Mutagenetix > Incidental Mutation

Incidental Mutation 'R6351:Ptprq'

514266

Institutional Source

Beutler Lab

Gene Symbol

Ptprq

Ensembl Gene

ENSMUSG00000035916

Gene Name

protein tyrosine phosphatase, receptor type, Q

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.203) question?

Stock #

R6351 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

107517049-107720051 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 107708668 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 334 (T334S)

Ref Sequence

ENSEMBL: ENSMUSP00000058572 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050702]

AlphaFold

P0C5E4

Predicted Effect

probably damaging
Transcript: ENSMUST00000050702
AA Change: T334S

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000058572
Gene: ENSMUSG00000035916
AA Change: T334S

Domain	Start	End	E-Value	Type
FN3	57	141	3.17e-13	SMART
FN3	156	294	1.55e-7	SMART
FN3	307	384	4.45e-8	SMART
FN3	398	555	1.17e-7	SMART
FN3	569	648	7.06e-11	SMART
FN3	666	743	7.68e-12	SMART
FN3	760	839	1.88e-6	SMART
FN3	855	932	1.33e-6	SMART
FN3	949	1037	2.31e-6	SMART
FN3	1054	1135	1.24e-6	SMART
FN3	1151	1229	2.39e-8	SMART
FN3	1244	1325	6.29e-8	SMART
FN3	1341	1416	2.87e-11	SMART
FN3	1431	1524	2.82e-10	SMART
FN3	1540	1622	6.35e-4	SMART
FN3	1642	1732	7.93e-5	SMART
transmembrane domain	1907	1929	N/A	INTRINSIC
PTPc	2003	2262	1.14e-130	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000218399

