Incidental Mutation 'IGL01063:Or5p55'
ID 51418
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5p55
Ensembl Gene ENSMUSG00000095301
Gene Name olfactory receptor family 5 subfamily P member 55
Synonyms GA_x6K02T2PBJ9-10296787-10297719, Olfr476, MOR204-3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # IGL01063
Quality Score
Status
Chromosome 7
Chromosomal Location 107566606-107567538 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 107566741 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 46 (I46F)
Ref Sequence ENSEMBL: ENSMUSP00000149760 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077249] [ENSMUST00000217173]
AlphaFold Q8VGI4
Predicted Effect probably damaging
Transcript: ENSMUST00000077249
AA Change: I46F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000076485
Gene: ENSMUSG00000095301
AA Change: I46F

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.7e-51 PFAM
Pfam:7tm_1 41 290 4.1e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217173
AA Change: I46F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,834,475 (GRCm39) V124I probably damaging Het
4930444P10Rik A T 1: 16,148,870 (GRCm39) L61* probably null Het
Abca7 T C 10: 79,847,131 (GRCm39) I1705T probably damaging Het
Ablim1 T A 19: 57,049,760 (GRCm39) I393F probably damaging Het
Adamts5 A G 16: 85,696,722 (GRCm39) L145P probably damaging Het
Ano6 T C 15: 95,846,310 (GRCm39) I537T probably damaging Het
AU018091 T C 7: 3,212,153 (GRCm39) I190V possibly damaging Het
Camk1 T A 6: 113,315,333 (GRCm39) D155V probably damaging Het
Cdh6 A C 15: 13,064,581 (GRCm39) I103S probably damaging Het
Cntnap1 A G 11: 101,072,614 (GRCm39) D537G probably benign Het
Col6a3 T C 1: 90,730,054 (GRCm39) K1144E probably damaging Het
Cpeb1 T A 7: 81,021,929 (GRCm39) E71D probably benign Het
Cps1 T C 1: 67,234,325 (GRCm39) L904P possibly damaging Het
Cyfip1 T A 7: 55,553,958 (GRCm39) F700I probably damaging Het
Dmp1 G A 5: 104,354,965 (GRCm39) M1I probably null Het
Efcab6 A T 15: 83,938,713 (GRCm39) M1K probably null Het
Extl2 A T 3: 115,821,131 (GRCm39) H312L possibly damaging Het
Fat4 C A 3: 38,944,728 (GRCm39) A1207D possibly damaging Het
Flnb T C 14: 7,926,518 (GRCm38) probably benign Het
Hdac10 G T 15: 89,008,071 (GRCm39) A593E possibly damaging Het
Hdhd2 T C 18: 77,052,969 (GRCm39) probably null Het
Kcnq2 A G 2: 180,751,582 (GRCm39) probably benign Het
Kdm7a A G 6: 39,142,064 (GRCm39) F405L probably damaging Het
Lypd6b C A 2: 49,833,642 (GRCm39) probably benign Het
Mki67 A T 7: 135,296,651 (GRCm39) D2794E possibly damaging Het
Mtmr14 T A 6: 113,243,287 (GRCm39) F40I probably damaging Het
Or2y3 G T 17: 38,393,544 (GRCm39) S108R possibly damaging Het
Or6d13 T A 6: 116,517,968 (GRCm39) C185S probably damaging Het
Or6x1 A T 9: 40,099,052 (GRCm39) I214F probably benign Het
Ppargc1a C A 5: 51,631,664 (GRCm39) V322L probably benign Het
Ppfibp1 T A 6: 146,931,195 (GRCm39) M917K probably benign Het
Prkg2 C T 5: 99,117,795 (GRCm39) probably null Het
Rfx4 A G 10: 84,704,246 (GRCm39) E296G possibly damaging Het
Rfx8 T A 1: 39,722,110 (GRCm39) K292* probably null Het
Scamp3 C A 3: 89,084,973 (GRCm39) probably benign Het
Scn4a A T 11: 106,221,190 (GRCm39) I823N possibly damaging Het
Sdk2 A G 11: 113,721,668 (GRCm39) V1316A probably damaging Het
Setd2 T C 9: 110,402,741 (GRCm39) V1794A probably damaging Het
Stard8 G T X: 98,116,694 (GRCm39) R983L probably damaging Het
Tbc1d23 A T 16: 57,013,038 (GRCm39) D311E probably benign Het
Tex21 T C 12: 76,245,592 (GRCm39) H568R probably benign Het
Tex35 T C 1: 156,932,667 (GRCm39) probably benign Het
Tgs1 T A 4: 3,591,292 (GRCm39) F442I possibly damaging Het
Traf2 C A 2: 25,414,931 (GRCm39) C303F probably benign Het
Trim56 A T 5: 137,143,354 (GRCm39) V54D possibly damaging Het
Yars2 C T 16: 16,124,406 (GRCm39) R338* probably null Het
Zfp668 A T 7: 127,465,454 (GRCm39) C577S probably damaging Het
Other mutations in Or5p55
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01403:Or5p55 APN 7 107,566,828 (GRCm39) missense possibly damaging 0.64
IGL01564:Or5p55 APN 7 107,567,198 (GRCm39) missense probably benign 0.11
IGL01615:Or5p55 APN 7 107,567,144 (GRCm39) missense probably damaging 1.00
IGL01777:Or5p55 APN 7 107,566,709 (GRCm39) missense probably damaging 1.00
IGL01999:Or5p55 APN 7 107,566,675 (GRCm39) missense probably benign
IGL02239:Or5p55 APN 7 107,567,254 (GRCm39) missense probably damaging 1.00
R0636:Or5p55 UTSW 7 107,566,679 (GRCm39) missense probably benign 0.00
R1986:Or5p55 UTSW 7 107,566,877 (GRCm39) missense probably benign
R5109:Or5p55 UTSW 7 107,567,104 (GRCm39) missense probably benign 0.06
R6363:Or5p55 UTSW 7 107,566,957 (GRCm39) missense possibly damaging 0.57
R6526:Or5p55 UTSW 7 107,566,669 (GRCm39) missense probably benign 0.03
R6907:Or5p55 UTSW 7 107,567,459 (GRCm39) missense probably damaging 1.00
R7063:Or5p55 UTSW 7 107,567,411 (GRCm39) missense probably benign
R7218:Or5p55 UTSW 7 107,566,874 (GRCm39) missense probably benign
R7240:Or5p55 UTSW 7 107,567,395 (GRCm39) missense probably benign 0.42
R7444:Or5p55 UTSW 7 107,566,811 (GRCm39) missense probably damaging 0.99
R7939:Or5p55 UTSW 7 107,566,986 (GRCm39) nonsense probably null
R8060:Or5p55 UTSW 7 107,566,612 (GRCm39) missense probably benign
R8953:Or5p55 UTSW 7 107,567,251 (GRCm39) missense probably benign 0.00
R9159:Or5p55 UTSW 7 107,567,524 (GRCm39) nonsense probably null
R9438:Or5p55 UTSW 7 107,567,000 (GRCm39) missense probably damaging 1.00
X0025:Or5p55 UTSW 7 107,567,395 (GRCm39) missense possibly damaging 0.75
Posted On 2013-06-21