Incidental Mutation 'R6395:Zfp619'
ID 514715
Institutional Source Beutler Lab
Gene Symbol Zfp619
Ensembl Gene ENSMUSG00000068959
Gene Name zinc finger protein 619
Synonyms 3000002G13Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R6395 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 39167190-39189844 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 39186454 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Glutamic Acid at position 828 (A828E)
Ref Sequence ENSEMBL: ENSMUSP00000103650 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108015]
AlphaFold G3X9T2
Predicted Effect possibly damaging
Transcript: ENSMUST00000108015
AA Change: A828E

PolyPhen 2 Score 0.913 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000103650
Gene: ENSMUSG00000068959
AA Change: A828E

DomainStartEndE-ValueType
KRAB 4 61 2.19e-20 SMART
ZnF_C2H2 218 240 2.91e-2 SMART
ZnF_C2H2 246 268 5.81e-2 SMART
ZnF_C2H2 274 296 3.16e-3 SMART
ZnF_C2H2 302 324 2.4e-3 SMART
ZnF_C2H2 330 352 2.95e-3 SMART
ZnF_C2H2 358 380 6.32e-3 SMART
ZnF_C2H2 386 408 8.47e-4 SMART
ZnF_C2H2 414 436 5.06e-2 SMART
ZnF_C2H2 442 464 1.58e-3 SMART
ZnF_C2H2 470 492 5.42e-2 SMART
ZnF_C2H2 526 548 2.09e-3 SMART
ZnF_C2H2 554 576 3.39e-3 SMART
ZnF_C2H2 582 604 1.56e-2 SMART
ZnF_C2H2 610 632 2.24e-3 SMART
ZnF_C2H2 638 660 4.72e-2 SMART
ZnF_C2H2 666 688 7.78e-3 SMART
ZnF_C2H2 694 716 5.9e-3 SMART
ZnF_C2H2 722 744 1.12e-3 SMART
ZnF_C2H2 748 770 6.42e-4 SMART
ZnF_C2H2 776 798 1.38e-3 SMART
ZnF_C2H2 804 826 9.44e-2 SMART
ZnF_C2H2 832 854 2.36e-2 SMART
ZnF_C2H2 860 882 8.94e-3 SMART
ZnF_C2H2 888 910 3.58e-2 SMART
ZnF_C2H2 916 938 6.42e-4 SMART
ZnF_C2H2 942 964 4.72e-2 SMART
ZnF_C2H2 970 992 2.3e-5 SMART
ZnF_C2H2 998 1020 8.34e-3 SMART
ZnF_C2H2 1026 1048 8.81e-2 SMART
ZnF_C2H2 1054 1076 1.69e-3 SMART
ZnF_C2H2 1082 1104 6.32e-3 SMART
ZnF_C2H2 1110 1132 1.47e-3 SMART
ZnF_C2H2 1138 1160 7.15e-2 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.6%
  • 20x: 98.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91 (MIM 603971) for further information on ZNFs.[supplied by OMIM, Aug 2009]
Allele List at MGI

All alleles(5) : Gene trapped(5)

Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actc1 C A 2: 113,879,731 (GRCm39) E243* probably null Het
Ahi1 T C 10: 20,855,491 (GRCm39) I600T possibly damaging Het
Apob A G 12: 8,058,507 (GRCm39) T2330A probably benign Het
Cabin1 A T 10: 75,582,576 (GRCm39) M280K probably benign Het
Ccdc117 T C 11: 5,484,762 (GRCm39) probably null Het
Cct8 G T 16: 87,283,364 (GRCm39) Y292* probably null Het
Celf1 A G 2: 90,834,203 (GRCm39) I165V probably benign Het
Cenpc1 A T 5: 86,183,429 (GRCm39) N453K probably benign Het
Chst10 T C 1: 38,910,770 (GRCm39) I131M probably damaging Het
Cltc A G 11: 86,616,006 (GRCm39) I420T probably damaging Het
Cspg4b T G 13: 113,506,003 (GRCm39) C2377W probably damaging Het
Dact3 A C 7: 16,617,086 (GRCm39) Q95P probably damaging Het
Dennd2c T C 3: 103,056,540 (GRCm39) probably null Het
Dock2 G T 11: 34,182,874 (GRCm39) H1586Q probably damaging Het
Dst T C 1: 34,221,771 (GRCm39) M2525T probably benign Het
Egflam T C 15: 7,261,176 (GRCm39) H786R probably damaging Het
Eml6 T C 11: 29,759,321 (GRCm39) T811A probably benign Het
Epha1 T C 6: 42,343,106 (GRCm39) T148A probably damaging Het
Fsip1 A C 2: 118,067,406 (GRCm39) S306A probably damaging Het
Gga2 A T 7: 121,607,661 (GRCm39) probably null Het
Gm10801 C CGTT 2: 98,494,152 (GRCm39) probably benign Het
Gm9837 T A 11: 53,360,885 (GRCm39) probably benign Het
Gnl2 A T 4: 124,940,058 (GRCm39) Q310L probably damaging Het
H2-M1 T C 17: 36,982,701 (GRCm39) D53G probably benign Het
Hmcn2 T A 2: 31,259,269 (GRCm39) D1036E probably damaging Het
Htr3a A T 9: 48,811,871 (GRCm39) D381E probably benign Het
Igdcc4 G A 9: 65,042,400 (GRCm39) G106R probably damaging Het
Igfbp2 A G 1: 72,864,078 (GRCm39) T114A probably damaging Het
Ints14 A G 9: 64,885,406 (GRCm39) probably null Het
Kcnt1 T A 2: 25,799,251 (GRCm39) M906K possibly damaging Het
Kif13a C T 13: 46,905,931 (GRCm39) V671M possibly damaging Het
Lars2 A G 9: 123,200,990 (GRCm39) Q18R probably benign Het
Mndal C T 1: 173,698,999 (GRCm39) C222Y possibly damaging Het
Msto1 C T 3: 88,812,781 (GRCm39) A1854V possibly damaging Het
Musk G A 4: 58,286,169 (GRCm39) G20R probably benign Het
Or6c215 G T 10: 129,638,013 (GRCm39) P127Q probably damaging Het
Oxct1 G T 15: 4,056,309 (GRCm39) S19I possibly damaging Het
Papss2 G A 19: 32,641,876 (GRCm39) G517D probably damaging Het
Parp14 T C 16: 35,676,918 (GRCm39) S1017G probably benign Het
Pde2a A G 7: 101,150,242 (GRCm39) Q227R probably benign Het
Pdlim5 G T 3: 142,020,183 (GRCm39) P92Q probably damaging Het
Pkd1l3 C T 8: 110,350,595 (GRCm39) T480I probably benign Het
Pla2g4c C T 7: 13,077,933 (GRCm39) T357I probably benign Het
Ppp3ca A G 3: 136,583,531 (GRCm39) R213G possibly damaging Het
Pramel18 G A 4: 101,767,189 (GRCm39) R146H probably benign Het
Prrc1 C T 18: 57,495,619 (GRCm39) S32L probably null Het
Prss47 C T 13: 65,197,116 (GRCm39) V207I probably benign Het
Prtg G A 9: 72,819,414 (GRCm39) V1136I possibly damaging Het
Psmb8 T A 17: 34,418,265 (GRCm39) M69K possibly damaging Het
Rb1 A T 14: 73,436,636 (GRCm39) D876E probably damaging Het
Rnasel T C 1: 153,637,867 (GRCm39) M680T probably damaging Het
Rnf111 G T 9: 70,383,692 (GRCm39) N80K possibly damaging Het
Senp1 C T 15: 97,946,074 (GRCm39) C557Y probably damaging Het
Serpina3a A T 12: 104,082,710 (GRCm39) Y161F probably damaging Het
Serpinb11 A T 1: 107,299,781 (GRCm39) probably null Het
Sgpl1 C A 10: 60,947,936 (GRCm39) probably null Het
Slc37a4 A G 9: 44,310,576 (GRCm39) Y60C probably damaging Het
Slc38a10 A G 11: 120,015,208 (GRCm39) S381P probably benign Het
Slc5a7 C T 17: 54,585,849 (GRCm39) V323I probably damaging Het
Slco1a7 T A 6: 141,668,818 (GRCm39) probably null Het
Smarcal1 A T 1: 72,655,716 (GRCm39) E665V possibly damaging Het
Specc1 C A 11: 62,023,164 (GRCm39) N736K probably damaging Het
Tas2r121 T C 6: 132,677,495 (GRCm39) Y159C probably benign Het
Tex54 A G 19: 8,718,462 (GRCm39) D68G probably benign Het
Trank1 A G 9: 111,196,268 (GRCm39) I1431V probably damaging Het
Ttll6 T C 11: 96,047,414 (GRCm39) V671A probably benign Het
