Incidental Mutation 'R6359:Gm2035'
ID514198
Institutional Source Beutler Lab
Gene Symbol Gm2035
Ensembl Gene ENSMUSG00000096619
Gene Namepredicted pseudogene 2035
Synonyms
MMRRC Submission
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.311) question?
Stock #R6359 (G1)
Quality Score225.009
Status Not validated
Chromosome12
Chromosomal Location87919423-87919857 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 87919505 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Methionine at position 118 (T118M)
Ref Sequence ENSEMBL: ENSMUSP00000137146 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000180053]
Predicted Effect probably benign
Transcript: ENSMUST00000180053
AA Change: T118M

PolyPhen 2 Score 0.093 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000137146
Gene: ENSMUSG00000096619
AA Change: T118M

DomainStartEndE-ValueType
low complexity region 3 25 N/A INTRINSIC
eIF1a 28 110 4.13e-45 SMART
low complexity region 125 144 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.8%
  • 20x: 93.3%
Validation Efficiency 100% (30/30)
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asic5 A T 3: 82,004,496 D133V possibly damaging Het
Atp11b A G 3: 35,778,061 I22V probably benign Het
Ccdc18 C T 5: 108,135,525 T34I probably damaging Het
Ces2a A G 8: 104,736,078 I100V probably benign Het
Ddi2 T A 4: 141,684,588 T338S probably damaging Het
Dync1li1 A G 9: 114,713,570 I267V probably benign Het
Fbxo10 A T 4: 45,041,796 V637E possibly damaging Het
Gak T C 5: 108,571,900 E458G probably damaging Het
Glp1r G T 17: 30,929,972 V287F probably damaging Het
Gsdmc2 T C 15: 63,825,017 E435G probably damaging Het
Hsd11b1 T A 1: 193,242,352 probably benign Het
Igkv13-84 T G 6: 68,939,608 F3V probably benign Het
Igsf9b C A 9: 27,309,599 A87E probably benign Het
Ints1 G T 5: 139,756,217 L1796I probably benign Het
Ipo8 A G 6: 148,777,250 L950P probably benign Het
Lama5 T C 2: 180,195,982 D931G probably benign Het
Lamb1 A G 12: 31,282,716 E327G probably damaging Het
Lrp1b T C 2: 41,295,596 Y1369C probably damaging Het
Mapk3 A G 7: 126,760,756 T67A probably benign Het
Mrpl4 T A 9: 21,007,734 V225E probably damaging Het
Ncln C T 10: 81,490,284 G278S probably damaging Het
Nlrp3 G A 11: 59,548,566 R323Q probably damaging Het
Nol8 A G 13: 49,664,070 D774G probably benign Het
Olfr266 A T 3: 106,822,415 I48N probably damaging Het
Olfr656 T C 7: 104,618,303 V208A probably damaging Het
Plekha8 G T 6: 54,613,119 C23F probably damaging Het
Prkag1 T C 15: 98,814,552 Y133C probably damaging Het
Spata31d1a A G 13: 59,703,106 S403P probably benign Het
Spata31d1c A T 13: 65,035,592 N316I possibly damaging Het
Tmem30c A T 16: 57,276,150 S203T probably benign Het
Ttn T G 2: 76,738,956 N18871H possibly damaging Het
Other mutations in Gm2035
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02314:Gm2035 APN 12 87919607 missense probably benign 0.00
IGL02347:Gm2035 APN 12 87919589 missense probably damaging 1.00
IGL02639:Gm2035 APN 12 87919499 missense probably benign 0.04
R4230:Gm2035 UTSW 12 87919797 missense unknown
R5969:Gm2035 UTSW 12 87919478 missense unknown
R6159:Gm2035 UTSW 12 87919751 missense probably damaging 1.00
R7181:Gm2035 UTSW 12 87919722 missense possibly damaging 0.49
R7183:Gm2035 UTSW 12 87919722 missense possibly damaging 0.49
R7184:Gm2035 UTSW 12 87919722 missense possibly damaging 0.49
R7653:Gm2035 UTSW 12 87919478 missense unknown
Predicted Primers
Posted On2018-04-27