Incidental Mutation 'R6338:Cdh23'
ID 514338
Institutional Source Beutler Lab
Gene Symbol Cdh23
Ensembl Gene ENSMUSG00000012819
Gene Name cadherin 23 (otocadherin)
Synonyms nmf252, bob, ahl, mdfw, 4930542A03Rik, sals, nmf112, nmf181, USH1D
MMRRC Submission 044492-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.608) question?
Stock # R6338 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 60302748-60696490 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 60413151 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 882 (D882G)
Ref Sequence ENSEMBL: ENSMUSP00000101103 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073242] [ENSMUST00000105461] [ENSMUST00000105462] [ENSMUST00000105463] [ENSMUST00000105464]
AlphaFold no structure available at present
PDB Structure Crystal structure of mouse cadherin-23 EC1 [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF NONSYNDROMIC DEAFNESS (DFNB12) ASSOCIATED MUTANT D124G OF MOUSE CADHERIN-23 EC1-2 [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 (ALL CATION BINDING SITES OCCUPIED BY CALCIUM) [X-RAY DIFFRACTION]
Structure of the N-terminus of Cadherin 23 [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2 FORM I [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2 FORM II [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF DEAFNESS ASSOCIATED MUTANT MOUSE CADHERIN-23 EC1- 2D124G AND PROTOCADHERIN-15 EC1-2 FORM I [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF DEAFNESS ASSOCIATED MUTANT MOUSE CADHERIN-23 EC1- 2S70P AND PROTOCADHERIN-15 EC1-2 FORM I [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2, FORM I 2.2A. [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000073242
AA Change: D882G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072973
Gene: ENSMUSG00000012819
AA Change: D882G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
CA 55 130 5.15e-13 SMART
CA 154 234 3.19e-18 SMART
CA 258 346 2.03e-11 SMART
CA 371 458 8.11e-11 SMART
CA 482 559 1.04e-22 SMART
CA 583 669 3.55e-25 SMART
CA 693 776 2.04e-25 SMART
CA 800 888 5.03e-16 SMART
CA 912 993 1.05e-27 SMART
CA 1017 1100 1.99e-19 SMART
CA 1124 1206 6.94e-19 SMART
CA 1231 1311 1.99e-19 SMART
CA 1335 1415 1.21e-18 SMART
CA 1440 1524 2.38e-26 SMART
CA 1549 1631 6.27e-26 SMART
CA 1656 1741 6.99e-24 SMART
CA 1765 1848 3.49e-24 SMART
CA 1872 1956 2.78e-18 SMART
CA 1984 2066 5.6e-14 SMART
CA 2090 2171 2.59e-27 SMART
CA 2195 2290 2.87e-11 SMART
CA 2317 2399 1.01e-20 SMART
CA 2423 2506 1.09e-25 SMART
CA 2530 2608 7.91e-23 SMART
CA 2634 2719 1.06e-23 SMART
CA 2750 2843 2e-10 SMART
Blast:CA 2867 2956 4e-51 BLAST
transmembrane domain 3067 3089 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000105461
AA Change: D882G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101101
Gene: ENSMUSG00000012819
AA Change: D882G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
CA 55 130 5.15e-13 SMART
CA 154 234 3.19e-18 SMART
CA 258 346 2.03e-11 SMART
CA 371 458 1.25e-11 SMART
CA 482 559 1.04e-22 SMART
CA 583 669 3.55e-25 SMART
CA 693 776 2.04e-25 SMART
CA 800 888 5.03e-16 SMART
CA 912 993 1.05e-27 SMART
CA 1017 1100 1.99e-19 SMART
CA 1124 1206 6.94e-19 SMART
CA 1231 1311 1.99e-19 SMART
CA 1335 1416 5.26e-19 SMART
CA 1441 1525 2.38e-26 SMART
CA 1550 1632 6.27e-26 SMART
CA 1657 1742 6.99e-24 SMART
CA 1766 1849 3.49e-24 SMART
CA 1873 1957 2.78e-18 SMART
CA 1985 2067 5.6e-14 SMART
CA 2091 2172 2.59e-27 SMART
CA 2196 2291 2.87e-11 SMART
CA 2318 2400 1.01e-20 SMART
CA 2424 2507 1.09e-25 SMART
