Incidental Mutation 'R6352:Mllt10'
ID 513266
Institutional Source Beutler Lab
Gene Symbol Mllt10
Ensembl Gene ENSMUSG00000026743
Gene Name myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
Synonyms B130021D15Rik, D630001B22Rik, Af10
MMRRC Submission 044504-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.704) question?
Stock # R6352 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 18060048-18217199 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 18128604 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Threonine at position 117 (K117T)
Ref Sequence ENSEMBL: ENSMUSP00000110319 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028076] [ENSMUST00000114669] [ENSMUST00000114671] [ENSMUST00000114680]
AlphaFold O54826
Predicted Effect possibly damaging
Transcript: ENSMUST00000028076
AA Change: K195T

PolyPhen 2 Score 0.476 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000028076
Gene: ENSMUSG00000026743
AA Change: K195T

DomainStartEndE-ValueType
PHD 24 72 8.51e-8 SMART
PHD 136 195 2.92e-6 SMART
low complexity region 217 248 N/A INTRINSIC
low complexity region 258 274 N/A INTRINSIC
low complexity region 308 326 N/A INTRINSIC
low complexity region 352 372 N/A INTRINSIC
low complexity region 490 515 N/A INTRINSIC
low complexity region 581 594 N/A INTRINSIC
low complexity region 609 627 N/A INTRINSIC
low complexity region 674 692 N/A INTRINSIC
coiled coil region 741 782 N/A INTRINSIC
low complexity region 836 879 N/A INTRINSIC
low complexity region 941 952 N/A INTRINSIC
low complexity region 966 986 N/A INTRINSIC
low complexity region 997 1018 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000114669
SMART Domains Protein: ENSMUSP00000110317
Gene: ENSMUSG00000026743

DomainStartEndE-ValueType
low complexity region 38 51 N/A INTRINSIC
low complexity region 66 84 N/A INTRINSIC
low complexity region 131 149 N/A INTRINSIC
coiled coil region 198 239 N/A INTRINSIC
low complexity region 293 336 N/A INTRINSIC
low complexity region 398 409 N/A INTRINSIC
low complexity region 423 443 N/A INTRINSIC
low complexity region 454 475 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000114671
AA Change: K117T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110319
Gene: ENSMUSG00000026743
AA Change: K117T

DomainStartEndE-ValueType
PHD 58 117 2.92e-6 SMART
low complexity region 139 170 N/A INTRINSIC
low complexity region 180 196 N/A INTRINSIC
low complexity region 230 248 N/A INTRINSIC
low complexity region 274 294 N/A INTRINSIC
low complexity region 412 437 N/A INTRINSIC
low complexity region 503 516 N/A INTRINSIC
low complexity region 531 549 N/A INTRINSIC
low complexity region 596 614 N/A INTRINSIC
coiled coil region 663 704 N/A INTRINSIC
low complexity region 758 801 N/A INTRINSIC
low complexity region 863 874 N/A INTRINSIC
low complexity region 888 908 N/A INTRINSIC
low complexity region 919 940 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000114680
AA Change: K195T

PolyPhen 2 Score 0.476 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000110328
Gene: ENSMUSG00000026743
AA Change: K195T

