Incidental Mutation 'R6351:Cux1'
| ID |
514239 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cux1
|
| Ensembl Gene |
ENSMUSG00000029705 |
| Gene Name |
cut-like homeobox 1 |
| Synonyms |
CDP, Cutl1, Cux, Cux-1 |
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.892)
|
| Stock # |
R6351 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
136276989-136596344 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 136338646 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 582
(S582T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000004097
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000004097]
[ENSMUST00000175918]
[ENSMUST00000175975]
[ENSMUST00000175998]
[ENSMUST00000176172]
[ENSMUST00000176216]
[ENSMUST00000176778]
[ENSMUST00000176423]
[ENSMUST00000176745]
[ENSMUST00000177297]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000004097
AA Change: S582T
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000004097
Gene: ENSMUSG00000029705
AA Change: S582T
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
low complexity region
|
425 |
436 |
N/A |
INTRINSIC |
|
CUT
|
452 |
538 |
5.06e-39 |
SMART |
|
low complexity region
|
602 |
608 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
642 |
N/A |
INTRINSIC |
|
CUT
|
841 |
929 |
3.31e-43 |
SMART |
|
low complexity region
|
956 |
972 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1011 |
N/A |
INTRINSIC |
|
CUT
|
1024 |
1110 |
3.78e-38 |
SMART |
|
HOX
|
1150 |
1212 |
6.32e-15 |
SMART |
|
low complexity region
|
1224 |
1239 |
N/A |
INTRINSIC |
|
low complexity region
|
1317 |
1379 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148082
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175918
|
| SMART Domains |
Protein: ENSMUSP00000135606
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
73 |
328 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000175975
AA Change: S660T
PolyPhen 2
Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000135223
Gene: ENSMUSG00000029705
AA Change: S660T
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
235 |
251 |
N/A |
INTRINSIC |
|
low complexity region
|
277 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
331 |
342 |
N/A |
INTRINSIC |
|
CUT
|
358 |
444 |
5.06e-39 |
SMART |
|
low complexity region
|
508 |
514 |
N/A |
INTRINSIC |
|
low complexity region
|
526 |
548 |
N/A |
INTRINSIC |
|
CUT
|
747 |
835 |
3.31e-43 |
SMART |
|
low complexity region
|
862 |
878 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
917 |
N/A |
INTRINSIC |
|
CUT
|
930 |
1016 |
3.78e-38 |
SMART |
|
HOX
|
1056 |
1118 |
6.32e-15 |
SMART |
|
low complexity region
|
1130 |
1145 |
N/A |
INTRINSIC |
|
low complexity region
|
1223 |
1285 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175998
|
| SMART Domains |
Protein: ENSMUSP00000135816
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
coiled coil region
|
76 |
148 |
N/A |
INTRINSIC |
|
Pfam:CASP_C
|
204 |
430 |
8.6e-72 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176172
AA Change: S673T
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000135086
Gene: ENSMUSG00000029705
AA Change: S673T
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
99 |
354 |
N/A |
INTRINSIC |
|
low complexity region
|
420 |
436 |
N/A |
INTRINSIC |
|
low complexity region
|
462 |
474 |
N/A |
INTRINSIC |
|
low complexity region
|
516 |
527 |
N/A |
INTRINSIC |
|
CUT
|
543 |
629 |
5.06e-39 |
SMART |
|
low complexity region
|
693 |
699 |
N/A |
INTRINSIC |
|
low complexity region
|
711 |
733 |
N/A |
INTRINSIC |
|
CUT
|
932 |
1020 |
3.31e-43 |
SMART |
|
low complexity region
|
1047 |
1063 |
N/A |
INTRINSIC |
|
low complexity region
|
1081 |
1102 |
N/A |
INTRINSIC |
|
CUT
|
1115 |
1201 |
3.78e-38 |
SMART |
|
HOX
|
1241 |
1303 |
6.32e-15 |
SMART |
|
low complexity region
|
1315 |
1330 |
N/A |
