Incidental Mutation 'R6370:Lrrn1'
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ID513463
Institutional Source Beutler Lab
Gene Symbol Lrrn1
Ensembl Gene ENSMUSG00000034648
Gene Nameleucine rich repeat protein 1, neuronal
Synonyms2810047E21Rik, NLRR-1
MMRRC Submission
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.364) question?
Stock #R6370 (G1)
Quality Score225.009
Status Validated
Chromosome6
Chromosomal Location107529768-107570214 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 107569224 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 661 (Y661C)
Ref Sequence ENSEMBL: ENSMUSP00000037096 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049285]
Predicted Effect probably damaging
Transcript: ENSMUST00000049285
AA Change: Y661C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000037096
Gene: ENSMUSG00000034648
AA Change: Y661C

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
LRRNT 31 76 2.89e-1 SMART
LRR 94 117 1.06e1 SMART
LRR 118 141 1.89e-1 SMART
LRR_TYP 142 165 4.3e-5 SMART
LRR 166 189 1.76e-1 SMART
LRR 214 237 4.09e1 SMART
LRR 238 261 1.53e1 SMART
LRR 262 285 2.63e0 SMART
LRR 311 335 1.45e2 SMART
LRR 336 359 4.21e1 SMART
LRRCT 371 423 2.14e-10 SMART
IGc2 438 506 6.34e-15 SMART
FN3 523 605 8.71e-2 SMART
transmembrane domain 631 653 N/A INTRINSIC
low complexity region 690 701 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.1%
Validation Efficiency 95% (54/57)
MGI Phenotype PHENOTYPE: Homozygous null mutant mice exhibited decreased exploratory activity and the female mutants exhibited an increased anxiety-like response during open field testing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asb6 A G 2: 30,827,012 V67A probably damaging Het
Atic T A 1: 71,578,660 F590I probably damaging Het
Atxn10 T C 15: 85,393,385 F351S probably damaging Het
Bcl2l13 A G 6: 120,865,622 N92S probably benign Het
Carm1 G T 9: 21,587,519 A518S probably benign Het
Ccar1 C T 10: 62,764,529 R541H probably damaging Het
Cfhr2 A T 1: 139,822,327 L96Q probably damaging Het
Chrnb4 A G 9: 55,034,859 L377S probably benign Het
Clcn3 A G 8: 60,923,024 Y639H probably damaging Het
Cngb1 C T 8: 95,264,422 M717I probably benign Het
Ctcf T C 8: 105,664,220 M153T probably benign Het
Cyp2b19 T C 7: 26,763,358 S222P probably benign Het
Dixdc1 A T 9: 50,682,223 probably null Het
Entpd2 G A 2: 25,397,417 G47S probably damaging Het
Erbb3 A G 10: 128,570,074 M1158T possibly damaging Het
Faah T C 4: 116,003,056 D333G probably damaging Het
Foxred2 T A 15: 77,943,306 T618S probably benign Het
Gm2381 G A 7: 42,820,586 A38V probably benign Het
Gpx5 A T 13: 21,288,702 probably null Het
Gtdc1 A G 2: 44,756,322 V98A probably damaging Het
Hal T C 10: 93,497,506 I312T probably damaging Het
Krtap21-1 T C 16: 89,403,631 Y41C unknown Het
Larp6 A G 9: 60,737,363 E262G probably damaging Het
Lsm14a A G 7: 34,357,481 V244A probably benign Het
Marc1 T C 1: 184,795,492 D257G probably damaging Het
Mfrp T C 9: 44,106,261 C517R probably damaging Het
Ncoa3 T C 2: 166,065,905 S1145P probably benign Het
Nosip G T 7: 45,076,740 probably null Het
Olfr1186 T A 2: 88,499,368 C94* probably null Het
Olfr568 A T 7: 102,877,170 T17S probably benign Het
Olfr664 T C 7: 104,733,917 K149R probably benign Het
Phykpl T C 11: 51,586,716 S112P probably damaging Het
Pik3cb A T 9: 99,040,934 I1015K probably damaging Het
Pomt2 A G 12: 87,109,199 W818R probably damaging Het
