Incidental Mutation 'R6348:Tmem210'
ID 514432
Institutional Source Beutler Lab
Gene Symbol Tmem210
Ensembl Gene ENSMUSG00000026963
Gene Name transmembrane protein 210
Synonyms 4930571C24Rik
MMRRC Submission 044502-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R6348 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 25178157-25179201 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 25178796 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 82 (S82P)
Ref Sequence ENSEMBL: ENSMUSP00000028340 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028335] [ENSMUST00000028337] [ENSMUST00000028340] [ENSMUST00000028341] [ENSMUST00000114307] [ENSMUST00000114308] [ENSMUST00000114314] [ENSMUST00000114317] [ENSMUST00000114312] [ENSMUST00000114318] [ENSMUST00000114310]
AlphaFold Q9D2F0
Predicted Effect probably benign
Transcript: ENSMUST00000028335
SMART Domains Protein: ENSMUSP00000028335
Gene: ENSMUSG00000026959

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 38 357 6.6e-35 PFAM
PBPe 433 795 2.71e-97 SMART
Lig_chan-Glu_bd 439 507 2.99e-18 SMART
Pfam:CaM_bdg_C0 835 863 1.5e-18 PFAM
PDB:3BYA|B 875 898 4e-6 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000028337
SMART Domains Protein: ENSMUSP00000028337
Gene: ENSMUSG00000026961

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LRRNT 42 75 1.86e0 SMART
LRR 72 93 7.57e0 SMART
LRR 95 117 6.96e0 SMART
LRR_TYP 118 141 1e-5 SMART
LRR 142 165 6.22e0 SMART
LRR 166 189 2.86e-1 SMART
LRRCT 201 254 3.01e-5 SMART
transmembrane domain 267 289 N/A INTRINSIC
low complexity region 293 308 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000028340
AA Change: S82P

PolyPhen 2 Score 0.272 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000028340
Gene: ENSMUSG00000026963
AA Change: S82P

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
Pfam:TMEM210 32 144 1.1e-65 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000028341
SMART Domains Protein: ENSMUSP00000028341
Gene: ENSMUSG00000026965

DomainStartEndE-ValueType
low complexity region 6 19 N/A INTRINSIC
low complexity region 123 133 N/A INTRINSIC
low complexity region 153 164 N/A INTRINSIC
low complexity region 221 229 N/A INTRINSIC
low complexity region 456 467 N/A INTRINSIC
CULLIN 515 663 6.72e-9 SMART
APC2 772 832 3.67e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000114307
SMART Domains Protein: ENSMUSP00000109946
Gene: ENSMUSG00000026959

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 38 357 1e-34 PFAM
PBPe 433 795 2.71e-97 SMART
Lig_chan-Glu_bd 439 507 2.99e-18 SMART
Pfam:CaM_bdg_C0 835 863 3.2e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114308
SMART Domains Protein: ENSMUSP00000109947
Gene: ENSMUSG00000026959

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 38 378 8e-31 PFAM
PBPe 454 816 2.71e-97 SMART
Lig_chan-Glu_bd 460 528 2.99e-18 SMART
Pfam:CaM_bdg_C0 856 884 3.3e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114314
SMART Domains Protein: ENSMUSP00000109953
Gene: ENSMUSG00000026959

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 38 357 1.1e-34 PFAM
PBPe 433 795 2.71e-97 SMART
Lig_chan-Glu_bd 439 507 2.99e-18 SMART
Pfam:CaM_bdg_C0 835 863 3.3e-19 PFAM
PDB:3BYA|B 875 898 4e-6 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000114317
SMART Domains Protein: ENSMUSP00000109956
Gene: ENSMUSG00000026959

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 38 378 7.7e-31 PFAM
PBPe 454 816 2.71e-97 SMART
Lig_chan-Glu_bd 460 528 2.99e-18 SMART
Pfam:CaM_bdg_C0 856 884 3.3e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144102
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127171
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129723
Predicted Effect probably benign
Transcript: ENSMUST00000114312
SMART Domains Protein: ENSMUSP00000109951
Gene: ENSMUSG00000026959

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 38 357 5.9e-35 PFAM
PBPe 433 795 2.71e-97 SMART
Lig_chan-Glu_bd 439 507 2.99e-18 SMART
Pfam:CaM_bdg_C0 835 863 1.4e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114318
SMART Domains Protein: ENSMUSP00000109957
Gene: ENSMUSG00000026959

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 38 378 8.4e-31 PFAM
PBPe 454 816 2.71e-97 SMART
Lig_chan-Glu_bd 460 528 2.99e-18 SMART
Pfam:CaM_bdg_C0 856 884 3.4e-19 PFAM
PDB:3BYA|B 896 919 4e-6 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135426
Predicted Effect probably benign
Transcript: ENSMUST00000114310
SMART Domains Protein: ENSMUSP00000109949
Gene: ENSMUSG00000026959