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.2%
20x: 94.9%

Validation Efficiency

99% (95/96)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This locus encodes a member of the type III receptor-like protein-tyrosine phosphatase family. The encoded protein catalyzes the dephosphorylation of phosphotyrosine and phosphatidylinositol and plays roles in cellular proliferation and differentiation. Mutations at this locus have been linked to autosomal recessive deafness. [provided by RefSeq, Mar 2014]
PHENOTYPE: Homozygotes for targeted mutations show absence of shaft connectors from vestibular hair bundles, postnatal degeneration in cochlear hair-bundle structure, reduced transducer currents but otherwise normal adaptation properties, a progressive loss of basal-coil cochlear hair cells, and deafness. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 95 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700025F22Rik	C	T	19: 11,142,401	G14D	probably damaging	Het
4932438A13Rik	G	A	3: 36,908,228	A493T	probably damaging	Het
Acaa1a	C	A	9: 119,341,564	S17*	probably null	Het
Adamts16	T	A	13: 70,836,203	S114C	probably damaging	Het
Agpat5	T	C	8: 18,846,708	V50A	probably benign	Het
Agrn	T	C	4: 156,179,434	N124S	probably benign	Het
AI481877	T	C	4: 59,069,317	D703G	probably benign	Het
Ak8	T	C	2: 28,735,626	I227T	probably benign	Het
Akap6	A	G	12: 53,142,025	E2074G	probably damaging	Het
Apc	T	A	18: 34,312,212	S702R	probably damaging	Het
Ascc3	T	C	10: 50,720,673	I1233T	probably damaging	Het
Asphd2	A	T	5: 112,385,832	F318I	probably damaging	Het
Bnc2	T	C	4: 84,293,143	T397A	probably benign	Het
Bpifb4	C	T	2: 153,957,134	T528I	probably damaging	Het
Brinp3	A	G	1: 146,901,585	E590G	probably damaging	Het
Ccdc149	A	G	5: 52,385,135	S372P	probably benign	Het
Cdhr2	A	G	13: 54,726,776	H887R	probably benign	Het
Clcn6	C	T	4: 148,017,500	V376I	probably benign	Het
Cntln	T	G	4: 85,115,354	C1305W	probably damaging	Het
Cspg4	A	G	9: 56,892,644	D1564G	probably benign	Het
Cux1	A	T	5: 136,309,792	S582T	probably damaging	Het
Cwh43	G	A	5: 73,411,905	A97T	possibly damaging	Het
Dsc1	A	T	18: 20,086,769	F781L	probably damaging	Het
Dsc3	G	T	18: 19,966,291	H723N	probably benign	Het
Ear10	A	T	14: 43,923,055	V105D	probably damaging	Het
Ecel1	A	G	1: 87,149,509	V659A	possibly damaging	Het
Eogt	A	T	6: 97,120,194	F316I	probably damaging	Het
Etaa1	T	C	11: 17,947,188	N310D	possibly damaging	Het
Exoc3l2	G	A	7: 19,469,708	R75Q	possibly damaging	Het
Fam186a	A	C	15: 99,941,742	L2207R	probably damaging	Het
Fam187b	T	C	7: 30,977,599	Y178H	probably damaging	Het
Fat1	A	T	8: 45,033,495	Q3362L	probably damaging	Het
Fat3	A	T	9: 15,938,398	S3903T	probably damaging	Het
Fsip2	G	A	2: 82,992,684	V6254I	possibly damaging	Het
Gabra5	T	C	7: 57,413,780	T299A	probably damaging	Het
Gbp11	T	C	5: 105,327,598	T295A	probably benign	Het
Glcci1	C	T	6: 8,573,203	Q44*	probably null	Het
Gpc5	A	T	14: 115,399,200	T432S	probably benign	Het
