Incidental Mutation 'R6364:Gm7298'
ID 513406
Institutional Source Beutler Lab
Gene Symbol Gm7298
Ensembl Gene ENSMUSG00000108022
Gene Name predicted gene 7298
Synonyms
MMRRC Submission 044514-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.235) question?
Stock # R6364 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 121711454-121761598 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 121756402 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 1016 (R1016G)
Ref Sequence ENSEMBL: ENSMUSP00000145242 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000204124]
AlphaFold A0A0N4SVU1
Predicted Effect possibly damaging
Transcript: ENSMUST00000204124
AA Change: R1016G

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000145242
Gene: ENSMUSG00000108022
AA Change: R1016G

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:A2M_N 128 221 4e-18 PFAM
A2M_N_2 449 599 1e-45 SMART
A2M 740 830 2.1e-39 SMART
Pfam:Thiol-ester_cl 963 992 1.9e-15 PFAM
Pfam:A2M_comp 1012 1268 1.6e-90 PFAM
A2M_recep 1378 1465 4.3e-42 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 92.8%
Validation Efficiency 99% (69/70)
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts3 T C 5: 89,869,673 (GRCm39) Y234C possibly damaging Het
Ambra1 C A 2: 91,603,661 (GRCm39) H548Q possibly damaging Het
Ap3d1 T C 10: 80,546,328 (GRCm39) probably null Het
Apol11b A G 15: 77,522,258 (GRCm39) V13A possibly damaging Het
Arhgdib C T 6: 136,909,253 (GRCm39) probably null Het
B3galt1 T A 2: 67,949,016 (GRCm39) S244T probably damaging Het
Bace2 A G 16: 97,214,633 (GRCm39) I274V probably benign Het
Bfsp2 A T 9: 103,325,827 (GRCm39) V272D probably damaging Het
Blm A T 7: 80,144,274 (GRCm39) C782* probably null Het
Cfi G A 3: 129,666,495 (GRCm39) S406N probably benign Het
Chd1l G A 3: 97,494,483 (GRCm39) A399V probably damaging Het
Cic C A 7: 24,972,248 (GRCm39) H660N possibly damaging Het
Cops3 A G 11: 59,726,230 (GRCm39) probably benign Het
Dlec1 G A 9: 118,950,939 (GRCm39) V502I possibly damaging Het
Dync2i1 A T 12: 116,205,352 (GRCm39) D412E probably damaging Het
Epop A G 11: 97,519,513 (GRCm39) S199P probably benign Het
Evi5 G T 5: 107,989,979 (GRCm39) P80Q probably damaging Het
Faf1 T C 4: 109,818,997 (GRCm39) V623A possibly damaging Het
Fam83c T C 2: 155,676,443 (GRCm39) D109G probably damaging Het
Fam83d T C 2: 158,625,179 (GRCm39) probably null Het
Flacc1 G T 1: 58,697,531 (GRCm39) A403D probably damaging Het
Foxn3 T C 12: 99,354,952 (GRCm39) N71D probably benign Het
Grin2d T C 7: 45,507,878 (GRCm39) E396G possibly damaging Het
Htra2 C A 6: 83,030,027 (GRCm39) V311F probably damaging Het
Kif6 A T 17: 49,927,651 (GRCm39) T33S probably benign Het
Kmt2c T C 5: 25,514,634 (GRCm39) I3070V probably null Het
Krtap5-2 A T 7: 141,728,800 (GRCm39) C293* probably null Het
Lrp3 T A 7: 34,903,134 (GRCm39) D404V probably benign Het
LTO1 A G 7: 144,473,005 (GRCm39) D105G probably benign Het
Mc2r T G 18: 68,540,607 (GRCm39) I229L probably benign Het
Mtnr1b A G 9: 15,774,300 (GRCm39) M253T possibly damaging Het