CA 2531 2609 7.91e-23 SMART
CA 2635 2720 1.06e-23 SMART
CA 2751 2844 2e-10 SMART
Blast:CA 2868 2957 4e-51 BLAST
transmembrane domain 3068 3090 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000105462
AA Change: D885G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101102
Gene: ENSMUSG00000012819
AA Change: D885G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
CA 55 130 5.15e-13 SMART
CA 154 234 3.19e-18 SMART
CA 261 349 2.03e-11 SMART
CA 374 461 8.11e-11 SMART
CA 485 562 1.04e-22 SMART
CA 586 672 3.55e-25 SMART
CA 696 779 2.04e-25 SMART
CA 803 891 5.03e-16 SMART
CA 915 996 1.05e-27 SMART
CA 1020 1103 1.99e-19 SMART
CA 1127 1209 6.94e-19 SMART
CA 1234 1314 1.99e-19 SMART
CA 1338 1418 1.21e-18 SMART
CA 1443 1527 2.38e-26 SMART
CA 1552 1634 6.27e-26 SMART
CA 1659 1744 6.99e-24 SMART
CA 1768 1851 3.49e-24 SMART
CA 1875 1959 2.78e-18 SMART
CA 1987 2069 5.6e-14 SMART
CA 2093 2174 2.59e-27 SMART
CA 2198 2293 2.87e-11 SMART
CA 2320 2402 1.01e-20 SMART
CA 2426 2509 1.09e-25 SMART
CA 2533 2611 7.91e-23 SMART
CA 2637 2722 1.06e-23 SMART
CA 2753 2846 2e-10 SMART
Blast:CA 2870 2959 4e-51 BLAST
transmembrane domain 3070 3092 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000105463
AA Change: D882G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101103
Gene: ENSMUSG00000012819
AA Change: D882G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
CA 55 130 5.15e-13 SMART
CA 154 234 3.19e-18 SMART
CA 258 346 2.03e-11 SMART
CA 371 458 1.25e-11 SMART
CA 482 559 1.04e-22 SMART
CA 583 669 3.55e-25 SMART
CA 693 776 2.04e-25 SMART
CA 800 888 5.03e-16 SMART
CA 912 993 1.05e-27 SMART
CA 1017 1100 1.99e-19 SMART
CA 1124 1206 6.94e-19 SMART
CA 1231 1311 1.99e-19 SMART
CA 1335 1416 5.26e-19 SMART
CA 1441 1525 2.38e-26 SMART
CA 1550 1632 6.27e-26 SMART
CA 1657 1742 6.99e-24 SMART
CA 1766 1849 3.49e-24 SMART
CA 1873 1957 2.78e-18 SMART
CA 1985 2067 5.6e-14 SMART
CA 2091 2172 2.59e-27 SMART
CA 2196 2291 2.87e-11 SMART
CA 2318 2400 1.01e-20 SMART
CA 2424 2507 1.09e-25 SMART
CA 2531 2609 7.91e-23 SMART
CA 2635 2720 1.06e-23 SMART
CA 2751 2844 2e-10 SMART
Blast:CA 2868 2957 4e-51 BLAST
transmembrane domain 3068 3090 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000105464
AA Change: D880G

PolyPhen 2 Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000101104
Gene: ENSMUSG00000012819
AA Change: D880G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
CA 55 130 5.15e-13 SMART
CA 154 234 3.19e-18 SMART
CA 258 346 2.03e-11 SMART
CA 371 456 3.58e-12 SMART
CA 480 557 1.04e-22 SMART
CA 581 667 3.55e-25 SMART
CA 691 774 2.04e-25 SMART
CA 798 886 5.03e-16 SMART
CA 910 991 1.05e-27 SMART
CA 1015 1098 1.99e-19 SMART
CA 1122 1204 6.94e-19 SMART
CA 1229 1309 1.99e-19 SMART
CA 1333 1414 5.26e-19 SMART
CA 1439 1523 2.38e-26 SMART
CA 1548 1630 6.27e-26 SMART
CA 1655 1740 6.99e-24 SMART
CA 1764 1847 3.49e-24 SMART
CA 1871 1955 2.78e-18 SMART
CA 1983 2065 5.6e-14 SMART
CA 2089 2170 2.59e-27 SMART
CA 2194 2289 2.87e-11 SMART
CA 2316 2398 1.01e-20 SMART
CA 2422 2505 1.09e-25 SMART
CA 2529 2607 7.91e-23 SMART
CA 2633 2718 1.06e-23 SMART
CA 2749 2842 2e-10 SMART
Blast:CA 2866 2955 3e-51 BLAST
transmembrane domain 3066 3088 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128249
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135638
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.7%
  • 10x: 98.1%
  • 20x: 93.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated with breast cancer. Alternative splice variants encoding different isoforms have been described. [provided by RefSeq, May 2013]
