Incidental Mutation 'R6374:Vmn2r79'
| ID |
513686 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r79
|
| Ensembl Gene |
ENSMUSG00000090362 |
| Gene Name |
vomeronasal 2, receptor 79 |
| Synonyms |
EG621430 |
| MMRRC Submission |
044524-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.093)
|
| Stock # |
R6374 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
86645673-86687176 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 86651498 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 299
(I299T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132478
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164462]
|
| AlphaFold |
E9Q067 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164462
AA Change: I299T
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000132478
Gene: ENSMUSG00000090362
AA Change: I299T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
464 |
1.9e-31 |
PFAM |
|
Pfam:NCD3G
|
506 |
559 |
3.1e-21 |
PFAM |
|
Pfam:7tm_3
|
592 |
827 |
2.8e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.5%
- 20x: 92.4%
|
| Validation Efficiency |
99% (75/76) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921509C19Rik |
A |
C |
2: 151,314,800 (GRCm39) |
S293A |
possibly damaging |
Het |
| 5430401F13Rik |
A |
T |
6: 131,529,892 (GRCm39) |
Q162L |
unknown |
Het |
| Abca8a |
A |
T |
11: 109,974,216 (GRCm39) |
Y239* |
probably null |
Het |
| Aox3 |
T |
C |
1: 58,211,320 (GRCm39) |
I959T |
probably benign |
Het |
| Atad2b |
T |
C |
12: 5,068,002 (GRCm39) |
V1000A |
probably damaging |
Het |
| Atic |
C |
T |
1: 71,604,100 (GRCm39) |
T221M |
probably damaging |
Het |
| Atp1a2 |
C |
T |
1: 172,116,942 (GRCm39) |
R225H |
probably damaging |
Het |
| BC024139 |
A |
G |
15: 76,004,657 (GRCm39) |
|
probably null |
Het |
| Bpi |
A |
T |
2: 158,113,974 (GRCm39) |
T291S |
probably damaging |
Het |
| Ccdc170 |
C |
T |
10: 4,499,746 (GRCm39) |
Q556* |
probably null |
Het |
| Cd3e |
G |
A |
9: 44,920,661 (GRCm39) |
L12F |
probably benign |
Het |
| Cdc42ep1 |
A |
T |
15: 78,731,649 (GRCm39) |
R31S |
probably damaging |
Het |
| Cyp21a1 |
G |
T |
17: 35,023,110 (GRCm39) |
|
probably null |
Het |
| Dnase1l3 |
A |
G |
14: 7,974,115 (GRCm38) |
M192T |
probably damaging |
Het |
| Dnmt1 |
A |
T |
9: 20,835,341 (GRCm39) |
H330Q |
possibly damaging |
Het |
| Enah |
T |
C |
1: 181,751,145 (GRCm39) |
E232G |
unknown |
Het |
| Etnppl |
C |
T |
3: 130,414,342 (GRCm39) |
T73I |
probably damaging |
Het |
| Fam83b |
T |
A |
9: 76,400,189 (GRCm39) |
I305F |
probably benign |
Het |
| Galnt15 |
T |
A |
14: 31,780,116 (GRCm39) |
I471N |
probably damaging |
Het |
| Gm19965 |
T |
A |
1: 116,750,021 (GRCm39) |
N567K |
probably benign |
Het |
| Golga1 |
T |
C |
2: 38,924,080 (GRCm39) |
Q435R |
probably benign |
Het |
| Gpat2 |
G |
C |
2: 127,273,838 (GRCm39) |
G294R |
possibly damaging |
Het |
| Hao1 |
T |
G |
2: 134,365,024 (GRCm39) |
D201A |
probably benign |
Het |
| Heg1 |
T |
C |
16: 33,547,499 (GRCm39) |
L786P |
possibly damaging |
Het |
| Hnrnpll |
A |
T |
17: 80,357,303 (GRCm39) |
C238S |
possibly damaging |
Het |
| Hrg |
A |
G |
16: 22,779,742 (GRCm39) |
Y340C |
probably damaging |
Het |
| Kyat3 |
A |
T |
3: 142,443,998 (GRCm39) |
I411F |
probably damaging |
Het |
| Myo1a |
T |
C |
10: 127,543,549 (GRCm39) |
Y202H |
probably damaging |
Het |
| Nags |
T |
C |
11: 102,037,337 (GRCm39) |
C143R |
possibly damaging |
Het |
| Ncoa6 |
T |
C |
2: 155,263,076 (GRCm39) |
N453D |
probably damaging |
Het |
| Nup35 |
G |
T |
2: 80,488,730 (GRCm39) |
M322I |
probably benign |
Het |
| Oprl1 |
T |
C |
2: 181,357,721 (GRCm39) |
V69A |
