Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01060:Vmn2r56'

51408

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r56

Ensembl Gene

ENSMUSG00000090762

Gene Name

vomeronasal 2, receptor 56

Synonyms

EG629079

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.087) question?

Stock #

IGL01060

Quality Score

Status

Chromosome

Chromosomal Location

12693998-12733105 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 12713089 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 379 (I379F)

Ref Sequence

ENSEMBL: ENSMUSP00000129566 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000163852]

AlphaFold

A0A3B2WBA1

Predicted Effect

probably damaging
Transcript: ENSMUST00000163852
AA Change: I379F

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000129566
Gene: ENSMUSG00000090762
AA Change: I379F

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	5	397	1.9e-55	PFAM
Pfam:NCD3G	439	492	6.4e-20	PFAM
Pfam:7tm_3	523	760	1.3e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110038F14Rik	G	A	15: 76,950,275	V124I	probably damaging	Het
Anks4b	A	G	7: 120,173,925	T3A	possibly damaging	Het
Arhgef26	T	A	3: 62,340,121	S209T	probably benign	Het
Ccdc78	A	G	17: 25,788,832	D281G	probably damaging	Het
Ccnb3	A	T	X: 6,980,274	N1362K	probably benign	Het
Dnah2	T	C	11: 69,478,092	N1662S	possibly damaging	Het
Ern2	T	A	7: 122,170,092	R904W	probably damaging	Het
Fam120c	C	T	X: 151,469,587	P1045S	probably benign	Het
Gm12887	C	T	4: 121,616,413		probably benign	Het
Gpld1	G	A	13: 24,982,566	G627S	probably damaging	Het
Ikbkap	C	T	4: 56,784,537		probably null	Het
Krt77	T	A	15: 101,860,880		probably benign	Het
Ltf	A	T	9: 111,022,882		probably null	Het
Map3k6	G	T	4: 133,247,302		probably null	Het
Nsd1	G	A	13: 55,263,429	G1431D	probably damaging	Het
Plekhm2	C	T	4: 141,642,645		probably null	Het
Popdc2	T	A	16: 38,373,965	N249K	probably damaging	Het
Ppm1h	A	G	10: 122,907,571	D400G	possibly damaging	Het
Rps6ka1	A	T	4: 133,860,870	S320T	probably damaging	Het
Rsph6a	C	T	7: 19,054,868	R42*	probably null	Het
Sap130	T	C	18: 31,715,443	L967P	probably damaging	Het
Smyd2	T	C	1: 189,897,470	E121G	possibly damaging	Het
Sspo	G	A	6: 48,449,479	W144*	probably null	Het
Taar6	A	G	10: 23,985,072	V192A	probably benign	Het
Tbc1d24	A	T	17: 24,185,828	V114E	probably damaging	Het
Trim16	T	C	11: 62,820,704	I67T	probably benign	Het
Ttll7	A	G	3: 146,909,582	D267G	possibly damaging	Het
Ttn	T	C	2: 76,889,729		probably benign	Het
Zfp14	T	C	7: 30,038,085	T492A	probably damaging	Het

Other mutations in Vmn2r56

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00902:Vmn2r56	APN	7	12715499	missense	probably benign	0.38
IGL01433:Vmn2r56	APN	7	12715614	missense	probably benign
IGL01859:Vmn2r56	APN	7	12716005	missense	probably damaging	1.00
IGL01874:Vmn2r56	APN	7	12715675	missense	probably benign	0.03
IGL02208:Vmn2r56	APN	7	12715481	missense	probably benign	0.01
PIT4445001:Vmn2r56	UTSW	7	12715226	critical splice donor site	probably null
R0077:Vmn2r56	UTSW	7	12715405	missense	probably benign	0.01
R0278:Vmn2r56	UTSW	7	12715717	missense	probably damaging	0.99
R0512:Vmn2r56	UTSW	7	12715423	missense	probably benign
R0658:Vmn2r56	UTSW	7	12710308	missense	probably benign	0.10
R0789:Vmn2r56	UTSW	7	12732835	missense	probably damaging	1.00
R1534:Vmn2r56	UTSW	7	12694027	missense	probably benign
R1731:Vmn2r56	UTSW	7	12733045	missense	probably benign
R1817:Vmn2r56	UTSW	7	12715615	missense	probably benign
R2047:Vmn2r56	UTSW	7	12732991	missense	probably damaging	1.00
R2139:Vmn2r56	UTSW	7	12712963	nonsense	probably null
R2160:Vmn2r56	UTSW	7	12694219	missense	probably benign	0.43
R2449:Vmn2r56	UTSW	7	12694155	missense	possibly damaging	0.67
R2877:Vmn2r56	UTSW	7	12711027	missense	probably benign
R2878:Vmn2r56	UTSW	7	12711027	missense	probably benign
R4910:Vmn2r56	UTSW	7	12715535	missense	possibly damaging	0.64
R5072:Vmn2r56	UTSW	7	12694056	missense	probably benign	0.40
R5340:Vmn2r56	UTSW	7	12715872	missense	probably damaging	1.00
R5697:Vmn2r56	UTSW	7	12715990	missense	probably damaging	1.00
R5798:Vmn2r56	UTSW	7	12712965	missense	probably benign	0.00
R6166:Vmn2r56	UTSW	7	12694020	missense	probably damaging	1.00
R6290:Vmn2r56	UTSW	7	12694882	missense	probably damaging	1.00
R6458:Vmn2r56	UTSW	7	12694057	missense	probably damaging	0.99
R6751:Vmn2r56	UTSW	7	12694792	missense	probably benign
R6978:Vmn2r56	UTSW	7	12715406	missense	probably benign	0.01
R7090:Vmn2r56	UTSW	7	12715327	missense	probably damaging	1.00
R7200:Vmn2r56	UTSW	7	12710332	missense	probably damaging	1.00
R7861:Vmn2r56	UTSW	7	12715424	missense	probably benign	0.00
R8222:Vmn2r56	UTSW	7	12711033	missense	probably benign
R8282:Vmn2r56	UTSW	7	12715674	nonsense	probably null
R8786:Vmn2r56	UTSW	7	12715466	missense	probably damaging	1.00
R8970:Vmn2r56	UTSW	7	12694705	missense	probably damaging	1.00
R9230:Vmn2r56	UTSW	7	12710310	missense	possibly damaging	0.70
RF002:Vmn2r56	UTSW	7	12694830	missense	probably benign	0.02

Posted On

2013-06-21