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 39 299 3.6e-24 PFAM
Blast:PBPe 352 420 9e-37 BLAST
PBPe 454 816 2.71e-97 SMART
Lig_chan-Glu_bd 460 528 2.99e-18 SMART
Pfam:CaM_bdg_C0 856 884 8.4e-17 PFAM
PDB:3BYA|B 896 919 4e-6 PDB
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.2%
Validation Efficiency 100% (37/37)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alox5 A T 6: 116,391,556 (GRCm39) H400Q probably damaging Het
Arhgef16 G T 4: 154,371,540 (GRCm39) Q218K probably benign Het
Asxl3 A T 18: 22,650,330 (GRCm39) H773L possibly damaging Het
Atic C T 1: 71,615,857 (GRCm39) R468W probably damaging Het
Bfsp2 A T 9: 103,357,271 (GRCm39) V52D probably benign Het
Bicd2 A G 13: 49,533,322 (GRCm39) H636R probably damaging Het
Chac2 A G 11: 30,927,406 (GRCm39) V171A probably damaging Het
Chd9 A G 8: 91,737,903 (GRCm39) I1512V possibly damaging Het
Cnbd1 T C 4: 18,860,462 (GRCm39) D428G probably damaging Het
Crlf1 T C 8: 70,945,990 (GRCm39) S22P probably benign Het
Crybg1 A G 10: 43,879,947 (GRCm39) F414L probably damaging Het
Dnah14 A T 1: 181,454,285 (GRCm39) D765V possibly damaging Het
Fat3 A G 9: 15,849,287 (GRCm39) probably null Het
Gabbr1 A T 17: 37,367,791 (GRCm39) M414L possibly damaging Het
Grip2 A T 6: 91,757,419 (GRCm39) D412E probably damaging Het
Herc1 G A 9: 66,395,258 (GRCm39) A4198T possibly damaging Het
Hsd3b3 C T 3: 98,663,265 (GRCm39) probably null Het
Ifi213 G A 1: 173,417,848 (GRCm39) T188I possibly damaging Het
Il36rn G A 2: 24,169,726 (GRCm39) A29T probably damaging Het
Klk1b11 T C 7: 43,647,275 (GRCm39) probably null Het
Mepce A T 5: 137,783,698 (GRCm39) D209E possibly damaging Het
Mtr A C 13: 12,262,840 (GRCm39) V111G possibly damaging Het
Mtrex T A 13: 113,047,451 (GRCm39) H298L possibly damaging Het
Or2h1b A G 17: 37,462,497 (GRCm39) V122A probably damaging Het
Or8k24 T A 2: 86,216,513 (GRCm39) Q83L probably benign Het
Or9k2b A T 10: 130,016,166 (GRCm39) N194K probably benign Het
P2rx1 G A 11: 72,890,148 (GRCm39) R3Q probably benign Het
Phc2 G A 4: 128,598,944 (GRCm39) G34S probably benign Het
Poglut3 G A 9: 53,301,740 (GRCm39) V131M probably damaging Het
Ppm1a A G 12: 72,837,449 (GRCm39) H332R probably benign Het
Sdk2 A G 11: 113,784,334 (GRCm39) V135A probably benign Het
Slc2a4 T C 11: 69,835,848 (GRCm39) T334A probably benign Het
Slc6a15 T G 10: 103,240,228 (GRCm39) V317G probably damaging Het
Speer2 T C 16: 69,654,895 (GRCm39) D190G possibly damaging Het
Tbc1d21 G A 9: 58,268,501 (GRCm39) A286V probably benign Het
Top6bl G C 19: 4,722,106 (GRCm39) P105A probably damaging Het
Zbtb26 C T 2: 37,325,687 (GRCm39) V450M probably benign Het
Other mutations in Tmem210
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02651:Tmem210 APN 2 25,179,101 (GRCm39) missense possibly damaging 0.71
R0135:Tmem210 UTSW 2 25,178,480 (GRCm39) missense probably damaging 0.99
R1758:Tmem210 UTSW 2 25,178,435 (GRCm39) missense probably damaging 0.96
R3837:Tmem210 UTSW 2 25,178,444 (GRCm39) missense possibly damaging 0.60
R3838:Tmem210 UTSW 2 25,178,444 (GRCm39) missense possibly damaging 0.60
R6170:Tmem210 UTSW 2 25,178,776 (GRCm39) critical splice acceptor site probably null
R6349:Tmem210 UTSW 2 25,179,048 (GRCm39) missense possibly damaging 0.85
Predicted Primers PCR Primer
(F):5'- TACTGACCCTGGGCTGTTAGTC -3'
(R):5'- GGTCTATGCGATCTTCCTGGAC -3'

Sequencing Primer
(F):5'- CATGCTTTGAGGGGCCTC -3'
(R):5'- GCGATCTTCCTGGACTCCGTAG -3'
Posted On 2018-04-27