Grhl1	G	A	12: 24,584,858	E228K	probably damaging	Het
Hyal5	T	C	6: 24,891,709		probably null	Het
Idh2	TCCCAGG	T	7: 80,098,331		probably benign	Het
Ints9	A	G	14: 64,993,007	I128V	probably damaging	Het
Kcnt2	A	T	1: 140,375,112	N130I	probably damaging	Het
Krba1	T	C	6: 48,414,128	V717A	probably benign	Het
Lrp12	T	A	15: 39,878,188	D377V	probably damaging	Het
Magi1	G	T	6: 93,943,229	D135E	possibly damaging	Het
Map10	T	A	8: 125,671,245	L459Q	probably damaging	Het
Mitf	A	G	6: 98,003,912	D238G	possibly damaging	Het
Mylk	G	T	16: 34,921,971	R951L	probably benign	Het
Nacad	T	A	11: 6,600,165	K1009*	probably null	Het
Nacad	T	A	11: 6,599,235	D1272V	probably damaging	Het
Ncor1	T	C	11: 62,373,298	D786G	probably benign	Het
Oas2	G	A	5: 120,748,538	R188C	probably benign	Het
Odf2l	A	G	3: 145,135,718	I300V	probably benign	Het
Olfr1502	A	G	19: 13,861,822	T10A	probably benign	Het
Olfr338	T	A	2: 36,377,196	V140D	possibly damaging	Het
Olfr484	A	G	7: 108,124,430	S278P	probably damaging	Het
Olfr624	A	G	7: 103,670,956	I25T	possibly damaging	Het
Olfr64	A	T	7: 103,893,135	L200*	probably null	Het
Pes1	T	A	11: 3,978,865	D574E	probably benign	Het
Phf20	C	T	2: 156,294,210	R650C	possibly damaging	Het
Pias4	G	A	10: 81,157,264	T248I	probably damaging	Het
Pkhd1	T	C	1: 20,211,951	T2889A	probably benign	Het
Plcxd1	C	A	5: 110,102,167		probably null	Het
Plekha7	A	G	7: 116,176,898	F194L	probably damaging	Het
Plxnb2	T	C	15: 89,157,770	N1642S	possibly damaging	Het
Pnpla7	A	T	2: 25,011,564	D534V	probably damaging	Het
Ppp2r5c	A	T	12: 110,554,879	S279C	probably damaging	Het
Rab39	T	C	9: 53,686,521	D148G	probably benign	Het
Reep3	A	T	10: 67,034,653	F121L	probably benign	Het
Reln	G	T	5: 21,901,663	C3236*	probably null	Het
Rrp8	C	T	7: 105,734,809	C162Y	probably damaging	Het
Scrib	C	A	15: 76,064,986	Q399H	possibly damaging	Het
Sertad1	T	A	7: 27,489,799	Y182N	possibly damaging	Het
Sfrp5	A	G	19: 42,201,824	V63A	possibly damaging	Het
Slc46a1	T	C	11: 78,467,159	M346T	probably benign	Het
Sycp2	A	G	2: 178,363,416	L886S	probably damaging	Het
Teddm1b	A	T	1: 153,874,759	I105F	probably benign	Het
Thumpd1	A	T	7: 119,720,605	I46N	possibly damaging	Het
Tmod4	A	G	3: 95,127,853	N223S	probably damaging	Het
Tnfrsf10b	G	C	14: 69,773,401	C85S	probably damaging	Het
Tox	T	C	4: 6,741,536	Q148R	probably benign	Het
Tox	T	C	4: 6,697,439	T455A	probably benign	Het
Trp53bp1	A	C	2: 121,269,945	S109R	probably damaging	Het
Tshz2	A	T	2: 169,884,968	T26S	probably benign	Het
Tubb4a	T	A	17: 57,081,016	N337Y	probably damaging	Het
Tubb6	T	A	18: 67,401,388	V119E	probably damaging	Het
Unk	C	T	11: 116,054,946	T481I	probably benign	Het
Vmn2r112	C	T	17: 22,601,278	T44I	probably benign	Het
Vstm5	G	A	9: 15,257,533	G131D	probably damaging	Het
Wscd1	T	C	11: 71,759,883	L12P	probably damaging	Het
Zfp369	T	A	13: 65,296,230	S396T	possibly damaging	Het
Zfp932	T	A	5: 110,009,343	C302*	probably null	Het
Zfp972	A	T	2: 177,906,935		probably null	Het
Zfyve21	C	A	12: 111,827,594	A212E	probably benign	Het

