Incidental Mutation 'IGL01096:Wee2'
ID51302
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wee2
Ensembl Gene ENSMUSG00000037159
Gene NameWEE1 homolog 2 (S. pombe)
SynonymsLOC381759, Wee1b
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01096
Quality Score
Status
Chromosome6
Chromosomal Location40439088-40466813 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 40463253 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 445 (E445G)
Ref Sequence ENSEMBL: ENSMUSP00000038754 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038907]
Predicted Effect probably benign
Transcript: ENSMUST00000038907
AA Change: E445G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000038754
Gene: ENSMUSG00000037159
AA Change: E445G

DomainStartEndE-ValueType
low complexity region 117 128 N/A INTRINSIC
Pfam:Pkinase 208 481 3.6e-51 PFAM
Pfam:Pkinase_Tyr 209 478 9.6e-25 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg3 A T 8: 95,039,593 M351L possibly damaging Het
Alk T C 17: 71,921,896 K725E possibly damaging Het
Dspp T A 5: 104,175,367 H125Q possibly damaging Het
Elmo2 A T 2: 165,296,987 probably benign Het
Erg A G 16: 95,390,053 probably benign Het
Fam20c A G 5: 138,809,155 E513G possibly damaging Het
Gatsl3 A C 11: 4,221,850 E309A probably damaging Het
Gm9839 G T 1: 32,520,836 T55N possibly damaging Het
Gpd2 A T 2: 57,338,867 M228L probably damaging Het
Hp A T 8: 109,575,401 M305K probably benign Het
Ifng T A 10: 118,445,269 probably benign Het
Igkv9-123 T C 6: 67,954,465 D39G possibly damaging Het
Melk T A 4: 44,347,262 F431I probably benign Het
Olfr1180 A G 2: 88,411,791 M289T probably damaging Het
Olfr1335 A G 4: 118,809,456 V136A probably damaging Het
Olfr536 A T 7: 140,504,184 S92T probably damaging Het
Olfr639 A C 7: 104,012,114 L196W probably damaging Het
Olfr944 G A 9: 39,218,116 G253D probably damaging Het
Pappa T C 4: 65,189,316 Y655H probably damaging Het
Prss58 A T 6: 40,895,465 I208N probably damaging Het
Ryr2 T A 13: 11,703,544 I2720F probably damaging Het
Slc13a1 G T 6: 24,104,077 T322K probably damaging Het
Spag17 T C 3: 100,063,375 F1292L probably benign Het
Tbx5 A G 5: 119,883,026 T366A probably benign Het
Tmeff2 G A 1: 50,930,546 probably benign Het
Tmem101 C A 11: 102,154,552 probably null Het
Tpp2 C A 1: 43,960,888 P389T probably damaging Het
Tyk2 A G 9: 21,108,863 Y1000H probably damaging Het
Ush2a C A 1: 188,678,377 N2407K probably damaging Het
Vmn1r94 C T 7: 20,167,636 V248I probably damaging Het
Vmn2r12 T A 5: 109,086,259 I696F probably damaging Het
Vmn2r83 A G 10: 79,477,828 E90G probably damaging Het
Washc5 T C 15: 59,350,211 probably benign Het
Zfp518b T C 5: 38,672,788 T625A probably benign Het
Other mutations in Wee2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00335:Wee2 APN 6 40462061 missense probably damaging 1.00
IGL01978:Wee2 APN 6 40455153 missense probably damaging 1.00
IGL03026:Wee2 APN 6 40461981 missense probably benign 0.00
IGL03091:Wee2 APN 6 40462034 missense probably benign 0.02
IGL03350:Wee2 APN 6 40449731 missense probably damaging 1.00
IGL03352:Wee2 APN 6 40452655 critical splice donor site probably null
R0420:Wee2 UTSW 6 40456995 missense probably benign 0.04
R0506:Wee2 UTSW 6 40463253 missense probably benign 0.04
R1205:Wee2 UTSW 6 40443941 start gained probably benign
R1702:Wee2 UTSW 6 40464201 missense probably benign 0.04
R3982:Wee2 UTSW 6 40455241 missense possibly damaging 0.86
R3983:Wee2 UTSW 6 40455241 missense possibly damaging 0.86
R5946:Wee2 UTSW 6 40463212 missense probably null 1.00
R6020:Wee2 UTSW 6 40449620 splice site probably null
R6127:Wee2 UTSW 6 40449767 missense probably damaging 1.00
R6189:Wee2 UTSW 6 40449683 missense probably damaging 1.00
R6342:Wee2 UTSW 6 40444255 missense probably benign 0.05
R6347:Wee2 UTSW 6 40455105 missense probably damaging 1.00
R6350:Wee2 UTSW 6 40455105 missense probably damaging 1.00
R6513:Wee2 UTSW 6 40452619 missense probably benign 0.00
R7091:Wee2 UTSW 6 40462002 missense probably benign 0.00
R8258:Wee2 UTSW 6 40444180 missense probably benign 0.00
R8259:Wee2 UTSW 6 40444180 missense probably benign 0.00
Posted On2013-06-21