Ptpn21 A T 12: 98,689,034 M558K possibly damaging Het
Rnf213 T A 11: 119,477,078 N4647K probably damaging Het
Rsf1 GCG GCGACGGCGACG 7: 97,579,907 probably benign Homo
Rxrg T C 1: 167,634,437 V227A probably damaging Het
Satb1 A T 17: 51,782,797 S341T possibly damaging Het
Skint5 T G 4: 113,614,110 Q983P unknown Het
Slc6a18 G A 13: 73,668,159 T367I probably benign Het
Slc7a1 A G 5: 148,340,673 L344P probably damaging Het
Slc7a6 T A 8: 106,195,437 F399I probably benign Het
St3gal1 A G 15: 67,111,346 V187A possibly damaging Het
Sugt1 T C 14: 79,610,334 V208A probably benign Het
Syt3 A G 7: 44,395,683 K480E probably damaging Het
Thop1 C T 10: 81,077,983 T186I probably benign Het
Trim55 G A 3: 19,691,486 E509K possibly damaging Het
Upf2 A G 2: 5,976,010 N469S unknown Het
Usp24 G T 4: 106,380,521 K1125N probably null Het
Usp5 A T 6: 124,820,428 D494E probably benign Het
Vmn2r51 T C 7: 10,098,216 K481R probably damaging Het
Vps16 C A 2: 130,443,384 A787D probably damaging Het
Washc4 C T 10: 83,571,362 H488Y possibly damaging Het
Wdfy4 C A 14: 33,068,850 A2053S probably benign Het
Zfp74 A T 7: 29,932,410 D136E probably damaging Het
Other mutations in Lrrn1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00834:Lrrn1 APN 6 107568308 missense probably benign 0.06
IGL00949:Lrrn1 APN 6 107569300 missense probably benign 0.15
IGL01594:Lrrn1 APN 6 107567493 missense probably damaging 0.99
IGL02814:Lrrn1 APN 6 107567352 missense probably damaging 1.00
IGL02824:Lrrn1 APN 6 107568534 missense possibly damaging 0.57
IGL02931:Lrrn1 APN 6 107567748 missense probably damaging 1.00
R0399:Lrrn1 UTSW 6 107569120 missense probably benign
R1109:Lrrn1 UTSW 6 107567264 missense probably benign
R1620:Lrrn1 UTSW 6 107568366 missense probably damaging 1.00
R1826:Lrrn1 UTSW 6 107567568 missense probably benign 0.05
R1893:Lrrn1 UTSW 6 107568122 missense possibly damaging 0.82
R2327:Lrrn1 UTSW 6 107568833 missense probably benign 0.05
R3684:Lrrn1 UTSW 6 107567949 missense probably benign 0.13
R3757:Lrrn1 UTSW 6 107569208 missense possibly damaging 0.81
R4538:Lrrn1 UTSW 6 107568637 missense probably benign 0.21
R4922:Lrrn1 UTSW 6 107568350 missense probably damaging 1.00
R4946:Lrrn1 UTSW 6 107568890 missense probably benign 0.16
R4970:Lrrn1 UTSW 6 107569344 missense probably benign 0.06
R4977:Lrrn1 UTSW 6 107568707 missense probably benign
R5121:Lrrn1 UTSW 6 107569207 missense possibly damaging 0.89
R5186:Lrrn1 UTSW 6 107569224 missense probably damaging 1.00
R5625:Lrrn1 UTSW 6 107567354 missense probably damaging 0.99
R5736:Lrrn1 UTSW 6 107567384 missense probably damaging 1.00
R5873:Lrrn1 UTSW 6 107568975 missense probably damaging 0.98
R5949:Lrrn1 UTSW 6 107567504 missense probably benign 0.00
R6046:Lrrn1 UTSW 6 107568527 missense probably benign 0.00
R7138:Lrrn1 UTSW 6 107568375 missense probably damaging 1.00
R7169:Lrrn1 UTSW 6 107567604 missense probably damaging 1.00
R7413:Lrrn1 UTSW 6 107569122 missense probably benign 0.00
R7449:Lrrn1 UTSW 6 107568521 missense possibly damaging 0.91
R7969:Lrrn1 UTSW 6 107567850 missense probably damaging 1.00
R8077:Lrrn1 UTSW 6 107568822 missense probably damaging 0.99
R8288:Lrrn1 UTSW 6 107566994 start gained probably benign
Predicted Primers PCR Primer
(F):5'- ACGGTGTCCAACATCCATCAG -3'
(R):5'- TGTGCTCCTTACTACCAGAAGC -3'

Sequencing Primer
(F):5'- GTGTCCAACATCCATCAGCAGAC -3'
(R):5'- GTGCTCCTTACTACCAGAAGCAAAAC -3'
Posted On2018-04-27