Incidental Mutation 'IGL01060:Rsph6a'
| ID |
51411 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Rsph6a
|
| Ensembl Gene |
ENSMUSG00000040866 |
| Gene Name |
radial spoke head 6 homolog A (Chlamydomonas) |
| Synonyms |
Rshl1, RSP4 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
IGL01060
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
18788615-18808372 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 18788793 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Stop codon
at position 42
(R42*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076153
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023882]
[ENSMUST00000035521]
[ENSMUST00000076887]
[ENSMUST00000146903]
|
| AlphaFold |
Q8CDR2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000023882
|
| SMART Domains |
Protein: ENSMUSP00000023882
Gene: ENSMUSG00000023118
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
106 |
118 |
N/A |
INTRINSIC |
|
Pfam:DUF3453
|
119 |
352 |
1.1e-63 |
PFAM |
|
low complexity region
|
473 |
485 |
N/A |
INTRINSIC |
|
Pfam:Symplekin_C
|
887 |
1068 |
4.3e-78 |
PFAM |
|
low complexity region
|
1123 |
1149 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000035521
AA Change: R42*
|
| SMART Domains |
Protein: ENSMUSP00000046526
Gene: ENSMUSG00000040866
AA Change: R42*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Pfam:Radial_spoke
|
191 |
685 |
2.3e-200 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000076887
AA Change: R42*
|
| SMART Domains |
Protein: ENSMUSP00000076153
Gene: ENSMUSG00000040866
AA Change: R42*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Pfam:Radial_spoke
|
188 |
287 |
3e-18 |
PFAM |
|
Pfam:Radial_spoke
|
285 |
433 |
4.6e-53 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000130328
|
| SMART Domains |
Protein: ENSMUSP00000115900
Gene: ENSMUSG00000023118
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Symplekin_C
|
1 |
92 |
3.9e-44 |
PFAM |
|
low complexity region
|
125 |
143 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131230
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138440
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144991
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148861
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000146903
|
| SMART Domains |
Protein: ENSMUSP00000138740
Gene: ENSMUSG00000023118
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3453
|
117 |
230 |
1.1e-35 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is similar to a sea urchin radial spoke head protein. Radial spoke protein complexes form part of the axoneme of eukaryotic flagella and are located between the axoneme's outer ring of doublet microtubules and central pair of microtubules. In Chlamydomonas, radial spoke proteins are thought to regulate the activity of dynein and the symmetry of flagellar bending patterns. This gene maps to a region of chromosome 19 that is linked to primary ciliary dyskinesia-2 (CILD2). [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110038F14Rik |
G |
A |
15: 76,834,475 (GRCm39) |
V124I |
probably damaging |
Het |
| Anks4b |
A |
G |
7: 119,773,148 (GRCm39) |
T3A |
possibly damaging |
Het |
| Arhgef26 |
T |
A |
3: 62,247,542 (GRCm39) |
S209T |
probably benign |
Het |
| Ccdc78 |
A |
G |
17: 26,007,806 (GRCm39) |
D281G |
probably damaging |
Het |
| Ccnb3 |
A |
T |
X: 6,846,513 (GRCm39) |
N1362K |
probably benign |
Het |
| Dnah2 |
T |
C |
11: 69,368,918 (GRCm39) |
N1662S |
possibly damaging |
Het |
| Elp1 |
C |
T |
4: 56,784,537 (GRCm39) |
|
probably null |
Het |
| Ern2 |
T |
A |
7: 121,769,315 (GRCm39) |
R904W |
probably damaging |
Het |
| Fam120c |
C |
T |
X: 150,252,583 (GRCm39) |
P1045S |
probably benign |
Het |
| Gm12887 |
C |
T |
4: 121,473,610 (GRCm39) |
|
probably benign |
Het |
| Gpld1 |
G |
A |
13: 25,166,549 (GRCm39) |
G627S |
probably damaging |
Het |
| Krt77 |
T |
A |
15: 101,769,315 (GRCm39) |
|
probably benign |
Het |
| Ltf |
A |
T |
9: 110,851,950 (GRCm39) |
|
probably null |
Het |
| Map3k6 |
G |
T |
4: 132,974,613 (GRCm39) |
|
probably null |
Het |
| Nsd1 |
G |
A |
13: 55,411,242 (GRCm39) |
G1431D |
probably damaging |
Het |
| Plekhm2 |
C |
T |
4: 141,369,956 (GRCm39) |
|
probably null |