PHENOTYPE: Mutant mice exhibit circling behavior, tilting of the head and are deaf. Mice homozygous for a targeted knock-out exhibit abnormal outer hair cells morphology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acer3 T C 7: 98,257,715 (GRCm38) Y128C probably damaging Het
Adam30 T G 3: 98,161,541 (GRCm38) I102S probably damaging Het
Adcy8 A T 15: 64,920,617 (GRCm38) D163E possibly damaging Het
Agrn C T 4: 156,170,585 (GRCm38) E1614K probably benign Het
Aldh16a1 A T 7: 45,141,961 (GRCm38) W107R probably damaging Het
Arfgef2 A G 2: 166,845,570 (GRCm38) D238G probably damaging Het
Arhgap11a T C 2: 113,833,725 (GRCm38) S738G probably benign Het
Arid5b C A 10: 68,098,561 (GRCm38) G504* probably null Het
Carmil3 T C 14: 55,499,849 (GRCm38) V763A possibly damaging Het
Cd209e T A 8: 3,849,154 (GRCm38) D186V probably damaging Het
Cdh4 T C 2: 179,890,812 (GRCm38) V689A probably damaging Het
Cntn6 T A 6: 104,726,139 (GRCm38) V174E probably damaging Het
Col7a1 C T 9: 108,956,633 (GRCm38) T390M unknown Het
Crybg1 T C 10: 43,992,509 (GRCm38) D1017G probably damaging Het
Csmd1 T G 8: 15,932,492 (GRCm38) K2725T possibly damaging Het
Dnaaf2 T C 12: 69,198,122 (GRCm38) E55G probably damaging Het
Fam13a A G 6: 58,953,499 (GRCm38) V476A probably damaging Het
Fem1b A T 9: 62,797,011 (GRCm38) D322E probably benign Het
Frmpd1 G A 4: 45,274,489 (GRCm38) V466I probably benign Het
Gm11639 C T 11: 104,843,208 (GRCm38) R2027* probably null Het
Gm20671 A T 5: 32,820,647 (GRCm38) D1794E probably damaging Het
Gpatch2 G T 1: 187,225,514 (GRCm38) R22L probably damaging Het
Gtf2h1 A G 7: 46,816,456 (GRCm38) T450A probably benign Het
Kcnc2 G C 10: 112,271,856 (GRCm38) G51R probably benign Het
Krit1 T G 5: 3,836,857 (GRCm38) M702R probably benign Het
Krt34 T C 11: 100,038,490 (GRCm38) N298S probably benign Het
Lrrcc1 T A 3: 14,547,316 (GRCm38) N376K possibly damaging Het
Myo15a A G 11: 60,478,133 (GRCm38) E573G probably damaging Het
Olfr1224-ps1 T A 2: 89,156,371 (GRCm38) K268I probably damaging Het
Olfr391-ps A T 11: 73,799,319 (GRCm38) L146Q possibly damaging Het
Or11j4 T A 14: 50,393,400 (GRCm38) F215I possibly damaging Het
Or1af1 A T 2: 37,219,822 (GRCm38) D111V probably damaging Het
Or2y17 A G 11: 49,340,867 (GRCm38) S112G probably benign Het
Or56b2 T A 7: 104,688,171 (GRCm38) V52E possibly damaging Het
Phf20 A T 2: 156,273,686 (GRCm38) Q309L possibly damaging Het
Plcd1 G A 9: 119,074,991 (GRCm38) R292C probably damaging Het
Pold3 A G 7: 100,088,105 (GRCm38) V342A possibly damaging Het
Polr2a A T 11: 69,739,679 (GRCm38) probably null Het
Ptprcap A G 19: 4,156,224 (GRCm38) E102G probably benign Het
Rab11fip5 T C 6: 85,341,378 (GRCm38) E843G possibly damaging Het
Rai14 T C 15: 10,574,976 (GRCm38) D632G probably damaging Het
Rnf149 A T 1: 39,560,742 (GRCm38) C268S probably null Het
Slc6a13 T A 6: 121,334,839 (GRCm38) F392I probably damaging Het
Slc7a11 C T 3: 50,384,043 (GRCm38) probably null Het
Slf1 T A 13: 77,084,462 (GRCm38) probably null Het
Stard9 G A 2: 120,697,485 (GRCm38) V1408I probably benign Het
Suclg1 T C 6: 73,264,246 (GRCm38) I183T probably damaging Het
Syne1 T C 10: 5,255,475 (GRCm38) E3497G probably benign Het
Tax1bp1 C T 6: 52,729,376 (GRCm38) R121* probably null Het
Tdpoz2 C T 3: 93,652,336 (GRCm38) V110I probably benign Het
Ubn2 A G 6: 38,490,714 (GRCm38) T788A probably benign Het
Unc13c T A 9: 73,734,447 (GRCm38) I1255F probably damaging Het
