Incidental Mutation 'R6371:Yeats2'
ID 513541
Institutional Source Beutler Lab
Gene Symbol Yeats2
Ensembl Gene ENSMUSG00000041215
Gene Name YEATS domain containing 2
Synonyms
MMRRC Submission 044521-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.964) question?
Stock # R6371 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 19959813-20051323 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 20040460 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 1127 (E1127G)
Ref Sequence ENSEMBL: ENSMUSP00000155892 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090052] [ENSMUST00000115560] [ENSMUST00000232019] [ENSMUST00000232338]
AlphaFold Q3TUF7
Predicted Effect probably benign
Transcript: ENSMUST00000090052
AA Change: E1112G

PolyPhen 2 Score 0.406 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000087506
Gene: ENSMUSG00000041215
AA Change: E1112G

DomainStartEndE-ValueType
Pfam:YEATS 179 262 2.6e-27 PFAM
low complexity region 299 309 N/A INTRINSIC
low complexity region 312 333 N/A INTRINSIC
low complexity region 409 429 N/A INTRINSIC
low complexity region 458 467 N/A INTRINSIC
internal_repeat_1 471 675 3.72e-6 PROSPERO
low complexity region 683 702 N/A INTRINSIC
low complexity region 738 775 N/A INTRINSIC
internal_repeat_1 785 978 3.72e-6 PROSPERO
low complexity region 1240 1249 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000115560
AA Change: E1165G

PolyPhen 2 Score 0.406 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000111222
Gene: ENSMUSG00000041215
AA Change: E1165G

DomainStartEndE-ValueType
Pfam:YEATS 232 314 2.1e-28 PFAM
low complexity region 352 362 N/A INTRINSIC
low complexity region 365 386 N/A INTRINSIC
low complexity region 462 482 N/A INTRINSIC
low complexity region 511 520 N/A INTRINSIC
internal_repeat_1 524 728 4.68e-6 PROSPERO
low complexity region 736 755 N/A INTRINSIC
low complexity region 791 828 N/A INTRINSIC
internal_repeat_1 838 1031 4.68e-6 PROSPERO
low complexity region 1293 1302 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000232019
AA Change: E1127G

PolyPhen 2 Score 0.541 (Sensitivity: 0.88; Specificity: 0.91)
Predicted Effect probably benign
Transcript: ENSMUST00000232338
Predicted Effect probably benign
Transcript: ENSMUST00000232613
Predicted Effect noncoding transcript
Transcript: ENSMUST00000232671
Meta Mutation Damage Score 0.1202 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.7%
  • 10x: 98.2%
  • 20x: 94.1%
Validation Efficiency 98% (50/51)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] YEATS2 is a scaffolding subunit of the ADA2A (TADA2A; MIM 602276)-containing (ATAC) histone acetyltransferase complex (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]
Allele List at MGI

All alleles(34) : Targeted(1) Gene trapped(33)

Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam6b C T 12: 113,453,894 (GRCm39) S237L probably damaging Het
Ank3 T G 10: 69,644,709 (GRCm39) L58V probably damaging Het
Arsb A T 13: 93,926,574 (GRCm39) I115F possibly damaging Het
Atad2b T C 12: 5,023,970 (GRCm39) Y32H probably damaging Het
Brd1 A C 15: 88,598,201 (GRCm39) M515R probably benign Het
Cbx7 A G 15: 79,803,023 (GRCm39) S30P possibly damaging Het
Cdk12 A G 11: 98,136,114 (GRCm39) T1123A unknown Het
Cep170b A G 12: 112,707,379 (GRCm39) D375G probably damaging Het
Clcn3 T C 8: 61,390,369 (GRCm39) K164E probably benign Het
Clip4 A C 17: 72,163,459 (GRCm39) K677T probably damaging Het
Clrn2 T C 5: 45,617,540 (GRCm39) I137T possibly damaging Het
Cntln T C 4: 84,802,816 (GRCm39) S39P probably damaging Het
Crocc2 T A 1: 93,143,353 (GRCm39) N1318K probably benign Het
Emc1 C T 4: 139,098,976 (GRCm39) Q820* probably null Het
Fbxl2 G A 9: 113,818,451 (GRCm39) T170I probably damaging Het
Fyb2 A G 4: 104,852,975 (GRCm39) T552A probably damaging Het
Garin5b A G 7: 4,762,358 (GRCm39) V257A probably benign Het
Gm2381 G A 7: 42,470,010 (GRCm39) A38V probably benign Het
Gpt2 G A 8: 86,244,681 (GRCm39) E325K probably benign Het
Helz2 C T 2: 180,875,260 (GRCm39) E1745K probably damaging Het
Hspg2 T C 4: 137,269,006 (GRCm39) Y2213H probably damaging Het
Ifnar2 T C 16: 91,184,986 (GRCm39) Y24H possibly damaging Het
Inpp5d T A 1: 87,627,397 (GRCm39) L566Q probably damaging Het
Itgb2 C A 10: 77,384,431 (GRCm39) P184H probably damaging Het
Kcnb2 T A 1: 15,781,436 (GRCm39) D769E probably benign Het
Lrp1b A G 2: 40,741,666 (GRCm39) M3087T possibly damaging Het
Ltbp3 A G 19: 5,795,800 (GRCm39) probably null Het
Ms4a6b A G 19: 11,497,728 (GRCm39) E9G probably damaging Het
Nat3 G A 8: 67,976,831 (GRCm39) probably null Het
Ndufaf1 A T 2: 119,490,534 (GRCm39) D175E probably damaging Het
Nop58 T G 1: 59,750,471 (GRCm39) probably benign Het
Or10al6 A G 17: 38,083,326 (GRCm39) T261A probably benign Het
Or8s16 A G 15: 98,211,219 (GRCm39) Y71H possibly damaging Het
P3h4 C T 11: 100,302,575 (GRCm39) E354K probably benign Het
Plekhm2 T G 4: 141,356,843 (GRCm39) T787P possibly damaging Het
Ppia C T 11: 6,368,230 (GRCm39) T37I probably benign Het
Reln T A 5: 22,200,511 (GRCm39) M1330L probably benign Het
Ric1 A G 19: 29,539,426 (GRCm39) E53G probably benign Het
Sgip1 T A 4: 102,823,482 (GRCm39) V721E probably damaging Het
Slc33a1 A T 3: 63,850,709 (GRCm39) D538E probably benign Het
Son T C 16: 91,471,629 (GRCm39) Het
Srebf1 A T 11: 60,094,341 (GRCm39) S591R probably damaging Het
St3gal1 A G 15: 66,983,195 (GRCm39) V187A possibly damaging Het
Taok2 G A 7: 126,469,319 (GRCm39) R1170W probably damaging Het
Tsc2 A T 17: 24,845,688 (GRCm39) V210E probably benign Het
Ttc6 T A 12: 57,775,249 (GRCm39) N1648K possibly damaging Het
Vgll3 C T 16: 65,636,131 (GRCm39) P94L probably damaging Het
Vmn2r54 A T 7: 12,349,362 (GRCm39) V740E probably damaging Het
Zfp709 T A 8: 72,643,329 (GRCm39) Y252N probably damaging Het
Other mutations in Yeats2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01118:Yeats2 APN 16 20,005,054 (GRCm39) missense probably damaging 0.99
IGL01128:Yeats2 APN 16 19,980,718 (GRCm39) splice site probably benign
IGL01139:Yeats2 APN 16 20,033,143 (GRCm39) missense probably damaging 1.00
IGL01394:Yeats2 APN 16 19,980,782 (GRCm39) missense probably damaging 0.99
IGL01482:Yeats2 APN 16 20,041,671 (GRCm39) missense probably damaging 1.00
IGL01924:Yeats2 APN 16 20,024,917 (GRCm39) missense probably damaging 1.00
IGL01925:Yeats2 APN 16 19,998,430 (GRCm39) splice site probably benign
IGL02106:Yeats2 APN 16 20,011,970 (GRCm39) missense possibly damaging 0.79
IGL02370:Yeats2 APN 16 19,969,221 (GRCm39) missense probably damaging 0.99
IGL02447:Yeats2 APN 16 20,012,429 (GRCm39) missense probably benign 0.00
IGL02669:Yeats2 APN 16 20,005,033 (GRCm39) missense probably benign 0.13
IGL03155:Yeats2 APN 16 20,048,323 (GRCm39) critical splice donor site probably null
tyrion UTSW 16 20,032,151 (GRCm39) splice site probably benign
P0045:Yeats2 UTSW 16 19,975,695 (GRCm39) missense possibly damaging 0.47
R0051:Yeats2 UTSW 16 20,012,474 (GRCm39) nonsense probably null
R0051:Yeats2 UTSW 16 20,012,474 (GRCm39) nonsense probably null
R0118:Yeats2 UTSW 16 19,975,692 (GRCm39) nonsense probably null
R0157:Yeats2 UTSW 16 20,040,427 (GRCm39) makesense probably null
