Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01120:Prss3b'

51345

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prss3b

Ensembl Gene

ENSMUSG00000029882

Gene Name

serine protease 3B

Synonyms

2210010C04Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

IGL01120

Quality Score

Status

Chromosome

Chromosomal Location

41007202-41012443 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 41008607 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 236 (Y236N)

Ref Sequence

ENSEMBL: ENSMUSP00000031931 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000031931]

AlphaFold

Q9CPN9

Predicted Effect

probably damaging
Transcript: ENSMUST00000031931
AA Change: Y236N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000031931
Gene: ENSMUSG00000029882
AA Change: Y236N

Domain	Start	End	E-Value	Type
Tryp_SPc	24	240	3.52e-102	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd11	T	A	5: 135,040,329 (GRCm39)		probably null	Het
Armcx5	T	C	X: 134,647,112 (GRCm39)	I396T	probably damaging	Het
Atm	T	C	9: 53,372,422 (GRCm39)		probably null	Het
Atp6v1c2	C	T	12: 17,358,294 (GRCm39)	E88K	probably damaging	Het
Caskin1	A	G	17: 24,724,343 (GRCm39)	T1044A	possibly damaging	Het
Cyp3a59	T	A	5: 146,039,671 (GRCm39)	S315T	probably damaging	Het
Dnaja1	T	A	4: 40,730,248 (GRCm39)	I240N	probably damaging	Het
Dnttip2	C	T	3: 122,072,386 (GRCm39)		probably benign	Het
Elavl2	A	T	4: 91,152,309 (GRCm39)	M136K	probably damaging	Het
Eml5	C	T	12: 98,810,278 (GRCm39)	V893I	probably benign	Het
Fbxw4	G	T	19: 45,628,955 (GRCm39)	A2E	probably benign	Het
Flg2	T	G	3: 93,108,475 (GRCm39)	S168A	probably damaging	Het
Fndc3a	G	A	14: 72,794,102 (GRCm39)	T857I	probably benign	Het
Gria1	A	G	11: 57,208,495 (GRCm39)	K797E	probably damaging	Het
Herc1	T	C	9: 66,336,162 (GRCm39)	F1569S	probably benign	Het
Kash5	G	T	7: 44,833,622 (GRCm39)	S560Y	probably damaging	Het
Lrrc45	T	C	11: 120,610,836 (GRCm39)	V524A	probably benign	Het
Myo19	T	C	11: 84,798,104 (GRCm39)	L708P	probably damaging	Het
Nup107	A	G	10: 117,606,146 (GRCm39)		probably benign	Het
Or10ab4	T	G	7: 107,654,774 (GRCm39)	M195R	probably damaging	Het
Or52h9	T	C	7: 104,202,552 (GRCm39)	V142A	probably benign	Het
Palm	A	G	10: 79,652,621 (GRCm39)		probably benign	Het
Phf14	T	C	6: 11,962,739 (GRCm39)	V462A	probably damaging	Het
Pkhd1l1	G	A	15: 44,368,708 (GRCm39)		probably null	Het
Pkp3	T	A	7: 140,664,095 (GRCm39)	L424*	probably null	Het
Prss29	A	G	17: 25,541,107 (GRCm39)	K184E	probably benign	Het
Ptcd1	C	T	5: 145,089,053 (GRCm39)		probably benign	Het
Pth1r	T	C	9: 110,556,198 (GRCm39)	H225R	probably damaging	Het
Rffl	C	T	11: 82,696,848 (GRCm39)	V332I	probably damaging	Het
Rsl1	T	C	13: 67,325,230 (GRCm39)		probably benign	Het
Scart2	T	C	7: 139,876,472 (GRCm39)	L648P	probably benign	Het
Scn9a	T	C	2: 66,357,316 (GRCm39)	K986R	probably benign	Het
Slc22a15	A	G	3: 101,804,482 (GRCm39)	L181P	probably damaging	Het
Slc34a1	T	A	13: 55,556,884 (GRCm39)	L241H	probably damaging	Het
Slc4a4	C	A	5: 89,280,238 (GRCm39)	H354Q	probably damaging	Het
Sorcs2	T	C	5: 36,178,596 (GRCm39)	E1131G	probably damaging	Het
Ssc4d	C	A	5: 135,996,817 (GRCm39)	D95Y	probably damaging	Het
Tcte1	A	T	17: 45,850,594 (GRCm39)	D290V	probably damaging	Het
Thyn1	T	A	9: 26,915,070 (GRCm39)	M74K	probably benign	Het
Tlr4	C	T	4: 66,758,662 (GRCm39)	T485I	probably benign	Het
Trem1	A	G	17: 48,544,277 (GRCm39)	T101A	probably benign	Het
Ttc17	T	C	2: 94,202,141 (GRCm39)	E387G	probably damaging	Het
Vmn2r103	A	T	17: 20,013,259 (GRCm39)	T127S	probably benign	Het

Other mutations in Prss3b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01625:Prss3b	APN	6	41,009,882 (GRCm39)	missense	probably benign	0.01
IGL02159:Prss3b	APN	6	41,009,891 (GRCm39)	missense	probably benign	0.34
IGL03161:Prss3b	APN	6	41,011,240 (GRCm39)	missense	probably damaging	0.96
R0419:Prss3b	UTSW	6	41,011,281 (GRCm39)	missense	probably benign	0.05
R1715:Prss3b	UTSW	6	41,009,870 (GRCm39)	splice site	probably null
R2057:Prss3b	UTSW	6	41,009,315 (GRCm39)	missense	probably benign	0.06
R2059:Prss3b	UTSW	6	41,009,315 (GRCm39)	missense	probably benign	0.06
R2136:Prss3b	UTSW	6	41,012,396 (GRCm39)	missense	probably benign	0.28
R2446:Prss3b	UTSW	6	41,008,582 (GRCm39)	missense	probably benign	0.15
R4862:Prss3b	UTSW	6	41,009,345 (GRCm39)	missense	possibly damaging	0.74
R5068:Prss3b	UTSW	6	41,009,370 (GRCm39)	missense	probably benign	0.35
R5369:Prss3b	UTSW	6	41,009,940 (GRCm39)	missense	probably benign	0.00
R6392:Prss3b	UTSW	6	41,009,306 (GRCm39)	missense	probably damaging	1.00
R7010:Prss3b	UTSW	6	41,009,247 (GRCm39)	missense	probably benign	0.42
R7567:Prss3b	UTSW	6	41,010,127 (GRCm39)	missense	probably benign	0.04
R7727:Prss3b	UTSW	6	41,010,127 (GRCm39)	missense	probably benign	0.04
R7962:Prss3b	UTSW	6	41,012,387 (GRCm39)	missense	probably benign	0.01
R8373:Prss3b	UTSW	6	41,008,622 (GRCm39)	missense	possibly damaging	0.53
R8529:Prss3b	UTSW	6	41,009,369 (GRCm39)	missense	probably benign	0.00
R8883:Prss3b	UTSW	6	41,009,305 (GRCm39)	nonsense	probably null
R8916:Prss3b	UTSW	6	41,010,103 (GRCm39)	missense	probably damaging	1.00
R9066:Prss3b	UTSW	6	41,008,640 (GRCm39)	missense	probably benign	0.41
R9095:Prss3b	UTSW	6	41,010,038 (GRCm39)	missense	possibly damaging	0.76
R9180:Prss3b	UTSW	6	41,008,681 (GRCm39)	missense	probably damaging	1.00
R9389:Prss3b	UTSW	6	41,010,079 (GRCm39)	missense	probably benign	0.02

Posted On

2013-06-21