Incidental Mutation 'R6351:Kcnt2'
| ID |
514208 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kcnt2
|
| Ensembl Gene |
ENSMUSG00000052726 |
| Gene Name |
potassium channel, subfamily T, member 2 |
| Synonyms |
E330038N15Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.099)
|
| Stock # |
R6351 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
140173896-140539805 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 140302850 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Isoleucine
at position 130
(N130I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112887
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000119786]
[ENSMUST00000120709]
[ENSMUST00000120796]
|
| AlphaFold |
D3Z649 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000119786
AA Change: N130I
PolyPhen 2
Score 0.540 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000113535
Gene: ENSMUSG00000052726
AA Change: N130I
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.6e-15 |
PFAM |
|
Pfam:BK_channel_a
|
422 |
476 |
2.3e-16 |
PFAM |
|
low complexity region
|
598 |
613 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
699 |
714 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120709
AA Change: N130I
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000112887
Gene: ENSMUSG00000052726
AA Change: N130I
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.7e-15 |
PFAM |
|
Pfam:BK_channel_a
|
422 |
527 |
1.5e-39 |
PFAM |
|
low complexity region
|
648 |
663 |
N/A |
INTRINSIC |
|
low complexity region
|
670 |
682 |
N/A |
INTRINSIC |
|
low complexity region
|
749 |
764 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120796
AA Change: N130I
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000113333
Gene: ENSMUSG00000052726
AA Change: N130I
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
64 |
83 |
N/A |
INTRINSIC |
|
transmembrane domain
|
103 |
125 |
N/A |
INTRINSIC |
|
transmembrane domain
|
138 |
160 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans_2
|
199 |
282 |
2.8e-15 |
PFAM |
|
Pfam:BK_channel_a
|
422 |
527 |
1.5e-39 |
PFAM |
|
low complexity region
|
648 |
663 |
N/A |
INTRINSIC |
|
low complexity region
|
670 |
682 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.6911 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.2%
- 20x: 94.9%
|
| Validation Efficiency |
99% (95/96) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele are viable with normal pain and itch responses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acaa1a |
C |
A |
9: 119,170,630 (GRCm39) |
S17* |
probably null |
Het |
| Adamts16 |
T |
A |
13: 70,984,322 (GRCm39) |
S114C |
probably damaging |
Het |
| Agpat5 |
T |
C |
8: 18,896,724 (GRCm39) |
V50A |
probably benign |
Het |
| Agrn |
T |
C |
4: 156,263,891 (GRCm39) |
N124S |
probably benign |
Het |
| Ak8 |
T |
C |
2: 28,625,638 (GRCm39) |
I227T |
probably benign |
Het |
| Akap6 |
A |
G |
12: 53,188,808 (GRCm39) |
E2074G |
probably damaging |
Het |
| Apc |
T |
A |
18: 34,445,265 (GRCm39) |
S702R |
probably damaging |
Het |
| Ascc3 |
T |
C |
10: 50,596,769 (GRCm39) |
I1233T |
probably damaging |
Het |
| Asphd2 |
A |
T |
5: 112,533,698 (GRCm39) |
F318I |
probably damaging |
Het |
| Bltp1 |
G |
A |
3: 36,962,377 (GRCm39) |
A493T |
probably damaging |
Het |
| Bnc2 |
T |
C |
4: 84,211,380 (GRCm39) |
T397A |
probably benign |
Het |
| Bpifb4 |
C |
T |
2: 153,799,054 (GRCm39) |
T528I |
probably damaging |
Het |
| Brinp3 |
A |
G |
1: 146,777,323 (GRCm39) |
E590G |
probably damaging |
Het |
| Ccdc149 |
A |
G |
5: 52,542,477 (GRCm39) |
S372P |
probably benign |
Het |
| Cdhr2 |
A |
G |
13: 54,874,589 (GRCm39) |
H887R |
probably benign |
Het |
| Clcn6 |
C |
T |
4: 148,101,957 (GRCm39) |
V376I |
probably benign |
Het |
| Cntln |
T |
G |
4: 85,033,591 (GRCm39) |
C1305W |
probably damaging |
Het |
| Cspg4 |
A |
G |
9: 56,799,928 (GRCm39) |
D1564G |
probably benign |
Het |
| Cux1 |
A |
T |
5: 136,338,646 (GRCm39) |