Usp44 G T 10: 93,846,513 (GRCm38) R275I probably damaging Het
Uspl1 A G 5: 149,215,034 (GRCm38) N1015D probably benign Het
Wbp2nl G T 15: 82,299,045 (GRCm38) W13C possibly damaging Het
Zc3h14 T A 12: 98,758,590 (GRCm38) D170E possibly damaging Het
Other mutations in Cdh23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00229:Cdh23 APN 10 60,523,548 (GRCm38) missense probably benign 0.03
IGL00429:Cdh23 APN 10 60,421,141 (GRCm38) missense probably damaging 0.97
IGL01014:Cdh23 APN 10 60,307,522 (GRCm38) missense probably damaging 0.99
IGL01284:Cdh23 APN 10 60,466,097 (GRCm38) missense possibly damaging 0.95
IGL01305:Cdh23 APN 10 60,312,624 (GRCm38) missense probably damaging 1.00
IGL01367:Cdh23 APN 10 60,310,787 (GRCm38) missense probably damaging 1.00
IGL01396:Cdh23 APN 10 60,385,069 (GRCm38) missense possibly damaging 0.93
IGL01412:Cdh23 APN 10 60,314,694 (GRCm38) missense probably damaging 1.00
IGL01461:Cdh23 APN 10 60,409,147 (GRCm38) missense possibly damaging 0.53
IGL01469:Cdh23 APN 10 60,597,725 (GRCm38) missense probably benign 0.03
IGL01695:Cdh23 APN 10 60,331,833 (GRCm38) missense probably benign 0.20
IGL01734:Cdh23 APN 10 60,303,513 (GRCm38) missense probably benign
IGL01767:Cdh23 APN 10 60,315,724 (GRCm38) missense probably damaging 1.00
IGL01796:Cdh23 APN 10 60,311,137 (GRCm38) missense probably benign 0.31
IGL01843:Cdh23 APN 10 60,419,819 (GRCm38) splice site probably null
IGL02025:Cdh23 APN 10 60,385,143 (GRCm38) missense probably damaging 1.00
IGL02071:Cdh23 APN 10 60,523,560 (GRCm38) missense possibly damaging 0.93
IGL02160:Cdh23 APN 10 60,597,765 (GRCm38) splice site probably benign
IGL02175:Cdh23 APN 10 60,331,308 (GRCm38) missense possibly damaging 0.92
IGL02220:Cdh23 APN 10 60,305,124 (GRCm38) missense probably damaging 1.00
IGL02302:Cdh23 APN 10 60,323,523 (GRCm38) missense possibly damaging 0.87
IGL02331:Cdh23 APN 10 60,465,543 (GRCm38) missense probably damaging 0.99
IGL02452:Cdh23 APN 10 60,317,942 (GRCm38) missense probably damaging 0.99
IGL02499:Cdh23 APN 10 60,385,179 (GRCm38) missense probably damaging 1.00
IGL02548:Cdh23 APN 10 60,650,122 (GRCm38) missense probably benign 0.37
IGL02593:Cdh23 APN 10 60,465,995 (GRCm38) splice site probably benign
IGL02626:Cdh23 APN 10 60,391,801 (GRCm38) missense probably damaging 1.00
IGL02951:Cdh23 APN 10 60,311,364 (GRCm38) missense probably damaging 1.00
IGL03145:Cdh23 APN 10 60,376,814 (GRCm38) missense probably damaging 0.99
dee_dee UTSW 10 60,308,056 (GRCm38) nonsense probably null
hersey UTSW 10 60,308,036 (GRCm38) missense probably damaging 1.00
ANU22:Cdh23 UTSW 10 60,312,624 (GRCm38) missense probably damaging 1.00
IGL02980:Cdh23 UTSW 10 60,314,620 (GRCm38) missense probably damaging 1.00
PIT4362001:Cdh23 UTSW 10 60,465,458 (GRCm38) missense probably benign 0.15
R0013:Cdh23 UTSW 10 60,413,173 (GRCm38) missense possibly damaging 0.90
R0045:Cdh23 UTSW 10 60,530,978 (GRCm38) missense probably damaging 1.00
R0045:Cdh23 UTSW 10 60,530,978 (GRCm38) missense probably damaging 1.00
R0082:Cdh23 UTSW 10 60,312,587 (GRCm38) missense probably damaging 1.00
R0124:Cdh23 UTSW 10 60,308,056 (GRCm38) nonsense probably null
R0172:Cdh23 UTSW 10 60,319,632 (GRCm38) missense probably damaging 1.00
R0195:Cdh23 UTSW 10 60,317,059 (GRCm38) missense probably damaging 0.99
R0365:Cdh23 UTSW 10 60,379,315 (GRCm38) missense probably damaging 0.99
R0437:Cdh23 UTSW 10 60,410,797 (GRCm38) missense probably damaging 1.00
