Incidental Mutation 'R6364:Vmn2r108'
ID 513442
Institutional Source Beutler Lab
Gene Symbol Vmn2r108
Ensembl Gene ENSMUSG00000091805
Gene Name vomeronasal 2, receptor 108
Synonyms EG627805
MMRRC Submission 044514-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R6364 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 20682635-20701498 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 20691260 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 421 (I421T)
Ref Sequence ENSEMBL: ENSMUSP00000130373 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167314]
AlphaFold E9PYS0
Predicted Effect probably benign
Transcript: ENSMUST00000167314
AA Change: I421T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: I421T

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 83 467 6e-33 PFAM
Pfam:NCD3G 510 563 9.2e-22 PFAM
Pfam:7tm_3 593 831 2.2e-51 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 92.8%
Validation Efficiency 99% (69/70)
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts3 T C 5: 89,869,673 (GRCm39) Y234C possibly damaging Het
Ambra1 C A 2: 91,603,661 (GRCm39) H548Q possibly damaging Het
Ap3d1 T C 10: 80,546,328 (GRCm39) probably null Het
Apol11b A G 15: 77,522,258 (GRCm39) V13A possibly damaging Het
Arhgdib C T 6: 136,909,253 (GRCm39) probably null Het
B3galt1 T A 2: 67,949,016 (GRCm39) S244T probably damaging Het
Bace2 A G 16: 97,214,633 (GRCm39) I274V probably benign Het
Bfsp2 A T 9: 103,325,827 (GRCm39) V272D probably damaging Het
Blm A T 7: 80,144,274 (GRCm39) C782* probably null Het
Cfi G A 3: 129,666,495 (GRCm39) S406N probably benign Het
Chd1l G A 3: 97,494,483 (GRCm39) A399V probably damaging Het
Cic C A 7: 24,972,248 (GRCm39) H660N possibly damaging Het
Cops3 A G 11: 59,726,230 (GRCm39) probably benign Het
Dlec1 G A 9: 118,950,939 (GRCm39) V502I possibly damaging Het
Dync2i1 A T 12: 116,205,352 (GRCm39) D412E probably damaging Het
Epop A G 11: 97,519,513 (GRCm39) S199P probably benign Het
Evi5 G T 5: 107,989,979 (GRCm39) P80Q probably damaging Het
Faf1 T C 4: 109,818,997 (GRCm39) V623A possibly damaging Het
Fam83c T C 2: 155,676,443 (GRCm39) D109G probably damaging Het
Fam83d T C 2: 158,625,179 (GRCm39) probably null Het
Flacc1 G T 1: 58,697,531 (GRCm39) A403D probably damaging Het
Foxn3 T C 12: 99,354,952 (GRCm39) N71D probably benign Het
Gm7298 A G 6: 121,756,402 (GRCm39) R1016G possibly damaging Het
Grin2d T C 7: 45,507,878 (GRCm39) E396G possibly damaging Het
Htra2 C A 6: 83,030,027 (GRCm39) V311F probably damaging Het
Kif6 A T 17: 49,927,651 (GRCm39) T33S probably benign Het
Kmt2c T C 5: 25,514,634 (GRCm39) I3070V probably null Het
Krtap5-2 A T 7: 141,728,800 (GRCm39) C293* probably null Het
Lrp3 T A 7: 34,903,134 (GRCm39) D404V probably benign Het
LTO1 A G 7: 144,473,005 (GRCm39) D105G probably benign Het
