|Institutional Source||Beutler Lab|
|Gene Name||glutathione peroxidase 5|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6370 (G1)|
|Chromosomal Location||21286429-21292731 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||A to T at 21288702 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000106117 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000110491]|
|Predicted Effect||probably null
|Coding Region Coverage||
|Validation Efficiency||95% (54/57)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike several other characterized glutathione peroxidases, this enzyme is not a selenoprotein, lacking the selenocysteine residue. Thus, it is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2016]
PHENOTYPE: Male mice homozygous for a knock-out allele exhibit age-dependent reduced fertility due to increased sensitivity of sperm DNA to oxidative attack. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gpx5||
(F):5'- CCGTGGATGCTAACAGACTC -3'
(R):5'- CATGTCACCAACCCCTGCTG -3'
(F):5'- CGTGGATGCTAACAGACTCATATCTC -3'
(R):5'- AACCCCTGCTGCATCTCTAC -3'