Mutagenetix > Incidental Mutations

Incidental Mutation 'R6354:Vmn2r72'

512965

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r72

Ensembl Gene

ENSMUSG00000051877

Gene Name

vomeronasal 2, receptor 72

Synonyms

Vmn2r72-ps, EG244114

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

R6354 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

85737784-85754981 bp(-) (GRCm38)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

A to G at 85750539 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000133014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063425]

Predicted Effect

probably null
Transcript: ENSMUST00000063425

SMART Domains

Protein: ENSMUSP00000133014
Gene: ENSMUSG00000051877

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	2.3e-28	PFAM
Pfam:NCD3G	512	564	1.2e-18	PFAM
Pfam:7tm_3	594	832	4e-53	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 100.0%
3x: 99.8%
10x: 98.5%
20x: 95.3%

Validation Efficiency

100% (56/56)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700012B07Rik	T	C	11: 109,794,216	K152E	probably benign	Het
Adamts20	C	A	15: 94,347,810	C537F	probably damaging	Het
Apc	A	T	18: 34,312,528	T808S	probably benign	Het
Atad3a	A	G	4: 155,753,945	I205T	possibly damaging	Het
Casz1	G	T	4: 148,952,542	G1754C	unknown	Het
Ccdc62	C	T	5: 123,944,204	A232V	probably damaging	Het
Cdc27	C	A	11: 104,534,748	D81Y	probably damaging	Het
Cep126	A	G	9: 8,099,927	S869P	probably damaging	Het
Ciita	A	T	16: 10,523,746	K983N	probably damaging	Het
Clstn1	A	C	4: 149,643,216	Q523P	probably benign	Het
Cpb2	T	C	14: 75,257,705		probably null	Het
Crybg2	A	G	4: 134,091,136	D1710G	probably benign	Het
Csmd3	C	T	15: 47,881,489	G1370D	probably damaging	Het
Cwf19l1	G	T	19: 44,127,473	D172E	probably benign	Het
Cyp4a14	A	G	4: 115,487,244	F475L	probably damaging	Het
Fam98c	C	T	7: 29,152,847	V298M	probably damaging	Het
Gcsh	T	C	8: 116,983,843	N127S	probably benign	Het
Gimap4	T	C	6: 48,686,880	F10S	possibly damaging	Het
Gm4787	C	T	12: 81,377,981	A468T	probably damaging	Het
Gm5111	G	A	6: 48,590,334		probably benign	Het
Gm7137	C	A	10: 77,787,647		probably benign	Het
Inpp1	A	G	1: 52,797,065	S81P	probably damaging	Het
Iqce	T	C	5: 140,676,335		probably null	Het
Ivl	CCTGCTGCTGCTGCT	CCTGCTGCTGCT	3: 92,571,910		probably benign	Het
Krtap13	C	A	16: 88,751,243	C119F	probably damaging	Het
Lama2	G	T	10: 27,212,068	D904E	probably damaging	Het
Lrrc37a	T	A	11: 103,464,387	I2535F	unknown	Het
Lrrc40	T	A	3: 158,061,264	L452*	probably null	Het
Meis1	A	T	11: 19,016,184	M63K	possibly damaging	Het
Mpo	T	A	11: 87,797,346	I277N	possibly damaging	Het
Mtmr11	T	A	3: 96,168,676	F406I	probably benign	Het
Muc4	T	C	16: 32,754,358	S1411P	probably benign	Het
Odf3	A	G	7: 140,850,614		probably null	Het
Olfr10	A	T	11: 49,317,638	I31F	probably damaging	Het
Olfr1189	T	A	2: 88,592,134	I110N	probably damaging	Het
Olfr683	G	A	7: 105,143,708	T195I	probably benign	Het
Phf21a	G	A	2: 92,348,937	G298R	probably damaging	Het
Phldb2	T	C	16: 45,825,114	Y368C	probably damaging	Het
Pik3cb	G	T	9: 99,073,643	T407K	probably benign	Het
Robo3	A	T	9: 37,417,217		probably benign	Het
Sgsm1	T	G	5: 113,282,656	T288P	probably damaging	Het
Slc5a7	A	G	17: 54,277,033	S410P	probably damaging	Het
Tmc6	A	C	11: 117,774,236	C404G	probably benign	Het
Tnrc6c	A	T	11: 117,749,614	Q1410L	possibly damaging	Het
Trak1	A	T	9: 121,451,726	T384S	probably null	Het
Txlna	A	T	4: 129,634,412	L244Q	probably damaging	Het
Ube3c	T	C	5: 29,663,583	F939L	probably damaging	Het
Vmn2r65	T	A	7: 84,940,366	I781F	probably benign	Het
Vps36	T	C	8: 22,205,755	S109P	probably damaging	Het
Wdr66	C	T	5: 123,302,755	T1125I	probably damaging	Het
Wrn	T	C	8: 33,343,638	I82M	possibly damaging	Het
Zbtb49	T	C	5: 38,203,559	R511G	possibly damaging	Het
Zeb1	A	G	18: 5,772,743	T1011A	possibly damaging	Het
Zfhx4	T	C	3: 5,401,951	S2390P	probably benign	Het
Zfp619	C	A	7: 39,534,819	T91K	probably benign	Het
Zfp644	A	G	5: 106,636,753	S643P	probably benign	Het

