Incidental Mutation 'IGL01095:Il5ra'
ID 51299
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Il5ra
Ensembl Gene ENSMUSG00000005364
Gene Name interleukin 5 receptor, alpha
Synonyms CDw125, Il5r, IL-5 receptor alpha chain, CD125
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # IGL01095
Quality Score
Status
Chromosome 6
Chromosomal Location 106687336-106725998 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) A to T at 106719605 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000144825 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167925] [ENSMUST00000204659] [ENSMUST00000205004]
AlphaFold P21183
Predicted Effect probably benign
Transcript: ENSMUST00000167925
SMART Domains Protein: ENSMUSP00000129781
Gene: ENSMUSG00000005364

DomainStartEndE-ValueType
FN3 27 159 6.27e0 SMART
FN3 236 312 1.28e1 SMART
transmembrane domain 335 357 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000204659
SMART Domains Protein: ENSMUSP00000144718
Gene: ENSMUSG00000005364

DomainStartEndE-ValueType
FN3 27 159 6.27e0 SMART
FN3 236 312 1.28e1 SMART
transmembrane domain 335 357 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000205004
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]
PHENOTYPE: Mice homozygous for disruptions in this gene display a generally normal phenotype but with some immune system deficiencies. Mice homozygous for one knock-out allele exhibit increased metastasis of injected B16F10 melanoma cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34l T A 8: 44,079,133 (GRCm39) I364L probably benign Het
Adgra1 A G 7: 139,425,570 (GRCm39) T28A possibly damaging Het
Aldh8a1 A G 10: 21,265,180 (GRCm39) E269G probably benign Het
Alkbh7 A G 17: 57,304,470 (GRCm39) probably null Het
Ap1g2 T C 14: 55,342,571 (GRCm39) T129A probably benign Het
Ap1s1 A G 5: 137,070,663 (GRCm39) I117T probably damaging Het
Brca1 G A 11: 101,415,195 (GRCm39) P119S possibly damaging Het
Chid1 A G 7: 141,110,142 (GRCm39) V62A probably damaging Het
Cpa1 A T 6: 30,642,968 (GRCm39) I299F probably benign Het
Cuzd1 A G 7: 130,917,865 (GRCm39) V245A probably damaging Het
Ddx39b T C 17: 35,465,937 (GRCm39) S71P probably benign Het
Ddx42 A G 11: 106,138,325 (GRCm39) Y708C probably damaging Het
Dnah3 C A 7: 119,550,820 (GRCm39) L3166F probably benign Het
Erap1 A G 13: 74,816,213 (GRCm39) E114G probably benign Het
Fap G A 2: 62,354,545 (GRCm39) T448I possibly damaging Het
Fhl2 A T 1: 43,170,841 (GRCm39) Y158N probably benign Het
Fscb A G 12: 64,520,155 (GRCm39) V437A possibly damaging Het
Il18 A T 9: 50,490,629 (GRCm39) D88V probably damaging Het
Jakmip3 A T 7: 138,622,546 (GRCm39) Q302L probably damaging Het
Lrp2 A T 2: 69,322,776 (GRCm39) Y1857* probably null Het
Meis2 T C 2: 115,694,905 (GRCm39) T406A probably benign Het
Mre11a T A 9: 14,721,120 (GRCm39) S346R probably benign Het
Myh15 A T 16: 48,952,378 (GRCm39) K816M probably damaging Het
Mysm1 C T 4: 94,856,106 (GRCm39) probably null Het
Nyap1 C A 5: 137,736,346 (GRCm39) R47L probably damaging Het
Oas3 A G 5: 120,910,954 (GRCm39) Y209H probably damaging Het
Or2v2 T G 11: 49,003,680 (GRCm39) Y291S probably damaging Het
Or4g16 A G 2: 111,136,966 (GRCm39) R139G probably benign Het
Or6c209 A G 10: 129,483,498 (GRCm39) D167G probably benign Het
