Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01060:Zfp14'

51409

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp14

Ensembl Gene

ENSMUSG00000053985

Gene Name

zinc finger protein 14

Synonyms

4732429I09Rik, Zfp-14, Krox-9

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01060

Quality Score

Status

Chromosome

Chromosomal Location

30036359-30051380 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 30038085 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 492 (T492A)

Ref Sequence

ENSEMBL: ENSMUSP00000146824 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077787] [ENSMUST00000207072] [ENSMUST00000207873]

AlphaFold

P10755

Predicted Effect

probably damaging
Transcript: ENSMUST00000077787
AA Change: T492A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000076960
Gene: ENSMUSG00000053985
AA Change: T492A

Domain	Start	End	E-Value	Type
KRAB	8	69	2.39e-21	SMART
ZnF_C2H2	140	162	8.47e-4	SMART
ZnF_C2H2	168	190	5.9e-3	SMART
ZnF_C2H2	196	218	2.75e-3	SMART
ZnF_C2H2	224	246	6.42e-4	SMART
ZnF_C2H2	252	274	1.03e-2	SMART
ZnF_C2H2	280	302	5.5e-3	SMART
ZnF_C2H2	308	330	2.02e-1	SMART
ZnF_C2H2	336	358	8.6e-5	SMART
ZnF_C2H2	364	386	4.17e-3	SMART
ZnF_C2H2	392	414	2.57e-3	SMART
ZnF_C2H2	420	442	9.44e-2	SMART
ZnF_C2H2	448	470	1.03e-2	SMART
ZnF_C2H2	476	498	5.9e-3	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000207072
AA Change: T492A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

Predicted Effect

probably damaging
Transcript: ENSMUST00000207873
AA Change: T492A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110038F14Rik	G	A	15: 76,950,275	V124I	probably damaging	Het
Anks4b	A	G	7: 120,173,925	T3A	possibly damaging	Het
Arhgef26	T	A	3: 62,340,121	S209T	probably benign	Het
Ccdc78	A	G	17: 25,788,832	D281G	probably damaging	Het
Ccnb3	A	T	X: 6,980,274	N1362K	probably benign	Het
Dnah2	T	C	11: 69,478,092	N1662S	possibly damaging	Het
Ern2	T	A	7: 122,170,092	R904W	probably damaging	Het
Fam120c	C	T	X: 151,469,587	P1045S	probably benign	Het
Gm12887	C	T	4: 121,616,413		probably benign	Het
Gpld1	G	A	13: 24,982,566	G627S	probably damaging	Het
Ikbkap	C	T	4: 56,784,537		probably null	Het
Krt77	T	A	15: 101,860,880		probably benign	Het
Ltf	A	T	9: 111,022,882		probably null	Het
Map3k6	G	T	4: 133,247,302		probably null	Het
Nsd1	G	A	13: 55,263,429	G1431D	probably damaging	Het
Plekhm2	C	T	4: 141,642,645		probably null	Het
Popdc2	T	A	16: 38,373,965	N249K	probably damaging	Het
Ppm1h	A	G	10: 122,907,571	D400G	possibly damaging	Het
Rps6ka1	A	T	4: 133,860,870	S320T	probably damaging	Het
Rsph6a	C	T	7: 19,054,868	R42*	probably null	Het
Sap130	T	C	18: 31,715,443	L967P	probably damaging	Het
Smyd2	T	C	1: 189,897,470	E121G	possibly damaging	Het
Sspo	G	A	6: 48,449,479	W144*	probably null	Het
Taar6	A	G	10: 23,985,072	V192A	probably benign	Het
Tbc1d24	A	T	17: 24,185,828	V114E	probably damaging	Het
Trim16	T	C	11: 62,820,704	I67T	probably benign	Het
Ttll7	A	G	3: 146,909,582	D267G	possibly damaging	Het
Ttn	T	C	2: 76,889,729		probably benign	Het
Vmn2r56	T	A	7: 12,713,089	I379F	probably damaging	Het

Other mutations in Zfp14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00790:Zfp14	APN	7	30038887	nonsense	probably null
IGL01018:Zfp14	APN	7	30038101	missense	probably damaging	1.00
IGL03223:Zfp14	APN	7	30038433	missense	probably damaging	1.00
R0052:Zfp14	UTSW	7	30038328	missense	probably damaging	0.99
R0052:Zfp14	UTSW	7	30038328	missense	probably damaging	0.99
R1860:Zfp14	UTSW	7	30038691	missense	probably damaging	1.00
R2852:Zfp14	UTSW	7	30039171	missense	probably benign	0.01
R2887:Zfp14	UTSW	7	30038765	missense	probably damaging	0.98
R4585:Zfp14	UTSW	7	30038916	missense	probably damaging	0.99
R4586:Zfp14	UTSW	7	30038916	missense	probably damaging	0.99
R4625:Zfp14	UTSW	7	30038595	nonsense	probably null
R4988:Zfp14	UTSW	7	30038057	missense	probably benign
R5791:Zfp14	UTSW	7	30038262	missense	probably damaging	0.99
R6709:Zfp14	UTSW	7	30038132	missense	probably damaging	1.00
R7799:Zfp14	UTSW	7	30038943	missense	possibly damaging	0.87
R8375:Zfp14	UTSW	7	30039154	missense	possibly damaging	0.87
R8784:Zfp14	UTSW	7	30043536	missense	probably damaging	1.00
R8997:Zfp14	UTSW	7	30038175	missense	probably damaging	1.00
R9721:Zfp14	UTSW	7	30039184	missense	probably benign	0.00
X0017:Zfp14	UTSW	7	30038657	missense	probably damaging	0.98
Z1186:Zfp14	UTSW	7	30039152	missense	probably damaging	0.98

Posted On

2013-06-21