INTRINSIC |
|
low complexity region
|
1408 |
1470 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176216
|
| SMART Domains |
Protein: ENSMUSP00000135054
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
369 |
390 |
9.35e-5 |
PROSPERO |
|
Pfam:CASP_C
|
421 |
647 |
1.2e-71 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176778
AA Change: S665T
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000135892
Gene: ENSMUSG00000029705
AA Change: S665T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
86 |
N/A |
INTRINSIC |
|
coiled coil region
|
195 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
519 |
N/A |
INTRINSIC |
|
CUT
|
535 |
621 |
5.06e-39 |
SMART |
|
low complexity region
|
685 |
691 |
N/A |
INTRINSIC |
|
low complexity region
|
703 |
725 |
N/A |
INTRINSIC |
|
CUT
|
924 |
1012 |
3.31e-43 |
SMART |
|
low complexity region
|
1039 |
1055 |
N/A |
INTRINSIC |
|
low complexity region
|
1073 |
1094 |
N/A |
INTRINSIC |
|
CUT
|
1107 |
1193 |
3.78e-38 |
SMART |
|
HOX
|
1233 |
1295 |
6.32e-15 |
SMART |
|
low complexity region
|
1307 |
1322 |
N/A |
INTRINSIC |
|
low complexity region
|
1400 |
1462 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000176486
AA Change: S544T
|
| SMART Domains |
Protein: ENSMUSP00000135370
Gene: ENSMUSG00000029705
AA Change: S544T
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
363 |
N/A |
INTRINSIC |
|
low complexity region
|
429 |
445 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
483 |
N/A |
INTRINSIC |
|
low complexity region
|
525 |
536 |
N/A |
INTRINSIC |
|
CUT
|
552 |
638 |
5.06e-39 |
SMART |
|
Blast:CUT
|
641 |
840 |
3e-50 |
BLAST |
|
CUT
|
919 |
1007 |
3.31e-43 |
SMART |
|
low complexity region
|
1034 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1068 |
1089 |
N/A |
INTRINSIC |
|
CUT
|
1102 |
1188 |
3.78e-38 |
SMART |
|
HOX
|
1228 |
1290 |
6.32e-15 |
SMART |
|
low complexity region
|
1302 |
1317 |
N/A |
INTRINSIC |
|
low complexity region
|
1395 |
1457 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176423
|
| SMART Domains |
Protein: ENSMUSP00000135036
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
52 |
64 |
N/A |
INTRINSIC |
|
coiled coil region
|
76 |
148 |
N/A |
INTRINSIC |
|
low complexity region
|
217 |
226 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176745
|
| SMART Domains |
Protein: ENSMUSP00000135512
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
363 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
367 |
388 |
8.95e-5 |
PROSPERO |
|
Pfam:CASP_C
|
419 |
645 |
1.2e-71 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177297
|
| SMART Domains |
Protein: ENSMUSP00000134819
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
369 |
390 |
8.99e-6 |
PROSPERO |
|
Pfam:CASP_C
|
422 |
527 |
1.8e-17 |
PFAM |
|
| Meta Mutation Damage Score |
0.0851 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.2%
- 20x: 94.9%
|
| Validation Efficiency |
99% (95/96) |
| MGI Phenotype |
PHENOTYPE: Homozygotes for a targeted null mutation exhibit delayed lung development and neonatal mortality. Survivors show growth retardation and hair defects. Homozygotes for a partially deleted protein have curly hair, and females tend to lose their litters. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acaa1a |
C |
A |
9: 119,170,630 (GRCm39) |
S17* |
probably null |
Het |
| Adamts16 |
T |
A |
13: 70,984,322 (GRCm39) |
S114C |
probably damaging |
Het |
| Agpat5 |
T |
C |
8: 18,896,724 (GRCm39) |
V50A |
probably benign |
Het |
| Agrn |
T |
C |
4: 156,263,891 (GRCm39) |
N124S |
probably benign |
Het |
| Ak8 |
T |
C |
2: 28,625,638 (GRCm39) |
I227T |
probably benign |
Het |
| Akap6 |
A |
G |
12: 53,188,808 (GRCm39) |
E2074G |
probably damaging |
Het |
| Apc |
T |
A |
18: 34,445,265 (GRCm39) |
S702R |
probably damaging |
Het |
| Ascc3 |
T |
C |
10: 50,596,769 (GRCm39) |