Other mutations in Ptprq

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00340:Ptprq	APN	10	107,576,929 (GRCm38)	missense	probably damaging	0.98
IGL00537:Ptprq	APN	10	107,710,522 (GRCm38)	missense	probably benign	0.07
IGL00547:Ptprq	APN	10	107,718,541 (GRCm38)	missense	probably damaging	0.99
IGL00586:Ptprq	APN	10	107,608,122 (GRCm38)	splice site	probably benign
IGL00648:Ptprq	APN	10	107,646,716 (GRCm38)	missense	probably benign	0.10
IGL01123:Ptprq	APN	10	107,686,218 (GRCm38)	missense	probably damaging	0.96
IGL01343:Ptprq	APN	10	107,638,839 (GRCm38)	missense	probably damaging	0.96
IGL01348:Ptprq	APN	10	107,711,904 (GRCm38)	missense	probably damaging	1.00
IGL01433:Ptprq	APN	10	107,576,880 (GRCm38)	missense	probably damaging	0.99
IGL01510:Ptprq	APN	10	107,712,048 (GRCm38)	missense	probably damaging	1.00
IGL01535:Ptprq	APN	10	107,699,596 (GRCm38)	missense	probably benign
IGL01631:Ptprq	APN	10	107,643,538 (GRCm38)	missense	probably benign	0.00
IGL01633:Ptprq	APN	10	107,699,723 (GRCm38)	splice site	probably benign
IGL01702:Ptprq	APN	10	107,517,866 (GRCm38)	missense	probably benign	0.00
IGL01733:Ptprq	APN	10	107,662,599 (GRCm38)	missense	probably benign	0.10
IGL01806:Ptprq	APN	10	107,699,608 (GRCm38)	missense	probably damaging	1.00
IGL01832:Ptprq	APN	10	107,565,839 (GRCm38)	critical splice donor site	probably null
IGL01961:Ptprq	APN	10	107,643,654 (GRCm38)	missense	probably damaging	1.00
IGL02108:Ptprq	APN	10	107,646,617 (GRCm38)	missense	probably damaging	1.00
IGL02120:Ptprq	APN	10	107,667,472 (GRCm38)	missense	probably damaging	1.00
IGL02160:Ptprq	APN	10	107,653,565 (GRCm38)	missense	probably benign	0.00
IGL02178:Ptprq	APN	10	107,686,319 (GRCm38)	missense	probably benign	0.03
IGL02249:Ptprq	APN	10	107,582,359 (GRCm38)	missense	probably damaging	1.00
IGL02267:Ptprq	APN	10	107,646,558 (GRCm38)	missense	probably damaging	1.00
IGL02527:Ptprq	APN	10	107,686,563 (GRCm38)	missense	probably benign	0.04
IGL02529:Ptprq	APN	10	107,635,365 (GRCm38)	missense	probably benign	0.03
IGL02542:Ptprq	APN	10	107,662,555 (GRCm38)	missense	probably damaging	1.00
IGL02582:Ptprq	APN	10	107,643,999 (GRCm38)	missense	probably benign	0.00
IGL02708:Ptprq	APN	10	107,652,700 (GRCm38)	missense	probably damaging	1.00
IGL02894:Ptprq	APN	10	107,667,424 (GRCm38)	missense	probably benign
IGL02903:Ptprq	APN	10	107,666,586 (GRCm38)	missense	possibly damaging	0.51
IGL02951:Ptprq	APN	10	107,667,460 (GRCm38)	missense	probably benign	0.03
IGL02982:Ptprq	APN	10	107,586,684 (GRCm38)	missense	probably damaging	1.00
IGL03000:Ptprq	APN	10	107,542,657 (GRCm38)	missense	probably damaging	1.00
IGL03024:Ptprq	APN	10	107,685,566 (GRCm38)	missense	possibly damaging	0.69
IGL03240:Ptprq	APN	10	107,688,507 (GRCm38)	missense	probably benign
P0043:Ptprq	UTSW	10	107,580,225 (GRCm38)	missense	probably benign	0.03
PIT4812001:Ptprq	UTSW	10	107,666,567 (GRCm38)	missense	probably damaging	1.00
R0200:Ptprq	UTSW	10	107,685,157 (GRCm38)	missense	probably benign
R0268:Ptprq	UTSW	10	107,705,548 (GRCm38)	missense	probably benign
R0276:Ptprq	UTSW	10	107,542,735 (GRCm38)	critical splice acceptor site	probably null
R0279:Ptprq	UTSW	10	107,608,417 (GRCm38)	missense	probably damaging	0.96
