Incidental Mutation 'IGL01060:Zfp14'
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ID51409
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp14
Ensembl Gene ENSMUSG00000053985
Gene Namezinc finger protein 14
Synonyms4732429I09Rik, Zfp-14, Krox-9
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01060
Quality Score
Status
Chromosome7
Chromosomal Location30036359-30051380 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 30038085 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 492 (T492A)
Ref Sequence ENSEMBL: ENSMUSP00000146824 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077787] [ENSMUST00000207072] [ENSMUST00000207873]
Predicted Effect probably damaging
Transcript: ENSMUST00000077787
AA Change: T492A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000076960
Gene: ENSMUSG00000053985
AA Change: T492A

DomainStartEndE-ValueType
KRAB 8 69 2.39e-21 SMART
ZnF_C2H2 140 162 8.47e-4 SMART
ZnF_C2H2 168 190 5.9e-3 SMART
ZnF_C2H2 196 218 2.75e-3 SMART
ZnF_C2H2 224 246 6.42e-4 SMART
ZnF_C2H2 252 274 1.03e-2 SMART
ZnF_C2H2 280 302 5.5e-3 SMART
ZnF_C2H2 308 330 2.02e-1 SMART
ZnF_C2H2 336 358 8.6e-5 SMART
ZnF_C2H2 364 386 4.17e-3 SMART
ZnF_C2H2 392 414 2.57e-3 SMART
ZnF_C2H2 420 442 9.44e-2 SMART
ZnF_C2H2 448 470 1.03e-2 SMART
ZnF_C2H2 476 498 5.9e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000207072
AA Change: T492A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000207873
AA Change: T492A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,950,275 V124I probably damaging Het
Anks4b A G 7: 120,173,925 T3A possibly damaging Het
Arhgef26 T A 3: 62,340,121 S209T probably benign Het
Ccdc78 A G 17: 25,788,832 D281G probably damaging Het
Ccnb3 A T X: 6,980,274 N1362K probably benign Het
Dnah2 T C 11: 69,478,092 N1662S possibly damaging Het
Ern2 T A 7: 122,170,092 R904W probably damaging Het
Fam120c C T X: 151,469,587 P1045S probably benign Het
Gm12887 C T 4: 121,616,413 probably benign Het
Gpld1 G A 13: 24,982,566 G627S probably damaging Het
Ikbkap C T 4: 56,784,537 probably null Het
Krt77 T A 15: 101,860,880 probably benign Het
Ltf A T 9: 111,022,882 probably null Het
Map3k6 G T 4: 133,247,302 probably null Het
Nsd1 G A 13: 55,263,429 G1431D probably damaging Het
Plekhm2 C T 4: 141,642,645 probably null Het
Popdc2 T A 16: 38,373,965 N249K probably damaging Het
Ppm1h A G 10: 122,907,571 D400G possibly damaging Het
Rps6ka1 A T 4: 133,860,870 S320T probably damaging Het
Rsph6a C T 7: 19,054,868 R42* probably null Het
Sap130 T C 18: 31,715,443 L967P probably damaging Het
Smyd2 T C 1: 189,897,470 E121G possibly damaging Het
Sspo G A 6: 48,449,479 W144* probably null Het
Taar6 A G 10: 23,985,072 V192A probably benign Het
Tbc1d24 A T 17: 24,185,828 V114E probably damaging Het
Trim16 T C 11: 62,820,704 I67T probably benign Het
Ttll7 A G 3: 146,909,582 D267G possibly damaging Het
Ttn T C 2: 76,889,729 probably benign Het
Vmn2r56 T A 7: 12,713,089 I379F probably damaging Het
Other mutations in Zfp14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00790:Zfp14 APN 7 30038887 nonsense probably null
IGL01018:Zfp14 APN 7 30038101 missense probably damaging 1.00
IGL03223:Zfp14 APN 7 30038433 missense probably damaging 1.00
R0052:Zfp14 UTSW 7 30038328 missense probably damaging 0.99
R0052:Zfp14 UTSW 7 30038328 missense probably damaging 0.99
R1860:Zfp14 UTSW 7 30038691 missense probably damaging 1.00
R2852:Zfp14 UTSW 7 30039171 missense probably benign 0.01
R2887:Zfp14 UTSW 7 30038765 missense probably damaging 0.98
R4585:Zfp14 UTSW 7 30038916 missense probably damaging 0.99
R4586:Zfp14 UTSW 7 30038916 missense probably damaging 0.99
R4625:Zfp14 UTSW 7 30038595 nonsense probably null
R4988:Zfp14 UTSW 7 30038057 missense probably benign
R5791:Zfp14 UTSW 7 30038262 missense probably damaging 0.99
R6709:Zfp14 UTSW 7 30038132 missense probably damaging 1.00
R7799:Zfp14 UTSW 7 30038943 missense possibly damaging 0.87
R8375:Zfp14 UTSW 7 30039154 missense possibly damaging 0.87
R8784:Zfp14 UTSW 7 30043536 missense probably damaging 1.00
X0017:Zfp14 UTSW 7 30038657 missense probably damaging 0.98
Z1186:Zfp14 UTSW 7 30039152 missense probably damaging 0.98
Posted On2013-06-21