Incidental Mutation 'IGL01077:Supt5'
ID51460
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Supt5
Ensembl Gene ENSMUSG00000003435
Gene Namesuppressor of Ty 5
SynonymsSupt5h, Spt5
Accession Numbers
Is this an essential gene? Essential (E-score: 1.000) question?
Stock #IGL01077
Quality Score
Status
Chromosome7
Chromosomal Location28314891-28338746 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to T at 28323788 bp
ZygosityHeterozygous
Amino Acid Change Tryptophan to Stop codon at position 323 (W323*)
Ref Sequence ENSEMBL: ENSMUSP00000147164 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003527] [ENSMUST00000207563] [ENSMUST00000208243] [ENSMUST00000209141]
Predicted Effect probably null
Transcript: ENSMUST00000003527
AA Change: W323*
SMART Domains Protein: ENSMUSP00000003527
Gene: ENSMUSG00000003435
AA Change: W323*

DomainStartEndE-ValueType
low complexity region 2 29 N/A INTRINSIC
coiled coil region 36 63 N/A INTRINSIC
Pfam:Spt5_N 73 170 8.1e-17 PFAM
NGN 174 265 2.2e-14 SMART
KOW 270 297 8.77e0 SMART
KOW 417 444 8.69e-4 SMART
KOW 469 496 9.1e-7 SMART
KOW 591 618 2.46e-3 SMART
low complexity region 677 695 N/A INTRINSIC
KOW 697 724 3.93e-2 SMART
CTD 766 902 2.09e-31 SMART
KOW 1028 1055 9.69e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000207563
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207649
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207879
Predicted Effect probably benign
Transcript: ENSMUST00000208243
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208367
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208726
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209105
Predicted Effect probably null
Transcript: ENSMUST00000209141
AA Change: W323*
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox1 A T 1: 58,057,410 probably benign Het
Arhgap4 A G X: 73,900,093 probably benign Het
Ascc3 T G 10: 50,649,317 probably benign Het
Cacng5 C T 11: 107,881,705 V106I probably benign Het
Car10 T C 11: 93,597,143 I222T possibly damaging Het
Cep250 G A 2: 155,962,134 V55M probably damaging Het
Chst4 T A 8: 110,029,965 Y422F probably benign Het
Dnajc13 T C 9: 104,231,021 E185G probably benign Het
Dtx2 T A 5: 136,029,203 M454K possibly damaging Het
Flg2 T A 3: 93,220,206 S2142T unknown Het
Ganc C T 2: 120,446,515 T686M possibly damaging Het
Gm53 C T 11: 96,251,768 noncoding transcript Het
Gria3 T C X: 41,588,492 V254A possibly damaging Het
H2-DMb2 G T 17: 34,148,613 A3S probably damaging Het
H2-DMb2 A G 17: 34,147,720 Y42C probably damaging Het
Myzap T C 9: 71,546,760 E343G probably damaging Het
Nap1l2 T C X: 103,185,316 D332G probably benign Het
Npr1 T G 3: 90,458,362 D628A probably damaging Het
Raet1e T C 10: 22,181,320 L181S probably damaging Het
Rnf43 G T 11: 87,731,892 M606I probably benign Het
Serpinb6b G A 13: 32,978,066 D283N possibly damaging Het
Skiv2l2 A T 13: 112,914,489 I184K probably damaging Het
Slit2 A G 5: 48,217,443 probably null Het
Svep1 T A 4: 58,068,760 I3009F possibly damaging Het
Tedc1 C T 12: 113,163,188 R357* probably null Het
Tll1 T C 8: 64,070,232 Y482C probably benign Het
Trappc8 G A 18: 20,836,978 T985I probably benign Het
Zfp945 T C 17: 22,852,385 K180R probably damaging Het
Other mutations in Supt5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00468:Supt5 APN 7 28315382 missense probably benign 0.08
IGL01477:Supt5 APN 7 28317264 missense possibly damaging 0.94
IGL01813:Supt5 APN 7 28323975 missense probably damaging 0.99
IGL02405:Supt5 APN 7 28315824 missense probably benign 0.00
IGL02525:Supt5 APN 7 28318947 splice site probably benign
IGL02584:Supt5 APN 7 28326167 missense probably benign 0.08
IGL03387:Supt5 APN 7 28320083 missense possibly damaging 0.89
R0420:Supt5 UTSW 7 28317329 splice site probably benign
R0715:Supt5 UTSW 7 28329037 missense probably damaging 1.00
R1226:Supt5 UTSW 7 28328747 missense probably benign 0.03
R1655:Supt5 UTSW 7 28330024 missense probably benign 0.00
R1801:Supt5 UTSW 7 28317214 critical splice donor site probably null
R2424:Supt5 UTSW 7 28315165 missense possibly damaging 0.47
R2883:Supt5 UTSW 7 28329320 missense possibly damaging 0.75
R4280:Supt5 UTSW 7 28317073 missense probably damaging 1.00
R4614:Supt5 UTSW 7 28325972 missense possibly damaging 0.65
R4792:Supt5 UTSW 7 28316329 missense probably benign 0.19
R4997:Supt5 UTSW 7 28316037 missense probably benign 0.05
R5041:Supt5 UTSW 7 28315380 missense probably damaging 1.00
R5062:Supt5 UTSW 7 28329015 splice site probably null
R5119:Supt5 UTSW 7 28316370 missense probably damaging 1.00
R5170:Supt5 UTSW 7 28316083 missense probably benign 0.05
R5687:Supt5 UTSW 7 28317763 missense probably benign 0.27
R5720:Supt5 UTSW 7 28322568 missense probably damaging 0.97
R5935:Supt5 UTSW 7 28329475 missense probably benign 0.09
R6032:Supt5 UTSW 7 28316175 missense probably damaging 1.00
R6032:Supt5 UTSW 7 28316175 missense probably damaging 1.00
R6049:Supt5 UTSW 7 28315197 missense probably benign 0.32
R7043:Supt5 UTSW 7 28320010 missense probably benign 0.00
R7085:Supt5 UTSW 7 28331489 missense unknown
R7152:Supt5 UTSW 7 28323900 missense probably benign 0.00
R7201:Supt5 UTSW 7 28316788 missense probably benign 0.03
R7401:Supt5 UTSW 7 28323772 missense probably damaging 0.99
Posted On2013-06-21