Mc2r T G 18: 68,540,607 (GRCm39) I229L probably benign Het
Mtnr1b A G 9: 15,774,300 (GRCm39) M253T possibly damaging Het
Nfat5 A G 8: 108,094,909 (GRCm39) N531S probably benign Het
Niban3 G A 8: 72,051,733 (GRCm39) G23S probably benign Het
Npr2 T A 4: 43,643,622 (GRCm39) I550N probably damaging Het
Npy6r T C 18: 44,409,578 (GRCm39) I333T possibly damaging Het
Nup88 C T 11: 70,838,612 (GRCm39) R468Q probably benign Het
Nup98 G A 7: 101,825,522 (GRCm39) T422I probably damaging Het
Or10aa1 T A 1: 173,869,778 (GRCm39) H87Q possibly damaging Het
Otud4 A G 8: 80,372,970 (GRCm39) N96S probably damaging Het
Paqr6 T C 3: 88,273,265 (GRCm39) F86L probably damaging Het
Ppp4r3b A T 11: 29,138,035 (GRCm39) T90S probably benign Het
Ptbp2 A T 3: 119,534,091 (GRCm39) N23K probably damaging Het
Ralgapb G T 2: 158,304,029 (GRCm39) G596V probably damaging Het
Rdm1 G A 11: 101,521,068 (GRCm39) R94H probably benign Het
Rergl A T 6: 139,477,746 (GRCm39) F28I probably damaging Het
Rif1 G T 2: 51,997,681 (GRCm39) S1000I probably damaging Het
Rnf141 C T 7: 110,420,516 (GRCm39) A163T possibly damaging Het
Scaf4 G A 16: 90,057,136 (GRCm39) Q72* probably null Het
Sdk1 G T 5: 141,948,464 (GRCm39) S603I probably benign Het
Sdsl T C 5: 120,598,674 (GRCm39) I147M probably damaging Het
Serpina6 T C 12: 103,620,495 (GRCm39) N85D probably benign Het
Serpinf2 A G 11: 75,327,315 (GRCm39) I204T probably damaging Het
Shank2 A G 7: 143,964,146 (GRCm39) S795G probably benign Het
Simc1 C T 13: 54,672,413 (GRCm39) Q254* probably null Het
Slc30a3 G A 5: 31,246,083 (GRCm39) P216S possibly damaging Het
Smim14 T A 5: 65,610,639 (GRCm39) I53F probably benign Het
Sp3 T C 2: 72,801,285 (GRCm39) T243A probably benign Het
Srpk2 A G 5: 23,745,465 (GRCm39) F164L probably damaging Het
Stard9 T C 2: 120,543,910 (GRCm39) F4403L probably damaging Het
Tbc1d30 T C 10: 121,130,630 (GRCm39) T267A possibly damaging Het
Tgm7 T A 2: 120,926,878 (GRCm39) R424* probably null Het
Tmbim6 T C 15: 99,304,066 (GRCm39) L113P probably damaging Het
Tmcc1 G A 6: 116,020,722 (GRCm39) probably benign Het
Tomm7 A G 5: 24,049,028 (GRCm39) L15P probably damaging Het
Tpcn1 T C 5: 120,691,875 (GRCm39) Y263C probably damaging Het
Trim34b T C 7: 103,985,733 (GRCm39) F456S probably damaging Het
Uox C T 3: 146,330,332 (GRCm39) R163* probably null Het
Wdr43 A G 17: 71,964,649 (GRCm39) E676G probably damaging Het
Zcchc14 G T 8: 122,331,598 (GRCm39) probably benign Het
Zfp64 C A 2: 168,754,186 (GRCm39) G25V probably damaging Het
Zswim8 C A 14: 20,763,079 (GRCm39) P326H probably damaging Het
Other mutations in Vmn2r108
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00903:Vmn2r108 APN 17 20,682,774 (GRCm39) missense probably damaging 0.98
IGL01143:Vmn2r108 APN 17 20,682,727 (GRCm39) missense possibly damaging 0.82