probably damaging |
Het |
| Or51v14 |
A |
G |
7: 103,261,128 (GRCm39) |
L144P |
probably benign |
Het |
| Pappa2 |
T |
A |
1: 158,784,215 (GRCm39) |
Y265F |
probably damaging |
Het |
| Pcsk6 |
C |
T |
7: 65,629,903 (GRCm39) |
P343L |
possibly damaging |
Het |
| Peak1 |
C |
A |
9: 56,164,950 (GRCm39) |
D993Y |
probably damaging |
Het |
| Polr2a |
T |
C |
11: 69,627,758 (GRCm39) |
Y1383C |
probably damaging |
Het |
| Ppme1 |
A |
G |
7: 99,990,272 (GRCm39) |
S226P |
probably damaging |
Het |
| Prom1 |
C |
T |
5: 44,213,325 (GRCm39) |
C127Y |
probably damaging |
Het |
| Ptpn6 |
A |
T |
6: 124,709,532 (GRCm39) |
|
probably null |
Het |
| Reln |
T |
C |
5: 22,285,712 (GRCm39) |
E419G |
probably benign |
Het |
| Rnf32 |
C |
T |
5: 29,430,266 (GRCm39) |
Q362* |
probably null |
Het |
| Sbspon |
T |
C |
1: 15,953,887 (GRCm39) |
D131G |
probably benign |
Het |
| Scyl3 |
T |
C |
1: 163,776,783 (GRCm39) |
S392P |
probably benign |
Het |
| Shtn1 |
T |
A |
19: 59,026,728 (GRCm39) |
D121V |
possibly damaging |
Het |
| Sin3a |
A |
G |
9: 57,024,765 (GRCm39) |
T1042A |
probably benign |
Het |
| Sipa1l2 |
A |
T |
8: 126,171,369 (GRCm39) |
V1371D |
probably damaging |
Het |
| Slc20a2 |
T |
C |
8: 23,055,668 (GRCm39) |
V584A |
possibly damaging |
Het |
| Smc6 |
T |
A |
12: 11,355,874 (GRCm39) |
|
probably null |
Het |
| Spata31h1 |
T |
A |
10: 82,124,731 (GRCm39) |
|
probably benign |
Het |
| Specc1 |
C |
T |
11: 62,047,418 (GRCm39) |
T849I |
possibly damaging |
Het |
| Spta1 |
T |
A |
1: 174,041,734 (GRCm39) |
L1368H |
probably damaging |
Het |
| Sqle |
A |
G |
15: 59,187,959 (GRCm39) |
E89G |
possibly damaging |
Het |
| Strbp |
A |
G |
2: 37,493,020 (GRCm39) |
V422A |
probably damaging |
Het |
| Sult6b1 |
G |
T |
17: 79,214,360 (GRCm39) |
T21K |
probably benign |
Het |
| Tex15 |
A |
G |
8: 34,065,940 (GRCm39) |
E1790G |
probably damaging |
Het |
| Tmem88b |
T |
A |
4: 155,870,221 (GRCm39) |
|
probably benign |
Het |
| Traf3ip3 |
T |
C |
1: 192,864,318 (GRCm39) |
D355G |
possibly damaging |
Het |
| Trim24 |
T |
A |
6: 37,930,484 (GRCm39) |
V576E |
probably benign |
Het |
| Trim30c |
C |
T |
7: 104,039,609 (GRCm39) |
G62D |
probably benign |
Het |
| Trim66 |
T |
G |
7: 109,085,269 (GRCm39) |
K100N |
probably benign |
Het |
| Tsnaxip1 |
A |
T |
8: 106,568,172 (GRCm39) |
T313S |
possibly damaging |
Het |
| Ugt2b37 |
A |
T |
5: 87,390,279 (GRCm39) |
I389N |
probably damaging |
Het |
| Unc13a |
C |
T |
8: 72,094,097 (GRCm39) |
V1335M |
possibly damaging |
Het |
| Urah |
A |
G |
7: 140,415,124 (GRCm39) |
T5A |
probably benign |
Het |
| Usp34 |
T |
C |
11: 23,388,914 (GRCm39) |
Y2185H |
probably damaging |
Het |
| Usp44 |
T |
C |
10: 93,692,172 (GRCm39) |
S643P |
probably benign |
Het |
| Vars2 |
A |
G |
17: 35,970,937 (GRCm39) |
V631A |
probably damaging |
Het |
| Vmn2r11 |
G |
A |
5: 109,201,679 (GRCm39) |
T275I |
possibly damaging |
Het |
| Vmn2r54 |
C |
A |
7: 12,349,420 (GRCm39) |
V721F |
probably damaging |
Het |
| Vps13d |
T |
C |
4: 144,849,251 (GRCm39) |
T2387A |
probably damaging |
Het |
| Washc5 |
A |
T |
15: 59,209,044 (GRCm39) |
L610Q |
probably benign |
Het |
| Zbtb21 |
T |
C |
16: 97,751,568 (GRCm39) |
E905G |
probably damaging |
Het |
| Zfhx4 |
A |
G |
3: 5,309,095 (GRCm39) |
T774A |
probably damaging |
Het |
| Zfp534 |
T |
C |
4: 147,759,299 (GRCm39) |
I457V |
probably benign |
Het |
| Zfp964 |
T |
C |
8: 70,111,994 (GRCm39) |
Y29H |
possibly damaging |
Het |
| Znrf4 |
A |
G |
17: 56,818,702 (GRCm39) |
F202L |
probably damaging |
Het |
|
| Other mutations in Vmn2r79 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01401:Vmn2r79