I1233T |
probably damaging |
Het |
| Asphd2 |
A |
T |
5: 112,533,698 (GRCm39) |
F318I |
probably damaging |
Het |
| Bltp1 |
G |
A |
3: 36,962,377 (GRCm39) |
A493T |
probably damaging |
Het |
| Bnc2 |
T |
C |
4: 84,211,380 (GRCm39) |
T397A |
probably benign |
Het |
| Bpifb4 |
C |
T |
2: 153,799,054 (GRCm39) |
T528I |
probably damaging |
Het |
| Brinp3 |
A |
G |
1: 146,777,323 (GRCm39) |
E590G |
probably damaging |
Het |
| Ccdc149 |
A |
G |
5: 52,542,477 (GRCm39) |
S372P |
probably benign |
Het |
| Cdhr2 |
A |
G |
13: 54,874,589 (GRCm39) |
H887R |
probably benign |
Het |
| Clcn6 |
C |
T |
4: 148,101,957 (GRCm39) |
V376I |
probably benign |
Het |
| Cntln |
T |
G |
4: 85,033,591 (GRCm39) |
C1305W |
probably damaging |
Het |
| Cspg4 |
A |
G |
9: 56,799,928 (GRCm39) |
D1564G |
probably benign |
Het |
| Cwh43 |
G |
A |
5: 73,569,248 (GRCm39) |
A97T |
possibly damaging |
Het |
| Dsc1 |
A |
T |
18: 20,219,826 (GRCm39) |
F781L |
probably damaging |
Het |
| Dsc3 |
G |
T |
18: 20,099,348 (GRCm39) |
H723N |
probably benign |
Het |
| Ear10 |
A |
T |
14: 44,160,512 (GRCm39) |
V105D |
probably damaging |
Het |
| Ecel1 |
A |
G |
1: 87,077,231 (GRCm39) |
V659A |
possibly damaging |
Het |
| Eogt |
A |
T |
6: 97,097,155 (GRCm39) |
F316I |
probably damaging |
Het |
| Etaa1 |
T |
C |
11: 17,897,188 (GRCm39) |
N310D |
possibly damaging |
Het |
| Exoc3l2 |
G |
A |
7: 19,203,633 (GRCm39) |
R75Q |
possibly damaging |
Het |
| Fam186a |
A |
C |
15: 99,839,623 (GRCm39) |
L2207R |
probably damaging |
Het |
| Fam187b |
T |
C |
7: 30,677,024 (GRCm39) |
Y178H |
probably damaging |
Het |
| Fat1 |
A |
T |
8: 45,486,532 (GRCm39) |
Q3362L |
probably damaging |
Het |
| Fat3 |
A |
T |
9: 15,849,694 (GRCm39) |
S3903T |
probably damaging |
Het |
| Fsip2 |
G |
A |
2: 82,823,028 (GRCm39) |
V6254I |
possibly damaging |
Het |
| Gabra5 |
T |
C |
7: 57,063,528 (GRCm39) |
T299A |
probably damaging |
Het |
| Gbp11 |
T |
C |
5: 105,475,464 (GRCm39) |
T295A |
probably benign |
Het |
| Glcci1 |
C |
T |
6: 8,573,203 (GRCm39) |
Q44* |
probably null |
Het |
| Gpc5 |
A |
T |
14: 115,636,612 (GRCm39) |
T432S |
probably benign |
Het |
| Grhl1 |
G |
A |
12: 24,634,857 (GRCm39) |
E228K |
probably damaging |
Het |
| Hyal5 |
T |
C |
6: 24,891,708 (GRCm39) |
|
probably null |
Het |
| Idh2 |
TCCCAGG |
T |
7: 79,748,079 (GRCm39) |
|
probably benign |
Het |
| Ints9 |
A |
G |
14: 65,230,456 (GRCm39) |
I128V |
probably damaging |
Het |
| Kcnt2 |
A |
T |
1: 140,302,850 (GRCm39) |
N130I |
probably damaging |
Het |
| Krba1 |
T |
C |
6: 48,391,062 (GRCm39) |
V717A |
probably benign |
Het |
| Lrp12 |
T |
A |
15: 39,741,584 (GRCm39) |
D377V |
probably damaging |
Het |
| Magi1 |
G |
T |
6: 93,920,210 (GRCm39) |
D135E |
possibly damaging |
Het |
| Map10 |
T |
A |
8: 126,397,984 (GRCm39) |
L459Q |
probably damaging |
Het |
| Mitf |
A |
G |
6: 97,980,873 (GRCm39) |
D238G |
possibly damaging |
Het |
| Ms4a19 |
C |
T |
19: 11,119,765 (GRCm39) |
G14D |
probably damaging |
Het |
| Mylk |
G |
T |
16: 34,742,341 (GRCm39) |
R951L |
probably benign |
Het |
| Nacad |
T |
A |
11: 6,549,235 (GRCm39) |
D1272V |
probably damaging |
Het |
| Nacad |
T |
A |
11: 6,550,165 (GRCm39) |
K1009* |
probably null |
Het |
| Ncor1 |
T |
C |
11: 62,264,124 (GRCm39) |
D786G |
probably benign |
Het |
| Oas2 |
G |
A |
5: 120,886,603 (GRCm39) |
R188C |
probably benign |
Het |
| Odf2l |
A |
G |
3: 144,841,479 (GRCm39) |
I300V |
probably benign |
Het |
| Or1j10 |
T |
A |
2: 36,267,208 (GRCm39) |
V140D |
possibly damaging |
Het |
| Or51b17 |
A |
T |
7: 103,542,342 (GRCm39) |
L200* |
probably null |
Het |
| Or51v8 |
A |
G |
7: 103,320,163 (GRCm39) |
I25T |
possibly damaging |
Het |
| Or5p60 |
A |
G |
7: 107,723,637 (GRCm39) |
S278P |
probably damaging |
Het |
| Or9i1 |
A |
G |
19: 13,839,186 (GRCm39) |
T10A |
probably benign |
Het |
| Pes1 |
T |
A |
