Incidental Mutation 'R6352:Fmo5'
ID 513269
Institutional Source Beutler Lab
Gene Symbol Fmo5
Ensembl Gene ENSMUSG00000028088
Gene Name flavin containing monooxygenase 5
Synonyms 5033418D19Rik
MMRRC Submission 044504-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R6352 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 97536120-97562598 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 97552991 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 313 (V313A)
Ref Sequence ENSEMBL: ENSMUSP00000102665 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029729] [ENSMUST00000107049] [ENSMUST00000107050]
AlphaFold P97872
Predicted Effect probably benign
Transcript: ENSMUST00000029729
AA Change: V313A

PolyPhen 2 Score 0.157 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000029729
Gene: ENSMUSG00000028088
AA Change: V313A

DomainStartEndE-ValueType
Pfam:FMO-like 3 533 9.7e-280 PFAM
Pfam:Pyr_redox_2 5 224 3.4e-8 PFAM
Pfam:Pyr_redox_3 7 221 2.2e-21 PFAM
Pfam:NAD_binding_8 8 69 1.7e-6 PFAM
Pfam:K_oxygenase 81 223 9.6e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000107049
AA Change: V313A

PolyPhen 2 Score 0.157 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000102664
Gene: ENSMUSG00000028088
AA Change: V313A

DomainStartEndE-ValueType
Pfam:FMO-like 3 533 9.7e-280 PFAM
Pfam:Pyr_redox_2 5 224 3.4e-8 PFAM
Pfam:Pyr_redox_3 7 221 2.2e-21 PFAM
Pfam:NAD_binding_8 8 69 1.7e-6 PFAM
Pfam:K_oxygenase 81 223 9.6e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000107050
AA Change: V313A

PolyPhen 2 Score 0.157 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000102665
Gene: ENSMUSG00000028088
AA Change: V313A