Other mutations in Vmn2r72

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00931:Vmn2r72	APN	7	85749646	missense	probably benign	0.01
IGL01019:Vmn2r72	APN	7	85738334	missense	probably benign	0.26
IGL01445:Vmn2r72	APN	7	85749646	missense	probably benign	0.06
IGL02076:Vmn2r72	APN	7	85738367	missense	probably damaging	1.00
IGL02082:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02086:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02089:Vmn2r72	APN	7	85738166	missense	probably benign	0.00
IGL02125:Vmn2r72	APN	7	85750711	missense	probably benign	0.00
IGL02146:Vmn2r72	APN	7	85737962	missense	probably damaging	1.00
IGL02272:Vmn2r72	APN	7	85750693	missense	probably benign
IGL02514:Vmn2r72	APN	7	85738699	missense	possibly damaging	0.90
IGL02662:Vmn2r72	APN	7	85738183	missense	probably benign	0.26
IGL02697:Vmn2r72	APN	7	85738671	missense	probably benign	0.36
IGL02733:Vmn2r72	APN	7	85751813	missense	probably benign	0.05
IGL03070:Vmn2r72	APN	7	85752041	splice site	probably benign
IGL03150:Vmn2r72	APN	7	85751176	missense	probably damaging	1.00
IGL03159:Vmn2r72	APN	7	85754954	missense	probably benign	0.05
IGL03333:Vmn2r72	APN	7	85750867	missense	probably benign	0.10
R0081:Vmn2r72	UTSW	7	85751836	missense	probably benign	0.01
R0090:Vmn2r72	UTSW	7	85754876	missense	probably benign
R0655:Vmn2r72	UTSW	7	85738111	nonsense	probably null
R0778:Vmn2r72	UTSW	7	85749739	missense	probably benign	0.00
R1169:Vmn2r72	UTSW	7	85751309	missense	probably benign	0.01
R1172:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1173:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1175:Vmn2r72	UTSW	7	85751944	missense	probably damaging	1.00
R1248:Vmn2r72	UTSW	7	85749188	missense	probably benign	0.02
R1302:Vmn2r72	UTSW	7	85738257	missense	probably damaging	1.00
R1506:Vmn2r72	UTSW	7	85749211	missense	probably benign
R1632:Vmn2r72	UTSW	7	85751792	missense	probably benign	0.13
R1775:Vmn2r72	UTSW	7	85738170	missense	probably benign	0.01
R1962:Vmn2r72	UTSW	7	85749161	missense	probably benign	0.00
R2201:Vmn2r72	UTSW	7	85738236	missense	probably benign	0.12
R2290:Vmn2r72	UTSW	7	85738341	missense	probably damaging	1.00
R2327:Vmn2r72	UTSW	7	85738256	missense	probably damaging	1.00
R2424:Vmn2r72	UTSW	7	85750953	missense	probably damaging	1.00
R2655:Vmn2r72	UTSW	7	85751269	missense	possibly damaging	0.95
R2860:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2861:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R2862:Vmn2r72	UTSW	7	85750836	missense	probably damaging	0.99
R3009:Vmn2r72	UTSW	7	85749642	missense	probably benign	0.00
R3797:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3798:Vmn2r72	UTSW	7	85738077	missense	probably benign	0.44
