Incidental Mutation 'R6341:Mmp15'
ID 514395
Institutional Source Beutler Lab
Gene Symbol Mmp15
Ensembl Gene ENSMUSG00000031790
Gene Name matrix metallopeptidase 15
Synonyms Membrane type 2-MMP, MT2-MMP
MMRRC Submission 044495-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6341 (G1)
Quality Score 182.009
Status Not validated
Chromosome 8
Chromosomal Location 95352268-95375080 bp(+) (GRCm38)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) G to T at 95365463 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000034243 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034243]
AlphaFold O54732
Predicted Effect probably null
Transcript: ENSMUST00000034243
SMART Domains Protein: ENSMUSP00000034243
Gene: ENSMUSG00000031790

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
Pfam:PG_binding_1 42 102 3.2e-13 PFAM
ZnMc 131 301 5.31e-59 SMART
low complexity region 306 353 N/A INTRINSIC
HX 370 413 5.92e-8 SMART
HX 415 459 2.31e-10 SMART
HX 462 508 2.98e-13 SMART
HX 510 555 2.01e-10 SMART
Pfam:DUF3377 586 657 1.2e-32 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212235
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.6%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. A deficiency of the encoded protein in mice is compatible with normal development and postnatal growth. [provided by RefSeq, Feb 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acap2 T C 16: 31,105,546 (GRCm38) D658G possibly damaging Het
Amz2 A G 11: 109,428,827 (GRCm38) H13R probably benign Het
Ankrd27 G T 7: 35,627,403 (GRCm38) probably null Het
Atp8a1 T C 5: 67,682,927 (GRCm38) T704A possibly damaging Het
Cabin1 A T 10: 75,658,739 (GRCm38) M1602K probably damaging Het
Ccdc74a T C 16: 17,648,114 (GRCm38) S105P probably damaging Het
Cdh26 T A 2: 178,471,573 (GRCm38) probably null Het
Cxcl10 T C 5: 92,348,213 (GRCm38) I22V probably benign Het
Cyp2c68 A C 19: 39,712,489 (GRCm38) V295G possibly damaging Het
Ddx10 A T 9: 53,204,251 (GRCm38) D594E probably benign Het
Ddx5 T C 11: 106,785,542 (GRCm38) probably null Het
Ddx58 T A 4: 40,222,199 (GRCm38) probably null Het
Duox1 T C 2: 122,337,721 (GRCm38) I1109T probably damaging Het
Dusp15 T C 2: 152,946,284 (GRCm38) probably null Het
Ecel1 A G 1: 87,150,471 (GRCm38) probably null Het
Efcab6 T G 15: 83,935,938 (GRCm38) Q714P possibly damaging Het
Erc1 A G 6: 119,777,998 (GRCm38) L464P possibly damaging Het
Fam129c C T 8: 71,600,077 (GRCm38) P65L probably damaging Het
Fam234a T A 17: 26,213,693 (GRCm38) H494L probably damaging Het
Gfpt1 T C 6: 87,088,145 (GRCm38) V694A probably damaging Het
Gli2 T C 1: 118,836,224 (GRCm38) D1399G probably damaging Het
Gm10110 T C 14: 89,896,708 (GRCm38) noncoding transcript Het
Hdac3 A G 18: 37,944,164 (GRCm38) L219P probably damaging Het
Hlcs A G 16: 94,231,163 (GRCm38) F52S probably damaging Het
Ints7 C A 1: 191,613,127 (GRCm38) T643K probably damaging Het
Ireb2 A G 9: 54,908,780 (GRCm38) I878M probably damaging Het
Itga3 A T 11: 95,055,851 (GRCm38) probably null Het
Lrfn5 T A 12: 61,843,582 (GRCm38) Y552* probably null Het
Mafb T C 2: 160,366,451 (GRCm38) T76A probably damaging Het
Man2b1 A T 8: 85,095,399 (GRCm38) S748C probably damaging Het
Mmp17 A T 5: 129,601,955 (GRCm38) R335W probably damaging Het
Muc5ac A T 7: 141,801,492 (GRCm38) D1005V probably damaging Het
Myh3 T C 11: 67,082,996 (GRCm38) F165S probably benign Het
Nacc1 T C 8: 84,674,791 (GRCm38) D419G probably benign Het
Neb G A 2: 52,209,474 (GRCm38) S4545L probably damaging Het
Npas2 T C 1: 39,300,687 (GRCm38) I106T probably damaging Het
Ogfrl1 T G 1: 23,369,863 (GRCm38) K427N probably benign Het
Olfr1448 T C 19: 12,919,479 (GRCm38) T277A probably benign Het
Pde4dip T A 3: 97,694,911 (GRCm38) Q2283L probably benign Het
Phax C T 18: 56,573,101 (GRCm38) T21M possibly damaging Het
Pitpnm1 A T 19: 4,102,829 (GRCm38) K79* probably null Het
Pkd1 T A 17: 24,580,227 (GRCm38) F2807I probably damaging Het
Plekha4 C T 7: 45,541,148 (GRCm38) R427C probably damaging Het
Ptprj A T 2: 90,458,349 (GRCm38) F757L probably benign Het
Rad1 A G 15: 10,492,821 (GRCm38) D208G probably damaging Het