R0335:Ptprq	UTSW	10	107,708,728 (GRCm38)	missense	probably benign
R0344:Ptprq	UTSW	10	107,705,582 (GRCm38)	missense	probably benign
R0357:Ptprq	UTSW	10	107,686,199 (GRCm38)	splice site	probably benign
R0454:Ptprq	UTSW	10	107,582,530 (GRCm38)	nonsense	probably null
R0479:Ptprq	UTSW	10	107,643,994 (GRCm38)	nonsense	probably null
R0491:Ptprq	UTSW	10	107,608,175 (GRCm38)	missense	probably damaging	0.98
R0519:Ptprq	UTSW	10	107,538,920 (GRCm38)	splice site	probably benign
R0523:Ptprq	UTSW	10	107,580,220 (GRCm38)	missense	possibly damaging	0.54
R0553:Ptprq	UTSW	10	107,710,627 (GRCm38)	missense	probably benign	0.33
R0746:Ptprq	UTSW	10	107,517,831 (GRCm38)	missense	probably damaging	1.00
R0755:Ptprq	UTSW	10	107,582,539 (GRCm38)	missense	probably benign	0.09
R1434:Ptprq	UTSW	10	107,586,714 (GRCm38)	missense	probably damaging	1.00
R1445:Ptprq	UTSW	10	107,662,562 (GRCm38)	missense	probably damaging	1.00
R1470:Ptprq	UTSW	10	107,718,574 (GRCm38)	missense	probably damaging	0.97
R1470:Ptprq	UTSW	10	107,718,574 (GRCm38)	missense	probably damaging	0.97
R1558:Ptprq	UTSW	10	107,644,043 (GRCm38)	missense	probably damaging	1.00
R1567:Ptprq	UTSW	10	107,565,887 (GRCm38)	missense	probably benign	0.13
R1711:Ptprq	UTSW	10	107,534,699 (GRCm38)	nonsense	probably null
R1720:Ptprq	UTSW	10	107,686,294 (GRCm38)	missense	probably damaging	1.00
R1746:Ptprq	UTSW	10	107,638,830 (GRCm38)	missense	probably damaging	1.00
R1776:Ptprq	UTSW	10	107,685,089 (GRCm38)	missense	probably damaging	1.00
R1822:Ptprq	UTSW	10	107,718,478 (GRCm38)	missense	probably damaging	1.00
R1872:Ptprq	UTSW	10	107,643,999 (GRCm38)	missense	probably benign	0.19
R1944:Ptprq	UTSW	10	107,582,388 (GRCm38)	missense	probably benign	0.23
R1945:Ptprq	UTSW	10	107,582,388 (GRCm38)	missense	probably benign	0.23
R2006:Ptprq	UTSW	10	107,666,546 (GRCm38)	missense	probably damaging	1.00
R2014:Ptprq	UTSW	10	107,667,422 (GRCm38)	missense	probably damaging	0.96
R2015:Ptprq	UTSW	10	107,667,422 (GRCm38)	missense	probably damaging	0.96
R2097:Ptprq	UTSW	10	107,653,493 (GRCm38)	missense	probably benign	0.05
R2172:Ptprq	UTSW	10	107,590,994 (GRCm38)	nonsense	probably null
R2174:Ptprq	UTSW	10	107,705,553 (GRCm38)	missense	probably damaging	1.00
R2248:Ptprq	UTSW	10	107,643,070 (GRCm38)	splice site	probably null
R2404:Ptprq	UTSW	10	107,686,599 (GRCm38)	missense	probably damaging	1.00
R3423:Ptprq	UTSW	10	107,582,476 (GRCm38)	missense	probably damaging	0.99
R3683:Ptprq	UTSW	10	107,708,628 (GRCm38)	missense	probably benign	0.01
R3875:Ptprq	UTSW	10	107,685,104 (GRCm38)	missense	possibly damaging	0.88
R3945:Ptprq	UTSW	10	107,686,392 (GRCm38)	splice site	probably benign
R3946:Ptprq	UTSW	10	107,686,392 (GRCm38)	splice site	probably benign
R3974:Ptprq	UTSW	10	107,712,062 (GRCm38)	missense	possibly damaging	0.88
R3982:Ptprq	UTSW	10	107,543,396 (GRCm38)	missense	probably damaging	0.99
R4105:Ptprq	UTSW	10	107,572,967 (GRCm38)	missense	probably damaging	1.00
R4118:Ptprq	UTSW	10	107,711,920 (GRCm38)	missense	probably benign	0.37
R4175:Ptprq	UTSW	10	107,711,917 (GRCm38)	missense	probably benign
R4231:Ptprq	UTSW	10	107,686,283 (GRCm38)	nonsense	probably null
R4356:Ptprq	UTSW	10	107,608,364 (GRCm38)	missense	probably damaging	0.99
R4435:Ptprq	UTSW	10	107,685,055 (GRCm38)	missense	possibly damaging	0.89
