Incidental Mutation 'R6364:Vmn2r108'
ID |
513442 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r108
|
Ensembl Gene |
ENSMUSG00000091805 |
Gene Name |
vomeronasal 2, receptor 108 |
Synonyms |
EG627805 |
MMRRC Submission |
044514-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.073)
|
Stock # |
R6364 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
17 |
Chromosomal Location |
20682635-20701498 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 20691260 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Threonine
at position 421
(I421T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000130373
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167314]
|
AlphaFold |
E9PYS0 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000167314
AA Change: I421T
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
SMART Domains |
Protein: ENSMUSP00000130373 Gene: ENSMUSG00000091805 AA Change: I421T
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
83 |
467 |
6e-33 |
PFAM |
Pfam:NCD3G
|
510 |
563 |
9.2e-22 |
PFAM |
Pfam:7tm_3
|
593 |
831 |
2.2e-51 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.7%
- 20x: 92.8%
|
Validation Efficiency |
99% (69/70) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 72 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adamts3 |
T |
C |
5: 89,869,673 (GRCm39) |
Y234C |
possibly damaging |
Het |
Ambra1 |
C |
A |
2: 91,603,661 (GRCm39) |
H548Q |
possibly damaging |
Het |
Ap3d1 |
T |
C |
10: 80,546,328 (GRCm39) |
|
probably null |
Het |
Apol11b |
A |
G |
15: 77,522,258 (GRCm39) |
V13A |
possibly damaging |
Het |
Arhgdib |
C |
T |
6: 136,909,253 (GRCm39) |
|
probably null |
Het |
B3galt1 |
T |
A |
2: 67,949,016 (GRCm39) |
S244T |
probably damaging |
Het |
Bace2 |
A |
G |
16: 97,214,633 (GRCm39) |
I274V |
probably benign |
Het |
Bfsp2 |
A |
T |
9: 103,325,827 (GRCm39) |
V272D |
probably damaging |
Het |
Blm |
A |
T |
7: 80,144,274 (GRCm39) |
C782* |
probably null |
Het |
Cfi |
G |
A |
3: 129,666,495 (GRCm39) |
S406N |
probably benign |
Het |
Chd1l |
G |
A |
3: 97,494,483 (GRCm39) |
A399V |
probably damaging |
Het |
Cic |
C |
A |
7: 24,972,248 (GRCm39) |
H660N |
possibly damaging |
Het |
Cops3 |
A |
G |
11: 59,726,230 (GRCm39) |
|
probably benign |
Het |
Dlec1 |
G |
A |
9: 118,950,939 (GRCm39) |
V502I |
possibly damaging |
Het |
Dync2i1 |
A |
T |
12: 116,205,352 (GRCm39) |
D412E |
probably damaging |
Het |
Epop |
A |
G |
11: 97,519,513 (GRCm39) |
S199P |
probably benign |
Het |
Evi5 |
G |
T |
5: 107,989,979 (GRCm39) |
P80Q |
probably damaging |
Het |
Faf1 |
T |
C |
4: 109,818,997 (GRCm39) |
V623A |
possibly damaging |
Het |
Fam83c |
T |
C |
2: 155,676,443 (GRCm39) |
D109G |
probably damaging |
Het |
Fam83d |
T |