|
APN |
7 |
86,686,481 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01675:Vmn2r79
|
APN |
7 |
86,645,856 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01760:Vmn2r79
|
APN |
7 |
86,651,366 (GRCm39) |
missense |
probably benign |
|
|
IGL01834:Vmn2r79
|
APN |
7 |
86,686,354 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01843:Vmn2r79
|
APN |
7 |
86,686,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01914:Vmn2r79
|
APN |
7 |
86,686,571 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01980:Vmn2r79
|
APN |
7 |
86,686,290 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02438:Vmn2r79
|
APN |
7 |
86,651,744 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02740:Vmn2r79
|
APN |
7 |
86,653,366 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03052:Vmn2r79
|
UTSW |
7 |
86,652,799 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4445001:Vmn2r79
|
UTSW |
7 |
86,651,408 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0096:Vmn2r79
|
UTSW |
7 |
86,686,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0096:Vmn2r79
|
UTSW |
7 |
86,686,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0270:Vmn2r79
|
UTSW |
7 |
86,652,594 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0336:Vmn2r79
|
UTSW |
7 |
86,651,287 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0418:Vmn2r79
|
UTSW |
7 |
86,651,611 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1070:Vmn2r79
|
UTSW |
7 |
86,652,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1234:Vmn2r79
|
UTSW |
7 |
86,653,307 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1459:Vmn2r79
|
UTSW |
7 |
86,687,002 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1513:Vmn2r79
|
UTSW |
7 |
86,686,652 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1624:Vmn2r79
|
UTSW |
7 |
86,653,247 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1633:Vmn2r79
|
UTSW |
7 |
86,687,042 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1676:Vmn2r79
|
UTSW |
7 |
86,651,839 (GRCm39) |
missense |
probably benign |
|
|
R1781:Vmn2r79
|
UTSW |
7 |
86,651,555 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1794:Vmn2r79
|
UTSW |
7 |
86,650,621 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1823:Vmn2r79
|
UTSW |
7 |
86,687,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2013:Vmn2r79
|
UTSW |
7 |
86,653,289 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2018:Vmn2r79
|
UTSW |
7 |
86,651,634 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2019:Vmn2r79
|
UTSW |
7 |
86,651,634 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2177:Vmn2r79
|
UTSW |
7 |
86,645,839 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2984:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3719:Vmn2r79
|
UTSW |
7 |
86,651,245 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3798:Vmn2r79
|
UTSW |
7 |
86,651,402 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3969:Vmn2r79
|
UTSW |
7 |
86,652,801 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4182:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4183:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4245:Vmn2r79
|
UTSW |
7 |
86,651,624 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R4301:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4391:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4393:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4394:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4396:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4397:Vmn2r79
|
UTSW |
7 |
86,651,099 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4592:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4697:Vmn2r79
