Incidental Mutation 'R6387:Gdf10'
ID |
514676 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Gdf10
|
Ensembl Gene |
ENSMUSG00000021943 |
Gene Name |
growth differentiation factor 10 |
Synonyms |
Bmp3b |
MMRRC Submission |
044536-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R6387 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
14 |
Chromosomal Location |
33645544-33658471 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 33645961 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Threonine
at position 37
(S37T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000128621
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168727]
|
AlphaFold |
P97737 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000168727
AA Change: S37T
PolyPhen 2
Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
|
SMART Domains |
Protein: ENSMUSP00000128621 Gene: ENSMUSG00000021943 AA Change: S37T
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
29 |
N/A |
INTRINSIC |
low complexity region
|
56 |
67 |
N/A |
INTRINSIC |
TGFB
|
374 |
476 |
1e-50 |
SMART |
|
Meta Mutation Damage Score |
0.0827 |
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.3%
|
Validation Efficiency |
98% (42/43) |
MGI Phenotype |
FUNCTION: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein has been shown to promote neural repair after stroke and may act as a tumor suppressor. [provided by RefSeq, Jul 2016] PHENOTYPE: Mice homozygous for disruption of this gene display a normal phenotype. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 42 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930522L14Rik |
T |
C |
5: 109,884,881 (GRCm39) |
K326E |
possibly damaging |
Het |
Acot1 |
A |
G |
12: 84,056,627 (GRCm39) |
D115G |
probably benign |
Het |
Adm |
T |
C |
7: 110,227,502 (GRCm39) |
I6T |
possibly damaging |
Het |
Ahi1 |
A |
G |
10: 20,844,942 (GRCm39) |
Y349C |
probably damaging |
Het |
Aldh1a1 |
A |
G |
19: 20,595,323 (GRCm39) |
E84G |
probably damaging |
Het |
Ankrd31 |
A |
G |
13: 96,967,081 (GRCm39) |
D520G |
probably damaging |
Het |
Ano4 |
A |
T |
10: 88,807,267 (GRCm39) |
Y736* |
probably null |
Het |
Atp6v1a |
A |
G |
16: 43,907,806 (GRCm39) |
F612S |
possibly damaging |
Het |
Bltp3b |
C |
T |
10: 89,638,919 (GRCm39) |
Q442* |
probably null |
Het |
Calcb |
G |
A |
7: 114,319,025 (GRCm39) |
V17I |
possibly damaging |
Het |
Cfap70 |
C |
T |
14: 20,498,643 (GRCm39) |
V15M |
probably damaging |
Het |
Chad |
C |
T |
11: 94,458,663 (GRCm39) |
H271Y |
possibly damaging |
Het |
Csgalnact1 |
C |
T |
8: 68,811,365 (GRCm39) |
G435D |
probably damaging |
Het |
Enpp5 |
G |
A |
17: 44,396,155 (GRCm39) |
G356S |
probably damaging |
Het |
Eprs1 |
T |
A |
1: 185,119,281 (GRCm39) |
M487K |
possibly damaging |
Het |
Fat4 |
A |
G |
3: 39,037,934 (GRCm39) |
E3862G |
probably damaging |
Het |
Hhatl |
T |
A |
9: 121,619,467 (GRCm39) |
H39L |
probably benign |
Het |
Icam4 |
A |
C |
9: 20,941,505 (GRCm39) |
S215R |
possibly damaging |
Het |
Ighv1-18 |
T |
C |
12: 114,646,280 (GRCm39) |
E108G |
probably damaging |
Het |
Iqcd |
T |
C |
5: 120,744,920 (GRCm39) |
I416T |
probably benign |
Het |
Marf1 |
T |
A |
16: 13,959,504 (GRCm39) |
*577L |
probably null |
Het |
Mark2 |
A |
G |
19: 7,263,267 (GRCm39) |
F167L |
probably damaging |
Het |
Mpdz |
T |
C |
4: 81,299,946 (GRCm39) |
T351A |
possibly damaging |
Het |
Mrps27 |
A |
G |
13: 99,536,825 (GRCm39) |
I113V |
possibly damaging |
Het |
Numbl |
C |
T |
7: 26,976,115 (GRCm39) |
T265I |
probably damaging |
Het |
Obsl1 |
C |
T |
1: 75,468,006 (GRCm39) |
A1296T |
probably benign |
Het |
Or10g9 |
A |
G |
9: 39,912,148 (GRCm39) |
I125T |
probably damaging |