C |
2: 158,625,179 (GRCm39) |
|
probably null |
Het |
Flacc1 |
G |
T |
1: 58,697,531 (GRCm39) |
A403D |
probably damaging |
Het |
Foxn3 |
T |
C |
12: 99,354,952 (GRCm39) |
N71D |
probably benign |
Het |
Gm7298 |
A |
G |
6: 121,756,402 (GRCm39) |
R1016G |
possibly damaging |
Het |
Grin2d |
T |
C |
7: 45,507,878 (GRCm39) |
E396G |
possibly damaging |
Het |
Htra2 |
C |
A |
6: 83,030,027 (GRCm39) |
V311F |
probably damaging |
Het |
Kif6 |
A |
T |
17: 49,927,651 (GRCm39) |
T33S |
probably benign |
Het |
Kmt2c |
T |
C |
5: 25,514,634 (GRCm39) |
I3070V |
probably null |
Het |
Krtap5-2 |
A |
T |
7: 141,728,800 (GRCm39) |
C293* |
probably null |
Het |
Lrp3 |
T |
A |
7: 34,903,134 (GRCm39) |
D404V |
probably benign |
Het |
LTO1 |
A |
G |
7: 144,473,005 (GRCm39) |
D105G |
probably benign |
Het |
Mc2r |
T |
G |
18: 68,540,607 (GRCm39) |
I229L |
probably benign |
Het |
Mtnr1b |
A |
G |
9: 15,774,300 (GRCm39) |
M253T |
possibly damaging |
Het |
Nfat5 |
A |
G |
8: 108,094,909 (GRCm39) |
N531S |
probably benign |
Het |
Niban3 |
G |
A |
8: 72,051,733 (GRCm39) |
G23S |
probably benign |
Het |
Npr2 |
T |
A |
4: 43,643,622 (GRCm39) |
I550N |
probably damaging |
Het |
Npy6r |
T |
C |
18: 44,409,578 (GRCm39) |
I333T |
possibly damaging |
Het |
Nup88 |
C |
T |
11: 70,838,612 (GRCm39) |
R468Q |
probably benign |
Het |
Nup98 |
G |
A |
7: 101,825,522 (GRCm39) |
T422I |
probably damaging |
Het |
Or10aa1 |
T |
A |
1: 173,869,778 (GRCm39) |
H87Q |
possibly damaging |
Het |
Otud4 |
A |
G |
8: 80,372,970 (GRCm39) |
N96S |
probably damaging |
Het |
Paqr6 |
T |
C |
3: 88,273,265 (GRCm39) |
F86L |
probably damaging |
Het |
Ppp4r3b |
A |
T |
11: 29,138,035 (GRCm39) |
T90S |
probably benign |
Het |
Ptbp2 |
A |
T |
3: 119,534,091 (GRCm39) |
N23K |
probably damaging |
Het |
Ralgapb |
G |
T |
2: 158,304,029 (GRCm39) |
G596V |
probably damaging |
Het |
Rdm1 |
G |
A |
11: 101,521,068 (GRCm39) |
R94H |
probably benign |
Het |
Rergl |
A |
T |
6: 139,477,746 (GRCm39) |
F28I |
probably damaging |
Het |
Rif1 |
G |
T |
2: 51,997,681 (GRCm39) |
S1000I |
probably damaging |
Het |
Rnf141 |
C |
T |
7: 110,420,516 (GRCm39) |
A163T |
possibly damaging |
Het |
Scaf4 |
G |
A |
16: 90,057,136 (GRCm39) |
Q72* |
probably null |
Het |
Sdk1 |
G |
T |
5: 141,948,464 (GRCm39) |
S603I |
probably benign |
Het |
Sdsl |
T |
C |
5: 120,598,674 (GRCm39) |
I147M |
probably damaging |
Het |
Serpina6 |
T |
C |
12: 103,620,495 (GRCm39) |
N85D |
probably benign |
Het |
Serpinf2 |
A |
G |
11: 75,327,315 (GRCm39) |
I204T |
probably damaging |
Het |
Shank2 |
A |
G |
7: 143,964,146 (GRCm39) |
S795G |
probably benign |
Het |
Simc1 |
C |
T |
13: 54,672,413 (GRCm39) |
Q254* |
probably null |
Het |
Slc30a3 |
G |
A |
5: 31,246,083 (GRCm39) |
P216S |
