Incidental Mutation 'R6350:Larp1'
ID 514158
Institutional Source Beutler Lab
Gene Symbol Larp1
Ensembl Gene ENSMUSG00000037331
Gene Name La ribonucleoprotein 1, translational regulator
Synonyms Larp, 3110040D16Rik, 1810024J12Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6350 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 57899890-57952860 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 57940657 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 594 (D594E)
Ref Sequence ENSEMBL: ENSMUSP00000136673 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071487] [ENSMUST00000178636]
AlphaFold Q6ZQ58
Predicted Effect probably benign
Transcript: ENSMUST00000071487
AA Change: D594E

PolyPhen 2 Score 0.114 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000071421
Gene: ENSMUSG00000037331
AA Change: D594E

DomainStartEndE-ValueType
low complexity region 6 20 N/A INTRINSIC
low complexity region 37 87 N/A INTRINSIC
low complexity region 106 120 N/A INTRINSIC
low complexity region 122 136 N/A INTRINSIC
low complexity region 304 331 N/A INTRINSIC
LA 376 452 1.98e-40 SMART
low complexity region 538 555 N/A INTRINSIC
low complexity region 562 571 N/A INTRINSIC
low complexity region 575 589 N/A INTRINSIC
low complexity region 758 766 N/A INTRINSIC
DM15 861 902 7.3e-20 SMART
DM15 903 941 3.85e-19 SMART
DM15 942 977 8.59e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000178636
AA Change: D594E

PolyPhen 2 Score 0.141 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000136673
Gene: ENSMUSG00000037331
AA Change: D594E