|
UTSW |
7 |
86,687,168 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4897:Vmn2r79
|
UTSW |
7 |
86,650,675 (GRCm39) |
missense |
probably benign |
|
|
R5016:Vmn2r79
|
UTSW |
7 |
86,686,548 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5058:Vmn2r79
|
UTSW |
7 |
86,651,423 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5177:Vmn2r79
|
UTSW |
7 |
86,651,177 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6078:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6079:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6138:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6257:Vmn2r79
|
UTSW |
7 |
86,651,778 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6260:Vmn2r79
|
UTSW |
7 |
86,686,365 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6307:Vmn2r79
|
UTSW |
7 |
86,686,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6323:Vmn2r79
|
UTSW |
7 |
86,650,522 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6530:Vmn2r79
|
UTSW |
7 |
86,651,252 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6546:Vmn2r79
|
UTSW |
7 |
86,652,741 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6682:Vmn2r79
|
UTSW |
7 |
86,653,370 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6858:Vmn2r79
|
UTSW |
7 |
86,686,580 (GRCm39) |
missense |
probably benign |
|
|
R6965:Vmn2r79
|
UTSW |
7 |
86,651,100 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7130:Vmn2r79
|
UTSW |
7 |
86,651,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7156:Vmn2r79
|
UTSW |
7 |
86,686,851 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7604:Vmn2r79
|
UTSW |
7 |
86,652,592 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7691:Vmn2r79
|
UTSW |
7 |
86,687,111 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8055:Vmn2r79
|
UTSW |
7 |
86,686,541 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8070:Vmn2r79
|
UTSW |
7 |
86,651,336 (GRCm39) |
missense |
probably benign |
|
|
R8073:Vmn2r79
|
UTSW |
7 |
86,651,462 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8145:Vmn2r79
|
UTSW |
7 |
86,686,862 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8263:Vmn2r79
|
UTSW |
7 |
86,686,726 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8350:Vmn2r79
|
UTSW |
7 |
86,686,741 (GRCm39) |
nonsense |
probably null |
|
|
R8400:Vmn2r79
|
UTSW |
7 |
86,651,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8814:Vmn2r79
|
UTSW |
7 |
86,651,714 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8862:Vmn2r79
|
UTSW |
7 |
86,645,712 (GRCm39) |
missense |
probably benign |
0.23 |
|
R9146:Vmn2r79
|
UTSW |
7 |
86,650,681 (GRCm39) |
nonsense |
probably null |
|
|
R9276:Vmn2r79
|
UTSW |
7 |
86,687,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9361:Vmn2r79
|
UTSW |
7 |
86,652,822 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9676:Vmn2r79
|
UTSW |
7 |
86,686,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
U15987:Vmn2r79
|
UTSW |
7 |
86,653,319 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
X0054:Vmn2r79
|
UTSW |
7 |
86,653,270 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1088:Vmn2r79
|
UTSW |
7 |
86,651,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r79
|
UTSW |
7 |
86,686,377 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Vmn2r79
|
UTSW |
7 |
86,651,526 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACACTGTCTGCTTAGCATTTGTAAC -3'
(R):5'- TTACAATCAGGTGGTGGCAAAG -3'
Sequencing Primer
(F):5'- CAGCAAAAGTTGTCATTGTCT -3'
(R):5'- TGGCAAAGAACACTTAAAGTAAGTCC -3'
|
| Posted On |
2018-04-27 |
Incidental Mutation