|Institutional Source||Beutler Lab|
|Gene Name||neuromedin U|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6408 (G1)|
|Chromosomal Location||76333495-76363788 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 76343971 bp|
|Amino Acid Change||Phenylalanine to Tyrosine at position 106 (F106Y)|
|Ref Sequence||ENSEMBL: ENSMUSP00000031146 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000031146]|
|Predicted Effect||probably damaging
AA Change: F106Y
PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
AA Change: F106Y
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.1908|
|Coding Region Coverage||
|Validation Efficiency||94% (45/48)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]
PHENOTYPE: Homozygous null mice are healthy and viable. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Nmu||
(F):5'- ACTGGGCTACACCATCAGAC -3'
(R):5'- ACTGTAGTGTAACTTCCTGTCC -3'
(F):5'- CCATCAGACCCAGACATAATTTATAG -3'
(R):5'- CATTGATTTTTGAGCAACGGATG -3'