R0486:Cdh23 UTSW 10 60,386,946 (GRCm38) missense probably damaging 1.00
R0494:Cdh23 UTSW 10 60,316,596 (GRCm38) splice site probably benign
R0545:Cdh23 UTSW 10 60,331,291 (GRCm38) missense probably benign 0.06
R0619:Cdh23 UTSW 10 60,433,777 (GRCm38) missense probably damaging 1.00
R0647:Cdh23 UTSW 10 60,323,374 (GRCm38) nonsense probably null
R0647:Cdh23 UTSW 10 60,307,902 (GRCm38) missense probably damaging 0.99
R0730:Cdh23 UTSW 10 60,323,714 (GRCm38) missense probably damaging 0.99
R0880:Cdh23 UTSW 10 60,406,421 (GRCm38) missense possibly damaging 0.51
R0942:Cdh23 UTSW 10 60,410,860 (GRCm38) missense possibly damaging 0.67
R0989:Cdh23 UTSW 10 60,534,510 (GRCm38) missense probably damaging 0.99
R1017:Cdh23 UTSW 10 60,331,793 (GRCm38) missense probably damaging 1.00
R1173:Cdh23 UTSW 10 60,312,392 (GRCm38) splice site probably benign
R1449:Cdh23 UTSW 10 60,376,951 (GRCm38) missense probably damaging 1.00
R1456:Cdh23 UTSW 10 60,487,120 (GRCm38) missense possibly damaging 0.84
R1519:Cdh23 UTSW 10 60,379,343 (GRCm38) missense possibly damaging 0.92
R1532:Cdh23 UTSW 10 60,314,331 (GRCm38) missense probably damaging 0.99
R1559:Cdh23 UTSW 10 60,419,699 (GRCm38) splice site probably benign
R1704:Cdh23 UTSW 10 60,314,611 (GRCm38) missense probably damaging 1.00
R1711:Cdh23 UTSW 10 60,523,536 (GRCm38) missense probably benign 0.07
R1760:Cdh23 UTSW 10 60,326,076 (GRCm38) missense probably damaging 1.00
R1782:Cdh23 UTSW 10 60,488,542 (GRCm38) missense probably damaging 1.00
R1791:Cdh23 UTSW 10 60,391,726 (GRCm38) missense possibly damaging 0.89
R1803:Cdh23 UTSW 10 60,331,281 (GRCm38) missense probably damaging 1.00
R1857:Cdh23 UTSW 10 60,323,297 (GRCm38) missense probably damaging 1.00
R1874:Cdh23 UTSW 10 60,436,818 (GRCm38) missense possibly damaging 0.52
R1914:Cdh23 UTSW 10 60,323,570 (GRCm38) missense probably damaging 0.99
R1958:Cdh23 UTSW 10 60,410,873 (GRCm38) missense probably benign 0.02
R1964:Cdh23 UTSW 10 60,385,222 (GRCm38) missense probably benign 0.31
R1966:Cdh23 UTSW 10 60,323,582 (GRCm38) missense probably damaging 1.00
R1981:Cdh23 UTSW 10 60,378,751 (GRCm38) missense probably damaging 1.00
R2010:Cdh23 UTSW 10 60,314,227 (GRCm38) missense probably damaging 0.99
R2036:Cdh23 UTSW 10 60,466,043 (GRCm38) missense possibly damaging 0.52
R2038:Cdh23 UTSW 10 60,312,587 (GRCm38) missense probably damaging 1.00
R2044:Cdh23 UTSW 10 60,596,730 (GRCm38) missense possibly damaging 0.72
R2111:Cdh23 UTSW 10 60,305,583 (GRCm38) missense probably damaging 0.99
R2112:Cdh23 UTSW 10 60,305,583 (GRCm38) missense probably damaging 0.99
R2211:Cdh23 UTSW 10 60,466,004 (GRCm38) missense possibly damaging 0.92
R2261:Cdh23 UTSW 10 60,317,128 (GRCm38) missense probably damaging 1.00
R2262:Cdh23 UTSW 10 60,317,128 (GRCm38) missense probably damaging 1.00
R2306:Cdh23 UTSW 10 60,323,445 (GRCm38) missense probably damaging 1.00
R2344:Cdh23 UTSW 10 60,316,724 (GRCm38) missense probably damaging 1.00
R2857:Cdh23 UTSW 10 60,382,653 (GRCm38) critical splice donor site probably null
R2858:Cdh23 UTSW 10 60,382,653 (GRCm38) critical splice donor site probably null
R2859:Cdh23 UTSW 10 60,382,653 (GRCm38) critical splice donor site probably null
R2876:Cdh23 UTSW 10 60,307,496 (GRCm38) missense probably damaging 1.00
R3034:Cdh23 UTSW 10 60,409,010 (GRCm38) splice site probably benign
R3424:Cdh23 UTSW 10 60,376,881 (GRCm38) missense possibly damaging 0.76
R3699:Cdh23 UTSW 10 60,327,370 (GRCm38) critical splice donor site probably null
R3700:Cdh23 UTSW 10 60,327,370 (GRCm38) critical splice donor site probably null