Nfat5 A G 8: 108,094,909 (GRCm39) N531S probably benign Het
Niban3 G A 8: 72,051,733 (GRCm39) G23S probably benign Het
Npr2 T A 4: 43,643,622 (GRCm39) I550N probably damaging Het
Npy6r T C 18: 44,409,578 (GRCm39) I333T possibly damaging Het
Nup88 C T 11: 70,838,612 (GRCm39) R468Q probably benign Het
Nup98 G A 7: 101,825,522 (GRCm39) T422I probably damaging Het
Or10aa1 T A 1: 173,869,778 (GRCm39) H87Q possibly damaging Het
Otud4 A G 8: 80,372,970 (GRCm39) N96S probably damaging Het
Paqr6 T C 3: 88,273,265 (GRCm39) F86L probably damaging Het
Ppp4r3b A T 11: 29,138,035 (GRCm39) T90S probably benign Het
Ptbp2 A T 3: 119,534,091 (GRCm39) N23K probably damaging Het
Ralgapb G T 2: 158,304,029 (GRCm39) G596V probably damaging Het
Rdm1 G A 11: 101,521,068 (GRCm39) R94H probably benign Het
Rergl A T 6: 139,477,746 (GRCm39) F28I probably damaging Het
Rif1 G T 2: 51,997,681 (GRCm39) S1000I probably damaging Het
Rnf141 C T 7: 110,420,516 (GRCm39) A163T possibly damaging Het
Scaf4 G A 16: 90,057,136 (GRCm39) Q72* probably null Het
Sdk1 G T 5: 141,948,464 (GRCm39) S603I probably benign Het
Sdsl T C 5: 120,598,674 (GRCm39) I147M probably damaging Het
Serpina6 T C 12: 103,620,495 (GRCm39) N85D probably benign Het
Serpinf2 A G 11: 75,327,315 (GRCm39) I204T probably damaging Het
Shank2 A G 7: 143,964,146 (GRCm39) S795G probably benign Het
Simc1 C T 13: 54,672,413 (GRCm39) Q254* probably null Het
Slc30a3 G A 5: 31,246,083 (GRCm39) P216S possibly damaging Het
Smim14 T A 5: 65,610,639 (GRCm39) I53F probably benign Het
Sp3 T C 2: 72,801,285 (GRCm39) T243A probably benign Het
Srpk2 A G 5: 23,745,465 (GRCm39) F164L probably damaging Het
Stard9 T C 2: 120,543,910 (GRCm39) F4403L probably damaging Het
Tbc1d30 T C 10: 121,130,630 (GRCm39) T267A possibly damaging Het
Tgm7 T A 2: 120,926,878 (GRCm39) R424* probably null Het
Tmbim6 T C 15: 99,304,066 (GRCm39) L113P probably damaging Het
Tmcc1 G A 6: 116,020,722 (GRCm39) probably benign Het
Tomm7 A G 5: 24,049,028 (GRCm39) L15P probably damaging Het
Tpcn1 T C 5: 120,691,875 (GRCm39) Y263C probably damaging Het
Trim34b T C 7: 103,985,733 (GRCm39) F456S probably damaging Het
Uox C T 3: 146,330,332 (GRCm39) R163* probably null Het
Vmn2r108 A G 17: 20,691,260 (GRCm39) I421T probably benign Het
Wdr43 A G 17: 71,964,649 (GRCm39) E676G probably damaging Het
Zcchc14 G T 8: 122,331,598 (GRCm39) probably benign Het
Zfp64 C A 2: 168,754,186 (GRCm39) G25V probably damaging Het
Zswim8 C A 14: 20,763,079 (GRCm39) P326H probably damaging Het
Other mutations in Gm7298
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0030:Gm7298 UTSW 6 121,751,009 (GRCm39) missense probably benign
R4978:Gm7298 UTSW 6 121,710,076 (GRCm39) critical splice donor site probably null
R4980:Gm7298 UTSW 6 121,736,198 (GRCm39) splice site probably null
R6000:Gm7298 UTSW 6 121,742,038 (GRCm39) missense possibly damaging 0.91
R6160:Gm7298 UTSW 6 121,741,886 (GRCm39) missense probably benign 0.28
R6180:Gm7298 UTSW 6 121,737,782 (GRCm39) missense probably benign 0.01