S582T |
probably damaging |
Het |
| Cwh43 |
G |
A |
5: 73,569,248 (GRCm39) |
A97T |
possibly damaging |
Het |
| Dsc1 |
A |
T |
18: 20,219,826 (GRCm39) |
F781L |
probably damaging |
Het |
| Dsc3 |
G |
T |
18: 20,099,348 (GRCm39) |
H723N |
probably benign |
Het |
| Ear10 |
A |
T |
14: 44,160,512 (GRCm39) |
V105D |
probably damaging |
Het |
| Ecel1 |
A |
G |
1: 87,077,231 (GRCm39) |
V659A |
possibly damaging |
Het |
| Eogt |
A |
T |
6: 97,097,155 (GRCm39) |
F316I |
probably damaging |
Het |
| Etaa1 |
T |
C |
11: 17,897,188 (GRCm39) |
N310D |
possibly damaging |
Het |
| Exoc3l2 |
G |
A |
7: 19,203,633 (GRCm39) |
R75Q |
possibly damaging |
Het |
| Fam186a |
A |
C |
15: 99,839,623 (GRCm39) |
L2207R |
probably damaging |
Het |
| Fam187b |
T |
C |
7: 30,677,024 (GRCm39) |
Y178H |
probably damaging |
Het |
| Fat1 |
A |
T |
8: 45,486,532 (GRCm39) |
Q3362L |
probably damaging |
Het |
| Fat3 |
A |
T |
9: 15,849,694 (GRCm39) |
S3903T |
probably damaging |
Het |
| Fsip2 |
G |
A |
2: 82,823,028 (GRCm39) |
V6254I |
possibly damaging |
Het |
| Gabra5 |
T |
C |
7: 57,063,528 (GRCm39) |
T299A |
probably damaging |
Het |
| Gbp11 |
T |
C |
5: 105,475,464 (GRCm39) |
T295A |
probably benign |
Het |
| Glcci1 |
C |
T |
6: 8,573,203 (GRCm39) |
Q44* |
probably null |
Het |
| Gpc5 |
A |
T |
14: 115,636,612 (GRCm39) |
T432S |
probably benign |
Het |
| Grhl1 |
G |
A |
12: 24,634,857 (GRCm39) |
E228K |
probably damaging |
Het |
| Hyal5 |
T |
C |
6: 24,891,708 (GRCm39) |
|
probably null |
Het |
| Idh2 |
TCCCAGG |
T |
7: 79,748,079 (GRCm39) |
|
probably benign |
Het |
| Ints9 |
A |
G |
14: 65,230,456 (GRCm39) |
I128V |
probably damaging |
Het |
| Krba1 |
T |
C |
6: 48,391,062 (GRCm39) |
V717A |
probably benign |
Het |
| Lrp12 |
T |
A |
15: 39,741,584 (GRCm39) |
D377V |
probably damaging |
Het |
| Magi1 |
G |
T |
6: 93,920,210 (GRCm39) |
D135E |
possibly damaging |
Het |
| Map10 |
T |
A |
8: 126,397,984 (GRCm39) |
L459Q |
probably damaging |
Het |
| Mitf |
A |
G |
6: 97,980,873 (GRCm39) |
D238G |
possibly damaging |
Het |
| Ms4a19 |
C |
T |
19: 11,119,765 (GRCm39) |
G14D |
probably damaging |
Het |
| Mylk |
G |
T |
16: 34,742,341 (GRCm39) |
R951L |
probably benign |
Het |
| Nacad |
T |
A |
11: 6,549,235 (GRCm39) |
D1272V |
probably damaging |
Het |
| Nacad |
T |
A |
11: 6,550,165 (GRCm39) |
K1009* |
probably null |
Het |
| Ncor1 |
T |
C |
11: 62,264,124 (GRCm39) |
D786G |
probably benign |
Het |
| Oas2 |
G |
A |
5: 120,886,603 (GRCm39) |
R188C |
probably benign |
Het |
| Odf2l |
A |
G |
3: 144,841,479 (GRCm39) |
I300V |
probably benign |
Het |
| Or1j10 |
T |
A |
2: 36,267,208 (GRCm39) |
V140D |
possibly damaging |
Het |
| Or51b17 |
A |
T |
7: 103,542,342 (GRCm39) |
L200* |
probably null |
Het |
| Or51v8 |
A |
G |
7: 103,320,163 (GRCm39) |
I25T |
possibly damaging |
Het |
| Or5p60 |
A |
G |
7: 107,723,637 (GRCm39) |
S278P |
probably damaging |
Het |
| Or9i1 |
A |
G |
19: 13,839,186 (GRCm39) |
T10A |
probably benign |
Het |
| Pes1 |
T |
A |
11: 3,928,865 (GRCm39) |
D574E |
probably benign |
Het |
| Phf20 |
C |
T |
2: 156,136,130 (GRCm39) |
R650C |
possibly damaging |
Het |
| Pias4 |
G |
A |
10: 80,993,098 (GRCm39) |
T248I |
probably damaging |
Het |
| Pkhd1 |
T |
C |
1: 20,282,175 (GRCm39) |
T2889A |
probably benign |
Het |
| Plcxd1 |
C |
A |
5: 110,250,033 (GRCm39) |
|
probably null |
Het |
| Plekha7 |
A |
G |
7: 115,776,133 (GRCm39) |
F194L |
probably damaging |
Het |
| Plxnb2 |
T |
C |
15: 89,041,973 (GRCm39) |
N1642S |
possibly damaging |
Het |
| Pnpla7 |
A |
T |
2: 24,901,576 (GRCm39) |
D534V |
probably damaging |
Het |
| Ppp2r5c |
A |
T |
12: 110,521,313 (GRCm39) |
S279C |
probably damaging |
Het |
| Ptprq |
T |
A |
10: 107,544,529 (GRCm39) |
T334S |
probably damaging |
Het |
| Rab39 |
T |
C |
9: 53,597,821 (GRCm39) |
D148G |
probably benign |
Het |
| Reep3 |
A |
T |
10: 66,870,432 (GRCm39) |
F121L |
probably benign |
Het |
| Reln |
G |
T |
5: 22,106,661 (GRCm39) |
C3236* |