DomainStartEndE-ValueType
PHD 24 72 8.51e-8 SMART
PHD 136 195 2.92e-6 SMART
low complexity region 217 248 N/A INTRINSIC
low complexity region 258 274 N/A INTRINSIC
low complexity region 308 326 N/A INTRINSIC
low complexity region 352 372 N/A INTRINSIC
low complexity region 490 515 N/A INTRINSIC
low complexity region 581 594 N/A INTRINSIC
low complexity region 609 627 N/A INTRINSIC
low complexity region 674 692 N/A INTRINSIC
coiled coil region 741 782 N/A INTRINSIC
low complexity region 836 879 N/A INTRINSIC
low complexity region 941 952 N/A INTRINSIC
low complexity region 966 986 N/A INTRINSIC
low complexity region 997 1018 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133649
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148229
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150422
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154041
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.2%
Validation Efficiency 96% (48/50)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700122O11Rik T C 17: 48,347,945 (GRCm39) S120G probably benign Het
Abca13 G A 11: 9,259,139 (GRCm39) probably null Het
Aco1 G A 4: 40,186,367 (GRCm39) R593Q probably benign Het
Adgra3 T A 5: 50,136,478 (GRCm39) D669V probably benign Het
Adgra3 T A 5: 50,147,592 (GRCm39) M483L probably benign Het
Ccdc42 T C 11: 68,485,191 (GRCm39) V88A probably damaging Het
Cdh16 G C 8: 105,343,624 (GRCm39) S624C probably damaging Het
Cpt1c A T 7: 44,616,219 (GRCm39) probably null Het
Cul9 T C 17: 46,822,241 (GRCm39) T1795A probably benign Het
Dnah2 C T 11: 69,339,053 (GRCm39) V3098I probably damaging Het
Fbxl16 T C 17: 26,037,919 (GRCm39) L426P probably damaging Het
Flt4 T C 11: 49,534,333 (GRCm39) I1168T probably benign Het
Fmo5 T C 3: 97,552,991 (GRCm39) V313A probably benign Het
Foxj3 A G 4: 119,442,975 (GRCm39) N133S probably damaging Het
Gbp8 T C 5: 105,162,926 (GRCm39) I489M possibly damaging Het
Gm10801 TC TCGAC 2: 98,494,151 (GRCm39) probably benign Het
Hdgfl1 T G 13: 26,953,733 (GRCm39) E113D probably benign Het
Heatr5a A T 12: 51,997,949 (GRCm39) S317T possibly damaging Het
Hycc2 A G 1: 58,596,471 (GRCm39) V38A probably damaging Het
Insr C T 8: 3,223,479 (GRCm39) probably null Het
Iqcf5 A G 9: 106,392,929 (GRCm39) E62G possibly damaging Het
Kcnj3 G A 2: 55,327,561 (GRCm39) V117I probably benign Het
Klf9 T A 19: 23,119,138 (GRCm39) M7K probably benign Het
Mboat1 G A 13: 30,386,403 (GRCm39) G139E possibly damaging Het
Mical3 T C 6: 120,929,434 (GRCm39) T1811A probably damaging Het
Mpped1 A G 15: 83,720,564 (GRCm39) D8G probably damaging Het
Myh4 A T 11: 67,143,108 (GRCm39) D1012V probably damaging Het
Myo9b C A 8: 71,801,054 (GRCm39) P1070T probably benign Het
Myo9b C T 8: 71,801,055 (GRCm39) P1071L probably benign Het
Nlrp1b T A 11: 71,072,527 (GRCm39) I439F probably damaging Het
Nlrp9a T A 7: 26,257,051 (GRCm39) I134N probably damaging Het
Nop2 C T 6: 125,114,170 (GRCm39) T212M probably benign Het
Notch4 T C 17: 34,786,435 (GRCm39) C188R probably damaging Het
Or10q12 A T 19: 13,745,828 (GRCm39) M41L probably benign Het
Or2ag19 G T 7: 106,444,429 (GRCm39) V204F probably damaging Het
Pgd C T 4: 149,245,209 (GRCm39) probably null Het
Plet1 T C 9: 50,412,407 (GRCm39) S142P probably damaging Het
Ptk7 A T 17: 46,887,816 (GRCm39) W539R probably benign Het
Ptprd A T 4: 76,009,789 (GRCm39) probably null Het
Rgs22 T G 15: 36,093,067 (GRCm39) Q402P probably damaging Het
Rpl10a T C 17: 28,549,820 (GRCm39) V167A possibly damaging Het
Sdr16c5 A G 4: 4,016,421 (GRCm39) S2P probably benign Het
Slc14a2 T C 18: 78,252,309 (GRCm39) M1V probably null Het
Spta1 T A 1: 174,039,212 (GRCm39) M1185K possibly damaging Het
Syde2 G T 3: 145,704,229 (GRCm39) E127* probably null Het
Thoc2l A G 5: 104,668,064 (GRCm39) E862G probably benign Het
Ugt2b38 T A 5: 87,571,860 (GRCm39) R57S possibly damaging Het