11: 3,928,865 (GRCm39) |
D574E |
probably benign |
Het |
| Phf20 |
C |
T |
2: 156,136,130 (GRCm39) |
R650C |
possibly damaging |
Het |
| Pias4 |
G |
A |
10: 80,993,098 (GRCm39) |
T248I |
probably damaging |
Het |
| Pkhd1 |
T |
C |
1: 20,282,175 (GRCm39) |
T2889A |
probably benign |
Het |
| Plcxd1 |
C |
A |
5: 110,250,033 (GRCm39) |
|
probably null |
Het |
| Plekha7 |
A |
G |
7: 115,776,133 (GRCm39) |
F194L |
probably damaging |
Het |
| Plxnb2 |
T |
C |
15: 89,041,973 (GRCm39) |
N1642S |
possibly damaging |
Het |
| Pnpla7 |
A |
T |
2: 24,901,576 (GRCm39) |
D534V |
probably damaging |
Het |
| Ppp2r5c |
A |
T |
12: 110,521,313 (GRCm39) |
S279C |
probably damaging |
Het |
| Ptprq |
T |
A |
10: 107,544,529 (GRCm39) |
T334S |
probably damaging |
Het |
| Rab39 |
T |
C |
9: 53,597,821 (GRCm39) |
D148G |
probably benign |
Het |
| Reep3 |
A |
T |
10: 66,870,432 (GRCm39) |
F121L |
probably benign |
Het |
| Reln |
G |
T |
5: 22,106,661 (GRCm39) |
C3236* |
probably null |
Het |
| Rrp8 |
C |
T |
7: 105,384,016 (GRCm39) |
C162Y |
probably damaging |
Het |
| Scrib |
C |
A |
15: 75,936,835 (GRCm39) |
Q399H |
possibly damaging |
Het |
| Sertad1 |
T |
A |
7: 27,189,224 (GRCm39) |
Y182N |
possibly damaging |
Het |
| Sfrp5 |
A |
G |
19: 42,190,263 (GRCm39) |
V63A |
possibly damaging |
Het |
| Shoc1 |
T |
C |
4: 59,069,317 (GRCm39) |
D703G |
probably benign |
Het |
| Slc46a1 |
T |
C |
11: 78,357,985 (GRCm39) |
M346T |
probably benign |
Het |
| Sycp2 |
A |
G |
2: 178,005,209 (GRCm39) |
L886S |
probably damaging |
Het |
| Teddm1b |
A |
T |
1: 153,750,505 (GRCm39) |
I105F |
probably benign |
Het |
| Thumpd1 |
A |
T |
7: 119,319,828 (GRCm39) |
I46N |
possibly damaging |
Het |
| Tmod4 |
A |
G |
3: 95,035,164 (GRCm39) |
N223S |
probably damaging |
Het |
| Tnfrsf10b |
G |
C |
14: 70,010,850 (GRCm39) |
C85S |
probably damaging |
Het |
| Tox |
T |
C |
4: 6,697,439 (GRCm39) |
T455A |
probably benign |
Het |
| Tox |
T |
C |
4: 6,741,536 (GRCm39) |
Q148R |
probably benign |
Het |
| Trp53bp1 |
A |
C |
2: 121,100,426 (GRCm39) |
S109R |
probably damaging |
Het |
| Tshz2 |
A |
T |
2: 169,726,888 (GRCm39) |
T26S |
probably benign |
Het |
| Tubb4a |
T |
A |
17: 57,388,016 (GRCm39) |
N337Y |
probably damaging |
Het |
| Tubb6 |
T |
A |
18: 67,534,458 (GRCm39) |
V119E |
probably damaging |
Het |
| Unk |
C |
T |
11: 115,945,772 (GRCm39) |
T481I |
probably benign |
Het |
| Vmn2r112 |
C |
T |
17: 22,820,259 (GRCm39) |
T44I |
probably benign |
Het |
| Vstm5 |
G |
A |
9: 15,168,829 (GRCm39) |
G131D |
probably damaging |
Het |
| Wscd1 |
T |
C |
11: 71,650,709 (GRCm39) |
L12P |
probably damaging |
Het |
| Zfp369 |
T |
A |
13: 65,444,044 (GRCm39) |
S396T |
possibly damaging |
Het |
| Zfp932 |
T |
A |
5: 110,157,209 (GRCm39) |
C302* |
probably null |
Het |
| Zfp972 |
A |
T |
2: 177,548,728 (GRCm39) |
|
probably null |
Het |
| Zfyve21 |
C |
A |
12: 111,794,028 (GRCm39) |
A212E |
probably benign |
Het |
|
| Other mutations in Cux1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00846:Cux1
|
APN |
5 |
136,355,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00966:Cux1
|
APN |
5 |
136,340,345 (GRCm39) |
intron |
probably benign |
|
|
IGL01129:Cux1
|
APN |
5 |
136,333,572 (GRCm39) |
intron |
probably benign |
|
|
IGL01885:Cux1
|
APN |
5 |
136,337,301 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01947:Cux1
|
APN |
5 |
136,303,979 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02259:Cux1
|
APN |
5 |
136,355,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02666:Cux1
|
APN |
5 |
136,304,169 (GRCm39) |
nonsense |
probably null |
|
|
IGL02826:Cux1
|
APN |
5 |
136,336,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03014:Cux1
|
UTSW |
5 |
136,594,379 (GRCm39) |
intron |
probably benign |
|
|
R0047:Cux1
|
UTSW |
5 |
136,392,107 (GRCm39) |
splice site |
probably benign |
|
|
R0047:Cux1
|