probably null |
Het |
| Rrp8 |
C |
T |
7: 105,384,016 (GRCm39) |
C162Y |
probably damaging |
Het |
| Scrib |
C |
A |
15: 75,936,835 (GRCm39) |
Q399H |
possibly damaging |
Het |
| Sertad1 |
T |
A |
7: 27,189,224 (GRCm39) |
Y182N |
possibly damaging |
Het |
| Sfrp5 |
A |
G |
19: 42,190,263 (GRCm39) |
V63A |
possibly damaging |
Het |
| Shoc1 |
T |
C |
4: 59,069,317 (GRCm39) |
D703G |
probably benign |
Het |
| Slc46a1 |
T |
C |
11: 78,357,985 (GRCm39) |
M346T |
probably benign |
Het |
| Sycp2 |
A |
G |
2: 178,005,209 (GRCm39) |
L886S |
probably damaging |
Het |
| Teddm1b |
A |
T |
1: 153,750,505 (GRCm39) |
I105F |
probably benign |
Het |
| Thumpd1 |
A |
T |
7: 119,319,828 (GRCm39) |
I46N |
possibly damaging |
Het |
| Tmod4 |
A |
G |
3: 95,035,164 (GRCm39) |
N223S |
probably damaging |
Het |
| Tnfrsf10b |
G |
C |
14: 70,010,850 (GRCm39) |
C85S |
probably damaging |
Het |
| Tox |
T |
C |
4: 6,697,439 (GRCm39) |
T455A |
probably benign |
Het |
| Tox |
T |
C |
4: 6,741,536 (GRCm39) |
Q148R |
probably benign |
Het |
| Trp53bp1 |
A |
C |
2: 121,100,426 (GRCm39) |
S109R |
probably damaging |
Het |
| Tshz2 |
A |
T |
2: 169,726,888 (GRCm39) |
T26S |
probably benign |
Het |
| Tubb4a |
T |
A |
17: 57,388,016 (GRCm39) |
N337Y |
probably damaging |
Het |
| Tubb6 |
T |
A |
18: 67,534,458 (GRCm39) |
V119E |
probably damaging |
Het |
| Unk |
C |
T |
11: 115,945,772 (GRCm39) |
T481I |
probably benign |
Het |
| Vmn2r112 |
C |
T |
17: 22,820,259 (GRCm39) |
T44I |
probably benign |
Het |
| Vstm5 |
G |
A |
9: 15,168,829 (GRCm39) |
G131D |
probably damaging |
Het |
| Wscd1 |
T |
C |
11: 71,650,709 (GRCm39) |
L12P |
probably damaging |
Het |
| Zfp369 |
T |
A |
13: 65,444,044 (GRCm39) |
S396T |
possibly damaging |
Het |
| Zfp932 |
T |
A |
5: 110,157,209 (GRCm39) |
C302* |
probably null |
Het |
| Zfp972 |
A |
T |
2: 177,548,728 (GRCm39) |
|
probably null |
Het |
| Zfyve21 |
C |
A |
12: 111,794,028 (GRCm39) |
A212E |
probably benign |
Het |
|
| Other mutations in Kcnt2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00561:Kcnt2
|
APN |
1 |
140,450,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00673:Kcnt2
|
APN |
1 |
140,523,789 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
IGL00806:Kcnt2
|
APN |
1 |
140,450,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01135:Kcnt2
|
APN |
1 |
140,282,293 (GRCm39) |
critical splice donor site |
probably null |
0.00 |
|
IGL01412:Kcnt2
|
APN |
1 |
140,498,155 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01777:Kcnt2
|
APN |
1 |
140,523,736 (GRCm39) |
missense |
probably benign |
0.20 |
|
IGL01780:Kcnt2
|
APN |
1 |
140,279,007 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02134:Kcnt2
|
APN |
1 |
140,304,121 (GRCm39) |
missense |
probably benign |
|
|
IGL02350:Kcnt2
|
APN |
1 |
140,279,007 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02357:Kcnt2
|
APN |
1 |
140,279,007 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02481:Kcnt2
|
APN |
1 |
140,282,299 (GRCm39) |
splice site |
probably benign |
|
|
IGL02483:Kcnt2
|
APN |
1 |
140,282,299 (GRCm39) |
splice site |
probably benign |
|
|
IGL02866:Kcnt2
|
APN |
1 |
140,352,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02891:Kcnt2
|
APN |
1 |
140,502,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03007:Kcnt2
|
APN |
1 |
140,282,245 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL03024:Kcnt2
|
APN |
1 |
140,498,193 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03231:Kcnt2
|
APN |
1 |
140,461,740 (GRCm39) |
intron |
probably benign |
|
|
BB002:Kcnt2
|
UTSW |
1 |
140,282,247 (GRCm39) |
nonsense |
probably null |
|
|
BB012:Kcnt2
|
UTSW |
1 |
140,282,247 (GRCm39) |
nonsense |
probably null |
|
|
R0230:Kcnt2
|
UTSW |
1 |
140,174,083 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0367:Kcnt2
|
UTSW |
1 |
140,278,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0486:Kcnt2
|
UTSW |
1 |
140,437,218 (GRCm39) |
nonsense |
probably null |