R3950:Cdh23 UTSW 10 60,657,326 (GRCm38) missense probably benign 0.04
R3951:Cdh23 UTSW 10 60,657,326 (GRCm38) missense probably benign 0.04
R3952:Cdh23 UTSW 10 60,657,326 (GRCm38) missense probably benign 0.04
R4108:Cdh23 UTSW 10 60,410,822 (GRCm38) missense possibly damaging 0.51
R4114:Cdh23 UTSW 10 60,421,040 (GRCm38) splice site probably null
R4273:Cdh23 UTSW 10 60,311,161 (GRCm38) missense possibly damaging 0.69
R4284:Cdh23 UTSW 10 60,303,493 (GRCm38) missense possibly damaging 0.91
R4334:Cdh23 UTSW 10 60,385,059 (GRCm38) missense probably damaging 0.99
R4474:Cdh23 UTSW 10 60,311,086 (GRCm38) missense probably damaging 1.00
R4532:Cdh23 UTSW 10 60,534,423 (GRCm38) missense probably benign 0.32
R4597:Cdh23 UTSW 10 60,409,044 (GRCm38) missense probably damaging 1.00
R4604:Cdh23 UTSW 10 60,337,666 (GRCm38) missense possibly damaging 0.93
R4793:Cdh23 UTSW 10 60,331,350 (GRCm38) missense probably damaging 1.00
R4816:Cdh23 UTSW 10 60,409,077 (GRCm38) missense possibly damaging 0.93
R4833:Cdh23 UTSW 10 60,385,038 (GRCm38) missense probably damaging 1.00
R4840:Cdh23 UTSW 10 60,419,777 (GRCm38) missense possibly damaging 0.53
R4857:Cdh23 UTSW 10 60,391,784 (GRCm38) missense probably damaging 1.00
R4869:Cdh23 UTSW 10 60,376,934 (GRCm38) missense probably damaging 1.00
R4894:Cdh23 UTSW 10 60,337,851 (GRCm38) missense probably benign 0.04
R4940:Cdh23 UTSW 10 60,307,935 (GRCm38) missense probably damaging 0.98
R5020:Cdh23 UTSW 10 60,308,032 (GRCm38) missense probably damaging 0.99
R5026:Cdh23 UTSW 10 60,304,848 (GRCm38) missense possibly damaging 0.88
R5081:Cdh23 UTSW 10 60,436,807 (GRCm38) missense possibly damaging 0.89
R5138:Cdh23 UTSW 10 60,312,282 (GRCm38) missense probably damaging 1.00
R5236:Cdh23 UTSW 10 60,312,572 (GRCm38) missense probably damaging 1.00
R5361:Cdh23 UTSW 10 60,657,265 (GRCm38) critical splice donor site probably null
R5384:Cdh23 UTSW 10 60,337,762 (GRCm38) missense probably damaging 0.99
R5500:Cdh23 UTSW 10 60,314,311 (GRCm38) missense probably damaging 1.00
R5512:Cdh23 UTSW 10 60,534,386 (GRCm38) splice site probably null
R5673:Cdh23 UTSW 10 60,307,857 (GRCm38) missense probably damaging 1.00
R5720:Cdh23 UTSW 10 60,393,023 (GRCm38) missense possibly damaging 0.71
R5726:Cdh23 UTSW 10 60,407,480 (GRCm38) missense probably damaging 0.98
R5732:Cdh23 UTSW 10 60,331,317 (GRCm38) missense possibly damaging 0.80
R5739:Cdh23 UTSW 10 60,305,609 (GRCm38) missense probably damaging 0.99
R5760:Cdh23 UTSW 10 60,406,392 (GRCm38) missense probably damaging 0.99
R5793:Cdh23 UTSW 10 60,306,128 (GRCm38) missense probably damaging 1.00
R5880:Cdh23 UTSW 10 60,384,934 (GRCm38) missense probably damaging 1.00
R5905:Cdh23 UTSW 10 60,534,535 (GRCm38) missense probably damaging 0.98
R5907:Cdh23 UTSW 10 60,428,379 (GRCm38) missense probably damaging 1.00
R5910:Cdh23 UTSW 10 60,377,821 (GRCm38) missense possibly damaging 0.81
R5932:Cdh23 UTSW 10 60,392,984 (GRCm38) missense probably damaging 1.00
R5996:Cdh23 UTSW 10 60,413,577 (GRCm38) missense possibly damaging 0.85
R6015:Cdh23 UTSW 10 60,307,982 (GRCm38) missense probably damaging 0.97
R6020:Cdh23 UTSW 10 60,331,326 (GRCm38) missense probably damaging 1.00
R6023:Cdh23 UTSW 10 60,465,542 (GRCm38) missense probably damaging 1.00
R6028:Cdh23 UTSW 10 60,534,535 (GRCm38) missense probably damaging 0.98
R6066:Cdh23 UTSW 10 60,433,758 (GRCm38) missense probably damaging 1.00
R6137:Cdh23 UTSW 10 60,434,512 (GRCm38) missense probably damaging 0.96
