Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01123:Agbl3'

51350

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Agbl3

Ensembl Gene

ENSMUSG00000038836

Gene Name

ATP/GTP binding protein-like 3

Synonyms

4930431N21Rik, 2900053G10Rik, 6530406M24Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01123

Quality Score

Status

Chromosome

Chromosomal Location

34780432-34859459 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 34846976 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 859 (Q859*)

Ref Sequence

ENSEMBL: ENSMUSP00000110669 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000115016] [ENSMUST00000115017] [ENSMUST00000148834]

AlphaFold

Q8CDP0

Predicted Effect

probably null
Transcript: ENSMUST00000115016
AA Change: Q864*

SMART Domains

Protein: ENSMUSP00000110668
Gene: ENSMUSG00000038836
AA Change: Q864*

Domain	Start	End	E-Value	Type
low complexity region	2	25	N/A	INTRINSIC
Pfam:Peptidase_M14	314	563	2.7e-19	PFAM
low complexity region	614	629	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000115017
AA Change: Q859*

SMART Domains

Protein: ENSMUSP00000110669
Gene: ENSMUSG00000038836
AA Change: Q859*

Domain	Start	End	E-Value	Type
low complexity region	2	25	N/A	INTRINSIC
Pfam:Peptidase_M14	309	560	1e-33	PFAM
low complexity region	609	624	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000148834

SMART Domains

Protein: ENSMUSP00000116066
Gene: ENSMUSG00000038836

Domain	Start	End	E-Value	Type
low complexity region	2	25	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000202017

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mice for a targeted allele are viable and fertile. Mice homozygous for a knock-out allele exhibit normal response to herpes simplex virus (HSV) and vaccinia virus (VACV) infection. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310057J18Rik	G	T	10: 28,973,938	D167E	probably damaging	Het
Aadat	A	T	8: 60,526,614	E170V	probably benign	Het
Acsf2	T	C	11: 94,570,450	E300G	probably benign	Het
Arhgap11a	T	C	2: 113,834,773		probably benign	Het
Arhgef40	C	A	14: 51,994,346	Q730K	probably damaging	Het
Armc3	C	T	2: 19,201,805	P13L	possibly damaging	Het
B3gnt2	T	A	11: 22,836,490	T233S	probably benign	Het
Bnc1	G	A	7: 81,973,707	Q591*	probably null	Het
Bsn	A	T	9: 108,115,986	F856I	probably damaging	Het
CK137956	T	A	4: 127,935,850	T558S	probably benign	Het
Coq8b	G	A	7: 27,240,084	V180I	probably damaging	Het
Csmd1	A	T	8: 17,534,928	L16Q	possibly damaging	Het
Dhx37	A	G	5: 125,419,088	S769P	possibly damaging	Het
Diras1	T	A	10: 81,022,415	M1L	probably damaging	Het
Fam161b	A	G	12: 84,357,664	W81R	probably benign	Het
Fat4	A	T	3: 38,957,269	I2173L	probably benign	Het
Fbn2	T	C	18: 58,104,081	T617A	possibly damaging	Het
Gabrq	G	A	X: 72,836,833	D311N	probably benign	Het
Isl2	G	T	9: 55,545,462	G335C	probably damaging	Het
Kbtbd7	T	C	14: 79,428,612	V628A	probably damaging	Het
Kmt2d	T	C	15: 98,837,148	M5378V	unknown	Het
Lrrc23	G	T	6: 124,778,819	D75E	probably benign	Het
Mab21l3	G	A	3: 101,835,130	T38M	probably benign	Het
Matn1	T	C	4: 130,950,011	I177T	possibly damaging	Het
Mtor	T	C	4: 148,453,037	S60P	probably benign	Het
Naip6	T	C	13: 100,304,438	E278G	probably benign	Het
Nsun6	T	C	2: 15,048,978	I7V	possibly damaging	Het
Pabpc6	A	T	17: 9,668,147	S492T	probably benign	Het
Pakap	C	T	4: 57,757,627	Q188*	probably null	Het
Pom121	A	T	5: 135,391,706	V287D	unknown	Het
Ptprq	A	T	10: 107,686,218	F624Y	probably damaging	Het
Ptprr	A	G	10: 116,188,317	T178A	probably benign	Het
Pygm	A	G	19: 6,391,394	N473S	probably benign	Het
Ros1	A	T	10: 52,120,809	Y1256N	probably damaging	Het
Scpep1	T	C	11: 88,941,328	N192S	possibly damaging	Het
Serpina1f	A	G	12: 103,694,006	S6P	possibly damaging	Het
Sgca	T	A	11: 94,972,287	Q80L	probably damaging	Het
Skint6	A	G	4: 112,804,682	L1235P	possibly damaging	Het
Slc23a2	A	C	2: 132,056,816	N600K	probably benign	Het
Spata20	T	C	11: 94,483,395	T350A	probably benign	Het
Syne1	G	T	10: 5,344,921	Y1227*	probably null	Het
Unc13c	T	C	9: 73,933,197	Y124C	probably benign	Het
Usp40	G	A	1: 87,986,123	T416I	probably benign	Het
Vmn1r200	T	C	13: 22,395,401	W116R	probably benign	Het
Vps4a	T	C	8: 107,039,219		probably benign	Het
Zfyve16	A	G	13: 92,492,522	V1469A	probably damaging	Het