Wdr11 C T 7: 129,208,399 (GRCm39) L385F possibly damaging Het
Wdr74 T C 19: 8,716,822 (GRCm39) V200A possibly damaging Het
Other mutations in Mllt10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01646:Mllt10 APN 2 18,127,128 (GRCm39) missense probably damaging 1.00
IGL02366:Mllt10 APN 2 18,069,898 (GRCm39) missense probably damaging 0.99
IGL02990:Mllt10 APN 2 18,128,522 (GRCm39) splice site probably benign
IGL03034:Mllt10 APN 2 18,069,847 (GRCm39) start codon destroyed probably null 0.55
R0348:Mllt10 UTSW 2 18,167,424 (GRCm39) missense probably damaging 1.00
R0487:Mllt10 UTSW 2 18,211,948 (GRCm39) missense probably damaging 0.98
R0492:Mllt10 UTSW 2 18,151,698 (GRCm39) splice site probably benign
R0518:Mllt10 UTSW 2 18,076,017 (GRCm39) critical splice donor site probably null
R0720:Mllt10 UTSW 2 18,201,406 (GRCm39) missense probably benign
R0733:Mllt10 UTSW 2 18,208,577 (GRCm39) intron probably benign
R1532:Mllt10 UTSW 2 18,097,646 (GRCm39) critical splice donor site probably null
R1665:Mllt10 UTSW 2 18,213,601 (GRCm39) missense possibly damaging 0.93
R1768:Mllt10 UTSW 2 18,167,657 (GRCm39) missense probably damaging 1.00
R2098:Mllt10 UTSW 2 18,167,464 (GRCm39) missense possibly damaging 0.50
R2114:Mllt10 UTSW 2 18,167,380 (GRCm39) missense probably benign
R2116:Mllt10 UTSW 2 18,167,380 (GRCm39) missense probably benign
R2117:Mllt10 UTSW 2 18,167,380 (GRCm39) missense probably benign
R2179:Mllt10 UTSW 2 18,215,604 (GRCm39) missense probably damaging 1.00
R2192:Mllt10 UTSW 2 18,211,871 (GRCm39) missense probably benign 0.11
R2510:Mllt10 UTSW 2 18,069,935 (GRCm39) missense possibly damaging 0.94
R2511:Mllt10 UTSW 2 18,069,935 (GRCm39) missense possibly damaging 0.94
R4669:Mllt10 UTSW 2 18,208,444 (GRCm39) missense probably damaging 1.00
R5004:Mllt10 UTSW 2 18,175,079 (GRCm39) missense probably damaging 1.00
R5072:Mllt10 UTSW 2 18,114,685 (GRCm39) missense possibly damaging 0.72
R5187:Mllt10 UTSW 2 18,213,585 (GRCm39) nonsense probably null
R5561:Mllt10 UTSW 2 18,114,656 (GRCm39) missense probably damaging 0.98
R6141:Mllt10 UTSW 2 18,215,604 (GRCm39) missense probably damaging 1.00
R6844:Mllt10 UTSW 2 18,164,294 (GRCm39) missense probably benign 0.02
R7060:Mllt10 UTSW 2 18,164,371 (GRCm39) missense possibly damaging 0.64
R7464:Mllt10 UTSW 2 18,175,090 (GRCm39) missense probably benign
R7691:Mllt10 UTSW 2 18,208,423 (GRCm39) missense probably null 0.94
R7691:Mllt10 UTSW 2 18,208,422 (GRCm39) missense possibly damaging 0.94
R7937:Mllt10 UTSW 2 18,210,895 (GRCm39) missense probably damaging 1.00
R7956:Mllt10 UTSW 2 18,175,068 (GRCm39) missense probably benign 0.01
R7976:Mllt10 UTSW 2 18,167,214 (GRCm39) missense possibly damaging 0.94
R8079:Mllt10 UTSW 2 18,128,567 (GRCm39) missense probably damaging 0.99
R8084:Mllt10 UTSW 2 18,114,637 (GRCm39) missense probably damaging 0.99
R8518:Mllt10 UTSW 2 18,151,670 (GRCm39) missense probably damaging 0.99
R8768:Mllt10 UTSW 2 18,167,583 (GRCm39) missense probably damaging 1.00
R8826:Mllt10 UTSW 2 18,167,353 (GRCm39) missense probably benign 0.10
R8850:Mllt10 UTSW 2 18,201,469 (GRCm39) missense probably benign 0.33
R8932:Mllt10 UTSW 2 18,128,617 (GRCm39) missense probably benign 0.31
R9009:Mllt10 UTSW 2 18,167,163 (GRCm39) missense probably damaging 0.96
R9129:Mllt10 UTSW 2 18,167,404 (GRCm39) missense probably benign 0.41
R9514:Mllt10 UTSW 2 18,164,322 (GRCm39) missense probably damaging 1.00
R9602:Mllt10 UTSW 2 18,211,850 (GRCm39) missense probably damaging 1.00
R9706:Mllt10 UTSW 2 18,151,655 (GRCm39) missense possibly damaging 0.50
Z1177:Mllt10 UTSW 2 18,175,887 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- ATGCTGTCTTTCAGGTGCC -3'
(R):5'- GTCAATAAGGAACAGGCTAAATGTC -3'

Sequencing Primer
(F):5'- CTGTCTTTCAGGTGCCAAAAAGG -3'
(R):5'- CAGGCTAAATGTCTGCACTGG -3'
Posted On 2018-04-27