R6243:Gm7298 UTSW 6 121,756,096 (GRCm39) missense possibly damaging 0.88
R6266:Gm7298 UTSW 6 121,759,663 (GRCm39) missense probably damaging 1.00
R6268:Gm7298 UTSW 6 121,756,032 (GRCm39) missense possibly damaging 0.83
R6363:Gm7298 UTSW 6 121,765,565 (GRCm39) missense probably damaging 1.00
R6527:Gm7298 UTSW 6 121,746,669 (GRCm39) missense probably benign 0.01
R6538:Gm7298 UTSW 6 121,753,132 (GRCm39) missense probably damaging 0.98
R6801:Gm7298 UTSW 6 121,752,768 (GRCm39) missense probably benign 0.03
R6884:Gm7298 UTSW 6 121,737,480 (GRCm39) missense possibly damaging 0.74
R6935:Gm7298 UTSW 6 121,744,653 (GRCm39) missense probably benign 0.02
R7051:Gm7298 UTSW 6 121,751,993 (GRCm39) critical splice donor site probably null
R7144:Gm7298 UTSW 6 121,738,546 (GRCm39) missense probably damaging 0.99
R7178:Gm7298 UTSW 6 121,762,855 (GRCm39) missense probably damaging 0.98
R7398:Gm7298 UTSW 6 121,758,912 (GRCm39) missense probably benign 0.02
R7706:Gm7298 UTSW 6 121,712,570 (GRCm39) missense probably damaging 0.96
R7793:Gm7298 UTSW 6 121,737,563 (GRCm39) critical splice donor site probably null
R7829:Gm7298 UTSW 6 121,742,297 (GRCm39) missense probably damaging 1.00
R7877:Gm7298 UTSW 6 121,759,741 (GRCm39) nonsense probably null
R8010:Gm7298 UTSW 6 121,712,542 (GRCm39) missense probably benign
R8167:Gm7298 UTSW 6 121,761,414 (GRCm39) nonsense probably null
R8188:Gm7298 UTSW 6 121,763,537 (GRCm39) critical splice acceptor site probably null
R8248:Gm7298 UTSW 6 121,764,402 (GRCm39) missense probably benign 0.02
R8669:Gm7298 UTSW 6 121,742,002 (GRCm39) missense probably benign
R8806:Gm7298 UTSW 6 121,761,641 (GRCm39) synonymous silent
R8867:Gm7298 UTSW 6 121,748,788 (GRCm39) missense probably benign
R8907:Gm7298 UTSW 6 121,741,817 (GRCm39) missense probably benign 0.10
R8930:Gm7298 UTSW 6 121,742,030 (GRCm39) missense probably benign 0.01
R8932:Gm7298 UTSW 6 121,742,030 (GRCm39) missense probably benign 0.01
R8947:Gm7298 UTSW 6 121,757,553 (GRCm39) missense possibly damaging 0.62
R9016:Gm7298 UTSW 6 121,758,800 (GRCm39) missense possibly damaging 0.96
R9040:Gm7298 UTSW 6 121,764,438 (GRCm39) missense probably benign 0.20
R9069:Gm7298 UTSW 6 121,761,393 (GRCm39) missense probably benign
R9154:Gm7298 UTSW 6 121,756,436 (GRCm39) missense probably damaging 1.00
R9273:Gm7298 UTSW 6 121,756,604 (GRCm39) intron probably benign
R9371:Gm7298 UTSW 6 121,744,541 (GRCm39) missense probably benign 0.02
R9372:Gm7298 UTSW 6 121,748,746 (GRCm39) missense probably benign 0.21
R9490:Gm7298 UTSW 6 121,751,083 (GRCm39) missense probably benign 0.00
R9649:Gm7298 UTSW 6 121,764,491 (GRCm39) missense probably damaging 1.00
Z1176:Gm7298 UTSW 6 121,741,834 (GRCm39) missense possibly damaging 0.48
Z1176:Gm7298 UTSW 6 121,741,829 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- CTGGTCAGTAAGGCTCAGAAACTC -3'
(R):5'- AGGCACCCATAGACTTCCATG -3'

Sequencing Primer
(F):5'- GTAAGGCTCAGAAACTCTACCTTG -3'
(R):5'- GGCACCCATAGACTTCCATGATATAC -3'
Posted On 2018-04-27