R6211:Cdh23 UTSW 10 60,410,821 (GRCm38) missense possibly damaging 0.90
R6298:Cdh23 UTSW 10 60,426,672 (GRCm38) nonsense probably null
R6302:Cdh23 UTSW 10 60,305,093 (GRCm38) missense possibly damaging 0.74
R6356:Cdh23 UTSW 10 60,438,847 (GRCm38) missense probably damaging 1.00
R6441:Cdh23 UTSW 10 60,308,036 (GRCm38) missense probably damaging 1.00
R6714:Cdh23 UTSW 10 60,331,830 (GRCm38) missense possibly damaging 0.62
R6760:Cdh23 UTSW 10 60,306,168 (GRCm38) missense probably damaging 1.00
R6807:Cdh23 UTSW 10 60,378,871 (GRCm38) missense possibly damaging 0.95
R6855:Cdh23 UTSW 10 60,306,122 (GRCm38) missense possibly damaging 0.66
R6937:Cdh23 UTSW 10 60,487,114 (GRCm38) missense probably damaging 1.00
R6942:Cdh23 UTSW 10 60,438,856 (GRCm38) missense possibly damaging 0.93
R6961:Cdh23 UTSW 10 60,650,114 (GRCm38) missense probably benign 0.00
R7009:Cdh23 UTSW 10 60,337,306 (GRCm38) missense probably damaging 0.99
R7010:Cdh23 UTSW 10 60,530,991 (GRCm38) missense probably benign 0.03
R7032:Cdh23 UTSW 10 60,331,788 (GRCm38) missense probably damaging 1.00
R7046:Cdh23 UTSW 10 60,378,751 (GRCm38) missense probably damaging 1.00
R7111:Cdh23 UTSW 10 60,387,044 (GRCm38) missense probably damaging 1.00
R7196:Cdh23 UTSW 10 60,307,980 (GRCm38) missense probably damaging 0.99
R7198:Cdh23 UTSW 10 60,312,599 (GRCm38) missense possibly damaging 0.91
R7223:Cdh23 UTSW 10 60,331,817 (GRCm38) missense probably damaging 1.00
R7290:Cdh23 UTSW 10 60,376,841 (GRCm38) missense probably benign
R7335:Cdh23 UTSW 10 60,305,116 (GRCm38) missense probably damaging 1.00
R7340:Cdh23 UTSW 10 60,530,996 (GRCm38) missense probably benign 0.19
R7350:Cdh23 UTSW 10 60,410,910 (GRCm38) missense probably damaging 1.00
R7366:Cdh23 UTSW 10 60,315,692 (GRCm38) nonsense probably null
R7374:Cdh23 UTSW 10 60,317,900 (GRCm38) missense probably damaging 0.99
R7455:Cdh23 UTSW 10 60,306,224 (GRCm38) missense possibly damaging 0.82
R7537:Cdh23 UTSW 10 60,384,945 (GRCm38) missense probably benign 0.17
R7573:Cdh23 UTSW 10 60,323,550 (GRCm38) missense probably benign 0.17
R7578:Cdh23 UTSW 10 60,407,407 (GRCm38) missense probably benign 0.14
R7646:Cdh23 UTSW 10 60,305,152 (GRCm38) missense possibly damaging 0.95
R7703:Cdh23 UTSW 10 60,337,264 (GRCm38) missense probably damaging 1.00
R7763:Cdh23 UTSW 10 60,312,577 (GRCm38) missense probably damaging 1.00
R7797:Cdh23 UTSW 10 60,385,194 (GRCm38) missense probably benign 0.07
R7867:Cdh23 UTSW 10 60,314,611 (GRCm38) missense probably damaging 1.00
R7878:Cdh23 UTSW 10 60,314,200 (GRCm38) missense possibly damaging 0.69
R7915:Cdh23 UTSW 10 60,307,889 (GRCm38) missense probably damaging 0.97
R7922:Cdh23 UTSW 10 60,382,706 (GRCm38) missense probably benign 0.31
R7963:Cdh23 UTSW 10 60,336,188 (GRCm38) missense probably damaging 1.00
R7997:Cdh23 UTSW 10 60,596,739 (GRCm38) missense possibly damaging 0.81
R8167:Cdh23 UTSW 10 60,314,383 (GRCm38) missense probably benign 0.12
R8167:Cdh23 UTSW 10 60,337,693 (GRCm38) missense probably damaging 0.96
R8258:Cdh23 UTSW 10 60,315,656 (GRCm38) missense probably damaging 0.99
R8259:Cdh23 UTSW 10 60,315,656 (GRCm38) missense probably damaging 0.99
R8317:Cdh23 UTSW 10 60,436,789 (GRCm38) missense probably damaging 1.00
R8317:Cdh23 UTSW 10 60,311,258 (GRCm38) critical splice donor site probably null
R8326:Cdh23 UTSW 10 60,438,812 (GRCm38) missense possibly damaging 0.55
R8333:Cdh23 UTSW 10 60,314,611 (GRCm38) missense probably damaging 1.00
R8348:Cdh23 UTSW 10 60,331,728 (GRCm38) missense probably benign 0.43