Other mutations in Agbl3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00336:Agbl3	APN	6	34846836	missense	probably damaging	1.00
IGL00835:Agbl3	APN	6	34799732	missense	probably damaging	1.00
IGL00840:Agbl3	APN	6	34799159	missense	possibly damaging	0.95
IGL01090:Agbl3	APN	6	34799887	missense	probably benign	0.40
IGL01707:Agbl3	APN	6	34839454	missense	possibly damaging	0.78
IGL01728:Agbl3	APN	6	34782157	start codon destroyed	probably null
IGL02335:Agbl3	APN	6	34799750	missense	probably damaging	1.00
IGL02420:Agbl3	APN	6	34785307	missense	possibly damaging	0.47
IGL02551:Agbl3	APN	6	34823071	missense	possibly damaging	0.88
IGL02974:Agbl3	APN	6	34799822	missense	probably damaging	1.00
IGL03167:Agbl3	APN	6	34857659	missense	possibly damaging	0.92
IGL03182:Agbl3	APN	6	34803500	missense	probably damaging	1.00
R0044:Agbl3	UTSW	6	34799899	missense	probably damaging	1.00
R0499:Agbl3	UTSW	6	34839335	missense	probably benign
R0639:Agbl3	UTSW	6	34799705	missense	probably damaging	1.00
R0850:Agbl3	UTSW	6	34799204	missense	probably damaging	1.00
R1004:Agbl3	UTSW	6	34803451	missense	probably damaging	0.99
R1080:Agbl3	UTSW	6	34828235	missense	probably benign	0.14
R1589:Agbl3	UTSW	6	34857517	missense	possibly damaging	0.77
R2361:Agbl3	UTSW	6	34832505	missense	possibly damaging	0.87
R2495:Agbl3	UTSW	6	34846764	missense	probably damaging	1.00
R3236:Agbl3	UTSW	6	34823087	splice site	probably null
R3237:Agbl3	UTSW	6	34823087	splice site	probably null
R3420:Agbl3	UTSW	6	34793965	missense	probably benign	0.36
R3421:Agbl3	UTSW	6	34793965	missense	probably benign	0.36
R3422:Agbl3	UTSW	6	34793965	missense	probably benign	0.36
R3810:Agbl3	UTSW	6	34799729	missense	probably damaging	1.00
R3811:Agbl3	UTSW	6	34799729	missense	probably damaging	1.00
R4059:Agbl3	UTSW	6	34846899	missense	probably damaging	1.00
R4499:Agbl3	UTSW	6	34857598	missense	probably benign	0.00
R4687:Agbl3	UTSW	6	34798326	missense	probably damaging	1.00
R4854:Agbl3	UTSW	6	34785284	missense	probably damaging	0.97
R5354:Agbl3	UTSW	6	34814752	missense	probably benign	0.03
R5386:Agbl3	UTSW	6	34799196	missense	probably damaging	1.00
R5897:Agbl3	UTSW	6	34803573	missense	probably benign	0.21
R6018:Agbl3	UTSW	6	34799255	missense	probably damaging	1.00
R6148:Agbl3	UTSW	6	34857753	missense	possibly damaging	0.87
R6305:Agbl3	UTSW	6	34782210	missense	unknown
R6525:Agbl3	UTSW	6	34803594	nonsense	probably null
R6546:Agbl3	UTSW	6	34799299	missense	probably damaging	1.00
R6743:Agbl3	UTSW	6	34846953	missense	probably benign	0.03
R6986:Agbl3	UTSW	6	34839452	missense	probably benign	0.42
R7023:Agbl3	UTSW	6	34814769	missense	probably benign	0.02
R7411:Agbl3	UTSW	6	34814819	missense	probably damaging	0.99
R7469:Agbl3	UTSW	6	34814414	missense	probably damaging	1.00
R7631:Agbl3	UTSW	6	34857671	missense	possibly damaging	0.95
R7658:Agbl3	UTSW	6	34832508	missense	probably benign	0.11
R7743:Agbl3	UTSW	6	34846830	missense	probably damaging	1.00
R7801:Agbl3	UTSW	6	34839365	missense	probably benign	0.00
R8033:Agbl3	UTSW	6	34839494	missense	possibly damaging	0.95
R8203:Agbl3	UTSW	6	34799479	missense	probably damaging	1.00
R8769:Agbl3	UTSW	6	34857614	missense	probably damaging	0.96
R9072:Agbl3	UTSW	6	34799452	missense	probably damaging	1.00
R9073:Agbl3	UTSW	6	34799452	missense	probably damaging	1.00
R9210:Agbl3	UTSW	6	34798242	missense	probably damaging	0.98
R9255:Agbl3	UTSW	6	34812905	missense	probably damaging	1.00
R9536:Agbl3	UTSW	6	34846926	missense	probably benign
R9560:Agbl3	UTSW	6	34846908	missense	possibly damaging	0.94
R9662:Agbl3	UTSW	6	34832533	nonsense	probably null
RF014:Agbl3	UTSW	6	34799358	missense	possibly damaging	0.53
Z1177:Agbl3	UTSW	6	34799408	missense	probably damaging	1.00

Posted On

2013-06-21