R0184:Yeats2 UTSW 16 20,022,435 (GRCm39) missense possibly damaging 0.79
R0194:Yeats2 UTSW 16 19,971,719 (GRCm39) start codon destroyed probably null 1.00
R0612:Yeats2 UTSW 16 20,005,175 (GRCm39) missense probably benign 0.00
R0655:Yeats2 UTSW 16 20,012,574 (GRCm39) nonsense probably null
R0826:Yeats2 UTSW 16 20,011,966 (GRCm39) nonsense probably null
R1526:Yeats2 UTSW 16 20,024,836 (GRCm39) missense probably damaging 1.00
R1535:Yeats2 UTSW 16 20,008,115 (GRCm39) missense probably damaging 0.99
R1749:Yeats2 UTSW 16 20,005,018 (GRCm39) nonsense probably null
R1842:Yeats2 UTSW 16 19,989,988 (GRCm39) missense probably damaging 1.00
R1843:Yeats2 UTSW 16 20,048,314 (GRCm39) missense probably benign 0.01
R1926:Yeats2 UTSW 16 20,033,176 (GRCm39) missense probably benign
R2000:Yeats2 UTSW 16 20,005,141 (GRCm39) missense probably benign 0.20
R2017:Yeats2 UTSW 16 19,977,931 (GRCm39) missense probably benign 0.01
R2076:Yeats2 UTSW 16 20,005,032 (GRCm39) missense possibly damaging 0.47
R2153:Yeats2 UTSW 16 19,972,916 (GRCm39) missense probably damaging 1.00
R2167:Yeats2 UTSW 16 20,032,151 (GRCm39) splice site probably benign
R2981:Yeats2 UTSW 16 20,005,051 (GRCm39) missense probably damaging 0.99
R3160:Yeats2 UTSW 16 20,012,395 (GRCm39) missense probably damaging 1.00
R3161:Yeats2 UTSW 16 20,012,395 (GRCm39) missense probably damaging 1.00
R3162:Yeats2 UTSW 16 20,012,395 (GRCm39) missense probably damaging 1.00
R3774:Yeats2 UTSW 16 19,969,245 (GRCm39) missense probably damaging 1.00
R4250:Yeats2 UTSW 16 19,975,685 (GRCm39) missense possibly damaging 0.90
R4305:Yeats2 UTSW 16 20,027,172 (GRCm39) missense probably damaging 1.00
R4455:Yeats2 UTSW 16 19,980,743 (GRCm39) missense possibly damaging 0.88
R4458:Yeats2 UTSW 16 20,032,071 (GRCm39) missense probably damaging 0.99
R4811:Yeats2 UTSW 16 19,971,645 (GRCm39) splice site probably null
R4902:Yeats2 UTSW 16 20,026,418 (GRCm39) missense probably benign 0.00
R5043:Yeats2 UTSW 16 20,027,215 (GRCm39) missense probably damaging 1.00
R5047:Yeats2 UTSW 16 20,027,215 (GRCm39) missense probably damaging 1.00
R5319:Yeats2 UTSW 16 20,005,175 (GRCm39) missense probably benign 0.01
R5328:Yeats2 UTSW 16 19,989,955 (GRCm39) missense probably damaging 1.00
R5360:Yeats2 UTSW 16 19,972,912 (GRCm39) missense probably damaging 0.97
R5416:Yeats2 UTSW 16 20,030,319 (GRCm39) missense probably benign 0.01
R5672:Yeats2 UTSW 16 19,980,779 (GRCm39) missense probably damaging 1.00
R5684:Yeats2 UTSW 16 20,012,553 (GRCm39) missense possibly damaging 0.94
R5932:Yeats2 UTSW 16 20,011,913 (GRCm39) missense probably benign 0.06
R5946:Yeats2 UTSW 16 20,026,513 (GRCm39) nonsense probably null
R6168:Yeats2 UTSW 16 19,998,308 (GRCm39) missense probably benign 0.01
R6169:Yeats2 UTSW 16 20,038,417 (GRCm39) missense probably damaging 1.00
R6179:Yeats2 UTSW 16 20,033,225 (GRCm39) missense probably benign 0.16
R6877:Yeats2 UTSW 16 19,998,344 (GRCm39) missense probably benign 0.00
R7149:Yeats2 UTSW 16 19,972,939 (GRCm39) missense probably damaging 1.00
R7405:Yeats2 UTSW 16 20,041,663 (GRCm39) missense probably damaging 1.00
R8353:Yeats2 UTSW 16 20,041,637 (GRCm39) nonsense probably null
R8367:Yeats2 UTSW 16 20,041,575 (GRCm39) missense probably damaging 1.00
R8453:Yeats2 UTSW 16 20,041,637 (GRCm39) nonsense probably null
R8506:Yeats2 UTSW 16 19,971,684 (GRCm39) missense probably damaging 0.98
R8535:Yeats2 UTSW 16 19,977,926 (GRCm39) missense probably damaging 1.00
R8828:Yeats2 UTSW 16 19,969,260 (GRCm39) missense probably benign 0.45
R8905:Yeats2 UTSW 16 20,009,144 (GRCm39) missense probably benign 0.02
R8924:Yeats2 UTSW 16 19,969,312 (GRCm39) critical splice donor site probably null
R9087:Yeats2 UTSW 16 20,030,500 (GRCm39) critical splice donor site probably null
R9276:Yeats2 UTSW 16 19,975,786 (GRCm39) missense probably benign 0.34
R9338:Yeats2 UTSW 16 20,041,533 (GRCm39) missense probably damaging 0.99
R9338:Yeats2 UTSW 16 20,032,078 (GRCm39) missense possibly damaging 0.69
R9378:Yeats2 UTSW 16 20,033,228 (GRCm39) missense probably benign
R9569:Yeats2 UTSW 16 19,972,902 (GRCm39) missense probably damaging 1.00
R9664:Yeats2 UTSW 16 20,047,491 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CTTACTTCCACATGGCATGCAG -3'
(R):5'- AAAGTTTCTGACTGAGCAATGG -3'

Sequencing Primer
(F):5'- TGGCATGCAGAAACCCTC -3'
(R):5'- CTGACTGAGCAATGGTCTACC -3'
Posted On 2018-04-27