Incidental Mutation 'IGL01061:Vmn2r28'
| ID |
51416 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r28
|
| Ensembl Gene |
ENSMUSG00000066820 |
| Gene Name |
vomeronasal 2, receptor 28 |
| Synonyms |
EG665255 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.138)
|
| Stock # |
IGL01061
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
5479531-5493967 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 5488184 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tryptophan to Arginine
at position 355
(W355R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000083477
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086297]
|
| AlphaFold |
L7N203 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000086297
AA Change: W355R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000083477
Gene: ENSMUSG00000066820
AA Change: W355R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
470 |
1.7e-26 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
9.8e-21 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
2.8e-56 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 48 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aen |
G |
A |
7: 78,907,302 (GRCm38) |
M299I |
probably damaging |
Het |
| Ankfy1 |
T |
A |
11: 72,728,860 (GRCm38) |
C186* |
probably null |
Het |
| Ankmy1 |
A |
T |
1: 92,870,974 (GRCm38) |
|
probably benign |
Het |
| B3gnt2 |
T |
A |
11: 22,836,042 (GRCm38) |
E382V |
probably damaging |
Het |
| Carmil3 |
T |
G |
14: 55,498,630 (GRCm38) |
S610A |
possibly damaging |
Het |
| Cfap70 |
T |
C |
14: 20,447,625 (GRCm38) |
|
probably benign |
Het |
| Chek1 |
G |
A |
9: 36,714,519 (GRCm38) |
R277C |
possibly damaging |
Het |
| Cpb1 |
T |
A |
3: 20,266,516 (GRCm38) |
I92L |
probably benign |
Het |
| Ddx56 |
C |
T |
11: 6,264,671 (GRCm38) |
|
probably null |
Het |
| Dicer1 |
A |
T |
12: 104,706,327 (GRCm38) |
M887K |
probably null |
Het |
| Dnajc18 |
A |
G |
18: 35,680,942 (GRCm38) |
|
probably benign |
Het |
| Dock2 |
A |
G |
11: 34,705,826 (GRCm38) |
V401A |
probably damaging |
Het |
| Dock4 |
A |
C |
12: 40,702,969 (GRCm38) |
N434T |
probably benign |
Het |
| Ehbp1l1 |
A |
T |
19: 5,717,888 (GRCm38) |
M1129K |
probably benign |
Het |
| Fam83a |
A |
T |
15: 57,986,375 (GRCm38) |
Y105F |
possibly damaging |
Het |
| Fnbp1 |
C |
A |
2: 31,083,042 (GRCm38) |
D70Y |
probably damaging |
Het |
| Gtf3c2 |
A |
G |
5: 31,168,354 (GRCm38) |
F414L |
possibly damaging |
Het |
| Kdelc2 |
A |
G |
9: 53,388,587 (GRCm38) |
|
probably benign |
Het |
| Kndc1 |
A |
T |
7: 139,922,694 (GRCm38) |
E965D |
probably benign |
Het |
| Lrrc66 |
T |
C |
5: 73,615,499 (GRCm38) |
K209E |
probably benign |
Het |
| Mcm3 |
A |
T |
1: 20,814,496 (GRCm38) |
I261N |
possibly damaging |
Het |
| Mier3 |
T |
A |
13: 111,714,436 (GRCm38) |
|
probably benign |
Het |
| Muc6 |
T |
C |
7: 141,648,454 (GRCm38) |
E669G |
probably damaging |
Het |
| Myh1 |
T |
A |
11: 67,217,862 (GRCm38) |
M1368K |
probably benign |
Het |
| Nav1 |
A |
G |
1: 135,450,630 (GRCm38) |
I1653T |
probably damaging |
Het |
| Nuak1 |
C |
A |
10: 84,375,134 (GRCm38) |
L363F |
probably damaging |
Het |
| Olfr113 |
A |
G |
17: 37,574,904 (GRCm38) |
I173T |
possibly damaging |
Het |
| Olfr1502 |
T |
C |
19: 13,862,705 (GRCm38) |
V304A |
possibly damaging |
Het |
| Olfr690 |
A |
G |
7: 105,329,382 (GRCm38) |
I270T |
possibly damaging |
Het |
| Pkd1l3 |
A |
G |
8: 109,638,706 (GRCm38) |
H1153R |
probably damaging |
Het |
| Ppp6r2 |
A |
T |
15: 89,286,015 (GRCm38) |
|
probably benign |