possibly damaging |
Het |
Smim14 |
T |
A |
5: 65,610,639 (GRCm39) |
I53F |
probably benign |
Het |
Sp3 |
T |
C |
2: 72,801,285 (GRCm39) |
T243A |
probably benign |
Het |
Srpk2 |
A |
G |
5: 23,745,465 (GRCm39) |
F164L |
probably damaging |
Het |
Stard9 |
T |
C |
2: 120,543,910 (GRCm39) |
F4403L |
probably damaging |
Het |
Tbc1d30 |
T |
C |
10: 121,130,630 (GRCm39) |
T267A |
possibly damaging |
Het |
Tgm7 |
T |
A |
2: 120,926,878 (GRCm39) |
R424* |
probably null |
Het |
Tmbim6 |
T |
C |
15: 99,304,066 (GRCm39) |
L113P |
probably damaging |
Het |
Tmcc1 |
G |
A |
6: 116,020,722 (GRCm39) |
|
probably benign |
Het |
Tomm7 |
A |
G |
5: 24,049,028 (GRCm39) |
L15P |
probably damaging |
Het |
Tpcn1 |
T |
C |
5: 120,691,875 (GRCm39) |
Y263C |
probably damaging |
Het |
Trim34b |
T |
C |
7: 103,985,733 (GRCm39) |
F456S |
probably damaging |
Het |
Uox |
C |
T |
3: 146,330,332 (GRCm39) |
R163* |
probably null |
Het |
Wdr43 |
A |
G |
17: 71,964,649 (GRCm39) |
E676G |
probably damaging |
Het |
Zcchc14 |
G |
T |
8: 122,331,598 (GRCm39) |
|
probably benign |
Het |
Zfp64 |
C |
A |
2: 168,754,186 (GRCm39) |
G25V |
probably damaging |
Het |
Zswim8 |
C |
A |
14: 20,763,079 (GRCm39) |
P326H |
probably damaging |
Het |
|
Other mutations in Vmn2r108 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00903:Vmn2r108
|
APN |
17 |
20,682,774 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL01143:Vmn2r108
|
APN |
17 |
20,682,727 (GRCm39) |
missense |
possibly damaging |
0.82 |
IGL01311:Vmn2r108
|
APN |
17 |
20,682,939 (GRCm39) |
nonsense |
probably null |
|
IGL01411:Vmn2r108
|
APN |
17 |
20,691,282 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01414:Vmn2r108
|
APN |
17 |
20,691,942 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01536:Vmn2r108
|
APN |
17 |
20,683,543 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01748:Vmn2r108
|
APN |
17 |
20,683,476 (GRCm39) |
missense |
probably benign |
0.03 |
IGL01769:Vmn2r108
|
APN |
17 |
20,691,280 (GRCm39) |
missense |
probably benign |
0.02 |
IGL02022:Vmn2r108
|
APN |
17 |
20,691,987 (GRCm39) |
missense |
possibly damaging |
0.77 |
IGL02041:Vmn2r108
|
APN |
17 |
20,683,398 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02049:Vmn2r108
|
APN |
17 |
20,691,608 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02344:Vmn2r108
|
APN |
17 |
20,689,405 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02939:Vmn2r108
|
APN |
17 |
20,691,545 (GRCm39) |
missense |
probably benign |
0.05 |
IGL03202:Vmn2r108
|
APN |
17 |
20,691,319 (GRCm39) |
nonsense |
probably null |
|
PIT4498001:Vmn2r108
|
UTSW |
17 |
20,683,279 (GRCm39) |
missense |
probably damaging |
1.00 |
R0112:Vmn2r108
|
UTSW |
17 |
20,691,897 (GRCm39) |
missense |