IGL01311:Vmn2r108 APN 17 20,682,939 (GRCm39) nonsense probably null
IGL01411:Vmn2r108 APN 17 20,691,282 (GRCm39) missense probably benign 0.01
IGL01414:Vmn2r108 APN 17 20,691,942 (GRCm39) missense probably benign 0.00
IGL01536:Vmn2r108 APN 17 20,683,543 (GRCm39) missense probably damaging 1.00
IGL01748:Vmn2r108 APN 17 20,683,476 (GRCm39) missense probably benign 0.03
IGL01769:Vmn2r108 APN 17 20,691,280 (GRCm39) missense probably benign 0.02
IGL02022:Vmn2r108 APN 17 20,691,987 (GRCm39) missense possibly damaging 0.77
IGL02041:Vmn2r108 APN 17 20,683,398 (GRCm39) missense probably damaging 1.00
IGL02049:Vmn2r108 APN 17 20,691,608 (GRCm39) missense probably benign 0.00
IGL02344:Vmn2r108 APN 17 20,689,405 (GRCm39) missense probably damaging 1.00
IGL02939:Vmn2r108 APN 17 20,691,545 (GRCm39) missense probably benign 0.05
IGL03202:Vmn2r108 APN 17 20,691,319 (GRCm39) nonsense probably null
PIT4498001:Vmn2r108 UTSW 17 20,683,279 (GRCm39) missense probably damaging 1.00
R0112:Vmn2r108 UTSW 17 20,691,897 (GRCm39) missense probably benign 0.07
R0505:Vmn2r108 UTSW 17 20,683,096 (GRCm39) missense possibly damaging 0.77
R0833:Vmn2r108 UTSW 17 20,691,721 (GRCm39) missense probably benign
R0836:Vmn2r108 UTSW 17 20,691,721 (GRCm39) missense probably benign
R0943:Vmn2r108 UTSW 17 20,691,397 (GRCm39) nonsense probably null
R1411:Vmn2r108 UTSW 17 20,683,107 (GRCm39) missense probably damaging 0.98
R1442:Vmn2r108 UTSW 17 20,692,623 (GRCm39) nonsense probably null
R1587:Vmn2r108 UTSW 17 20,692,383 (GRCm39) missense probably damaging 1.00
R1751:Vmn2r108 UTSW 17 20,682,786 (GRCm39) missense probably damaging 1.00
R1773:Vmn2r108 UTSW 17 20,689,335 (GRCm39) missense probably damaging 1.00
R2021:Vmn2r108 UTSW 17 20,691,252 (GRCm39) missense probably benign 0.00
R2159:Vmn2r108 UTSW 17 20,689,363 (GRCm39) missense probably benign 0.41
R2224:Vmn2r108 UTSW 17 20,701,295 (GRCm39) nonsense probably null
R2226:Vmn2r108 UTSW 17 20,701,295 (GRCm39) nonsense probably null
R2517:Vmn2r108 UTSW 17 20,692,577 (GRCm39) missense probably damaging 1.00
R3710:Vmn2r108 UTSW 17 20,682,932 (GRCm39) missense probably benign
R4470:Vmn2r108 UTSW 17 20,682,990 (GRCm39) missense probably damaging 1.00
R4686:Vmn2r108 UTSW 17 20,691,636 (GRCm39) missense probably damaging 0.99
R4729:Vmn2r108 UTSW 17 20,692,632 (GRCm39) missense probably damaging 0.99
R4799:Vmn2r108 UTSW 17 20,682,891 (GRCm39) missense probably damaging 1.00
R4993:Vmn2r108 UTSW 17 20,701,449 (GRCm39) missense probably benign 0.04
R5088:Vmn2r108 UTSW 17 20,690,454 (GRCm39) missense possibly damaging 0.46
R5213:Vmn2r108 UTSW 17 20,691,755 (GRCm39) missense probably benign 0.00
R5289:Vmn2r108 UTSW 17 20,691,866 (GRCm39) missense probably damaging 1.00
R5290:Vmn2r108 UTSW 17 20,691,665 (GRCm39) missense probably benign 0.00