Het |
| Prelid3b |
T |
C |
2: 174,465,821 (GRCm38) |
|
probably null |
Het |
| Prrt3 |
T |
C |
6: 113,497,770 (GRCm38) |
K164E |
possibly damaging |
Het |
| Rab22a |
T |
A |
2: 173,688,210 (GRCm38) |
D60E |
probably damaging |
Het |
| Rab32 |
A |
G |
10: 10,557,874 (GRCm38) |
L72P |
probably damaging |
Het |
| Samm50 |
A |
G |
15: 84,202,254 (GRCm38) |
T225A |
probably benign |
Het |
| Snx27 |
T |
A |
3: 94,528,980 (GRCm38) |
|
probably benign |
Het |
| Taf7 |
G |
A |
18: 37,643,433 (GRCm38) |
T27M |
probably damaging |
Het |
| Tgm5 |
A |
T |
2: 121,071,496 (GRCm38) |
C231S |
probably benign |
Het |
| Tll1 |
A |
G |
8: 64,038,454 (GRCm38) |
|
probably null |
Het |
| Tmem150a |
A |
G |
6: 72,357,118 (GRCm38) |
D61G |
probably damaging |
Het |
| Ttll8 |
G |
A |
15: 88,917,250 (GRCm38) |
R412C |
possibly damaging |
Het |
| Ubr3 |
T |
A |
2: 69,983,225 (GRCm38) |
D1293E |
probably benign |
Het |
| Utp20 |
T |
C |
10: 88,770,704 (GRCm38) |
N1669D |
probably benign |
Het |
| Wdr60 |
C |
A |
12: 116,229,704 (GRCm38) |
A543S |
probably benign |
Het |
| Yars2 |
C |
T |
16: 16,306,542 (GRCm38) |
R338* |
probably null |
Het |
| Zfhx2 |
T |
A |
14: 55,073,882 (GRCm38) |
N452Y |
possibly damaging |
Het |
| Zfp180 |
T |
G |
7: 24,104,745 (GRCm38) |
D196E |
possibly damaging |
Het |
|
| Other mutations in Vmn2r28 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00095:Vmn2r28
|
APN |
7 |
5,488,069 (GRCm38) |
missense |
probably benign |
0.12 |
|
IGL01160:Vmn2r28
|
APN |
7 |
5,486,478 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01335:Vmn2r28
|
APN |
7 |
5,481,088 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
IGL01532:Vmn2r28
|
APN |
7 |
5,486,464 (GRCm38) |
missense |
probably benign |
0.16 |
|
IGL01791:Vmn2r28
|
APN |
7 |
5,488,162 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01875:Vmn2r28
|
APN |
7 |
5,481,303 (GRCm38) |
missense |
probably benign |
0.30 |
|
IGL02161:Vmn2r28
|
APN |
7 |
5,488,124 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
IGL02499:Vmn2r28
|
APN |
7 |
5,490,569 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL02858:Vmn2r28
|
APN |
7 |
5,481,004 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03061:Vmn2r28
|
APN |
7 |
5,484,016 (GRCm38) |
missense |
probably damaging |
0.98 |
|
G1patch:Vmn2r28
|
UTSW |
7 |
5,488,409 (GRCm38) |
missense |
probably benign |
0.13 |
|
R0288:Vmn2r28
|
UTSW |
7 |
5,488,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0361:Vmn2r28
|
UTSW |
7 |
5,493,716 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0396:Vmn2r28
|
UTSW |
7 |
5,488,514 (GRCm38) |
missense |
probably benign |
0.05 |
|
R0480:Vmn2r28
|
UTSW |
7 |
5,490,457 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0485:Vmn2r28
|
UTSW |
7 |
5,488,690 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0837:Vmn2r28
|
UTSW |
7 |
5,488,027 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1282:Vmn2r28
|
UTSW |
7 |
5,481,302 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1296:Vmn2r28
|
UTSW |
7 |
5,481,545 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R1829:Vmn2r28
|
UTSW |
7 |
5,493,811 (GRCm38) |
missense |
probably benign |
|
|
R1853:Vmn2r28
|
UTSW |
7 |
5,481,247 (GRCm38) |
nonsense |
probably null |
|
|
R1869:Vmn2r28
|
UTSW |
7 |
5,486,346 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1887:Vmn2r28
|
UTSW |
7 |
5,488,289 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R1961:Vmn2r28
|
UTSW |
7 |
5,481,071 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R1998:Vmn2r28