R3902:Vmn2r72	UTSW	7	85749735	missense	possibly damaging	0.52
R3959:Vmn2r72	UTSW	7	85751131	missense	probably benign	0.36
R3974:Vmn2r72	UTSW	7	85749809	missense	probably damaging	1.00
R4399:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4421:Vmn2r72	UTSW	7	85738500	missense	probably damaging	1.00
R4426:Vmn2r72	UTSW	7	85737828	nonsense	probably null
R4522:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4523:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4533:Vmn2r72	UTSW	7	85751926	missense	probably benign	0.44
R4691:Vmn2r72	UTSW	7	85737911	nonsense	probably null
R4781:Vmn2r72	UTSW	7	85737861	missense	probably benign	0.14
R4863:Vmn2r72	UTSW	7	85750598	missense	possibly damaging	0.91
R4952:Vmn2r72	UTSW	7	85751109	missense	probably benign
R4991:Vmn2r72	UTSW	7	85751130	missense	probably damaging	0.99
R4995:Vmn2r72	UTSW	7	85738485	missense	probably damaging	1.00
R5095:Vmn2r72	UTSW	7	85737853	missense	probably damaging	0.98
R5174:Vmn2r72	UTSW	7	85737840	missense	probably benign	0.00
R5276:Vmn2r72	UTSW	7	85738254	missense	possibly damaging	0.90
R5395:Vmn2r72	UTSW	7	85750897	missense	possibly damaging	0.71
R5560:Vmn2r72	UTSW	7	85751942	missense	probably damaging	0.96
R5933:Vmn2r72	UTSW	7	85737850	missense	probably benign	0.05
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6033:Vmn2r72	UTSW	7	85737929	missense	probably damaging	1.00
R6362:Vmn2r72	UTSW	7	85751174	missense	probably damaging	1.00
R6594:Vmn2r72	UTSW	7	85749684	missense	probably benign	0.32
R6794:Vmn2r72	UTSW	7	85737996	missense	probably damaging	1.00
R7113:Vmn2r72	UTSW	7	85749803	splice site	probably null
R7189:Vmn2r72	UTSW	7	85754917	missense	probably benign	0.36
R7266:Vmn2r72	UTSW	7	85738274	nonsense	probably null
R7323:Vmn2r72	UTSW	7	85750563	missense	probably benign
R7426:Vmn2r72	UTSW	7	85751140	missense	probably benign
R7606:Vmn2r72	UTSW	7	85751154	missense	possibly damaging	0.91
R7651:Vmn2r72	UTSW	7	85751938	missense	probably damaging	1.00
R7688:Vmn2r72	UTSW	7	85754890	missense	probably benign	0.32
R7753:Vmn2r72	UTSW	7	85750626	missense	probably damaging	1.00
R7843:Vmn2r72	UTSW	7	85749630	missense	probably benign	0.01
R8157:Vmn2r72	UTSW	7	85751233	missense	probably benign	0.09
R8254:Vmn2r72	UTSW	7	85751019	missense	probably damaging	1.00
R8389:Vmn2r72	UTSW	7	85751960	missense	probably damaging	0.99
R8444:Vmn2r72	UTSW	7	85738175	missense	probably benign
Z1176:Vmn2r72	UTSW	7	85749191	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- TTGCATACTAATGTCGACTGTGTC -3'
(R):5'- TTGCCACCATCTAATTGTAAAACGC -3'

Sequencing Primer
(F):5'- AATGTCGACTGTGTCATATTACATG -3'
(R):5'- GTAAAACGCTGAAGAATTGTCCC -3'

Posted On

2018-04-27