R8366:Cdh23 UTSW 10 60,325,020 (GRCm38) missense probably benign
R8504:Cdh23 UTSW 10 60,438,839 (GRCm38) missense probably benign 0.00
R8676:Cdh23 UTSW 10 60,410,910 (GRCm38) missense probably damaging 1.00
R8781:Cdh23 UTSW 10 60,331,788 (GRCm38) missense probably damaging 1.00
R8785:Cdh23 UTSW 10 60,311,335 (GRCm38) missense probably damaging 1.00
R8788:Cdh23 UTSW 10 60,488,593 (GRCm38) missense probably damaging 1.00
R8802:Cdh23 UTSW 10 60,409,098 (GRCm38) missense probably benign 0.04
R8837:Cdh23 UTSW 10 60,324,976 (GRCm38) missense probably benign 0.28
R8863:Cdh23 UTSW 10 60,376,834 (GRCm38) nonsense probably null
R8889:Cdh23 UTSW 10 60,307,505 (GRCm38) missense probably damaging 0.97
R8892:Cdh23 UTSW 10 60,307,505 (GRCm38) missense probably damaging 0.97
R8921:Cdh23 UTSW 10 60,305,129 (GRCm38) missense probably damaging 0.99
R8980:Cdh23 UTSW 10 60,337,846 (GRCm38) missense probably benign 0.06
R9000:Cdh23 UTSW 10 60,304,498 (GRCm38) missense possibly damaging 0.82
R9043:Cdh23 UTSW 10 60,315,699 (GRCm38) missense probably benign 0.00
R9046:Cdh23 UTSW 10 60,382,524 (GRCm38) intron probably benign
R9070:Cdh23 UTSW 10 60,337,760 (GRCm38) missense probably benign
R9075:Cdh23 UTSW 10 60,317,762 (GRCm38) missense probably damaging 1.00
R9132:Cdh23 UTSW 10 60,434,504 (GRCm38) splice site probably benign
R9155:Cdh23 UTSW 10 60,413,706 (GRCm38) missense probably damaging 0.99
R9171:Cdh23 UTSW 10 60,326,031 (GRCm38) missense probably benign 0.00
R9179:Cdh23 UTSW 10 60,317,885 (GRCm38) missense probably benign 0.06
R9186:Cdh23 UTSW 10 60,307,527 (GRCm38) missense possibly damaging 0.54
R9189:Cdh23 UTSW 10 60,307,527 (GRCm38) missense possibly damaging 0.54
R9207:Cdh23 UTSW 10 60,407,431 (GRCm38) missense probably damaging 1.00
R9240:Cdh23 UTSW 10 60,379,265 (GRCm38) missense probably benign 0.00
R9244:Cdh23 UTSW 10 60,413,663 (GRCm38) missense possibly damaging 0.93
R9284:Cdh23 UTSW 10 60,307,527 (GRCm38) missense possibly damaging 0.54
R9286:Cdh23 UTSW 10 60,307,527 (GRCm38) missense possibly damaging 0.54
R9287:Cdh23 UTSW 10 60,307,527 (GRCm38) missense possibly damaging 0.54
R9302:Cdh23 UTSW 10 60,307,527 (GRCm38) missense possibly damaging 0.54
R9352:Cdh23 UTSW 10 60,307,527 (GRCm38) missense possibly damaging 0.54
R9353:Cdh23 UTSW 10 60,307,527 (GRCm38) missense possibly damaging 0.54
R9423:Cdh23 UTSW 10 60,312,608 (GRCm38) missense probably damaging 1.00
R9513:Cdh23 UTSW 10 60,331,216 (GRCm38) missense probably damaging 0.99
R9577:Cdh23 UTSW 10 60,311,116 (GRCm38) missense probably damaging 1.00
R9598:Cdh23 UTSW 10 60,378,795 (GRCm38) missense probably benign 0.01
R9631:Cdh23 UTSW 10 60,407,389 (GRCm38) missense possibly damaging 0.49
R9652:Cdh23 UTSW 10 60,331,356 (GRCm38) missense probably damaging 1.00
R9725:Cdh23 UTSW 10 60,596,782 (GRCm38) missense probably benign 0.02
X0052:Cdh23 UTSW 10 60,385,134 (GRCm38) missense probably damaging 1.00
Z1088:Cdh23 UTSW 10 60,413,644 (GRCm38) missense probably benign 0.35
Z1176:Cdh23 UTSW 10 60,428,321 (GRCm38) missense probably benign
Z1176:Cdh23 UTSW 10 60,310,770 (GRCm38) missense probably damaging 1.00
Z1177:Cdh23 UTSW 10 60,434,614 (GRCm38) critical splice acceptor site probably null
Z1177:Cdh23 UTSW 10 60,323,555 (GRCm38) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- GGCTACTTGGCTTACATGCTG -3'
(R):5'- GGAAGAGACCCATGACTTAAGC -3'

Sequencing Primer
(F):5'- GGGTCTTAACTGGCATCCCTAG -3'
(R):5'- GATACTCAGTCTCCCATCT -3'
Posted On 2018-04-27