Mutagenetix > Incidental Mutation

Incidental Mutation 'R6358:Olfr259'

513319

Institutional Source

Beutler Lab

Gene Symbol

Olfr259

Ensembl Gene

ENSMUSG00000075160

Gene Name

olfactory receptor 259

Synonyms

GA_x6K02T2N869-1820-882, MOR172-3

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

R6358 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

87104578-87114567 bp(-) (GRCm38)

Type of Mutation

start gained

DNA Base Change (assembly)

T to C at 87108434 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000151207 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099862] [ENSMUST00000213978] [ENSMUST00000215828] [ENSMUST00000216088]

AlphaFold

Q7TS20

Predicted Effect

probably benign
Transcript: ENSMUST00000099862

SMART Domains

Protein: ENSMUSP00000097448
Gene: ENSMUSG00000075160

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	3.6e-53	PFAM
Pfam:7tm_1	41	290	5.3e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213978

Predicted Effect

probably benign
Transcript: ENSMUST00000215828

Predicted Effect

probably benign
Transcript: ENSMUST00000216088

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.2%
20x: 94.8%

Validation Efficiency

100% (61/61)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam39	T	C	8: 40,826,681	V703A	probably benign	Het
Adgrv1	T	A	13: 81,414,583	Q5389L	probably damaging	Het
Aldh18a1	A	T	19: 40,577,678	I42N	possibly damaging	Het
Ankrd28	A	C	14: 31,710,864	C575W	probably damaging	Het
Car14	T	A	3: 95,898,175	T329S	possibly damaging	Het
Cdhr2	T	C	13: 54,736,546	F1298S	probably damaging	Het
Crhr2	A	G	6: 55,093,043	I341T	probably benign	Het
D5Ertd579e	T	A	5: 36,616,236		probably null	Het
Emilin1	A	G	5: 30,918,218	E601G	probably damaging	Het
Erbin	T	A	13: 103,845,565	Q456L	probably damaging	Het
Glp1r	T	C	17: 30,932,644	V405A	probably benign	Het
Gm10220	C	G	5: 26,120,305		probably null	Het
Gm2016	A	G	12: 87,877,000	E139G	unknown	Het
Gm527	A	T	12: 64,923,548	H219L	possibly damaging	Het
Gorasp2	T	A	2: 70,672,760	M1K	probably null	Het
H2-DMa	T	A	17: 34,137,984	L152H	probably damaging	Het
Hsd3b7	T	A	7: 127,801,537	H54Q	probably damaging	Het
Hspa12b	T	C	2: 131,137,066		probably benign	Het
Iars	C	A	13: 49,727,143	T1006K	possibly damaging	Het
Jmjd1c	T	C	10: 67,225,939	V1357A	probably benign	Het
Magi3	T	C	3: 104,050,952	M606V	probably damaging	Het
Mia	T	C	7: 27,180,978	D24G	probably benign	Het
Mon2	A	T	10: 123,013,504	L1297Q	probably damaging	Het
Musk	T	A	4: 58,373,171	S691T	possibly damaging	Het
Myo5c	A	T	9: 75,296,012	E1463D	possibly damaging	Het
Ndufs6	C	T	13: 73,320,319	G87D	probably damaging	Het
Npnt	C	T	3: 132,904,718	V415I	probably benign	Het
Ntsr2	A	G	12: 16,656,768	I266V	probably benign	Het
Olfr736	A	T	14: 50,393,388	I211F	possibly damaging	Het
Pkmyt1	T	A	17: 23,733,656		probably null	Het
Polr1e	T	C	4: 45,026,813	L166P	probably damaging	Het
Ppib	T	G	9: 66,061,474	F48C	probably damaging	Het
Ppl	C	A	16: 5,087,929	E1501*	probably null	Het
Prpf8	T	C	11: 75,491,495	V384A	probably benign	Het
Ptch1	T	G	13: 63,513,689	S1212R	probably damaging	Het
Ralb	C	A	1: 119,476,005	D131Y	probably damaging	Het
Rfx4	T	A	10: 84,844,235	M141K	probably damaging	Het
Rgl2	T	A	17: 33,937,131		probably null	Het
Rpl27	A	G	11: 101,443,956		probably benign	Het
Sdc1	A	C	12: 8,791,297	T213P	probably damaging	Het
Setx	T	A	2: 29,171,348	N2256K	possibly damaging	Het
Shank2	A	G	7: 144,031,297	M12V	probably benign	Het
Slc22a28	T	A	19: 8,071,888	K332M	probably damaging	Het
Slf2	A	T	19: 44,935,425	H226L	probably benign	Het
Tbc1d10b	T	C	7: 127,203,412	S362G	probably benign	Het
Tbxas1	G	A	6: 38,952,112		probably benign	Het
Tctn1	A	G	5: 122,261,512	V83A	probably damaging	Het
Tgm4	A	G	9: 123,056,518	E375G	probably damaging	Het
Tmeff2	T	A	1: 51,133,114	Y247*	probably null	Het
Tmem167b	C	T	3: 108,558,895	R79H	possibly damaging	Het
Tmprss7	T	G	16: 45,669,573	M429L	probably benign	Het
Tnfsf18	T	A	1: 161,503,579	D99E	probably benign	Het
Tnrc18	A	T	5: 142,727,981	S2534T	probably damaging	Het
Tnxb	A	G	17: 34,678,994	E872G	probably damaging	Het
Tomm40l	C	T	1: 171,219,637	V237I	possibly damaging	Het
Trbv2	A	G	6: 41,047,902	Q84R	probably benign	Het
Tspan18	T	C	2: 93,209,874	R179G	probably benign	Het
Tspan8	G	T	10: 115,833,227	V56L	probably benign	Het
Zbtb22	T	C	17: 33,918,737	S619P	probably damaging	Het
Zfp2	A	T	11: 50,900,601	I205N	probably damaging	Het
Zfpm1	A	G	8: 122,337,111		probably benign	Het

Other mutations in Olfr259

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02264:Olfr259	APN	2	87107441	utr 3 prime	probably benign
IGL02540:Olfr259	APN	2	87108042	missense	probably damaging	1.00
IGL02572:Olfr259	APN	2	87108366	missense	possibly damaging	0.63
R2091:Olfr259	UTSW	2	87108262	missense	probably damaging	1.00
R2928:Olfr259	UTSW	2	87107763	missense	possibly damaging	0.88
R4107:Olfr259	UTSW	2	87107655	missense	probably damaging	1.00
R4332:Olfr259	UTSW	2	87107745	missense	possibly damaging	0.79
R4929:Olfr259	UTSW	2	87108183	missense	possibly damaging	0.79
R5027:Olfr259	UTSW	2	87107806	missense	probably benign	0.40
R6005:Olfr259	UTSW	2	87108063	missense	probably benign	0.00
R6191:Olfr259	UTSW	2	87107952	missense	probably damaging	1.00
R6399:Olfr259	UTSW	2	87107986	missense	probably benign	0.21
R6554:Olfr259	UTSW	2	87107626	missense	probably benign	0.34
R7836:Olfr259	UTSW	2	87107517	missense	probably damaging	1.00
R7881:Olfr259	UTSW	2	87108057	missense	probably damaging	0.99
R8069:Olfr259	UTSW	2	87108067	missense	probably damaging	1.00
R9322:Olfr259	UTSW	2	87108217	missense	probably damaging	0.98
R9743:Olfr259	UTSW	2	87107496	missense	probably damaging	0.99

Predicted Primers

Posted On

2018-04-27