DomainStartEndE-ValueType
Pfam:FMO-like 3 533 9.7e-280 PFAM
Pfam:Pyr_redox_2 4 228 8.5e-11 PFAM
Pfam:Pyr_redox_3 7 221 4.7e-11 PFAM
Pfam:NAD_binding_8 8 70 3.5e-7 PFAM
Pfam:K_oxygenase 80 222 2.9e-8 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.2%
Validation Efficiency 96% (48/50)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
PHENOTYPE: Mice homozygous for a knock-out allele show an age-related lean phenotype despite increased food intake, lower plasma levels of glucose and cholesterol, decreased fat storage in WAT, altered fatty acid oxidation, increased energy expenditure and respiratory quotient but normal physical activity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700122O11Rik T C 17: 48,347,945 (GRCm39) S120G probably benign Het
Abca13 G A 11: 9,259,139 (GRCm39) probably null Het
Aco1 G A 4: 40,186,367 (GRCm39) R593Q probably benign Het
Adgra3 T A 5: 50,136,478 (GRCm39) D669V probably benign Het
Adgra3 T A 5: 50,147,592 (GRCm39) M483L probably benign Het
Ccdc42 T C 11: 68,485,191 (GRCm39) V88A probably damaging Het
Cdh16 G C 8: 105,343,624 (GRCm39) S624C probably damaging Het
Cpt1c A T 7: 44,616,219 (GRCm39) probably null Het
Cul9 T C 17: 46,822,241 (GRCm39) T1795A probably benign Het
Dnah2 C T 11: 69,339,053 (GRCm39) V3098I probably damaging Het
Fbxl16 T C 17: 26,037,919 (GRCm39) L426P probably damaging Het
Flt4 T C 11: 49,534,333 (GRCm39) I1168T probably benign Het
Foxj3 A G 4: 119,442,975 (GRCm39) N133S probably damaging Het
Gbp8 T C 5: 105,162,926 (GRCm39) I489M possibly damaging Het
Gm10801 TC TCGAC 2: 98,494,151 (GRCm39) probably benign Het
Hdgfl1 T G 13: 26,953,733 (GRCm39) E113D probably benign Het
Heatr5a A T 12: 51,997,949 (GRCm39) S317T possibly damaging Het
Hycc2 A G 1: 58,596,471 (GRCm39) V38A probably damaging Het
Insr C T 8: 3,223,479 (GRCm39) probably null Het
Iqcf5 A G 9: 106,392,929 (GRCm39) E62G possibly damaging Het
Kcnj3 G A 2: 55,327,561 (GRCm39) V117I probably benign Het
Klf9 T A 19: 23,119,138 (GRCm39) M7K probably benign Het
Mboat1 G A 13: 30,386,403 (GRCm39) G139E possibly damaging Het
Mical3 T C 6: 120,929,434 (GRCm39) T1811A probably damaging Het
Mllt10 A C 2: 18,128,604 (GRCm39) K117T probably damaging Het
Mpped1 A G 15: 83,720,564 (GRCm39) D8G probably damaging Het
Myh4 A T 11: 67,143,108 (GRCm39) D1012V probably damaging Het
Myo9b C A 8: 71,801,054 (GRCm39) P1070T probably benign Het
Myo9b C T 8: 71,801,055 (GRCm39) P1071L probably benign Het
Nlrp1b T A 11: 71,072,527 (GRCm39) I439F probably damaging Het
Nlrp9a T A 7: 26,257,051 (GRCm39) I134N probably damaging Het
Nop2 C T 6: 125,114,170 (GRCm39) T212M probably benign Het
Notch4 T C 17: 34,786,435 (GRCm39) C188R probably damaging Het
Or10q12 A T 19: 13,745,828 (GRCm39) M41L probably benign Het
Or2ag19 G T 7: 106,444,429 (GRCm39) V204F probably damaging Het
Pgd C T 4: 149,245,209 (GRCm39) probably null Het
Plet1 T C 9: 50,412,407 (GRCm39) S142P probably damaging Het
Ptk7 A T 17: 46,887,816 (GRCm39) W539R probably benign Het
Ptprd A T 4: 76,009,789 (GRCm39) probably null Het
Rgs22 T G 15: 36,093,067 (GRCm39) Q402P probably damaging Het
Rpl10a T C 17: 28,549,820 (GRCm39) V167A possibly damaging Het
Sdr16c5 A G 4: 4,016,421 (GRCm39) S2P probably benign Het
Slc14a2 T C 18: 78,252,309 (GRCm39) M1V probably null Het
Spta1 T A 1: 174,039,212 (GRCm39) M1185K possibly damaging Het
Syde2 G T 3: 145,704,229 (GRCm39) E127* probably null Het
Thoc2l A G 5: 104,668,064 (GRCm39) E862G probably benign Het
Ugt2b38 T A 5: 87,571,860 (GRCm39) R57S possibly damaging Het
Wdr11 C T 7: 129,208,399 (GRCm39) L385F possibly damaging Het
Wdr74 T C 19: 8,716,822 (GRCm39) V200A possibly damaging Het
Other mutations in Fmo5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01469:Fmo5 APN 3 97,558,884 (GRCm39) missense probably benign 0.19
IGL01926:Fmo5 APN 3 97,544,797 (GRCm39) missense probably damaging 1.00
IGL03062:Fmo5 APN 3 97,542,909 (GRCm39) missense probably damaging 1.00
IGL03215:Fmo5 APN 3 97,549,122 (GRCm39) missense probably benign
IGL03323:Fmo5 APN 3 97,546,323 (GRCm39) splice site probably null
PIT4445001:Fmo5 UTSW 3 97,558,844 (GRCm39) missense probably benign 0.30
R0133:Fmo5 UTSW 3 97,552,952 (GRCm39) missense probably damaging 0.99
R0207:Fmo5 UTSW 3 97,552,997 (GRCm39) missense probably damaging 1.00
R0570:Fmo5 UTSW 3 97,536,456 (GRCm39) missense probably damaging 1.00
R2014:Fmo5 UTSW 3 97,542,998 (GRCm39) missense possibly damaging 0.56
R2093:Fmo5 UTSW 3 97,553,194 (GRCm39) missense probably benign 0.41
R3087:Fmo5 UTSW 3 97,549,011 (GRCm39) missense probably damaging 1.00
R3694:Fmo5 UTSW 3 97,553,230 (GRCm39) missense probably damaging 1.00
R3764:Fmo5 UTSW 3 97,553,033 (GRCm39) missense probably damaging 1.00
R4864:Fmo5 UTSW 3 97,553,195 (GRCm39) missense probably damaging 1.00
R4987:Fmo5 UTSW 3 97,542,894 (GRCm39) missense probably benign 0.23
R5152:Fmo5 UTSW 3 97,549,078 (GRCm39) missense probably benign 0.00
R5304:Fmo5 UTSW 3 97,558,938 (GRCm39) missense probably damaging 1.00
R5306:Fmo5 UTSW 3 97,549,076 (GRCm39) missense probably benign 0.00
R5563:Fmo5 UTSW 3 97,546,207 (GRCm39) missense probably damaging 1.00
R5888:Fmo5 UTSW 3 97,549,041 (GRCm39) missense probably benign 0.10
R8346:Fmo5 UTSW 3 97,552,962 (GRCm39) missense probably damaging 1.00
R8547:Fmo5 UTSW 3 97,558,811 (GRCm39) missense probably benign 0.03
R9258:Fmo5 UTSW 3 97,558,802 (GRCm39) missense probably benign 0.07
R9322:Fmo5 UTSW 3 97,546,190 (GRCm39) nonsense probably null
R9611:Fmo5 UTSW 3 97,549,089 (GRCm39) missense possibly damaging 0.85
Predicted Primers PCR Primer
(F):5'- CCGATGCTTACATGCTGATTC -3'
(R):5'- GCTCTGAAATGGGCATAATGG -3'

Sequencing Primer
(F):5'- GATGCTTACATGCTGATTCCTTTC -3'
(R):5'- CTGAAATGGGCATAATGGCTCCC -3'
Posted On 2018-04-27