probably benign |
0.07 |
R0505:Vmn2r108
|
UTSW |
17 |
20,683,096 (GRCm39) |
missense |
possibly damaging |
0.77 |
R0833:Vmn2r108
|
UTSW |
17 |
20,691,721 (GRCm39) |
missense |
probably benign |
|
R0836:Vmn2r108
|
UTSW |
17 |
20,691,721 (GRCm39) |
missense |
probably benign |
|
R0943:Vmn2r108
|
UTSW |
17 |
20,691,397 (GRCm39) |
nonsense |
probably null |
|
R1411:Vmn2r108
|
UTSW |
17 |
20,683,107 (GRCm39) |
missense |
probably damaging |
0.98 |
R1442:Vmn2r108
|
UTSW |
17 |
20,692,623 (GRCm39) |
nonsense |
probably null |
|
R1587:Vmn2r108
|
UTSW |
17 |
20,692,383 (GRCm39) |
missense |
probably damaging |
1.00 |
R1751:Vmn2r108
|
UTSW |
17 |
20,682,786 (GRCm39) |
missense |
probably damaging |
1.00 |
R1773:Vmn2r108
|
UTSW |
17 |
20,689,335 (GRCm39) |
missense |
probably damaging |
1.00 |
R2021:Vmn2r108
|
UTSW |
17 |
20,691,252 (GRCm39) |
missense |
probably benign |
0.00 |
R2159:Vmn2r108
|
UTSW |
17 |
20,689,363 (GRCm39) |
missense |
probably benign |
0.41 |
R2224:Vmn2r108
|
UTSW |
17 |
20,701,295 (GRCm39) |
nonsense |
probably null |
|
R2226:Vmn2r108
|
UTSW |
17 |
20,701,295 (GRCm39) |
nonsense |
probably null |
|
R2517:Vmn2r108
|
UTSW |
17 |
20,692,577 (GRCm39) |
missense |
probably damaging |
1.00 |
R3710:Vmn2r108
|
UTSW |
17 |
20,682,932 (GRCm39) |
missense |
probably benign |
|
R4470:Vmn2r108
|
UTSW |
17 |
20,682,990 (GRCm39) |
missense |
probably damaging |
1.00 |
R4686:Vmn2r108
|
UTSW |
17 |
20,691,636 (GRCm39) |
missense |
probably damaging |
0.99 |
R4729:Vmn2r108
|
UTSW |
17 |
20,692,632 (GRCm39) |
missense |
probably damaging |
0.99 |
R4799:Vmn2r108
|
UTSW |
17 |
20,682,891 (GRCm39) |
missense |
probably damaging |
1.00 |
R4993:Vmn2r108
|
UTSW |
17 |
20,701,449 (GRCm39) |
missense |
probably benign |
0.04 |
R5088:Vmn2r108
|
UTSW |
17 |
20,690,454 (GRCm39) |
missense |
possibly damaging |
0.46 |
R5213:Vmn2r108
|
UTSW |
17 |
20,691,755 (GRCm39) |
missense |
probably benign |
0.00 |
R5289:Vmn2r108
|
UTSW |
17 |
20,691,866 (GRCm39) |
missense |
probably damaging |
1.00 |
R5290:Vmn2r108
|
UTSW |
17 |
20,691,665 (GRCm39) |
missense |
probably benign |
0.00 |
R5713:Vmn2r108
|
UTSW |
17 |
20,691,290 (GRCm39) |
missense |
probably damaging |
1.00 |
R5753:Vmn2r108
|
UTSW |
17 |
20,683,179 (GRCm39) |
missense |
probably damaging |
0.99 |
R5792:Vmn2r108
|
UTSW |
17 |
20,683,398 (GRCm39) |
missense |
probably damaging |
0.99 |
R5798:Vmn2r108
|
UTSW |
17 |
20,692,545 (GRCm39) |
missense |
probably benign |
0.39 |
R5897:Vmn2r108
|
UTSW |
17 |
20,691,580 (GRCm39) |
missense |
probably benign |
0.01 |
R6018:Vmn2r108
|
UTSW |
17 |
20,683,268 (GRCm39) |
missense |
possibly damaging |
0.83 |
R6093:Vmn2r108
|
UTSW |
17 |
20,701,402 (GRCm39) |
missense |
probably benign |
0.00 |