|
|
R0543:Kcnt2
|
UTSW |
1 |
140,537,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0849:Kcnt2
|
UTSW |
1 |
140,435,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1123:Kcnt2
|
UTSW |
1 |
140,501,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1156:Kcnt2
|
UTSW |
1 |
140,356,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1425:Kcnt2
|
UTSW |
1 |
140,310,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1530:Kcnt2
|
UTSW |
1 |
140,411,970 (GRCm39) |
nonsense |
probably null |
|
|
R1546:Kcnt2
|
UTSW |
1 |
140,359,116 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1728:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1729:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1730:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1739:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1762:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1783:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1784:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1785:Kcnt2
|
UTSW |
1 |
140,282,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1862:Kcnt2
|
UTSW |
1 |
140,353,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1887:Kcnt2
|
UTSW |
1 |
140,511,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1889:Kcnt2
|
UTSW |
1 |
140,512,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1894:Kcnt2
|
UTSW |
1 |
140,353,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2005:Kcnt2
|
UTSW |
1 |
140,480,756 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2044:Kcnt2
|
UTSW |
1 |
140,302,892 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2115:Kcnt2
|
UTSW |
1 |
140,480,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2135:Kcnt2
|
UTSW |
1 |
140,356,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Kcnt2
|
UTSW |
1 |
140,437,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2212:Kcnt2
|
UTSW |
1 |
140,458,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2267:Kcnt2
|
UTSW |
1 |
140,501,421 (GRCm39) |
splice site |
probably null |
|
|
R2442:Kcnt2
|
UTSW |
1 |
140,304,091 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R3121:Kcnt2
|
UTSW |
1 |
140,356,622 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3176:Kcnt2
|
UTSW |
1 |
140,537,377 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3276:Kcnt2
|
UTSW |
1 |
140,537,377 (GRCm39) |
missense |
probably benign |
0.16 |
|
R3704:Kcnt2
|
UTSW |
1 |
140,461,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Kcnt2
|
UTSW |
1 |
140,512,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4164:Kcnt2
|
UTSW |
1 |
140,537,368 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4201:Kcnt2
|
UTSW |
1 |
140,353,070 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4501:Kcnt2
|
UTSW |
1 |
140,480,718 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4502:Kcnt2
|
UTSW |
1 |
140,435,485 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4632:Kcnt2
|
UTSW |
1 |
140,450,886 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4758:Kcnt2
|
UTSW |
1 |
140,446,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4790:Kcnt2
|
UTSW |
1 |
140,282,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4892:Kcnt2
|
UTSW |
1 |
140,440,763 (GRCm39) |
nonsense |
probably null |
|
|
R4973:Kcnt2
|
UTSW |
1 |
140,537,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5154:Kcnt2
|
UTSW |
1 |
140,278,994 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5296:Kcnt2
|
UTSW |
1 |
140,537,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5353:Kcnt2
|
UTSW |
1 |
140,354,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5605:Kcnt2
|
UTSW |
1 |
140,502,481 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R5806:Kcnt2
|
UTSW |
1 |
140,437,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5887:Kcnt2
|
UTSW |
1 |
140,353,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5917:Kcnt2
|
UTSW |
1 |
140,461,666 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5961:Kcnt2
