Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01064:Olfr635'

51424

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr635

Ensembl Gene

ENSMUSG00000094520

Gene Name

olfactory receptor 635

Synonyms

GA_x6K02T2PBJ9-6713641-6714588, MOR5-2

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.101) question?

Stock #

IGL01064

Quality Score

Status

Chromosome

Chromosomal Location

103971152-103987540 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 103979792 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 200 (Y200F)

Ref Sequence

ENSEMBL: ENSMUSP00000148103 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098185] [ENSMUST00000209473]

Predicted Effect

probably benign
Transcript: ENSMUST00000098185
AA Change: Y206F

PolyPhen 2 Score 0.095 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000095788
Gene: ENSMUSG00000094520
AA Change: Y206F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	39	318	1.2e-119	PFAM
Pfam:7TM_GPCR_Srsx	43	182	1.3e-9	PFAM
Pfam:7tm_1	49	300	1.9e-18	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000121874

Predicted Effect

probably benign
Transcript: ENSMUST00000209473
AA Change: Y200F

PolyPhen 2 Score 0.095 (Sensitivity: 0.93; Specificity: 0.85)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	T	11: 9,483,855	T4137S	probably benign	Het
Abcb1a	T	C	5: 8,732,388	Y924H	possibly damaging	Het
Ash1l	T	G	3: 89,072,484	C2772G	probably damaging	Het
Cfap206	C	T	4: 34,721,562	S162N	probably damaging	Het
Cpne6	T	C	14: 55,512,730	F106S	probably damaging	Het
Cysltr1	A	T	X: 106,578,736	I48N	probably damaging	Het
Dsg1a	A	T	18: 20,340,206	I779F	probably damaging	Het
Fpr-rs4	T	A	17: 18,022,517	L262H	probably damaging	Het
Gart	G	A	16: 91,623,007	R871C	probably damaging	Het
Get4	C	T	5: 139,252,522	R20C	probably damaging	Het
Gm13030	G	A	4: 138,873,558		probably benign	Het
Gm17654	A	T	14: 43,578,998	H49Q	unknown	Het
Gpnmb	A	G	6: 49,055,659	I506V	probably benign	Het
Ist1	T	C	8: 109,682,611	I86V	probably damaging	Het
Kcnip1	C	T	11: 33,633,192	D198N	probably damaging	Het
Kif5c	A	G	2: 49,694,816	I184V	possibly damaging	Het
Mink1	A	T	11: 70,603,481	M236L	probably benign	Het
Muc5ac	A	T	7: 141,807,473	N1507I	probably benign	Het
Nrxn2	G	T	19: 6,517,053	E1326D	probably damaging	Het
Olfr1329	A	T	4: 118,916,894	M191K	possibly damaging	Het
Olfr1469	T	C	19: 13,411,226	I219T	probably benign	Het
Patj	T	C	4: 98,496,973	S326P	possibly damaging	Het
Pdha2	T	C	3: 141,211,015	H244R	possibly damaging	Het
Pkhd1	C	T	1: 20,534,530		probably benign	Het
Ptk7	A	T	17: 46,573,566	L746*	probably null	Het
Rad54b	G	A	4: 11,604,866	G438D	probably damaging	Het
Rbm27	T	C	18: 42,319,814	V536A	possibly damaging	Het
Rundc3b	T	A	5: 8,569,553	M135L	probably damaging	Het
Sorcs2	T	C	5: 36,065,352	Y353C	probably damaging	Het
Srcap	T	C	7: 127,559,892		probably benign	Het
Sytl5	A	G	X: 9,905,595	H66R	probably benign	Het
Tlr7	T	A	X: 167,308,211	E93V	probably damaging	Het
Tmem156	A	G	5: 65,079,984	L76S	probably damaging	Het
Tmem246	C	T	4: 49,586,860	V103M	possibly damaging	Het
Tomm70a	T	C	16: 57,152,612	F571S	probably damaging	Het
Trmt10b	A	G	4: 45,314,347	Y261C	possibly damaging	Het

Other mutations in Olfr635

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01330:Olfr635	APN	7	103980142	utr 3 prime	probably benign
IGL01433:Olfr635	APN	7	103979332	missense	probably damaging	1.00
FR4304:Olfr635	UTSW	7	103979903	frame shift	probably null
FR4340:Olfr635	UTSW	7	103979903	frame shift	probably null
FR4342:Olfr635	UTSW	7	103979903	frame shift	probably null
R0271:Olfr635	UTSW	7	103979630	missense	possibly damaging	0.83
R1909:Olfr635	UTSW	7	103979790	nonsense	probably null
R2212:Olfr635	UTSW	7	103979402	missense	probably damaging	0.98
R2484:Olfr635	UTSW	7	103979338	missense	probably benign
R3412:Olfr635	UTSW	7	103979402	missense	probably damaging	0.98
R4513:Olfr635	UTSW	7	103979441	missense	probably benign	0.03
R4559:Olfr635	UTSW	7	103979560	missense	probably damaging	1.00
R5032:Olfr635	UTSW	7	103979374	missense	probably damaging	0.98
R5436:Olfr635	UTSW	7	103979266	missense	probably benign
R5591:Olfr635	UTSW	7	103980113	missense	probably benign	0.00
R5617:Olfr635	UTSW	7	103979714	missense	possibly damaging	0.91
R5911:Olfr635	UTSW	7	103979708	missense	probably benign
R6249:Olfr635	UTSW	7	103979611	missense	possibly damaging	0.85
R6275:Olfr635	UTSW	7	103979974	missense	probably damaging	1.00
R6806:Olfr635	UTSW	7	103979564	missense	possibly damaging	0.72
R7589:Olfr635	UTSW	7	103979791	missense	probably damaging	1.00
R8188:Olfr635	UTSW	7	103979536	missense	probably damaging	1.00
RF004:Olfr635	UTSW	7	103979903	frame shift	probably null
RF005:Olfr635	UTSW	7	103979561	missense	probably damaging	1.00

Posted On

2013-06-21