Incidental Mutation 'IGL01110:Zfp956'
| ID |
51329 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp956
|
| Ensembl Gene |
ENSMUSG00000045466 |
| Gene Name |
zinc finger protein 956 |
| Synonyms |
AI894139 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.103)
|
| Stock # |
IGL01110
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
47930324-47942234 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 47940346 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 235
(E235G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000098989
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000101445]
[ENSMUST00000140719]
|
| AlphaFold |
Q3UZY6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000101445
AA Change: E235G
PolyPhen 2
Score 0.278 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000098989
Gene: ENSMUSG00000045466
AA Change: E235G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3669
|
39 |
99 |
2.1e-9 |
PFAM |
|
KRAB
|
129 |
191 |
2.4e-1 |
SMART |
|
ZnF_C2H2
|
325 |
347 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
353 |
375 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
381 |
403 |
6.78e-3 |
SMART |
|
ZnF_C2H2
|
409 |
431 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
437 |
459 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
465 |
487 |
3.58e-2 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000140719
|
| SMART Domains |
Protein: ENSMUSP00000114227
Gene: ENSMUSG00000045466
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3669
|
22 |
101 |
2.4e-16 |
PFAM |
|
Blast:KRAB
|
129 |
179 |
2e-20 |
BLAST |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 23 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Bbs1 |
G |
A |
19: 4,942,953 (GRCm39) |
S479L |
possibly damaging |
Het |
| Capn6 |
G |
T |
X: 142,590,246 (GRCm39) |
P385H |
probably damaging |
Het |
| Cavin1 |
C |
A |
11: 100,861,300 (GRCm39) |
|
probably benign |
Het |
| Cdh9 |
A |
G |
15: 16,856,012 (GRCm39) |
D684G |
possibly damaging |
Het |
| Dlgap5 |
A |
G |
14: 47,631,783 (GRCm39) |
|
probably benign |
Het |
| Doc2g |
A |
G |
19: 4,056,577 (GRCm39) |
E321G |
probably damaging |
Het |
| Eef1akmt1 |
A |
C |
14: 57,787,247 (GRCm39) |
F210V |
probably damaging |
Het |
| Eya1 |
A |
G |
1: 14,353,354 (GRCm39) |
S65P |
probably damaging |
Het |
| Gpx8 |
C |
T |
13: 113,182,218 (GRCm39) |
V72I |
probably benign |
Het |
| Gria1 |
A |
G |
11: 57,180,207 (GRCm39) |
E650G |
probably damaging |
Het |
| Hic1 |
A |
T |
11: 75,056,345 (GRCm39) |
L848Q |
possibly damaging |
Het |
| Mmp1b |
C |
T |
9: 7,384,921 (GRCm39) |
D243N |
probably benign |
Het |
| Mov10l1 |
G |
T |
15: 88,905,460 (GRCm39) |
V872L |
probably benign |
Het |
| Or8g50 |
T |
C |
9: 39,648,693 (GRCm39) |
V194A |
probably benign |
Het |
| Or8h9 |
C |
T |
2: 86,789,265 (GRCm39) |
C179Y |
possibly damaging |
Het |
| Otof |
A |
G |
5: 30,619,069 (GRCm39) |
F25S |
probably damaging |
Het |
| Patj |
A |
C |
4: 98,301,261 (GRCm39) |
N182T |
probably damaging |
Het |
| Pik3r6 |
G |
A |
11: 68,419,652 (GRCm39) |
|
probably null |
Het |
| Ppil6 |
G |
A |
10: 41,374,406 (GRCm39) |
V96I |
probably benign |
Het |
| Sardh |
T |
A |
2: 27,105,125 (GRCm39) |
Q666L |
probably benign |
Het |
| Tasp1 |
A |
G |
2: 139,819,538 (GRCm39) |
S222P |
probably damaging |
Het |
| Tln2 |
G |
T |
9: 67,157,864 (GRCm39) |
C1158* |
probably null |
Het |
| Zfp707 |
T |
A |
15: 75,847,044 (GRCm39) |
C292S |
probably damaging |
Het |
|
| Other mutations in Zfp956 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
ANU74:Zfp956
|
UTSW |
6 |
47,940,507 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0603:Zfp956
|
UTSW |
6 |
47,932,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1243:Zfp956
|
UTSW |
6 |
47,932,985 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1879:Zfp956
|
UTSW |
6 |
47,940,678 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1999:Zfp956
|
UTSW |
6 |
47,940,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2106:Zfp956
|
UTSW |
6 |
47,941,359 (GRCm39) |
makesense |
probably null |
|
|
R2150:Zfp956
|
UTSW |
6 |
47,940,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4737:Zfp956
|
UTSW |
6 |
47,939,476 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4740:Zfp956
|
UTSW |
6 |
47,939,476 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4751:Zfp956
|
UTSW |
6 |
47,940,510 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4832:Zfp956
|
UTSW |
6 |
47,928,987 (GRCm39) |
unclassified |
probably benign |
|
|
R5325:Zfp956
|
UTSW |
6 |
47,928,012 (GRCm39) |
unclassified |
probably benign |
|
|
R5523:Zfp956
|
UTSW |
6 |
47,930,455 (GRCm39) |
start gained |
probably benign |
|
|
R6842:Zfp956
|
UTSW |
6 |
47,940,763 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7131:Zfp956
|
UTSW |
6 |
47,932,781 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7367:Zfp956
|
UTSW |
6 |
47,940,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8806:Zfp956
|
UTSW |
6 |
47,933,042 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9074:Zfp956
|
UTSW |
6 |
47,939,462 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9248:Zfp956
|
UTSW |
6 |
47,934,437 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9452:Zfp956
|
UTSW |
6 |
47,940,370 (GRCm39) |
missense |
probably benign |
|
|
R9464:Zfp956
|
UTSW |
6 |
47,941,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-06-21 |
Incidental Mutation