Rangrf T A 11: 68,972,712 (GRCm38) N156I probably benign Het
Rasl11b T C 5: 74,198,376 (GRCm38) S181P probably damaging Het
Rlf G A 4: 121,149,360 (GRCm38) Q808* probably null Het
Rogdi G T 16: 5,013,377 (GRCm38) probably null Het
Sec24a A T 11: 51,717,776 (GRCm38) V573D probably damaging Het
Sorbs2 A G 8: 45,770,578 (GRCm38) T200A probably damaging Het
Srgap2 C T 1: 131,291,629 (GRCm38) R259H probably benign Het
Ssc5d T A 7: 4,936,665 (GRCm38) V700E probably benign Het
Stt3a A T 9: 36,751,296 (GRCm38) H222Q probably damaging Het
Tcaf3 A T 6: 42,597,259 (GRCm38) D6E possibly damaging Het
Tdrd12 C T 7: 35,490,048 (GRCm38) R421H probably damaging Het
Top3b T C 16: 16,879,071 (GRCm38) M62T probably damaging Het
Trhr T G 15: 44,229,298 (GRCm38) Y310* probably null Het
Urb2 G T 8: 124,031,125 (GRCm38) E1190D probably damaging Het
Usp34 A G 11: 23,381,353 (GRCm38) T1085A probably damaging Het
Vmn1r179 T A 7: 23,929,066 (GRCm38) H227Q possibly damaging Het
Vmn1r31 A T 6: 58,472,010 (GRCm38) M290K probably benign Het
Wdr75 T C 1: 45,802,131 (GRCm38) probably null Het
Wnk1 A T 6: 119,948,585 (GRCm38) V1306D probably damaging Het
Xkr4 T C 1: 3,670,778 (GRCm38) T191A probably benign Het
Zc3h15 A G 2: 83,661,223 (GRCm38) E265G probably benign Het
Zcchc9 A G 13: 91,800,697 (GRCm38) F41S possibly damaging Het
Zfp251 T C 15: 76,854,137 (GRCm38) H247R probably damaging Het
Zfp433 A G 10: 81,720,123 (GRCm38) E152G probably damaging Het
Zfp770 A T 2: 114,196,759 (GRCm38) S276R probably benign Het
Other mutations in Mmp15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01467:Mmp15 APN 8 95,366,331 (GRCm38) missense probably benign 0.31
IGL03001:Mmp15 APN 8 95,368,217 (GRCm38) missense probably damaging 0.97
R0147:Mmp15 UTSW 8 95,372,317 (GRCm38) missense probably benign 0.18
R0148:Mmp15 UTSW 8 95,372,317 (GRCm38) missense probably benign 0.18
R0437:Mmp15 UTSW 8 95,370,772 (GRCm38) missense probably benign 0.04
R0465:Mmp15 UTSW 8 95,367,998 (GRCm38) missense probably damaging 1.00
R0548:Mmp15 UTSW 8 95,372,351 (GRCm38) missense probably damaging 1.00
R0574:Mmp15 UTSW 8 95,365,401 (GRCm38) missense possibly damaging 0.73
R0685:Mmp15 UTSW 8 95,372,134 (GRCm38) missense possibly damaging 0.81
R0763:Mmp15 UTSW 8 95,368,228 (GRCm38) missense probably benign 0.01
R1341:Mmp15 UTSW 8 95,372,303 (GRCm38) missense probably benign 0.03
R1428:Mmp15 UTSW 8 95,369,562 (GRCm38) missense probably benign 0.34
R1840:Mmp15 UTSW 8 95,365,420 (GRCm38) missense probably damaging 1.00
R2061:Mmp15 UTSW 8 95,370,779 (GRCm38) missense possibly damaging 0.91
R2219:Mmp15 UTSW 8 95,370,173 (GRCm38) missense probably benign 0.38
R4760:Mmp15 UTSW 8 95,368,196 (GRCm38) missense possibly damaging 0.61
R4762:Mmp15 UTSW 8 95,372,330 (GRCm38) missense probably benign 0.00
R5233:Mmp15 UTSW 8 95,371,068 (GRCm38) missense probably benign 0.08
R5394:Mmp15 UTSW 8 95,366,404 (GRCm38) missense probably damaging 0.96
R5502:Mmp15 UTSW 8 95,368,184 (GRCm38) missense possibly damaging 0.96
R5543:Mmp15 UTSW 8 95,368,101 (GRCm38) missense possibly damaging 0.85
R6027:Mmp15 UTSW 8 95,372,176 (GRCm38) missense probably benign 0.00
R6720:Mmp15 UTSW 8 95,365,314 (GRCm38) missense probably benign 0.22
R7788:Mmp15 UTSW 8 95,368,148 (GRCm38) missense probably damaging 1.00
R8033:Mmp15 UTSW 8 95,367,962 (GRCm38) missense probably benign 0.01
R8679:Mmp15 UTSW 8 95,366,354 (GRCm38) missense possibly damaging 0.83
R8791:Mmp15 UTSW 8 95,369,660 (GRCm38) nonsense probably null
R9028:Mmp15 UTSW 8 95,369,688 (GRCm38) missense probably benign 0.01
R9227:Mmp15 UTSW 8 95,366,331 (GRCm38) missense probably benign 0.06
R9230:Mmp15 UTSW 8 95,366,331 (GRCm38) missense probably benign 0.06
R9350:Mmp15 UTSW 8 95,366,374 (GRCm38) missense probably damaging 0.97
R9632:Mmp15 UTSW 8 95,372,103 (GRCm38) critical splice acceptor site probably null
R9695:Mmp15 UTSW 8 95,370,786 (GRCm38) missense possibly damaging 0.48
Predicted Primers PCR Primer
(F):5'- AACTGAATGTCCTTTGAATTGGGAG -3'
(R):5'- AAGGCTTCAGGCAACCATAC -3'

Sequencing Primer
(F):5'- TTCTGAGCAGTGACTGAGCAAAC -3'
(R):5'- GGCTTCAGGCAACCATACTAAAC -3'
Posted On 2018-04-27