Or8b42 A G 9: 38,341,811 (GRCm39) I78V probably benign Het
Or8d6 T C 9: 39,853,976 (GRCm39) V140A probably benign Het
Pde4b T C 4: 102,363,241 (GRCm39) probably null Het
Psd3 G A 8: 68,361,165 (GRCm39) T99M probably damaging Het
R3hcc1 T C 14: 69,937,477 (GRCm39) E390G probably damaging Het
Rabgap1l A C 1: 160,566,539 (GRCm39) C58W probably benign Het
Rasd1 A G 11: 59,855,117 (GRCm39) I121T probably damaging Het
Spta1 A G 1: 174,041,051 (GRCm39) N1284D probably benign Het
Tpr T C 1: 150,285,891 (GRCm39) V525A possibly damaging Het
Other mutations in Il5ra
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00715:Il5ra APN 6 106,689,435 (GRCm39) splice site probably benign
IGL00726:Il5ra APN 6 106,715,450 (GRCm39) missense probably damaging 1.00
IGL01562:Il5ra APN 6 106,708,865 (GRCm39) missense probably benign 0.00
IGL01569:Il5ra APN 6 106,708,794 (GRCm39) start codon destroyed probably null
IGL02346:Il5ra APN 6 106,719,619 (GRCm39) missense probably benign 0.02
IGL02573:Il5ra APN 6 106,693,712 (GRCm39) missense possibly damaging 0.93
IGL02659:Il5ra APN 6 106,719,644 (GRCm39) missense possibly damaging 0.49
R0037:Il5ra UTSW 6 106,719,647 (GRCm39) missense probably damaging 1.00
R0037:Il5ra UTSW 6 106,719,647 (GRCm39) missense probably damaging 1.00
R0294:Il5ra UTSW 6 106,689,362 (GRCm39) missense probably benign 0.41
R0463:Il5ra UTSW 6 106,708,851 (GRCm39) missense probably damaging 0.99
R0478:Il5ra UTSW 6 106,715,423 (GRCm39) missense probably benign
R0597:Il5ra UTSW 6 106,721,296 (GRCm39) start codon destroyed probably null 0.99
R1526:Il5ra UTSW 6 106,712,781 (GRCm39) missense possibly damaging 0.49
R1695:Il5ra UTSW 6 106,715,335 (GRCm39) nonsense probably null
R1888:Il5ra UTSW 6 106,708,874 (GRCm39) missense probably damaging 1.00
R1888:Il5ra UTSW 6 106,708,874 (GRCm39) missense probably damaging 1.00
R2176:Il5ra UTSW 6 106,715,233 (GRCm39) missense probably benign
R2207:Il5ra UTSW 6 106,689,402 (GRCm39) nonsense probably null
R2973:Il5ra UTSW 6 106,718,196 (GRCm39) missense probably benign 0.08
R4546:Il5ra UTSW 6 106,715,459 (GRCm39) nonsense probably null
R4842:Il5ra UTSW 6 106,715,336 (GRCm39) missense probably damaging 1.00
R4851:Il5ra UTSW 6 106,715,432 (GRCm39) missense probably benign 0.06
R4911:Il5ra UTSW 6 106,692,629 (GRCm39) missense probably damaging 1.00
R4936:Il5ra UTSW 6 106,715,123 (GRCm39) missense possibly damaging 0.90
R5297:Il5ra UTSW 6 106,715,095 (GRCm39) missense probably benign 0.09
R6035:Il5ra UTSW 6 106,718,226 (GRCm39) missense probably damaging 1.00
R6035:Il5ra UTSW 6 106,718,226 (GRCm39) missense probably damaging 1.00
R8103:Il5ra UTSW 6 106,692,611 (GRCm39) missense possibly damaging 0.87
R8338:Il5ra UTSW 6 106,689,350 (GRCm39) missense probably benign 0.09
R8497:Il5ra UTSW 6 106,715,066 (GRCm39) missense probably benign 0.01
R8936:Il5ra UTSW 6 106,692,604 (GRCm39) missense possibly damaging 0.94
R9397:Il5ra UTSW 6 106,721,258 (GRCm39) missense probably benign 0.10
R9576:Il5ra UTSW 6 106,712,688 (GRCm39) missense probably damaging 1.00
R9583:Il5ra UTSW 6 106,721,297 (GRCm39) start codon destroyed possibly damaging 0.84
R9583:Il5ra UTSW 6 106,689,331 (GRCm39) missense unknown
Z1177:Il5ra UTSW 6 106,718,095 (GRCm39) nonsense probably null
Posted On 2013-06-21