DomainStartEndE-ValueType
low complexity region 6 20 N/A INTRINSIC
low complexity region 37 87 N/A INTRINSIC
low complexity region 106 120 N/A INTRINSIC
low complexity region 122 136 N/A INTRINSIC
low complexity region 304 331 N/A INTRINSIC
LA 376 452 1.98e-40 SMART
low complexity region 538 555 N/A INTRINSIC
low complexity region 562 571 N/A INTRINSIC
low complexity region 575 589 N/A INTRINSIC
low complexity region 758 766 N/A INTRINSIC
DM15 861 902 7.3e-20 SMART
DM15 903 941 3.85e-19 SMART
DM15 942 977 8.59e-1 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik A G 15: 81,947,764 (GRCm39) K554E possibly damaging Het
Acsf2 T C 11: 94,449,156 (GRCm39) M609V probably benign Het
Acsm3 A G 7: 119,367,256 (GRCm39) T30A probably benign Het
Adam32 T C 8: 25,353,445 (GRCm39) K715E possibly damaging Het
Cdk5r1 T C 11: 80,369,068 (GRCm39) L245P probably damaging Het
Cntn3 A G 6: 102,147,579 (GRCm39) V926A probably damaging Het
Csf2rb G A 15: 78,229,752 (GRCm39) D440N probably damaging Het
D3Ertd751e T A 3: 41,708,278 (GRCm39) H138Q probably damaging Het
D630003M21Rik A G 2: 158,062,415 (GRCm39) L35P probably damaging Het
Faap100 A T 11: 120,265,406 (GRCm39) V490E probably damaging Het
Il3ra A G 14: 14,348,903 (GRCm38) D99G probably benign Het
Kcnmb1 A G 11: 33,914,711 (GRCm39) K4R probably damaging Het
Lnpep G T 17: 17,783,071 (GRCm39) H577N probably benign Het
Mief1 T C 15: 80,133,804 (GRCm39) I287T probably damaging Het
Mras T C 9: 99,293,560 (GRCm39) S27G probably damaging Het
Myh7b T A 2: 155,470,680 (GRCm39) C1043S probably benign Het
N4bp1 T C 8: 87,588,596 (GRCm39) D114G probably damaging Het
Nsmce4a A T 7: 130,140,829 (GRCm39) I219K probably damaging Het
Nynrin A T 14: 56,105,533 (GRCm39) I848F probably benign Het
Or2p2 T C 13: 21,256,775 (GRCm39) E232G probably benign Het
Or4f62 T A 2: 111,986,542 (GRCm39) I82N probably damaging Het
Patj T A 4: 98,293,855 (GRCm39) S36T probably benign Het
Pcdhb15 G A 18: 37,608,414 (GRCm39) V549M probably damaging Het
Prl2c5 T C 13: 13,357,631 (GRCm39) probably null Het
Ptbp3 A T 4: 59,482,624 (GRCm39) D386E probably damaging Het
Ptpra T C 2: 130,382,512 (GRCm39) L451P probably damaging Het
Repin1 A G 6: 48,574,562 (GRCm39) D497G probably damaging Het
Ryr2 A G 13: 11,776,282 (GRCm39) F1085S probably damaging Het
Slc6a18 G A 13: 73,826,044 (GRCm39) A2V possibly damaging Het
Wee2 C T 6: 40,432,039 (GRCm39) R203C probably damaging Het
Zmynd15 T C 11: 70,355,257 (GRCm39) V388A probably damaging Het
Other mutations in Larp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01537:Larp1 APN 11 57,933,648 (GRCm39) missense possibly damaging 0.91
IGL02114:Larp1 APN 11 57,947,881 (GRCm39) missense probably damaging 1.00
IGL03084:Larp1 APN 11 57,947,921 (GRCm39) missense probably damaging 1.00
IGL03126:Larp1 APN 11 57,941,703 (GRCm39) missense possibly damaging 0.65
IGL03278:Larp1 APN 11 57,934,882 (GRCm39) splice site probably benign
Bayou UTSW 11 57,949,422 (GRCm39) frame shift probably null
R0009:Larp1 UTSW 11 57,946,299 (GRCm39) missense possibly damaging 0.94
R0020:Larp1 UTSW 11 57,940,849 (GRCm39) missense probably damaging 1.00
R0479:Larp1 UTSW 11 57,933,646 (GRCm39) missense possibly damaging 0.92
R0845:Larp1 UTSW 11 57,938,576 (GRCm39) missense probably benign 0.00
R1691:Larp1 UTSW 11 57,938,874 (GRCm39) missense probably benign 0.08
R1793:Larp1 UTSW 11 57,940,764 (GRCm39) missense possibly damaging 0.60
R3618:Larp1 UTSW 11 57,948,172 (GRCm39) missense probably benign 0.03
R4689:Larp1 UTSW 11 57,932,439 (GRCm39) missense probably damaging 1.00
R4797:Larp1 UTSW 11 57,938,806 (GRCm39) nonsense probably null
R5089:Larp1 UTSW 11 57,938,693 (GRCm39) missense possibly damaging 0.92
R5309:Larp1 UTSW 11 57,941,634 (GRCm39) missense possibly damaging 0.72
R5883:Larp1 UTSW 11 57,933,125 (GRCm39) missense probably damaging 0.97
R5951:Larp1 UTSW 11 57,940,765 (GRCm39) missense probably benign 0.14
R6038:Larp1 UTSW 11 57,932,431 (GRCm39) missense possibly damaging 0.68
R6038:Larp1 UTSW 11 57,932,431 (GRCm39) missense possibly damaging 0.68
R6266:Larp1 UTSW 11 57,933,089 (GRCm39) missense probably damaging 0.99
R6650:Larp1 UTSW 11 57,949,422 (GRCm39) frame shift probably null
R6687:Larp1 UTSW 11 57,948,156 (GRCm39) missense probably damaging 0.99
R6736:Larp1 UTSW 11 57,933,473 (GRCm39) splice site probably null
R6881:Larp1 UTSW 11 57,940,849 (GRCm39) missense probably damaging 1.00
R7368:Larp1 UTSW 11 57,938,904 (GRCm39) missense probably damaging 1.00
R7547:Larp1 UTSW 11 57,943,405 (GRCm39) critical splice acceptor site probably null
R7838:Larp1 UTSW 11 57,938,540 (GRCm39) missense possibly damaging 0.82
R8260:Larp1 UTSW 11 57,949,515 (GRCm39) missense probably benign 0.05
R8446:Larp1 UTSW 11 57,942,035 (GRCm39) critical splice donor site probably null
R9381:Larp1 UTSW 11 57,949,532 (GRCm39) missense probably benign
R9450:Larp1 UTSW 11 57,941,890 (GRCm39) missense probably damaging 1.00
R9466:Larp1 UTSW 11 57,943,461 (GRCm39) missense possibly damaging 0.96
Z1177:Larp1 UTSW 11 57,940,613 (GRCm39) nonsense probably null
Z1186:Larp1 UTSW 11 57,933,166 (GRCm39) missense probably benign 0.00
Z1187:Larp1 UTSW 11 57,933,166 (GRCm39) missense probably benign 0.00
Z1188:Larp1 UTSW 11 57,933,166 (GRCm39) missense probably benign 0.00
Z1189:Larp1 UTSW 11 57,933,166 (GRCm39) missense probably benign 0.00
Z1190:Larp1 UTSW 11 57,933,166 (GRCm39) missense probably benign 0.00
Z1191:Larp1 UTSW 11 57,933,166 (GRCm39) missense probably benign 0.00
Z1192:Larp1 UTSW 11 57,933,166 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CCTCTTTGGGCAGCTAGAAAG -3'
(R):5'- TTGGCCAGTTCAGCACTCATC -3'

Sequencing Primer
(F):5'- AGGTCCTCATGTGTTACTATTCCCAG -3'
(R):5'- ACTCATCTTGGCACGCGAAG -3'
Posted On 2018-04-27