Incidental Mutation 'R6339:Dok2'
ID513847
Institutional Source Beutler Lab
Gene Symbol Dok2
Ensembl Gene ENSMUSG00000022102
Gene Namedocking protein 2
SynonymsFrip, DokR, Frip
MMRRC Submission
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.324) question?
Stock #R6339 (G1)
Quality Score199.009
Status Validated
Chromosome14
Chromosomal Location70766036-70778495 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 70775718 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Leucine at position 109 (I109L)
Ref Sequence ENSEMBL: ENSMUSP00000022698 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022698]
Predicted Effect probably benign
Transcript: ENSMUST00000022698
AA Change: I109L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000022698
Gene: ENSMUSG00000022102
AA Change: I109L

DomainStartEndE-ValueType
PH 8 119 2.32e-9 SMART
PTBI 150 249 3.65e-42 SMART
IRS 153 249 5.18e-36 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000164691
Predicted Effect noncoding transcript
Transcript: ENSMUST00000165654
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168355
Predicted Effect noncoding transcript
Transcript: ENSMUST00000169106
Predicted Effect noncoding transcript
Transcript: ENSMUST00000169599
Predicted Effect noncoding transcript
Transcript: ENSMUST00000171481
Predicted Effect noncoding transcript
Transcript: ENSMUST00000171864
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.7%
  • 10x: 98.2%
  • 20x: 94.1%
Validation Efficiency 97% (69/71)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice display abnormal granulocyte physiology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931408C20Rik T A 1: 26,682,505 D1198V probably benign Het
4933424G06Rik A T 1: 36,710,461 probably benign Het
Adgrg6 G T 10: 14,434,347 S743R probably damaging Het
Ak8 A G 2: 28,734,448 probably null Het
Alpk2 A G 18: 65,349,806 M377T probably benign Het
Ap1g1 G A 8: 109,844,368 V425I possibly damaging Het
Apob A T 12: 8,016,188 R4353W probably damaging Het
Arhgef38 T C 3: 133,133,662 K540R probably benign Het
AY761184 G A 8: 21,703,469 S45F possibly damaging Het
B3galt2 A T 1: 143,646,902 T259S possibly damaging Het
Btbd8 G A 5: 107,503,717 V159I probably benign Het
C2cd2l T C 9: 44,313,491 probably benign Het
Carmil3 T C 14: 55,499,849 V763A possibly damaging Het
Ccdc171 A T 4: 83,742,997 T1115S probably damaging Het
Chst2 C T 9: 95,405,750 G181D probably damaging Het
Col7a1 C T 9: 108,956,633 T390M unknown Het
Cpt1a A C 19: 3,362,152 D208A probably benign Het
Crocc2 A G 1: 93,214,032 E1183G probably benign Het
Dlg5 T A 14: 24,158,060 H1003L probably damaging Het
Dpy19l4 A T 4: 11,285,111 I465K probably damaging Het
Dync1h1 A T 12: 110,646,205 D2838V probably damaging Het
Frem3 A G 8: 80,613,015 R646G possibly damaging Het
Gcfc2 T A 6: 81,946,496 F514I probably damaging Het
Gm8104 T C 14: 43,101,485 M44T probably benign Het
Golph3l T A 3: 95,617,439 W334R probably damaging Het
Gpr179 A T 11: 97,344,176 F443I probably damaging Het
Ift172 A G 5: 31,256,583 V1467A probably benign Het
Ift172 A T 5: 31,286,945 D44E probably damaging Het
Il1rl1 C T 1: 40,461,856 A464V possibly damaging Het
Irx5 A G 8: 92,359,853 E188G probably damaging Het
Jak1 A G 4: 101,161,926 V710A probably damaging Het
Kcng4 A T 8: 119,632,954 F228I probably damaging Het
Lifr A G 15: 7,167,049 N238S probably benign Het
Ltbp3 C A 19: 5,747,477 H414Q probably damaging Het
Mcpt8 A G 14: 56,082,337 C219R probably benign Het
Mepce A T 5: 137,785,688 N125K possibly damaging Het
Mfap3 T C 11: 57,529,772 F193S probably damaging Het
Miox T A 15: 89,335,499 Y63* probably null Het
Msl2 A T 9: 101,101,750 H441L probably benign Het
Nemp2 T A 1: 52,640,910 S98T possibly damaging Het
Neto2 G T 8: 85,640,558 A547E probably benign Het
Nol12 T C 15: 78,940,833 probably benign Het
Npr3 T C 15: 11,845,275 I504V probably damaging Het
Olfr1204 A G 2: 88,852,871 D307G probably null Het
Pcdhb3 T C 18: 37,300,945 probably benign Het
Pear1 C A 3: 87,752,520 G720W probably damaging Het
Pibf1 T G 14: 99,107,398 D151E probably damaging Het
Pla2g6 T A 15: 79,308,816 N217I probably damaging Het
Plcd1 G A 9: 119,074,991 R292C probably damaging Het
Plcl1 C T 1: 55,696,315 L272F probably damaging Het
Ppp4r4 A T 12: 103,604,969 K656* probably null Het
Prr22 G A 17: 56,771,490 M214I probably benign Het
Ror1 G T 4: 100,411,931 R322L possibly damaging Het
Sh3tc2 G A 18: 61,975,571 W244* probably null Het
Slamf6 A G 1: 171,948,048 N320S probably null Het
Slc1a6 A C 10: 78,800,085 D328A possibly damaging Het
Sorl1 G T 9: 41,969,742 T2161K probably benign Het
Sstr2 T C 11: 113,624,549 F98S probably damaging Het
Stk33 A T 7: 109,321,465 D348E probably benign Het
Sulf1 T A 1: 12,838,440 L559Q probably damaging Het
Syne2 A G 12: 75,989,153 D3738G probably benign Het
Taok3 A T 5: 117,228,030 Q382L probably benign Het
Tet2 T A 3: 133,486,417 H752L possibly damaging Het
Tia1 A C 6: 86,426,656 K285T probably damaging Het
Tle3 G T 9: 61,401,924 probably null Het
Top1mt T C 15: 75,665,656 T414A possibly damaging Het
Ubc A T 5: 125,387,342 I307N probably damaging Het
Vmn2r96 A T 17: 18,583,862 D266V possibly damaging Het
Wbp2nl G T 15: 82,299,045 W13C possibly damaging Het
Zfp456 T A 13: 67,362,364 K102* probably null Het
Zkscan1 T C 5: 138,093,305 V100A probably damaging Het
Other mutations in Dok2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02095:Dok2 APN 14 70777861 missense possibly damaging 0.89
R1580:Dok2 UTSW 14 70776957 missense probably benign 0.19
R1631:Dok2 UTSW 14 70776953 missense probably damaging 1.00
R4783:Dok2 UTSW 14 70777874 missense probably benign 0.27
R4784:Dok2 UTSW 14 70777874 missense probably benign 0.27
R4860:Dok2 UTSW 14 70777516 missense probably damaging 1.00
R4860:Dok2 UTSW 14 70777516 missense probably damaging 1.00
R6939:Dok2 UTSW 14 70775605 missense probably benign 0.38
R7304:Dok2 UTSW 14 70776028 missense probably benign
R8046:Dok2 UTSW 14 70778042 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCGCAGCCGTGTTATATGGAG -3'
(R):5'- TCAAACTGGGCTCCCTTAAG -3'

Sequencing Primer
(F):5'- AGACTAGAGCTCCAGGATGTCC -3'
(R):5'- TGGGCTCCCTTAAGGAAGAACTC -3'
Posted On2018-04-27