UTSW |
5 |
136,392,107 (GRCm39) |
splice site |
probably benign |
|
|
R0057:Cux1
|
UTSW |
5 |
136,285,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Cux1
|
UTSW |
5 |
136,308,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0295:Cux1
|
UTSW |
5 |
136,342,066 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0361:Cux1
|
UTSW |
5 |
136,308,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0533:Cux1
|
UTSW |
5 |
136,336,713 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Cux1
|
UTSW |
5 |
136,315,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0801:Cux1
|
UTSW |
5 |
136,355,783 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0884:Cux1
|
UTSW |
5 |
136,336,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0976:Cux1
|
UTSW |
5 |
136,342,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1073:Cux1
|
UTSW |
5 |
136,281,395 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1222:Cux1
|
UTSW |
5 |
136,304,003 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1518:Cux1
|
UTSW |
5 |
136,337,133 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1686:Cux1
|
UTSW |
5 |
136,304,235 (GRCm39) |
nonsense |
probably null |
|
|
R1687:Cux1
|
UTSW |
5 |
136,341,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Cux1
|
UTSW |
5 |
136,421,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1797:Cux1
|
UTSW |
5 |
136,304,169 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1919:Cux1
|
UTSW |
5 |
136,392,173 (GRCm39) |
nonsense |
probably null |
|
|
R2051:Cux1
|
UTSW |
5 |
136,361,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2339:Cux1
|
UTSW |
5 |
136,315,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3438:Cux1
|
UTSW |
5 |
136,340,414 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3713:Cux1
|
UTSW |
5 |
136,594,397 (GRCm39) |
intron |
probably benign |
|
|
R3800:Cux1
|
UTSW |
5 |
136,344,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3964:Cux1
|
UTSW |
5 |
136,311,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4135:Cux1
|
UTSW |
5 |
136,336,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4198:Cux1
|
UTSW |
5 |
136,315,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4467:Cux1
|
UTSW |
5 |
136,341,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4498:Cux1
|
UTSW |
5 |
136,341,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4622:Cux1
|
UTSW |
5 |
136,337,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4623:Cux1
|
UTSW |
5 |
136,337,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4651:Cux1
|
UTSW |
5 |
136,596,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4652:Cux1
|
UTSW |
5 |
136,596,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4658:Cux1
|
UTSW |
5 |
136,279,448 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4665:Cux1
|
UTSW |
5 |
136,315,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4704:Cux1
|
UTSW |
5 |
136,278,055 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4867:Cux1
|
UTSW |
5 |
136,303,815 (GRCm39) |
intron |
probably benign |
|
|
R4965:Cux1
|
UTSW |
5 |
136,340,410 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R5090:Cux1
|
UTSW |
5 |
136,342,054 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5155:Cux1
|
UTSW |
5 |
136,594,295 (GRCm39) |
intron |
probably benign |
|
|
R5226:Cux1
|
UTSW |
5 |
136,399,027 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5252:Cux1
|
UTSW |
5 |
136,337,151 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5266:Cux1
|
UTSW |
5 |
136,341,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5399:Cux1
|
UTSW |
5 |
136,281,458 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5509:Cux1
|
UTSW |
5 |
136,304,171 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5609:Cux1
|
UTSW |
5 |
136,421,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5681:Cux1
|
UTSW |
5 |