R4678:Ptprq	UTSW	10	107,685,182 (GRCm38)	missense	probably benign	0.19
R4679:Ptprq	UTSW	10	107,685,182 (GRCm38)	missense	probably benign	0.19
R4745:Ptprq	UTSW	10	107,524,253 (GRCm38)	missense	probably damaging	1.00
R4771:Ptprq	UTSW	10	107,688,427 (GRCm38)	missense	probably benign
R4778:Ptprq	UTSW	10	107,591,022 (GRCm38)	missense	probably benign	0.15
R4808:Ptprq	UTSW	10	107,718,507 (GRCm38)	missense	probably damaging	1.00
R4809:Ptprq	UTSW	10	107,563,175 (GRCm38)	missense	probably damaging	1.00
R4818:Ptprq	UTSW	10	107,710,581 (GRCm38)	missense	possibly damaging	0.86
R4845:Ptprq	UTSW	10	107,653,532 (GRCm38)	missense	probably benign	0.00
R4901:Ptprq	UTSW	10	107,688,414 (GRCm38)	missense	probably benign	0.01
R4942:Ptprq	UTSW	10	107,688,429 (GRCm38)	missense	probably benign	0.01
R4946:Ptprq	UTSW	10	107,525,734 (GRCm38)	missense	probably benign
R4959:Ptprq	UTSW	10	107,686,555 (GRCm38)	missense	probably damaging	1.00
R4973:Ptprq	UTSW	10	107,686,555 (GRCm38)	missense	probably damaging	1.00
R5007:Ptprq	UTSW	10	107,608,276 (GRCm38)	missense	probably benign	0.00
R5053:Ptprq	UTSW	10	107,563,202 (GRCm38)	missense	probably damaging	1.00
R5055:Ptprq	UTSW	10	107,534,679 (GRCm38)	missense	probably benign	0.37
R5090:Ptprq	UTSW	10	107,526,089 (GRCm38)	missense	probably damaging	1.00
R5158:Ptprq	UTSW	10	107,534,704 (GRCm38)	missense	probably damaging	1.00
R5163:Ptprq	UTSW	10	107,524,331 (GRCm38)	missense	probably damaging	1.00
R5222:Ptprq	UTSW	10	107,662,564 (GRCm38)	missense	probably damaging	0.96
R5244:Ptprq	UTSW	10	107,586,695 (GRCm38)	missense	possibly damaging	0.62
R5249:Ptprq	UTSW	10	107,699,635 (GRCm38)	missense	probably damaging	0.99
R5503:Ptprq	UTSW	10	107,688,328 (GRCm38)	splice site	probably null
R5508:Ptprq	UTSW	10	107,686,231 (GRCm38)	missense	probably benign	0.00
R5601:Ptprq	UTSW	10	107,608,430 (GRCm38)	missense	probably benign
R5722:Ptprq	UTSW	10	107,686,365 (GRCm38)	missense	possibly damaging	0.72
R5819:Ptprq	UTSW	10	107,719,883 (GRCm38)	start gained	probably benign
R5862:Ptprq	UTSW	10	107,565,878 (GRCm38)	missense	probably benign	0.02
R5891:Ptprq	UTSW	10	107,576,895 (GRCm38)	missense	possibly damaging	0.94
R5916:Ptprq	UTSW	10	107,523,513 (GRCm38)	missense	probably damaging	1.00
R6054:Ptprq	UTSW	10	107,582,358 (GRCm38)	missense	probably damaging	1.00
R6058:Ptprq	UTSW	10	107,635,274 (GRCm38)	missense	probably benign	0.00
R6075:Ptprq	UTSW	10	107,525,760 (GRCm38)	missense	probably damaging	1.00
R6101:Ptprq	UTSW	10	107,580,266 (GRCm38)	missense	possibly damaging	0.93
R6189:Ptprq	UTSW	10	107,517,887 (GRCm38)	missense	probably damaging	1.00
R6235:Ptprq	UTSW	10	107,635,338 (GRCm38)	missense	possibly damaging	0.61
R6394:Ptprq	UTSW	10	107,642,943 (GRCm38)	nonsense	probably null
R6449:Ptprq	UTSW	10	107,705,583 (GRCm38)	missense	probably benign	0.00
R6526:Ptprq	UTSW	10	107,542,653 (GRCm38)	nonsense	probably null
R6544:Ptprq	UTSW	10	107,608,241 (GRCm38)	missense	probably damaging	1.00
R6609:Ptprq	UTSW	10	107,572,968 (GRCm38)	missense	probably damaging	0.99
R6862:Ptprq	UTSW	10	107,686,225 (GRCm38)	missense	probably damaging	0.96
R6874:Ptprq	UTSW	10	107,718,599 (GRCm38)	missense	possibly damaging	0.80