Het |
| Popdc2 |
T |
A |
16: 38,194,327 (GRCm39) |
N249K |
probably damaging |
Het |
| Ppm1h |
A |
G |
10: 122,743,476 (GRCm39) |
D400G |
possibly damaging |
Het |
| Rps6ka1 |
A |
T |
4: 133,588,181 (GRCm39) |
S320T |
probably damaging |
Het |
| Sap130 |
T |
C |
18: 31,848,496 (GRCm39) |
L967P |
probably damaging |
Het |
| Smyd2 |
T |
C |
1: 189,629,667 (GRCm39) |
E121G |
possibly damaging |
Het |
| Sspo |
G |
A |
6: 48,426,413 (GRCm39) |
W144* |
probably null |
Het |
| Taar6 |
A |
G |
10: 23,860,970 (GRCm39) |
V192A |
probably benign |
Het |
| Tbc1d24 |
A |
T |
17: 24,404,802 (GRCm39) |
V114E |
probably damaging |
Het |
| Trim16 |
T |
C |
11: 62,711,530 (GRCm39) |
I67T |
probably benign |
Het |
| Ttll7 |
A |
G |
3: 146,615,337 (GRCm39) |
D267G |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,720,073 (GRCm39) |
|
probably benign |
Het |
| Vmn2r56 |
T |
A |
7: 12,447,016 (GRCm39) |
I379F |
probably damaging |
Het |
| Zfp14 |
T |
C |
7: 29,737,510 (GRCm39) |
T492A |
probably damaging |
Het |
|
| Other mutations in Rsph6a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01656:Rsph6a
|
APN |
7 |
18,788,770 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02997:Rsph6a
|
APN |
7 |
18,788,764 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0396:Rsph6a
|
UTSW |
7 |
18,808,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0467:Rsph6a
|
UTSW |
7 |
18,791,594 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0545:Rsph6a
|
UTSW |
7 |
18,788,871 (GRCm39) |
nonsense |
probably null |
|
|
R0603:Rsph6a
|
UTSW |
7 |
18,799,886 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0848:Rsph6a
|
UTSW |
7 |
18,791,595 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1943:Rsph6a
|
UTSW |
7 |
18,808,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2133:Rsph6a
|
UTSW |
7 |
18,802,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3713:Rsph6a
|
UTSW |
7 |
18,791,475 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3762:Rsph6a
|
UTSW |
7 |
18,789,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3826:Rsph6a
|
UTSW |
7 |
18,791,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3827:Rsph6a
|
UTSW |
7 |
18,791,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3828:Rsph6a
|
UTSW |
7 |
18,791,539 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4355:Rsph6a
|
UTSW |
7 |
18,801,003 (GRCm39) |
splice site |
probably null |
|
|
R4429:Rsph6a
|
UTSW |
7 |
18,807,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4524:Rsph6a
|
UTSW |
7 |
18,799,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4799:Rsph6a
|
UTSW |
7 |
18,799,783 (GRCm39) |
nonsense |
probably null |
|
|
R4896:Rsph6a
|
UTSW |
7 |
18,791,665 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4906:Rsph6a
|
UTSW |
7 |
18,801,997 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5004:Rsph6a
|
UTSW |
7 |
18,791,665 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5637:Rsph6a
|
UTSW |
7 |
18,788,820 (GRCm39) |
missense |
probably benign |
|
|
R6066:Rsph6a
|
UTSW |
7 |
18,799,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7013:Rsph6a
|
UTSW |
7 |
18,788,820 (GRCm39) |
missense |
probably benign |
|
|
R7193:Rsph6a
|
UTSW |
7 |
18,799,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7689:Rsph6a
|
UTSW |
7 |
18,801,962 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8170:Rsph6a
|
UTSW |
7 |
18,791,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8177:Rsph6a
|
UTSW |
7 |
18,808,164 (GRCm39) |
missense |
unknown |
|
|
R8956:Rsph6a
|
UTSW |
7 |
18,799,364 (GRCm39) |
intron |
probably benign |
|
|
R9032:Rsph6a
|
UTSW |
7 |
18,799,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9085:Rsph6a
|
UTSW |
7 |
18,799,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9222:Rsph6a
|
UTSW |
7 |
18,801,986 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9529:Rsph6a
|
UTSW |
7 |
18,799,535 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9654:Rsph6a
|
UTSW |
7 |
18,799,332 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9672:Rsph6a
|
UTSW |
7 |
18,799,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Rsph6a
|
UTSW |
7 |
18,799,856 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2013-06-21 |
Incidental Mutation