R5713:Vmn2r108 UTSW 17 20,691,290 (GRCm39) missense probably damaging 1.00
R5753:Vmn2r108 UTSW 17 20,683,179 (GRCm39) missense probably damaging 0.99
R5792:Vmn2r108 UTSW 17 20,683,398 (GRCm39) missense probably damaging 0.99
R5798:Vmn2r108 UTSW 17 20,692,545 (GRCm39) missense probably benign 0.39
R5897:Vmn2r108 UTSW 17 20,691,580 (GRCm39) missense probably benign 0.01
R6018:Vmn2r108 UTSW 17 20,683,268 (GRCm39) missense possibly damaging 0.83
R6093:Vmn2r108 UTSW 17 20,701,402 (GRCm39) missense probably benign 0.00
R6156:Vmn2r108 UTSW 17 20,692,447 (GRCm39) missense probably benign 0.03
R6199:Vmn2r108 UTSW 17 20,682,644 (GRCm39) missense probably benign 0.01
R6259:Vmn2r108 UTSW 17 20,683,371 (GRCm39) missense possibly damaging 0.95
R6309:Vmn2r108 UTSW 17 20,691,660 (GRCm39) missense probably damaging 0.98
R6324:Vmn2r108 UTSW 17 20,691,977 (GRCm39) nonsense probably null
R6446:Vmn2r108 UTSW 17 20,692,609 (GRCm39) nonsense probably null
R6541:Vmn2r108 UTSW 17 20,701,480 (GRCm39) missense probably benign 0.02
R7025:Vmn2r108 UTSW 17 20,691,345 (GRCm39) missense possibly damaging 0.67
R7063:Vmn2r108 UTSW 17 20,701,410 (GRCm39) missense probably damaging 1.00
R7092:Vmn2r108 UTSW 17 20,701,338 (GRCm39) missense probably benign 0.10
R7096:Vmn2r108 UTSW 17 20,682,762 (GRCm39) missense probably damaging 1.00
R7203:Vmn2r108 UTSW 17 20,683,038 (GRCm39) missense probably benign 0.12
R7458:Vmn2r108 UTSW 17 20,692,532 (GRCm39) missense probably benign 0.17
R7619:Vmn2r108 UTSW 17 20,692,457 (GRCm39) missense probably benign 0.02
R7841:Vmn2r108 UTSW 17 20,690,305 (GRCm39) critical splice donor site probably null
R7944:Vmn2r108 UTSW 17 20,691,890 (GRCm39) missense probably damaging 0.99
R8048:Vmn2r108 UTSW 17 20,691,762 (GRCm39) missense probably benign 0.29
R8213:Vmn2r108 UTSW 17 20,690,350 (GRCm39) missense probably benign 0.03
R8218:Vmn2r108 UTSW 17 20,683,465 (GRCm39) missense probably damaging 1.00
R8507:Vmn2r108 UTSW 17 20,683,195 (GRCm39) nonsense probably null
R8708:Vmn2r108 UTSW 17 20,682,687 (GRCm39) missense probably damaging 0.98
R8845:Vmn2r108 UTSW 17 20,691,361 (GRCm39) missense probably benign 0.03
R9030:Vmn2r108 UTSW 17 20,690,312 (GRCm39) missense probably benign 0.01
R9226:Vmn2r108 UTSW 17 20,691,330 (GRCm39) missense probably benign
R9278:Vmn2r108 UTSW 17 20,692,561 (GRCm39) missense probably benign 0.11
X0022:Vmn2r108 UTSW 17 20,691,371 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r108 UTSW 17 20,691,375 (GRCm39) missense probably benign 0.01
Z1177:Vmn2r108 UTSW 17 20,691,219 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CACTTCAAACTGCATTGACCTC -3'
(R):5'- GACATTTACCTTCCTAAGTTATGGC -3'

Sequencing Primer
(F):5'- CTTCAAACTGCATTGACCTCTAAATG -3'
(R):5'- TTACCTTCCTAAGTTATGGCATTTG -3'
Posted On 2018-04-27