|
UTSW |
1 |
140,435,440 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6123:Kcnt2
|
UTSW |
1 |
140,290,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6225:Kcnt2
|
UTSW |
1 |
140,354,661 (GRCm39) |
nonsense |
probably null |
|
|
R6248:Kcnt2
|
UTSW |
1 |
140,437,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6380:Kcnt2
|
UTSW |
1 |
140,437,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6532:Kcnt2
|
UTSW |
1 |
140,511,844 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6693:Kcnt2
|
UTSW |
1 |
140,278,965 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6817:Kcnt2
|
UTSW |
1 |
140,173,931 (GRCm39) |
unclassified |
probably benign |
|
|
R6856:Kcnt2
|
UTSW |
1 |
140,523,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6944:Kcnt2
|
UTSW |
1 |
140,511,803 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6971:Kcnt2
|
UTSW |
1 |
140,440,646 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7052:Kcnt2
|
UTSW |
1 |
140,310,785 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7138:Kcnt2
|
UTSW |
1 |
140,523,778 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7261:Kcnt2
|
UTSW |
1 |
140,282,255 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7474:Kcnt2
|
UTSW |
1 |
140,498,216 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7524:Kcnt2
|
UTSW |
1 |
140,511,793 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7541:Kcnt2
|
UTSW |
1 |
140,304,122 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7558:Kcnt2
|
UTSW |
1 |
140,450,928 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7651:Kcnt2
|
UTSW |
1 |
140,498,199 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7730:Kcnt2
|
UTSW |
1 |
140,446,686 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7875:Kcnt2
|
UTSW |
1 |
140,501,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7883:Kcnt2
|
UTSW |
1 |
140,450,888 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7925:Kcnt2
|
UTSW |
1 |
140,282,247 (GRCm39) |
nonsense |
probably null |
|
|
R8040:Kcnt2
|
UTSW |
1 |
140,377,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8041:Kcnt2
|
UTSW |
1 |
140,537,398 (GRCm39) |
missense |
probably benign |
|
|
R8171:Kcnt2
|
UTSW |
1 |
140,437,203 (GRCm39) |
missense |
probably benign |
0.13 |
|
R8268:Kcnt2
|
UTSW |
1 |
140,450,954 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8905:Kcnt2
|
UTSW |
1 |
140,435,467 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8927:Kcnt2
|
UTSW |
1 |
140,356,535 (GRCm39) |
splice site |
probably null |
|
|
R8988:Kcnt2
|
UTSW |
1 |
140,356,587 (GRCm39) |
missense |
probably benign |
0.38 |
|
R9020:Kcnt2
|
UTSW |
1 |
140,512,049 (GRCm39) |
missense |
probably benign |
0.23 |
|
R9109:Kcnt2
|
UTSW |
1 |
140,353,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9167:Kcnt2
|
UTSW |
1 |
140,506,200 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9232:Kcnt2
|
UTSW |
1 |
140,411,931 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R9297:Kcnt2
|
UTSW |
1 |
140,352,933 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9298:Kcnt2
|
UTSW |
1 |
140,353,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9318:Kcnt2
|
UTSW |
1 |
140,352,933 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9404:Kcnt2
|
UTSW |
1 |
140,353,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0062:Kcnt2
|
UTSW |
1 |
140,440,729 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
Z1088:Kcnt2
|
UTSW |
1 |
140,511,896 (GRCm39) |
nonsense |
probably null |
|
|
Z1088:Kcnt2
|
UTSW |
1 |
140,501,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Kcnt2
|
UTSW |
1 |
140,304,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Kcnt2
|
UTSW |
1 |
140,537,386 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCTGGCGTCTTGTAAGAGTAC -3'
(R):5'- AAGTCTGAATCCATGCCTTTTAGC -3'
Sequencing Primer
(F):5'- ATACACTATGTCTGGTCTACTTTGG -3'
(R):5'- CTTACTGAGATGATGAAGGGG -3'
|
| Posted On |
2018-04-27 |
Incidental Mutation