCm38)	missense	probably benign	0.26
R1996:Vmn2r111	UTSW	17	22,548,081 (GRCm38)	missense	probably benign	0.21
R2040:Vmn2r111	UTSW	17	22,548,414 (GRCm38)	missense	probably damaging	1.00
R2075:Vmn2r111	UTSW	17	22,559,062 (GRCm38)	missense	probably damaging	1.00
R2134:Vmn2r111	UTSW	17	22,573,104 (GRCm38)	missense	possibly damaging	0.68
R2357:Vmn2r111	UTSW	17	22,559,170 (GRCm38)	splice site	probably benign
R3700:Vmn2r111	UTSW	17	22,571,161 (GRCm38)	nonsense	probably null
R3782:Vmn2r111	UTSW	17	22,571,320 (GRCm38)	missense	possibly damaging	0.89
R4085:Vmn2r111	UTSW	17	22,559,115 (GRCm38)	missense	probably benign	0.00
R4323:Vmn2r111	UTSW	17	22,573,178 (GRCm38)	missense	probably benign	0.02
R4900:Vmn2r111	UTSW	17	22,548,656 (GRCm38)	missense	possibly damaging	0.94
R5072:Vmn2r111	UTSW	17	22,548,041 (GRCm38)	missense	probably damaging	0.99
R5123:Vmn2r111	UTSW	17	22,571,143 (GRCm38)	missense	possibly damaging	0.82
R5181:Vmn2r111	UTSW	17	22,571,020 (GRCm38)	missense	possibly damaging	0.56
R5357:Vmn2r111	UTSW	17	22,548,102 (GRCm38)	nonsense	probably null
R5398:Vmn2r111	UTSW	17	22,573,271 (GRCm38)	start codon destroyed	probably null	0.88
R5434:Vmn2r111	UTSW	17	22,548,489 (GRCm38)	missense	probably damaging	0.99
R5462:Vmn2r111	UTSW	17	22,548,257 (GRCm38)	missense	probably damaging	1.00
R6149:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6149:Vmn2r111	UTSW	17	22,548,815 (GRCm38)	missense	probably benign	0.00
R6207:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6281:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6282:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6283:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6307:Vmn2r111	UTSW	17	22,573,089 (GRCm38)	missense	probably benign	0.00
R6323:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6325:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6367:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6369:Vmn2r111	UTSW	17	22,548,602 (GRCm38)	missense	probably damaging	1.00
R6489:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6490:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6546:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6547:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6557:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6654:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6655:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6657:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6659:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6660:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6664:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6798:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6799:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6801:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6893:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6895:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6897:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6922:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6923:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6944:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R6945:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7017:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7018:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7024:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7031:Vmn2r111	UTSW	17	22,571,245 (GRCm38)	missense	probably damaging	1.00
R7039:Vmn2r111	UTSW	17	22,548,184 (GRCm38)	missense	probably damaging	1.00
R7053:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7054:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7055:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7056:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7145:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7146:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7246:Vmn2r111	UTSW	17	22,548,714 (GRCm38)	missense	probably damaging	1.00
R7259:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7260:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7327:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7401:Vmn2r111	UTSW	17	22,571,086 (GRCm38)	missense	possibly damaging	0.93
R7514:Vmn2r111	UTSW	17	22,548,399 (GRCm38)	missense	probably benign	0.05
R7651:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7781:Vmn2r111	UTSW	17	22,570,733 (GRCm38)	missense	probably benign	0.17
R7816:Vmn2r111	UTSW	17	22,573,102 (GRCm38)	missense	probably damaging	0.97
R7821:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R7838:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8078:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8080:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8117:Vmn2r111	UTSW	17	22,571,488 (GRCm38)	missense	probably benign	0.12
R8171:Vmn2r111	UTSW	17	22,573,092 (GRCm38)	missense	probably benign	0.10
R8195:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8197:Vmn2r111	UTSW	17	22,559,051 (GRCm38)	missense	possibly damaging	0.50
R8411:Vmn2r111	UTSW	17	22,548,581 (GRCm38)	missense	probably benign	0.03
R8539:Vmn2r111	UTSW	17	22,571,293 (GRCm38)	missense	probably benign	0.23
R8540:Vmn2r111	UTSW	17	22,559,043 (GRCm38)	missense	probably damaging	1.00
R8540:Vmn2r111	UTSW	17	22,559,042 (GRCm38)	critical splice donor site	probably null
R8557:Vmn2r111	UTSW	17	22,571,929 (GRCm38)	nonsense	probably null
R8720:Vmn2r111	UTSW	17	22,573,213 (GRCm38)	missense	possibly damaging	0.88
R8729:Vmn2r111	UTSW	17	22,548,258 (GRCm38)	missense	probably damaging	1.00
R8843:Vmn2r111	UTSW	17	22,548,030 (GRCm38)	missense	probably benign	0.00
R9184:Vmn2r111	UTSW	17	22,571,841 (GRCm38)	missense	probably benign
R9374:Vmn2r111	UTSW	17	22,568,878 (GRCm38)	missense	probably benign	0.17
R9452:Vmn2r111	UTSW	17	22,559,151 (GRCm38)	missense	probably damaging	1.00
X0026:Vmn2r111	UTSW	17	22,548,695 (GRCm38)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- CCTATGCCTAGCAAGGTCATGC -3'
(R):5'- TTACAGAACTCAGACTGAAAATCGC -3'

Sequencing Primer
(F):5'- TCATGCTGGCACAAGAGATAC -3'
(R):5'- CAAATATGCTCTGGCTTTGGC -3'

Posted On

2018-04-27