136,337,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5993:Cux1
|
UTSW |
5 |
136,392,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6049:Cux1
|
UTSW |
5 |
136,361,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6290:Cux1
|
UTSW |
5 |
136,340,412 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6310:Cux1
|
UTSW |
5 |
136,304,018 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6531:Cux1
|
UTSW |
5 |
136,303,973 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6590:Cux1
|
UTSW |
5 |
136,368,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6663:Cux1
|
UTSW |
5 |
136,514,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6690:Cux1
|
UTSW |
5 |
136,368,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6777:Cux1
|
UTSW |
5 |
136,594,422 (GRCm39) |
intron |
probably benign |
|
|
R6786:Cux1
|
UTSW |
5 |
136,596,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6817:Cux1
|
UTSW |
5 |
136,402,027 (GRCm39) |
splice site |
probably null |
|
|
R6989:Cux1
|
UTSW |
5 |
136,308,502 (GRCm39) |
nonsense |
probably null |
|
|
R7011:Cux1
|
UTSW |
5 |
136,388,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Cux1
|
UTSW |
5 |
136,338,895 (GRCm39) |
splice site |
probably null |
|
|
R7699:Cux1
|
UTSW |
5 |
136,514,593 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7861:Cux1
|
UTSW |
5 |
136,281,458 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7876:Cux1
|
UTSW |
5 |
136,392,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7916:Cux1
|
UTSW |
5 |
136,311,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8023:Cux1
|
UTSW |
5 |
136,402,251 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8154:Cux1
|
UTSW |
5 |
136,281,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Cux1
|
UTSW |
5 |
136,311,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8289:Cux1
|
UTSW |
5 |
136,337,358 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8305:Cux1
|
UTSW |
5 |
136,388,863 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8319:Cux1
|
UTSW |
5 |
136,594,251 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8405:Cux1
|
UTSW |
5 |
136,304,241 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8483:Cux1
|
UTSW |
5 |
136,303,944 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8506:Cux1
|
UTSW |
5 |
136,337,358 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8671:Cux1
|
UTSW |
5 |
136,279,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8680:Cux1
|
UTSW |
5 |
136,336,710 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8737:Cux1
|
UTSW |
5 |
136,311,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8738:Cux1
|
UTSW |
5 |
136,402,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8793:Cux1
|
UTSW |
5 |
136,594,539 (GRCm39) |
missense |
unknown |
|
|
R8897:Cux1
|
UTSW |
5 |
136,315,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8926:Cux1
|
UTSW |
5 |
136,338,404 (GRCm39) |
intron |
probably benign |
|
|
R8954:Cux1
|
UTSW |
5 |
136,402,203 (GRCm39) |
nonsense |
probably null |
|
|
R9092:Cux1
|
UTSW |
5 |
136,514,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9205:Cux1
|
UTSW |
5 |
136,398,989 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Cux1
|
UTSW |
5 |
136,340,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9578:Cux1
|
UTSW |
5 |
136,282,919 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9682:Cux1
|
UTSW |
5 |
136,337,116 (GRCm39) |
missense |
probably benign |
|
|
R9701:Cux1
|
UTSW |
5 |
136,343,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9712:Cux1
|
UTSW |
5 |
136,338,673 (GRCm39) |
missense |
probably benign |
0.35 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGTGGAATCATACTCAGGG -3'
(R):5'- CCCACTTTCAGTCAGTCGTCAG -3'
Sequencing Primer
(F):5'- GAATCATACTCAGGGTCACTTTGGAG -3'
(R):5'- AGTCAGTCGTCAGCCTCAC -3'
|
| Posted On |
2018-04-27 |
Incidental Mutation