Ttn A T 2: 76,748,931 (GRCm39) probably benign Het
Uimc1 T C 13: 55,188,389 (GRCm39) T557A possibly damaging Het
Uri1 C A 7: 37,661,974 (GRCm39) V446L probably benign Het
Vpreb1b C T 16: 17,798,771 (GRCm39) R86C probably damaging Het
Vwa8 A G 14: 79,331,184 (GRCm39) K1231E probably benign Het
Xcr1 G A 9: 123,684,854 (GRCm39) R303C probably damaging Het
Zfp687 T C 3: 94,915,049 (GRCm39) S1151G possibly damaging Het
Other mutations in Zfp619
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02157:Zfp619 APN 7 39,184,288 (GRCm39) missense probably damaging 1.00
IGL02221:Zfp619 APN 7 39,186,334 (GRCm39) missense probably benign 0.00
IGL02625:Zfp619 APN 7 39,183,609 (GRCm39) splice site probably benign
3-1:Zfp619 UTSW 7 39,186,189 (GRCm39) missense probably damaging 1.00
R0035:Zfp619 UTSW 7 39,186,706 (GRCm39) missense probably damaging 1.00
R0035:Zfp619 UTSW 7 39,186,706 (GRCm39) missense probably damaging 1.00
R0113:Zfp619 UTSW 7 39,187,183 (GRCm39) missense probably benign 0.01
R0377:Zfp619 UTSW 7 39,186,221 (GRCm39) nonsense probably null
R0614:Zfp619 UTSW 7 39,187,099 (GRCm39) missense possibly damaging 0.79
R0848:Zfp619 UTSW 7 39,185,983 (GRCm39) missense probably damaging 1.00
R1157:Zfp619 UTSW 7 39,186,282 (GRCm39) missense probably damaging 0.98
R2047:Zfp619 UTSW 7 39,187,062 (GRCm39) missense probably damaging 0.99
R2074:Zfp619 UTSW 7 39,184,185 (GRCm39) missense probably benign 0.00
R2419:Zfp619 UTSW 7 39,185,307 (GRCm39) missense possibly damaging 0.71
R2571:Zfp619 UTSW 7 39,186,595 (GRCm39) missense probably damaging 1.00
R2890:Zfp619 UTSW 7 39,184,393 (GRCm39) missense probably benign 0.00
R3814:Zfp619 UTSW 7 39,184,823 (GRCm39) missense probably benign 0.01
R4003:Zfp619 UTSW 7 39,186,730 (GRCm39) missense possibly damaging 0.91
R4059:Zfp619 UTSW 7 39,184,823 (GRCm39) missense probably benign 0.01
R4503:Zfp619 UTSW 7 39,186,280 (GRCm39) missense probably damaging 1.00
R4664:Zfp619 UTSW 7 39,183,559 (GRCm39) missense probably benign 0.00
R4696:Zfp619 UTSW 7 39,186,412 (GRCm39) missense probably benign 0.00
R4895:Zfp619 UTSW 7 39,187,396 (GRCm39) missense possibly damaging 0.68
R4975:Zfp619 UTSW 7 39,186,504 (GRCm39) missense possibly damaging 0.90
R4977:Zfp619 UTSW 7 39,186,811 (GRCm39) missense probably damaging 1.00
R5049:Zfp619 UTSW 7 39,184,938 (GRCm39) missense probably benign 0.02
R5240:Zfp619 UTSW 7 39,186,642 (GRCm39) missense possibly damaging 0.68
R5468:Zfp619 UTSW 7 39,185,152 (GRCm39) missense unknown
R5546:Zfp619 UTSW 7 39,184,577 (GRCm39) missense probably benign 0.01
R5572:Zfp619 UTSW 7 39,184,663 (GRCm39) missense probably benign 0.01
R6106:Zfp619 UTSW 7 39,184,558 (GRCm39) missense probably benign 0.01
R6329:Zfp619 UTSW 7 39,186,969 (GRCm39) missense probably damaging 1.00
R6354:Zfp619 UTSW 7 39,184,243 (GRCm39) missense probably benign 0.02
R6490:Zfp619 UTSW 7 39,183,586 (GRCm39) missense probably benign 0.00
R6560:Zfp619 UTSW 7 39,186,954 (GRCm39) missense probably damaging 1.00
R6713:Zfp619 UTSW 7 39,187,322 (GRCm39) missense probably damaging 0.99
R7011:Zfp619 UTSW 7 39,187,186 (GRCm39) missense probably damaging 1.00
R7022:Zfp619 UTSW 7 39,184,387 (GRCm39) missense probably benign 0.00
R7046:Zfp619 UTSW 7 39,186,787 (GRCm39) missense possibly damaging 0.95
R7206:Zfp619 UTSW 7 39,184,824 (GRCm39) missense probably benign 0.00
R7780:Zfp619 UTSW 7 39,184,432 (GRCm39) missense possibly damaging 0.68
R7787:Zfp619 UTSW 7 39,186,226 (GRCm39) missense possibly damaging 0.91
R8001:Zfp619 UTSW 7 39,184,645 (GRCm39) missense probably benign 0.29
R8559:Zfp619 UTSW 7 39,186,559 (GRCm39) missense probably benign 0.31
R8775:Zfp619 UTSW 7 39,184,639 (GRCm39) missense possibly damaging 0.75
R8775-TAIL:Zfp619 UTSW 7 39,184,639 (GRCm39) missense possibly damaging 0.75
R9014:Zfp619 UTSW 7 39,187,246 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- CAGTAACCTGCGGATACACG -3'
(R):5'- CATAATGCTTTTCTCTAGCGTGGG -3'

Sequencing Primer
(F):5'- GTGTGGCAAAACCCTCAGTTC -3'
(R):5'- GGCTCTTTCGTGTAGCTGAAG -3'
Posted On 2018-05-04