Incidental Mutation 'IGL01107:Dusp11'
ID51325
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dusp11
Ensembl Gene ENSMUSG00000030002
Gene Namedual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01107
Quality Score
Status
Chromosome6
Chromosomal Location85942268-85961667 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 85952370 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000032071]
Predicted Effect probably benign
Transcript: ENSMUST00000032071
SMART Domains Protein: ENSMUSP00000032071
Gene: ENSMUSG00000030002

DomainStartEndE-ValueType
low complexity region 6 14 N/A INTRINSIC
Pfam:DSPc 74 203 2.5e-18 PFAM
low complexity region 230 243 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134793
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137527
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139164
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151394
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156821
Predicted Effect probably benign
Transcript: ENSMUST00000201530
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001O22Rik A T 2: 30,797,936 F215Y probably damaging Het
2700049A03Rik T C 12: 71,194,468 probably null Het
Akip1 C T 7: 109,711,838 T195M probably damaging Het
Arhgef16 T C 4: 154,280,244 N631S probably benign Het
Brat1 C T 5: 140,717,177 S544L probably damaging Het
Cfap65 C T 1: 74,919,183 probably null Het
D17Wsu92e A T 17: 27,786,069 probably null Het
Defa22 T A 8: 21,163,037 probably null Het
Dnajc4 C T 19: 6,989,501 R153H probably benign Het
E2f4 T A 8: 105,304,177 probably benign Het
Ece1 T A 4: 137,938,658 L271Q probably damaging Het
Fcgrt T C 7: 45,093,328 D343G probably damaging Het
Igsf10 T C 3: 59,331,524 E412G probably damaging Het
Il4ra G T 7: 125,575,914 L431F possibly damaging Het
Krt86 T A 15: 101,475,425 L200Q probably damaging Het
Lpcat1 T A 13: 73,494,828 F126I probably damaging Het
Prag1 A G 8: 36,099,931 T79A probably benign Het
Pramef12 A T 4: 144,393,094 I301N probably benign Het
Psg29 G T 7: 17,204,925 L41F probably benign Het
Rai14 C T 15: 10,599,711 probably benign Het
Reg3a A G 6: 78,383,245 D136G probably benign Het
Rif1 A G 2: 52,111,303 T1590A probably benign Het
Rorb A T 19: 18,957,328 L300* probably null Het
Sin3b T C 8: 72,731,105 C150R possibly damaging Het
Smarcc1 C A 9: 110,221,937 H942N probably damaging Het
Tas2r105 A G 6: 131,687,111 V118A probably benign Het
Tmem131 T C 1: 36,829,581 S388G probably damaging Het
Ttll9 C A 2: 153,002,889 probably benign Het
Ush1c A G 7: 46,209,901 L498P probably damaging Het
Vmn2r100 A G 17: 19,521,356 Y110C probably damaging Het
Zbtb11 T C 16: 56,006,007 Y800H probably damaging Het
Zdhhc20 T A 14: 57,865,589 E101V probably damaging Het
Other mutations in Dusp11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01584:Dusp11 APN 6 85953394 missense probably damaging 1.00
IGL02276:Dusp11 APN 6 85958617 missense probably damaging 1.00
IGL02727:Dusp11 APN 6 85961492 missense probably damaging 1.00
R0372:Dusp11 UTSW 6 85958730 splice site probably benign
R0413:Dusp11 UTSW 6 85952370 splice site probably benign
R1669:Dusp11 UTSW 6 85950026 missense probably benign 0.05
R2115:Dusp11 UTSW 6 85958669 missense probably damaging 1.00
R4610:Dusp11 UTSW 6 85950055 missense probably damaging 1.00
R4678:Dusp11 UTSW 6 85953381 missense probably damaging 0.98
R5288:Dusp11 UTSW 6 85947605 makesense probably null
R5386:Dusp11 UTSW 6 85947605 makesense probably null
R5756:Dusp11 UTSW 6 85952357 missense probably damaging 1.00
R5987:Dusp11 UTSW 6 85959233 nonsense probably null
R6591:Dusp11 UTSW 6 85961525 missense possibly damaging 0.53
R6691:Dusp11 UTSW 6 85961525 missense possibly damaging 0.53
R7684:Dusp11 UTSW 6 85950560 missense probably damaging 1.00
Posted On2013-06-21