R6156:Vmn2r108
|
UTSW |
17 |
20,692,447 (GRCm39) |
missense |
probably benign |
0.03 |
R6199:Vmn2r108
|
UTSW |
17 |
20,682,644 (GRCm39) |
missense |
probably benign |
0.01 |
R6259:Vmn2r108
|
UTSW |
17 |
20,683,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
R6309:Vmn2r108
|
UTSW |
17 |
20,691,660 (GRCm39) |
missense |
probably damaging |
0.98 |
R6324:Vmn2r108
|
UTSW |
17 |
20,691,977 (GRCm39) |
nonsense |
probably null |
|
R6446:Vmn2r108
|
UTSW |
17 |
20,692,609 (GRCm39) |
nonsense |
probably null |
|
R6541:Vmn2r108
|
UTSW |
17 |
20,701,480 (GRCm39) |
missense |
probably benign |
0.02 |
R7025:Vmn2r108
|
UTSW |
17 |
20,691,345 (GRCm39) |
missense |
possibly damaging |
0.67 |
R7063:Vmn2r108
|
UTSW |
17 |
20,701,410 (GRCm39) |
missense |
probably damaging |
1.00 |
R7092:Vmn2r108
|
UTSW |
17 |
20,701,338 (GRCm39) |
missense |
probably benign |
0.10 |
R7096:Vmn2r108
|
UTSW |
17 |
20,682,762 (GRCm39) |
missense |
probably damaging |
1.00 |
R7203:Vmn2r108
|
UTSW |
17 |
20,683,038 (GRCm39) |
missense |
probably benign |
0.12 |
R7458:Vmn2r108
|
UTSW |
17 |
20,692,532 (GRCm39) |
missense |
probably benign |
0.17 |
R7619:Vmn2r108
|
UTSW |
17 |
20,692,457 (GRCm39) |
missense |
probably benign |
0.02 |
R7841:Vmn2r108
|
UTSW |
17 |
20,690,305 (GRCm39) |
critical splice donor site |
probably null |
|
R7944:Vmn2r108
|
UTSW |
17 |
20,691,890 (GRCm39) |
missense |
probably damaging |
0.99 |
R8048:Vmn2r108
|
UTSW |
17 |
20,691,762 (GRCm39) |
missense |
probably benign |
0.29 |
R8213:Vmn2r108
|
UTSW |
17 |
20,690,350 (GRCm39) |
missense |
probably benign |
0.03 |
R8218:Vmn2r108
|
UTSW |
17 |
20,683,465 (GRCm39) |
missense |
probably damaging |
1.00 |
R8507:Vmn2r108
|
UTSW |
17 |
20,683,195 (GRCm39) |
nonsense |
probably null |
|
R8708:Vmn2r108
|
UTSW |
17 |
20,682,687 (GRCm39) |
missense |
probably damaging |
0.98 |
R8845:Vmn2r108
|
UTSW |
17 |
20,691,361 (GRCm39) |
missense |
probably benign |
0.03 |
R9030:Vmn2r108
|
UTSW |
17 |
20,690,312 (GRCm39) |
missense |
probably benign |
0.01 |
R9226:Vmn2r108
|
UTSW |
17 |
20,691,330 (GRCm39) |
missense |
probably benign |
|
R9278:Vmn2r108
|
UTSW |
17 |
20,692,561 (GRCm39) |
missense |
probably benign |
0.11 |
X0022:Vmn2r108
|
UTSW |
17 |
20,691,371 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Vmn2r108
|
UTSW |
17 |
20,691,375 (GRCm39) |
missense |
probably benign |
0.01 |
Z1177:Vmn2r108
|
UTSW |
17 |
20,691,219 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Predicted Primers |
PCR Primer
(F):5'- CACTTCAAACTGCATTGACCTC -3'
(R):5'- GACATTTACCTTCCTAAGTTATGGC -3'
Sequencing Primer
(F):5'- CTTCAAACTGCATTGACCTCTAAATG -3'
(R):5'- TTACCTTCCTAAGTTATGGCATTTG -3'
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Posted On |
2018-04-27 |