Het |
Pcdhb21 |
A |
G |
18: 37,648,385 (GRCm39) |
I505V |
probably benign |
Het |
Pfas |
A |
G |
11: 68,891,291 (GRCm39) |
F269L |
probably damaging |
Het |
Prkdc |
G |
A |
16: 15,516,679 (GRCm39) |
V1018I |
probably benign |
Het |
Prl4a1 |
T |
A |
13: 28,202,482 (GRCm39) |
V19E |
possibly damaging |
Het |
Ptpn22 |
A |
G |
3: 103,792,702 (GRCm39) |
D327G |
probably benign |
Het |
Smad3 |
G |
T |
9: 63,562,047 (GRCm39) |
D310E |
probably benign |
Het |
Sparcl1 |
T |
A |
5: 104,232,926 (GRCm39) |
D625V |
probably damaging |
Het |
Spta1 |
G |
A |
1: 174,058,899 (GRCm39) |
A1945T |
probably benign |
Het |
St3gal1 |
A |
G |
15: 66,983,195 (GRCm39) |
V187A |
possibly damaging |
Het |
Sympk |
T |
C |
7: 18,786,423 (GRCm39) |
Y1009H |
possibly damaging |
Het |
Trio |
A |
G |
15: 27,752,825 (GRCm39) |
F1026L |
probably damaging |
Het |
Unc5d |
T |
A |
8: 29,365,554 (GRCm39) |
K144* |
probably null |
Het |
Unk |
A |
G |
11: 115,945,766 (GRCm39) |
N479S |
possibly damaging |
Het |
Zfp710 |
T |
C |
7: 79,735,775 (GRCm39) |
I514T |
probably damaging |
Het |
Zfp993 |
A |
G |
4: 146,741,975 (GRCm39) |
T100A |
probably damaging |
Het |
|
Other mutations in Gdf10 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02558:Gdf10
|
APN |
14 |
33,645,937 (GRCm39) |
missense |
probably benign |
|
IGL03203:Gdf10
|
APN |
14 |
33,656,430 (GRCm39) |
missense |
possibly damaging |
0.94 |
R0178:Gdf10
|
UTSW |
14 |
33,646,058 (GRCm39) |
missense |
probably damaging |
1.00 |
R0890:Gdf10
|
UTSW |
14 |
33,654,113 (GRCm39) |
missense |
possibly damaging |
0.57 |
R1218:Gdf10
|
UTSW |
14 |
33,654,710 (GRCm39) |
missense |
probably benign |
0.01 |
R1219:Gdf10
|
UTSW |
14 |
33,654,710 (GRCm39) |
missense |
probably benign |
0.01 |
R1221:Gdf10
|
UTSW |
14 |
33,654,710 (GRCm39) |
missense |
probably benign |
0.01 |
R1670:Gdf10
|
UTSW |
14 |
33,654,000 (GRCm39) |
missense |
possibly damaging |
0.92 |
R1956:Gdf10
|
UTSW |
14 |
33,654,710 (GRCm39) |
missense |
probably benign |
0.01 |
R1957:Gdf10
|
UTSW |
14 |
33,654,710 (GRCm39) |
missense |
probably benign |
0.01 |
R1958:Gdf10
|
UTSW |
14 |
33,654,710 (GRCm39) |
missense |
probably benign |
0.01 |
R2154:Gdf10
|
UTSW |
14 |
33,656,346 (GRCm39) |
missense |
probably damaging |
0.99 |
R2260:Gdf10
|
UTSW |
14 |
33,654,234 (GRCm39) |
missense |
probably damaging |
1.00 |
R2971:Gdf10
|
UTSW |
14 |
33,646,148 (GRCm39) |
missense |
probably damaging |
1.00 |
R3896:Gdf10
|
UTSW |
14 |
33,656,438 (GRCm39) |
missense |
probably damaging |
1.00 |
R4027:Gdf10
|
UTSW |
14 |
33,654,572 (GRCm39) |
missense |
probably damaging |
1.00 |
R4393:Gdf10
|
UTSW |
14 |
33,654,695 (GRCm39) |
missense |
probably damaging |
1.00 |
R4782:Gdf10
|
UTSW |
14 |
33,653,870 (GRCm39) |
missense |
probably benign |
0.00 |
R5436:Gdf10
|
UTSW |
14 |
33,654,213 (GRCm39) |
missense |
probably damaging |
0.97 |
R5829:Gdf10
|
UTSW |
14 |
33,654,674 (GRCm39) |
missense |
probably damaging |
0.99 |
R8346:Gdf10
|
UTSW |
14 |
33,653,802 (GRCm39) |
missense |
probably benign |
0.00 |
R8742:Gdf10
|
UTSW |
14 |
33,654,426 (GRCm39) |
missense |
probably benign |
0.00 |
R9086:Gdf10
|
UTSW |
14 |
33,654,221 (GRCm39) |
missense |
probably damaging |
1.00 |
R9517:Gdf10
|
UTSW |
14 |
33,654,522 (GRCm39) |
missense |
probably benign |
0.31 |
Z1088:Gdf10
|
UTSW |
14 |
33,654,347 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Gdf10
|
UTSW |
14 |
33,654,489 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
Predicted Primers |
PCR Primer
(F):5'- AACACTGAGCCCTCCTTGTC -3'
(R):5'- ATGGATTAGGACTCCCGGTG -3'
Sequencing Primer
(F):5'- GTCTGTTCTCCTGGGCTCAGAC -3'
(R):5'- GATTAGGACTCCCGGTGCATCTTC -3'
|
Posted On |
2018-05-04 |