Incidental Mutation 'R6342:Kynu'
ID 513906
Institutional Source Beutler Lab
Gene Symbol Kynu
Ensembl Gene ENSMUSG00000026866
Gene Name kynureninase
Synonyms L-kynurenine hydrolase, 4432411A05Rik
MMRRC Submission 044496-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6342 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 43445341-43572734 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 43571463 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Tyrosine at position 460 (D460Y)
Ref Sequence ENSEMBL: ENSMUSP00000028223 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028223] [ENSMUST00000112826]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000028223
AA Change: D460Y

PolyPhen 2 Score 0.088 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000028223
Gene: ENSMUSG00000026866
AA Change: D460Y

DomainStartEndE-ValueType
Pfam:Aminotran_5 70 400 3.8e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000112826
SMART Domains Protein: ENSMUSP00000108445
Gene: ENSMUSG00000026866

DomainStartEndE-ValueType
Pfam:Aminotran_5 70 405 8.4e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148855
Meta Mutation Damage Score 0.1148 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.1%
Validation Efficiency 97% (31/32)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anxa9 T C 3: 95,204,101 (GRCm39) *346W probably null Het
Ap4b1 T C 3: 103,720,684 (GRCm39) V118A possibly damaging Het
Atrnl1 T C 19: 57,626,942 (GRCm39) S183P probably damaging Het
Cadm3 T C 1: 173,168,675 (GRCm39) T298A possibly damaging Het
Crtc1 A C 8: 70,892,207 (GRCm39) M1R probably null Het
Dalrd3 A T 9: 108,448,322 (GRCm39) K291* probably null Het
Dhrs9 C T 2: 69,223,531 (GRCm39) T93M probably benign Het
Dnmt1 G T 9: 20,821,089 (GRCm39) S1267* probably null Het
Dsg1b T C 18: 20,523,300 (GRCm39) I109T probably damaging Het
Epha3 C A 16: 63,403,863 (GRCm39) R745L probably damaging Het
Evi2 A G 11: 79,406,784 (GRCm39) S264P probably benign Het
Grin2a A T 16: 9,397,198 (GRCm39) L963Q probably damaging Het
Klhdc7a T A 4: 139,694,370 (GRCm39) R192S probably benign Het
Lrfn2 G A 17: 49,404,028 (GRCm39) G717D probably benign Het
Lrp3 C T 7: 34,901,731 (GRCm39) D696N probably benign Het
Ogfrl1 T G 1: 23,408,944 (GRCm39) K427N probably benign Het
Or51a5 T C 7: 102,771,563 (GRCm39) T143A probably damaging Het
Rad17 A T 13: 100,755,644 (GRCm39) I579N probably damaging Het
Rif1 T A 2: 52,009,168 (GRCm39) Y2316N probably damaging Het
Ros1 T A 10: 52,031,351 (GRCm39) D430V probably damaging Het
Rp9 A T 9: 22,361,154 (GRCm39) H44Q probably damaging Het
Rtl1 T C 12: 109,558,735 (GRCm39) T1035A possibly damaging Het
Slc2a5 A C 4: 150,223,983 (GRCm39) D225A possibly damaging Het
Tlx3 A T 11: 33,152,567 (GRCm39) V176E possibly damaging Het
Trpv3 G A 11: 73,174,689 (GRCm39) G352D probably damaging Het
Ubr4 C A 4: 139,156,850 (GRCm39) H2292N possibly damaging Het
Wee2 A G 6: 40,421,189 (GRCm39) H93R probably benign Het
Xirp2 T G 2: 67,341,994 (GRCm39) L1412V possibly damaging Het
Zfat T C 15: 68,052,831 (GRCm39) H321R probably damaging Het
Zfp623 C A 15: 75,819,837 (GRCm39) C264* probably null Het
Zfp687 G C 3: 94,919,188 (GRCm39) P195A probably benign Het
Other mutations in Kynu
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01524:Kynu APN 2 43,561,394 (GRCm39) missense possibly damaging 0.91
IGL01974:Kynu APN 2 43,571,352 (GRCm39) unclassified probably benign
R0099:Kynu UTSW 2 43,519,065 (GRCm39) critical splice donor site probably null
R0304:Kynu UTSW 2 43,569,893 (GRCm39) missense probably damaging 0.99
R1681:Kynu UTSW 2 43,569,837 (GRCm39) missense probably damaging 1.00
R1799:Kynu UTSW 2 43,494,169 (GRCm39) missense possibly damaging 0.65
R2016:Kynu UTSW 2 43,494,289 (GRCm39) nonsense probably null
R2345:Kynu UTSW 2 43,471,397 (GRCm39) missense probably damaging 1.00
R3085:Kynu UTSW 2 43,492,312 (GRCm39) missense probably benign 0.00
R3825:Kynu UTSW 2 43,571,451 (GRCm39) missense probably benign
R4091:Kynu UTSW 2 43,569,884 (GRCm39) missense possibly damaging 0.94
R4241:Kynu UTSW 2 43,571,422 (GRCm39) missense probably benign 0.00
R4594:Kynu UTSW 2 43,569,902 (GRCm39) missense probably benign 0.00
R4673:Kynu UTSW 2 43,569,815 (GRCm39) missense probably damaging 1.00
R4871:Kynu UTSW 2 43,569,830 (GRCm39) missense possibly damaging 0.58
R5371:Kynu UTSW 2 43,479,406 (GRCm39) missense probably benign 0.00
R6272:Kynu UTSW 2 43,525,001 (GRCm39) missense probably benign 0.01
R6866:Kynu UTSW 2 43,453,122 (GRCm39) nonsense probably null
R7203:Kynu UTSW 2 43,571,365 (GRCm39) missense probably damaging 1.00
R8163:Kynu UTSW 2 43,518,966 (GRCm39) missense probably damaging 1.00
R9024:Kynu UTSW 2 43,490,807 (GRCm39) missense possibly damaging 0.62
R9089:Kynu UTSW 2 43,489,620 (GRCm39) missense probably damaging 1.00
R9303:Kynu UTSW 2 43,569,768 (GRCm39) missense probably damaging 0.99
R9305:Kynu UTSW 2 43,569,768 (GRCm39) missense probably damaging 0.99
R9506:Kynu UTSW 2 43,571,414 (GRCm39) missense probably damaging 1.00
R9702:Kynu UTSW 2 43,479,469 (GRCm39) missense probably damaging 1.00
R9759:Kynu UTSW 2 43,569,881 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ACAATGACAAACATAGGTGCTCATG -3'
(R):5'- AAGCATGCACCAGGTTTTATG -3'

Sequencing Primer
(F):5'- GCTCATGTATTACATTTGAGGGAAG -3'
(R):5'- ACTCCATCACCTTTCAGTG -3'
Posted On 2018-04-27