Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01132:Klra1'

51365

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Klra1

Ensembl Gene

ENSMUSG00000079853

Gene Name

killer cell lectin-like receptor, subfamily A, member 1

Synonyms

Ly49o<129>, Ly49A

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

IGL01132

Quality Score

Status

Chromosome

Chromosomal Location

130363917-130386874 bp(-) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 130364274 bp

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 245 (C245*)

Ref Sequence

ENSEMBL: ENSMUSP00000032288 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032288]

Predicted Effect

probably null
Transcript: ENSMUST00000032288
AA Change: C245*

SMART Domains

Protein: ENSMUSP00000032288
Gene: ENSMUSG00000079853
AA Change: C245*

Domain	Start	End	E-Value	Type
Blast:CLECT	73	118	9e-8	BLAST
CLECT	139	254	4.02e-15	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127570

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110038F14Rik	G	A	15: 76,950,275	V124I	probably damaging	Het
Adcy6	T	C	15: 98,597,851	N619S	probably benign	Het
Adgrf5	G	T	17: 43,422,509	D75Y	possibly damaging	Het
Aldh1a7	T	C	19: 20,727,040	H30R	possibly damaging	Het
Birc6	T	C	17: 74,603,060	S1483P	probably damaging	Het
Cd209e	T	C	8: 3,851,274	T127A	probably benign	Het
Clmn	T	A	12: 104,774,551		probably null	Het
Dcc	A	T	18: 71,682,174	Y376*	probably null	Het
Dscaml1	C	T	9: 45,752,328	R1950*	probably null	Het
Eml2	A	T	7: 19,200,539	S388C	probably damaging	Het
Ext2	C	T	2: 93,791,073	M370I	probably benign	Het
Foxo1	C	T	3: 52,345,159	R248W	probably damaging	Het
Gan	T	A	8: 117,196,444		probably benign	Het
Myh10	A	T	11: 68,768,268	M491L	possibly damaging	Het
Myrf	A	G	19: 10,223,205	Y343H	probably damaging	Het
Olfr1084	A	T	2: 86,639,166	C181S	probably benign	Het
Olfr790	T	C	10: 129,501,646	V254A	probably damaging	Het
Olfr859	G	A	9: 19,808,654	S112N	probably damaging	Het
Oplah	C	T	15: 76,300,957	S852N	probably benign	Het
Prag1	T	C	8: 36,146,357	V1021A	probably damaging	Het
Rassf4	C	T	6: 116,659,607		probably benign	Het
Sf3b3	T	C	8: 110,842,781	I102V	probably benign	Het
Slc27a4	T	C	2: 29,804,302	I46T	probably benign	Het
Slc5a12	T	C	2: 110,597,822	V74A	probably damaging	Het
St5	A	G	7: 109,570,005		probably null	Het
Tas2r134	G	T	2: 51,627,659	C50F	probably damaging	Het
Tcte1	G	T	17: 45,539,862	A355S	possibly damaging	Het

Other mutations in Klra1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01320:Klra1	APN	6	130364261	missense	probably benign	0.02
IGL01322:Klra1	APN	6	130364261	missense	probably benign	0.02
IGL02149:Klra1	APN	6	130375330	missense	probably damaging	1.00
IGL02666:Klra1	APN	6	130364315	missense	probably damaging	1.00
IGL02895:Klra1	APN	6	130375240	missense	possibly damaging	0.51
R0004:Klra1	UTSW	6	130372873	missense	probably damaging	1.00
R0408:Klra1	UTSW	6	130377774	missense	probably benign	0.13
R0442:Klra1	UTSW	6	130372872	missense	probably damaging	1.00
R0498:Klra1	UTSW	6	130372819	critical splice donor site	probably null
R0765:Klra1	UTSW	6	130379092	splice site	probably benign
R1761:Klra1	UTSW	6	130372873	missense	probably damaging	1.00
R1922:Klra1	UTSW	6	130372865	missense	probably benign	0.01
R1987:Klra1	UTSW	6	130377779	missense	probably benign
R2882:Klra1	UTSW	6	130377863	splice site	probably null
R5054:Klra1	UTSW	6	130375284	missense	probably damaging	0.99
R5190:Klra1	UTSW	6	130375278	missense	probably damaging	1.00
R5572:Klra1	UTSW	6	130372839	missense	possibly damaging	0.73
R5825:Klra1	UTSW	6	130380629	missense	probably damaging	1.00
R6784:Klra1	UTSW	6	130372854	missense	probably benign	0.00
Z1176:Klra1	UTSW	6	130372851	missense	probably damaging	0.99

Posted On

2013-06-21