|
UTSW |
7 |
5,488,314 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R2392:Vmn2r28
|
UTSW |
7 |
5,484,131 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2432:Vmn2r28
|
UTSW |
7 |
5,488,702 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3055:Vmn2r28
|
UTSW |
7 |
5,481,392 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R3753:Vmn2r28
|
UTSW |
7 |
5,488,027 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3877:Vmn2r28
|
UTSW |
7 |
5,488,358 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4307:Vmn2r28
|
UTSW |
7 |
5,490,708 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5023:Vmn2r28
|
UTSW |
7 |
5,486,464 (GRCm38) |
missense |
probably benign |
0.16 |
|
R5057:Vmn2r28
|
UTSW |
7 |
5,486,464 (GRCm38) |
missense |
probably benign |
0.16 |
|
R5083:Vmn2r28
|
UTSW |
7 |
5,480,672 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R5427:Vmn2r28
|
UTSW |
7 |
5,486,377 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5472:Vmn2r28
|
UTSW |
7 |
5,487,944 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5511:Vmn2r28
|
UTSW |
7 |
5,484,012 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R5731:Vmn2r28
|
UTSW |
7 |
5,488,669 (GRCm38) |
missense |
probably benign |
0.41 |
|
R6091:Vmn2r28
|
UTSW |
7 |
5,493,791 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R6179:Vmn2r28
|
UTSW |
7 |
5,488,004 (GRCm38) |
nonsense |
probably null |
|
|
R6276:Vmn2r28
|
UTSW |
7 |
5,490,731 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6441:Vmn2r28
|
UTSW |
7 |
5,488,475 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6463:Vmn2r28
|
UTSW |
7 |
5,486,436 (GRCm38) |
missense |
probably benign |
0.07 |
|
R6528:Vmn2r28
|
UTSW |
7 |
5,490,685 (GRCm38) |
missense |
probably benign |
0.12 |
|
R6725:Vmn2r28
|
UTSW |
7 |
5,488,409 (GRCm38) |
missense |
probably benign |
0.13 |
|
R6760:Vmn2r28
|
UTSW |
7 |
5,481,230 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6849:Vmn2r28
|
UTSW |
7 |
5,480,807 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7110:Vmn2r28
|
UTSW |
7 |
5,490,734 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7146:Vmn2r28
|
UTSW |
7 |
5,481,496 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7407:Vmn2r28
|
UTSW |
7 |
5,481,309 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7563:Vmn2r28
|
UTSW |
7 |
5,488,201 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7611:Vmn2r28
|
UTSW |
7 |
5,481,256 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7808:Vmn2r28
|
UTSW |
7 |
5,493,679 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7862:Vmn2r28
|
UTSW |
7 |
5,490,614 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7916:Vmn2r28
|
UTSW |
7 |
5,480,819 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8183:Vmn2r28
|
UTSW |
7 |
5,488,148 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8334:Vmn2r28
|
UTSW |
7 |
5,484,060 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8519:Vmn2r28
|
UTSW |
7 |
5,486,348 (GRCm38) |
missense |
probably benign |
0.31 |
|
R8989:Vmn2r28
|
UTSW |
7 |
5,490,474 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9066:Vmn2r28
|
UTSW |
7 |
5,488,597 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9422:Vmn2r28
|
UTSW |
7 |
5,480,748 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9469:Vmn2r28
|
UTSW |
7 |
5,484,119 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9608:Vmn2r28
|
UTSW |
7 |
5,488,221 (GRCm38) |
missense |
probably benign |
0.05 |
|
| Posted On |
2013-06-21 |
Incidental Mutation