R6892:Ptprq	UTSW	10	107,576,004 (GRCm38)	missense	probably benign	0.00
R7082:Ptprq	UTSW	10	107,708,730 (GRCm38)	missense	probably benign	0.10
R7210:Ptprq	UTSW	10	107,685,171 (GRCm38)	missense	probably damaging	1.00
R7253:Ptprq	UTSW	10	107,608,273 (GRCm38)	missense	probably benign	0.30
R7293:Ptprq	UTSW	10	107,635,506 (GRCm38)	nonsense	probably null
R7445:Ptprq	UTSW	10	107,590,959 (GRCm38)	missense	probably damaging	1.00
R7632:Ptprq	UTSW	10	107,711,922 (GRCm38)	missense	probably benign	0.32
R7685:Ptprq	UTSW	10	107,643,978 (GRCm38)	missense	probably damaging	1.00
R7703:Ptprq	UTSW	10	107,644,146 (GRCm38)	missense	probably benign	0.01
R7774:Ptprq	UTSW	10	107,643,669 (GRCm38)	missense	probably damaging	0.96
R7897:Ptprq	UTSW	10	107,710,623 (GRCm38)	missense	probably benign	0.21
R7936:Ptprq	UTSW	10	107,652,711 (GRCm38)	missense	probably damaging	1.00
R7983:Ptprq	UTSW	10	107,608,411 (GRCm38)	nonsense	probably null
R8023:Ptprq	UTSW	10	107,652,616 (GRCm38)	nonsense	probably null
R8071:Ptprq	UTSW	10	107,644,035 (GRCm38)	missense	possibly damaging	0.62
R8084:Ptprq	UTSW	10	107,608,433 (GRCm38)	missense	probably benign
R8086:Ptprq	UTSW	10	107,646,639 (GRCm38)	nonsense	probably null
R8169:Ptprq	UTSW	10	107,582,490 (GRCm38)	missense	probably damaging	1.00
R8223:Ptprq	UTSW	10	107,699,638 (GRCm38)	missense	probably benign	0.00
R8235:Ptprq	UTSW	10	107,705,490 (GRCm38)	missense	probably benign	0.32
R8235:Ptprq	UTSW	10	107,582,541 (GRCm38)	missense	probably damaging	1.00
R8278:Ptprq	UTSW	10	107,686,378 (GRCm38)	missense	possibly damaging	0.87
R8710:Ptprq	UTSW	10	107,576,058 (GRCm38)	missense	possibly damaging	0.67
R8828:Ptprq	UTSW	10	107,646,652 (GRCm38)	missense	probably benign
R8830:Ptprq	UTSW	10	107,586,695 (GRCm38)	missense	possibly damaging	0.62
R8869:Ptprq	UTSW	10	107,699,608 (GRCm38)	missense	probably damaging	1.00
R9012:Ptprq	UTSW	10	107,653,550 (GRCm38)	missense	probably benign	0.09
R9072:Ptprq	UTSW	10	107,565,875 (GRCm38)	missense
R9153:Ptprq	UTSW	10	107,580,265 (GRCm38)	missense	probably damaging	0.98
R9202:Ptprq	UTSW	10	107,686,555 (GRCm38)	missense	probably damaging	1.00
R9252:Ptprq	UTSW	10	107,686,386 (GRCm38)	missense	probably benign	0.12
R9306:Ptprq	UTSW	10	107,586,738 (GRCm38)	missense	probably benign	0.00
R9492:Ptprq	UTSW	10	107,642,952 (GRCm38)	missense	probably damaging	1.00
R9519:Ptprq	UTSW	10	107,685,100 (GRCm38)	missense	probably damaging	1.00
R9581:Ptprq	UTSW	10	107,711,910 (GRCm38)	missense	possibly damaging	0.53
R9593:Ptprq	UTSW	10	107,688,393 (GRCm38)	missense	possibly damaging	0.92
R9621:Ptprq	UTSW	10	107,542,662 (GRCm38)	missense	probably damaging	1.00
R9732:Ptprq	UTSW	10	107,576,906 (GRCm38)	missense	probably damaging	1.00
R9743:Ptprq	UTSW	10	107,685,121 (GRCm38)	missense	probably damaging	1.00
R9771:Ptprq	UTSW	10	107,685,224 (GRCm38)	missense	probably damaging	0.99
R9788:Ptprq	UTSW	10	107,565,890 (GRCm38)	missense	probably benign	0.24
Z1088:Ptprq	UTSW	10	107,699,672 (GRCm38)	missense	possibly damaging	0.56
Z1176:Ptprq	UTSW	10	107,526,070 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGCCCTCTGAAGAATAGCGC -3'
(R):5'- AGTGTTTCTCAAGCTCAATATCCAC -3'

Sequencing Primer
(F):5'- TCTGAAGAATAGCGCTCAACATC -3'
(R):5'- GCAAATAGCTGCATTAGGACAATATG -3'

Posted On

2018-04-27